tetrazoles azides azodicarboxylic acid derivatives iso

1

Tetrazoles Triazoles Azides Azodicarboxylic acid derivatives Iso

cyanates Nitriles Miscellaneous Generic APIs Reagents for custom

synthesis Tetrazoles Triazoles Azides Azodicarboxylic acid deriva

tives Isocyanates Nitriles Miscellaneous Generic APIs Reagents

for custom synthesis Tetrazoles Triazoles Azides Azodicarboxy

lic acid derivatives Isocyanates Nitriles Miscellaneous Generic

APIs Reagents for custom synthesis Tetrazoles Triazoles Azides

Azodicarboxylic acid derivatives Isocyanates Nitriles Miscellaneous

Generic APIs Reagents for custom synthesis Tetrazoles Triazoles

Azides Azodicarboxylic acid derivatives Isocyanates Nitriles

Miscellaneous Generic APIs Reagents for custom synthesis Tetra

zoles Triazoles Azides Azodicarboxylic acid derivatives Isocyanates

Nitriles Miscellaneous Generic APIs Reagents for custom synthe

sis Tetrazoles Triazoles Azides Azodicarboxylic acid derivatives

Isocyanates Nitriles Miscellaneous Generic APIs Reagents for cus

tom synthesis Tetrazoles Triazoles Azides Azodicarboxylic acid De

rivatives Isocyanates Nitriles Miscellaneous Generic APIs Reagents

for custom synthesis Tetrazoles Triazoles Azides Azodicarboxylic

acid derivatives Isocyanates Nitriles Miscellaneous Generic APIs

Reagents for custom synthesis Tetrazoles Triazoles Azides Azodi

carboxylic acid derivatives Isocyanates Nitriles Miscellaneous Ge

nerics APIs Reagents for custom synthesis Tetrazoles Triazoles

Azides Azodicarboxylic acid derivatives Isocyanates Nitriles Mi

scellaneous Generic APIs Reagents for custom synthesis Tetrazoles

Triazoles Azides Azodicarboxylic acid derivatives Isocyanates Nitri

les Miscellaneous Generic APIs Reagents for custom synthesis

Tetrazoles Triazoles Azides Azodicarboxylic acid derivatives Iso

cyanates Nitriles Miscellaneous Generic APIs Reagents for custom

Table of content

Introduction 3

Quality and regulatory management 4

Products

Tetrazoles 5

Triazoles 8

Azides 9

Azodicarboxylic acid derivatives 11

Isocyanates 12

Nitriles 13

Miscellaneous 14

Generic APIs 15

Reagents for custom synthesis 16

CAS number index 17

Alphabetical index 18

Abbreviation index 19

3

Novasep’s product portfolio of specialty

chemicals and reagents is based on more than

140 years’ experience in organic synthesis.

It serves all fine chemical industries, including

applications such as polymer additives

& catalyzers, electronic chemicals, and reagents

for the life science industries. With our certified

and approved production sites, we ensure

reliable and sustainable manufacturing and

guarantee your supply chain.

Manufacturing services. In addition to

the catalog products, Novasep also offers

comprehensive services in process development,

contract manufacturing, and purification

technologies. In addition to standard organic

synthesis, we provide solutions for highly

energetic intermediates which are produced

in-situ and used directly in synthesis steps to

manufacture your specific product at our site

(p 16). One of our core areas of expertise is

the development of chemical synthesis

and the reliable transfer of processes into our

production plants for piloting and production.

We provide customized solutions for your

products from kilogram- to hundred-ton scale.

Novasep combines a broad range of chemical

technologies, including hazardous chemistry,

with complementary expertise, such as

advanced purification technologies, analytical

method development, raw material sourcing,

initial price indications, safety assessments,

Reach support, etc.

Fine chemicals: products and manufacturing services

4

Quality and regulatory management

Our quality management system is based on

the international quality standard ISO 9001.

Every manufacturing site has a quality system

in place ensuring that all products are of the

quality required for their intended use and that

quality management systems are maintained.

A dedicated regulatory team is in charge of

the submission and maintenance of regulatory

filings for various countries and regulatory bodies

including the US EPA, European ECHA (REACH)

and Japan CSCL. We file and maintain our

own CEPs.

Optionally and upon customer request, we

also offer products in full compliance with current

Good Manufacturing Practices (cGMP) or ICH

guidelines and we maintain our own ASMFs and

DMFs with different authorities worldwide (USA,

Europe, Canada, Japan, Korea, etc.) for generic

APIs. We also have accreditation to handle food

grade material or GMOs within our facilities.

Our teams are dedicated and conduct

continuous upgrades to ensure that all Novasep

plants meet the highest level of compliance with

ever stricter regulatory standards.

Environmental management. We act to uphold

the principles of responsible care and sustainable

development to safeguard employees, customers,

stockholders, society and the environment.

The Leverkusen site, our main production facility

for fine chemicals, is ISO 14001 certified,

demonstrating its compliance with environmental

management international norms.

Our full quality and inspection track record is available upon request. Contact us for more details or to assess you regulatory needs: [email protected]

CERTIFICATE IQNet and

DQS GmbH Deutsche Gesellschaft zur Zertifizierung von Managementsystemen

hereby certify that the company

Dynamit Nobel GmbH Explosivstoff- und Systemtechnik

Kalkstraße 218 51377 Leverkusen

Germany

has implemented and maintains a Quality and Environmental Management System.

Scope: Custom syntheses of life-science

Through an audit, documented in a report, it was verified that the management system fulfills the requirements of the following standard:

ISO 9001 : 2008 ISO 14001 : 2004 + Cor 1 : 2009

Date of certification 2012-06-05 Valid until 2015-06-04

Registration Number: DE-002074 QM08 UM

Michael Drechsel

Managing Director of DQS GmbH President of IQNet

IQNet Partners*:

AENOR Spain AFNOR Certification France AIB-Vinçotte International Belgium ANCE Mexico APCER Portugal CCC Cyprus CISQ Italy CQC China CQM China CQS Czech Republic Cro Cert Croatia DQS Holding GmbH Germany DS Denmark

ELOT Greece FCAV Brazil FONDONORMA Venezuela ICONTEC Colombia IMNC Mexico INNORPI Tunisia Inspecta Certification Finland IRAM Argentina JQA Japan KFQ Korea MSZT Hungary Nemko AS Norway NSAI Ireland

PCBC Poland Quality Austria Austria RR Russia SII Israel SIQ Slovenia SIRIM QAS International Malaysia SQS Switzerland SRAC Romania TEST St Petersburg Russia TSE Turkey YUQS Serbia

IQNet is represented in the USA by: AFNOR Certification, CISQ, DQS Holding GmbH and NSAI Inc.

* The list of IQNet partners is valid at the time of issue of this certificate. Updated information is available under www.iqnet-certification.com

5

Tetrazoles

Molecular formula: C2H4N4

CAS number: [4076-36-2]

5-METHYLTETRAZOLE / 5-MET

Molecular formula: CH2N4

CAS number: [288-94-8]

(solution in MeCN or H2O)

1-H-TETRAZOLE / 1H-T

Molecular formula: C7H5ClN4

CAS number: [50907-46-5]

5-(2-CHLOROPHENYL)-TETRAZOLE / 2-CPT

Molecular formula: C7H5BrN4

CAS number: [73096-42-1]

5-(2-BROMOPHENYL)-TETRAZOLE / 2-BPT

Molecular formula: C4H5N4O2Na

CAS number: [96107-94-7]

TETRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER SODIUM SALT / TCAE-Na

Molecular formula: C3H4N4O2

CAS number: [21732-17-2]

TETRAZOLE-1-ACETIC ACID / TAA-1

Tetr

azo

les


CAS number: [131183-10-3]

5-AMINOMETHYL- 2-METHYLTETRAZOLE / MAMT


CAS number: [31602-63-8]

5-AMINOMETHYLTETRAZOLE / 5-AMET

6

Tetrazoles

Molecular formula: C9H8N4O

CAS number: [74815-22-8]

4-(5-TETRAZOLYL)-BENZALDEHYDE / TBA

Molecular formula: CH3N5.H2O

CAS number: [15454-54-3]

5-AMINOTETRAZOLE MONOHYDRATE / 5-AT

Molecular formula: C7H6N4OS

CAS number: [52431-78-4]

1-(4-HYDROXYPHENYL)- 5-MERCAPTOTETRAZOLE / HPMT

5-MERCAPTOTETRAZOL-1-ACETIC ACID MONOSIDIUM SALT / 5-MTAA-Na

5-MERCAPTO-1-PHENYLTETRAZOLE / PMT

Molecular formula: C3H6N4S

CAS number: [15217-53-5]

1-ETHYL-5-MERCAPTOTETRAZOLE / EMT

Tetr

azo

les

Molecular formula: C2H3N4SNa

CAS number: [51138-06-8]

5-MERCAPTO-1-METHYLTETRAZOLE MONOSODIUM SALT / MMT-Na


CAS number: [13183-79-4]

5-MERCAPTO- 1-METHYLTETRAZOLE / MMT



Molecular formula:

CAS number: [113221-74-2]

C3H3N4NaO2S

7

Tetrazoles

Tetr

azo

les


CAS number: [69048-98-2]

1-ETHYLTETRAZOLINONE / 1-ET

8

Triazoles Tr

iazo

les


CAS number: [16681-70-2]

1,2,3-TRIAZOLE-4-CARBOXYLIC ACID / TCS



1,2,3-TRIAZOLE / 1,2,3-T



1,2,4-TRIAZOLIN-3-ONE / TO


CAS number: [84406-63-3]

5-NITRO-1,2,3-TRIAZOLE / 4-NT

9

Azides

Azi

de

s



TETRABUTYLAMMONIUM AZIDE / TBAZ

Molecular formula: NaN3

CAS number: [26628-22-8]

SODIUM AZIDE / NaN3


CAS number: [7438-05-3]

OCTYL AZIDE / OAZ

Molecular formula: C12H10N3O3P

CAS number: [26386-88-9]

DIPHENYLPHOSPHORYL AZIDE / DPPA

Molecular formula: C8H8N4O3S

CAS number: [2158-14-7]

4-ACETAMIDOBENZENESULFONYL AZIDE / ABSA


CAS number: [36982-84-0]

2,4,6-TRIISOPROPYLBENZENE SULFONYL AZIDE / TISA



4-TOLUENESULFONYL AZIDE / p-TSA

Molecular formula: C3H9N3Si

CAS number: [4648-54-8]

TRIMETHYLSILYL AZIDE / TMSA

10

AzidesA

zid

es



AZIDOACETIC ACID ETHYL ESTER / AEE

11


CAS number: [2446-83-5]

DIISOPROPYLAZODICARBOXYLATE / DIAD

O NN O

O

O

O NN O

O

O

N NN N

O

O

2.1

2.2

2.3


CAS number: [2449-05-0]

DIBENZYLAZODICARBOXYLATE / DBAD

O NN O

O

O

O NN O

O

O

N NN N

O

O

2.1

2.2

2.3


CAS number: [10465-81-3]

AZODICARBONYLDIPIPERIDIDE / ADDP

O NN O

O

O

O NN O

O

O

N NN N

O

O

2.1

2.2

2.3

Azidocarboxylic acid derivatives

Azi

do

ca

rbo

xyli

c a

cid

de

riva

tive

s

12

Molecular formula: C3H5NO


ETHYL ISOCYANATE / EIC



PROPYL ISOCYANATE / PIC

Isocyanates Is

oc

yan

ate

s


CAS number: [3158-26-7]

OCTYL ISOCYANATE / OIC


CAS number: [1795-48-8]

ISOPROPYL ISOCYANATE / IPIC

13

Nitriles

Nit

rile

s


CAS number: [5346-53-2]

5-AMINO-4-CYANO-1- (2-HYDROXYETHYL)PYRAZOLE / ACHEP


CAS number: [2407-68-3]

3-DIMETHYLAMINOACRYLNITRILE / DAPN

Molecular formula: C7H2ClN3O4

CAS number: [1930-72-9]

4-CHLORO-3,5- DINITROBENZONITRILE / CDBN

14

TRICYCLOHEXYLPHOSPHONIUM TRIFLATE / PCy3T

MiscellaneousM

isc

ell

an

eo

us

Molecular formula: C18H17NO3

CAS number: [27737-55-9]

ETHYL-4-(BENZYLOXY) INDOLE-2-CARBOXYLATE / BOICE

Molecular formula: C13H18BrNO2

CAS number: [120157-97-3]

TERT-BUTYL-[2-(4-BROMOPHENYL)-ETHYL]-CARBAMATE / BocBBPEA

Molecular formula: C2H6MgO2


MAGNESIUM METHYLATE / MAME

Molecular formula: C16H30MgO2

CAS number: [15602-15-0]

MAGNESIUM 2-ETHYLHEXANOATE

Molecular formula: C4H10N2Si

CAS number: [18107-18-1]

TRIMETHYLSILYLDIAZOMETHANE /TMSDAM

4-TOLUENESULFONYLHYDRAZIDE / P-TSH


CAS number: [1576-35-8]

STRONTIUM DICHLOROPHTHALATE / STRODIP

Molecular formula: C8H2Cl2O4Sr

CAS number: [94248-20-1]

Molecular formula: C19H34F3O3PS

CAS number: [952649-12-6]

15

Miscellaneous

Mis

ce

lla

ne

ou

s

Molecular formula: C10H10Cl2Ti

CAS number: [1271-19-8]

DICYCLOPENTADIENYLTITANIUM DICHLORIDE / DCPTC

Molecular formula: C6H5ClMg


PHENYLMAGNESIUM CHLORIDE / PMC

Molecular formula: C2H6ClOP

CAS number: [1111-92-8]

DIMETHYLPHOSPHINIC CHLORIDE / DPC

Generic APIs

For more information,

contact us: [email protected]

Novasep also offers a range of generics and pharma building blocks including:

NITROGLYCERIN

PACLITAXEL

Ge

ne

ric

AP

Is

16

Reagents for custom synthesisR

eag

ents

fo

r cu

sto

m s

ynth

esis

Molecular formula: C12H27N3Sn

CAS number: [17846-68-3]

TRIBUTYLTIN AZIDE / TBSnA

Molecular formula: CH2N2


DIAZOMETHANE / DAM

Molecular formula: C5H6


CYCLOPENTADIENE / Cp



ETHYLDIAZOACETATE / EDA

Molecular formula: B2H6

CAS number: [19287-45-7]

DIBORANE / DB



ETHOXYMETHYLENE MALONODINITRILE / EMMD

For productions involving particularly highly reactive starting materials that cannot be isolated,

Novasep offers custom synthesis services. In such cases, we produce the reagent in-situ and carry

out the whole synthesis for you. Here are examples of reagents offered for custom synthesis:

For more information and other custom synthesis projects,

contact us: [email protected]

17

[86-93-1] 5-Mercapto-1-phenyltetrazole 6

[100-59-4] Phenylmagnesium chloride 15

[109-88-6] Magnesium methylate 14

[109-90-0] Ethyl isocyanate 12

[110-78-1] Propyl isocyanate 12

[288-36-8] 1,2,3-Triazole 8

[288-94-8] 1-H-Tetrazole 5

[334-88-3] Diazomethane 16

[542-92-7] Cyclopentadiene 16

[623-73-4] Ethyldiazoacetate 16

[637-81-0] Azidoacetic acid ethyl ester 10

[930-33-6] 1,2,4-Triazolin-3-one 8

[941-55-9] 4-Toluenesulfonyl azide 9

[993-22-6] Tetrabutylammonium azide 9

[1111-92-8] Dimethylphosphinic chloride 15

[1271-19-8] Dicyclopentadienyltitanium dichloride 15

[1576-35-8] 4-Toluenesulfonylhydrazide 14

[1795-48-8] Isopropyl isocyanate 12

[1930-72-9] 4-Chloro-3,5-dinitrobenzonitrile 13

[2158-14-7] 4-Acetamidobenzenesulfonyl azide 9

[2407-68-3] 3-Dimethylaminoacrylnitrile 13

[2446-83-5] Diisopropylazodicarboxylate 11

[2449-05-0] Dibenzylazodicarboxylate 11

[3158-26-7] Octyl isocyanate 12

[4076-36-2] 5-Methyltetrazole 5

[4648-54-8] Trimethylsilyl azide 9

[5346-53-2] 5-Amino-4-cyano-1-(2-hydroxyethyl)pyrazole 13

[7438-05-3] Octyl azide 9

[10465-81-3] Azodicarbonyldipiperidide 11

CAS Name Page CAS Name Page

[13183-79-4] 5-Mercapto-1-methyltetrazole 6

[15217-53-5] 1-Ethyl-5-mercaptotetrazole 6

[15454-54-3] 5-Aminotetrazole monohydrate 6

[15602-15-0] Magnesium 2-ethylhexanoate 14

[16681-70-2] 1,2,3-triazole-4-carboxylic acid 8

[17846-68-3] Tributyltin azide 16

[18107-18-1] Trimethylsilyldiazomethane 14

[21732-17-2] Tetrazole-1-acetic acid 5

[26386-88-9] Diphenylphosphoryl azide 9

[26628-22-8] Sodium azide 9

[27737-55-9] Ethyl4-(benzyloxy)indole-2-carboxylate 14

[31602-63-8] 5-Aminomethyltetrazole 5

[36982-84-0] 2,4,6-Triisopropylbenzenesulfonyl azide 9

[50907-46-5] 5-(2-Chlorophenyl)-tetrazole 5

[51138-06-8] 5-Mercapto-1-methyltetrazole monosodium salt 6

[52431-78-4] 1-(4-Hydroxyphenyl)-5-mercaptotetrazole 6

[69048-98-2] 1-Ethyltetrazolinone 7

[73096-42-1] 5-(2-Bromophenyl)-tetrazole 5

[74815-22-8] 4-(5-Tetrazolyl)-benzaldehyde 6

[84406-63-3] 5-Nitro-1,2,3-triazole 8

[94248-20-1] Strontium dichlorophtalate 14

[96107-94-7] Tetrazole-5-carboxylic acid ethyl ester sodium salt 5

[113221-74-2] 5-Mercaptotetrazol-1-acetic acid monosidium salt 6

[120157-97-3] tert-Butyl-[2-(4-bromophenyl)-ethyl]-carbamate 14

[131183-10-3] 5-Aminomethyl-2-methyltetrazole 5

[952649-12-6] Tricyclohexylphosphonium triflate 15

[123-06-8] Ethoxymethylene malonodinitrile 16

[19287-45-7] Diborane 16

CAS number index

18

4-Acetamidobenzenesulfonyl azide 9

5-Amino-4-cyano-1-(2-hydroxyethyl)pyrazole 13

5-Aminomethyl-2-methyltetrazole 5

5-Aminomethyltetrazole 5

5-Aminotetrazole monohydrate 6

Azidoacetic acid ethyl ester 10

Azodicarbonyldipiperidide 11

5-(2-Bromophenyl)-tetrazole 5

4-Chloro-3,5-dinitrobenzonitrile 13

5-(2-Chlorophenyl)-tetrazole 5

Cyclopentadiene 16

Diazomethane 16

Dibenzylazodicarboxylate 11

Diborane 16

Dicyclopentadienyltitanium dichloride 15

Diisopropylazodicarboxylate 11

3-Dimethylaminoacrylnitrile 13

Dimethylphosphinic chloride 15

Diphenylphosphoryl azide 9

Ethoxymethylene malonodinitrile 16

Ethyldiazoacetate 16

Ethyl isocyanate 12

Ethyl4-(benzyloxy)indole-2-carboxylate 14

1-Ethyl-5-mercaptotetrazole 6

1-Ethyltetrazolinone 7

1-(4-Hydroxyphenyl)-5-mercaptotetrazole 6

Isopropyl isocyanate 12

Magnesium 2-ethylhexanoate 14

Magnesium methylate 14

Name Page Name Page

5-Mercapto-1-methyltetrazole 6

5-Mercapto-1-methyltetrazole monosodium salt 6

5-Mercapto-1-phenyltetrazole 6

5-Mercaptotetrazol-1-acetic acid monosidium salt 6

5-Methyltetrazole 5

5-Nitro-1,2,3-triazole 8

Octyl azide 9

Octyl isocyanate 12

Phenylmagnesium chloride 15

Propyl isocyanate 12

Sodium azide 9

Strontium dichlorophthalate 14

tert-Butyl-[2-(4-bromophenyl)-ethyl]-carbamate 14

Tetrabutylammonium azide 9

1-H-Tetrazole 5

Tetrazole-1-acetic acid 5

Tetrazole-5-carboxylic acid ethyl ester sodium salt 5

4-(5-Tetrazolyl)-benzaldehyde 6

4-Toluenesulfonyl azide 9

4-Toluenesulfonylhydrazide 14

1,2,3-Triazole 8

1,2,3-triazole-4-carboxylic acid 8

1,2,4-Triazolin-3-one 8

Tributyltin azide 16

Tricyclohexylphosphonium triflate 15

2,4,6-Triisopropylbenzenesulfonyl azide 9

Trimethylsilyl azide 9

Trimethylsilyldiazomethane 14

Alphabetical index

19

1,2,3-T 1,2,3-Triazole 8

1-ET 1-Ethyltetrazolinone 7

1-HT 1-H-Tetrazole 5

2-BPT 5-(2-Bromophenyl)-tetrazole 5

2-CPT 5-(2-Chlorophenyl)-tetrazole 5

4-NT 5-Nitro-1,2,3-triazole 8

5-AMET 5-Aminomethyltetrazole 5

5-AT 5-Aminotetrazole monohydrate 6

5-MET 5-Methyltetrazole 5

5-MTAA-Na 5-Mercaptotetrazol-1-acetic acid monosidium salt 6

ABSA 4-Acetamidobenzenesulfonyl azide 9

ACHEP 5-Amino-4-cyano-1-(2-hydroxyethyl)pyrazole 13

ADDP Azodicarbonyldipiperidide 11

AEE Azidoacetic acid ethyl ester 10

BocBBPEA tert-Butyl-[2-(4-bromophenyl)-ethyl]-carbamate 14

BOICE Ethyl4-(benzyloxy)indole-2-carboxylate 14

CDBN 4-Chloro-3,5-dinitrobenzonitrile 13

Cp Cyclopentadiene 16

DAM Diazomethane 16

DAPN 3-Dimethylaminoacrylnitrile 13

DB Diborane 16

DBAD Dibenzylazodicarboxylate 11

DCPTC Dicyclopentadienyltitanium dichloride 15

DIAD Diisopropylazodicarboxylate 11

DPC Dimethylphosphinic chloride 15

DPPA Diphenylphosphoryl azide 9

EDA Ethyl diazoacetate 16

EIC Ethyl isocyanate 12

Abbreviation Name Page Abbreviation Name Page

EMT 1-Ethyl-5-mercaptotetrazole 6

EMMD Ethoxymethylene malonodinitrile 16

HPMT 1-(4-Hydroxyphenyl)-5-mercaptotetrazole 6

IPIC Isopropyl isocyanate 12

MAME Magnesium methylate 14

MAMT 5-Aminomethyl-2-methyltetrazole 5

MMT 5-Mercapto-1-methyltetrazole 6

MMT-Na 5-Mercapto-1-methyltetrazole monosodium salt 6

OAZ Octyl azide 9

OIC Octyl isocyanate 12

PCy3T Tricyclohexylphosphonium triflate 15

PIC Propyl isocyanate 12

PMC Phenylmagnesium chloride 15

PMT 5-Mercapto-1-phenyltetrazole 6

p-TSA 4-Toluenesulfonyl azide 9

p-TSH 4-Toluenesulfonylhydrazide 14

STRODIP Strontium dichlorophthalate 14

TAA-1 Tetrazole-1-acetic acid 5

TBA 4-(5-Tetrazolyl)-benzaldehyde 6

TBAZ Tetrabutylammonium azide 9

TBSnA Tributyltin azide 16

TCAE-Na Tetrazole-5-carboxylic acid ethyl ester sodium salt 5

TCS 1,2,3-triazole-4-carboxylic acid 8

TISA 2,4,6-Triisopropylbenzenesulfonyl azide 9

TMSA Trimethylsilyl azide 9

TMSDAM Trimethylsilyldiazomethane 14

TO 1,2,4-Triazolin-3-one 8

Abbreviation indexAlphabetical index

Services and technologies for the fine chemicals and life sciences industries

[email protected] +49 214 357 491

ww

w.b

aill

y-c

rea

tion

s.fr

ww

w.b

aill

y-c

rea

tion

s.fr

tetrazoles azides azodicarboxylic acid derivatives iso

Documents