temperature controlled packaging: considerationspackaging ... · temperature controlled packaging:...
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Temperature Controlled Packaging: ConsiderationsPackaging: Considerations You Might Not Know
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Summary
Discussion PointsTemperature spread based on refrigerant coverageConditioning – Cold Shock and Refrigerant Bench TimesProduct Mass and TemperatureOpening up Product Temperature RangeAmbient Profile and CostUniversal vs Seasonal SolutionsUniversal vs Seasonal SolutionsShipping a Box on its SideCost versus Insulation ChoiceCost Versus PCM ChoiceCost Versus PCM Choice
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DEFINE THE PROBLEMBEST PRACTICES: Quality by Design (QbD)
DEFINE THE PROBLEM
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Define the Problem
• Who should be included? What business functions?• Engineering/ Packaging• Procurement• Regulatory• Logistics• Operations/ Manufacturing• Quality/ Validation
Establish a team • Quality/ Validation
• Marketing• End Customer?• Other?
a teamOt e
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Factors For Team to Consider• Duration, Temperature, Payload, Ambient ProfilesPerformance Needs• Reference Documents, Available ExcursionsRegulatory Needs• Packout Configuration: Universal / Seasonal, End User Needs • Ease of use, # of components, weight, pack-out time, dimensional, etc.End User Needs• Package Cost, freight cost, physical weight vs dimensional weightPricing (value) need• ErgonomicsSafety
Q lit • Tolerances / testing requirementsQuality • Sustainability, shipping lanes, return-reuse, conditioning, data monitoring, etc.Other
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Factors to Consider Distinguishing Between Various Factors Cost vs Quality
Packaging Cost vs Shipping Costs
Costs vs Ergonomics
SustainabilitySustainability
Use of Excursion Data vs Design Complexity
Ease of Use vs Cost
Single use vs Return/Reuse
Different Stakeholders / Different Views
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TEMPERATURE SPREAD BASEDTEMPERATURE SPREAD BASED ON REFRIGERANT COVERAGE
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Refrigerant Configurationsg g
6 sided 4 sided 2 sided
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Product probe locations
Top Center
Top Corner
Midside
Center
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Top Center Probe
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Top Corner Probe
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Center Probe
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Midside Probe
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Product Temperatures in Specification
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EF6040 pallet, product probe temperatures by location
Probe 28Bottom Corner
Probe 21Top Corner
Probe 24Mid Center
Probe 25Mid Center
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CONDITIONING – COLD SHOCKCONDITIONING COLD SHOCK AND REFRIGERANT BENCH TIMES
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Preventing Cold ShockCold Shock is the rapid decline in product temperature during the
initial packout phase, when frozen refrigerant comes into contact with
the product
• How to prevent cold shock
• Refrigerated gels or bricksRefrigerated gels or bricks
• Buffer pads e.g. corrugate, EPS, bubble wrap
• Bench time for frozen refrigerantsg
• PCMs with phase temperatures above cold shock temperatures
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Using PCMs to prevent Cold ShockPCM vs. water-based gel packPCM phases at 4°C keeps product >2°CWater-based gel phases at 0°C product drops below 2°C
Without PCMCold Shock / Product Frozen
With PCMPCM keeps product >2°C
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30
40
20
30
40
product >2 C
0
10
20
Tem
p °C
0
10
20
Tem
p °C
-20
-10
0 10 20 29 39 48 58 68 77 87 96
Time (hrs)Refrigerated Gel Frozen Gel Product Ambient
-20
-10
0 10 20 29 39 48 58 68 77 87 96
Time (hrs)
4°C PCM Frozen Gel Product Ambient Refrigerated Gel Frozen Gel Product Ambient4 C PCM Frozen Gel Product Ambient
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Hi h R f i t i b h ti fEffect of Bench Time on Refrigerants
Higher Refrigerant mass requires more bench time for warm upBench time at room temperature can help reduce cold shock
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PRODUCT MASS &PRODUCT MASS & TEMPERATURE
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Impact of Mass and Densityy The rate of change of thermal energy per unit volume To achieve the same change in temperature a greater mass (density) requires a
greater rate of change of thermal energy.
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Probe Locations and Methodology Product packaging and thermal mass
Small thermal mass will make product temperatures much more responsive to ambient di i
gy
conditions
75 ml Bottle5 ml vial with 1 ml to 3 ml fill
10 ml bottle
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Product Load Selection Thermal considerations for Product Load selection Thermal Mass or Capacitance
Effect of Conduction and Convection
Product Loads for TestingProduct Loads for Testing Bracketing Product Mass for Testing
Minimum Load
Maximum Load
Empty container
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Product Load Selection Thermal Mass or Capacitance Defined as the product of mass and specific heat ρ * Cp
Determines the rate of product thermal response to changes in ambient conditions
Product with Low Thermal Capacitance will respond more quickly to cold q yshock and change in ambient conditions
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Product Load SelectionEffect of Conduction & Convection
Top Ambient = 5 C
Effect of Conduction & Convection
Max Product Temperature= 17 CCorepack filled with DunnageSide Ambient = 22 C
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Max Product Temperature = 11 CCorepack filled with Air
Convection Currents
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Product Load Selection Difference between Maximum, Minimum and Empty Product Loads
Winter Ambient indicates that Empty Load Probe will have the lowest or
worst case temperatureworst case temperature.
Empty Load Probe
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Product Load Selection Difference between Maximum, Minimum and Empty Product Loads
Summer Ambient indicates that Empty Load Probe will have the highest or
worst case temperatureworst case temperature.
Empty Load Probe
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OPENING UP PRODUCTOPENING UP PRODUCT TEMPERATURE RANGE
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Effect of Product Temperature Range CRT Case Study
The narrower the product temperature criteria the more challenging is the thermal design more refrigerants more insulation
p g
thermal design, more refrigerants, more insulation
20°C - 25°C 15°C - 30°C 5°C - 30°C
24 lbs of Refrigerant 18 lbs of Refrigerant 12 lbs of Refrigerant
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Effect of Product Temperature Rangeg Refrigerated Case Study
61-Hr, 2-8°C 98-Hr, 2-15°C76-Hr, 2-10°C
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AMBIENT PROFILE AND COSTAMBIENT PROFILE AND COST
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Effect of Ambient Profiles on Package Designg g
An more extreme Ambient Profile will have the following impact on TAP design:TAP design:More refrigerant weight
More components
Higher insulation e.g. thickness, R-value
Higher Cost
L t i di i Larger container dimensions
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Effect of Ambient Profiles on Package Designg g
ISC Gold
ISC Silver
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Effect of Ambient Profiles on Package Designg g
ISC Gold profile vs. ISC Silver profile, 48 hours, 2°C to 8°C, Universal
Ambient Profile: ISC Silver Universal ISC Gold UniversalPayload Volume (L): 16.4 16.4
Shipper O.D. Volume (L): 109.7 141.2
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Number of Components: 11 15Weight (lbs): 31.6 40.5
Dimensional Weight (lbs): 40 52
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UNIVERSAL VS SEASONALUNIVERSAL VS SEASONAL SOLUTIONS
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Profile Bracketingg Packout Configuration Seasonal – One Ambient Profile
Simpler Packout
Lower Cost
Different packouts for each season
Possibility of Product Excursions if Seasonal Designs are not transitioned at the right time
Universal – One Summer and One Winter Ambient Profile
One packout for all seasons
Higher Cost
Product Temperature Stability year round
Bracketed – Upper and Lower Ambient Profiles for Each SeasonBracketed Upper and Lower Ambient Profiles for Each Season
Compromise between Seasonal and Universal
Better product stability due to transition between seasons
Different packouts for each seasonDifferent packouts for each season
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Profile Bracketing
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Profile Bracketing
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Profile Bracketing
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Profile Bracketing
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Profile Bracketing
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Profile Bracketing: Total Cost of Ownership
2-8C / 96-Hours Stratta™ , Universal Stratta, Summer Stratta, Winter
System Weight 30 lbs 24 lbs 22 lbs
I t ti l Di Wt 31 lb 27 lb 27 lbInternational Dim Wt. 31 lbs 27 lbs 27 lbs
System Price $81 $54 $54
Shipping Cost $62 $54 $58
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Total Cost $143 $108 $106
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SHIPPING A BOX ON ITS SIDESHIPPING A BOX ON ITS SIDE
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Impact of Orientation Experience with a small parcel shipping system qualified in the upright
orientation only
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Impact of Orientation
Carrier A “Place shipping labels on the package’s largest surface. While we cannot
ensure compliance with markings such as “Up” arrows or “This End Up,” properly placing the shipping label increases your chance for the preferred orientation.”orientation.
Carrier B “Note: Carrier B does not provide special handling for packages withNote: Carrier B does not provide special handling for packages with
"Fragile", package orientation (e.g., "UP" arrows or "This End Up" markings), or any other similar such markings.”
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Impact of Orientation
At local hub At main sort facilityUpright temporarily
Upright - In container for air transport
Upright temporarily
Upright on truck for final delivery
Loaded on delivery truck
final delivery
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Case Study 1y EPS Shipper with six sided frozen water based Polar Packs
LID
SHIPPER
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Case Study 1y
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Case Study 1y
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Case Study 2y EPS shipper with two sided coverage
Utilizes both refrigerated and frozen Polar Packs
COLLAR
BASE
COLLAR
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Case Study 2y
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Case Study 2y
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COST VS INSULATION CHOICECOST VS INSULATION CHOICE
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Insulation Type Comparison
P k
Example: EPS vs PUR vs VIP
Package Size
Total Cost WeightR-
Value
Total Cost Can Be
Reduced
Container C tCost
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Insulation Type ComparisonExample: EPS vs PUR vs VIP
32 kgs18 kgs18 kgs 9 kgs
EPS PACKAGING Size PUR PACKAGING Size VIP PACKAGING Size
5” PUR = 1” VIP
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Total Cost of Ownership: Case Study
2-8C / 96-Hours, Univ. PUR VIP Stratta™ (EPS/VIP)
System Weight 38 lbs 32 lbs 30 lbs
International Dim Wt. 55 lbs 24 lbs 31 lbs
System Price $92 $118 $81
Shipping Cost $110 $64 $62
Total Cost $202 $182 $143
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Total Cost $202 $182 $143
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COST VS PCM TYPECOST VS PCM TYPE
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PCM Type Comparison
P k
Example: Water vs Advanced PCM
Package Size
Total Cost Weight
Advanced PCM
Total Cost Can Be
Reduced
Container C t
Water
Cost
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PCM Type ComparisonExample: Water vs Advanced PCM
25 kgs 12 kgs
Packaging Size w/waterPackaging Size w/Advanced PCM