Teluguakula Narasaraju, Ph.D. Assistant Research Professor Department of Physiological Sciences Center for Veterinary Health Sciences Oklahoma State University- Stillwater Contact Information: E-mail: narasa@okstate.edu Phone: (405) 714-3046 Office: (405) 744 8806 Stillwater, OK 74078 Education: 1992: B.Sc, Biology, Chemistry, Sri Krishnadevaraya University (Anantapur, India) 1994: M.Sc, Biochemistry, Sri Venkateswara University (Tirupati, AP, India) 2001: Ph.D, Microbiology, Osmania University (Hyderabad, AP, India) Academic Appointments: 2001-2004: Postdoctoral Fellow, Department of Physiological Sciences, Oklahoma State University, Stillwater, OK, USA 2005-2010: Research Fellow A, Department of Microbiology, National University of Singapore, Kent Ridge, Singapore 2010-present: Assistant Research Professor, Department of Physiological Sciences, Oklahoma State University, Stillwater, OK, USA Research Interests: Influenza virus pathogenesis and therapy Awards and Honors 1995: UGC Junior Research Fellow 1997: UGC Senior Research Fellow 2001: DBT-Postdoctoral fellowship, India 2009: Best Poster presentation award in “8th Asia Pacific Congress for Medical virology”, Hong Kong 2010: Best Poster presentation award in SMA (Singapore-MIT alliance) Annual Symposium, Singapore, 2012: Scholarship award in 9th Asia Pacific Congress for Medical Virology, Adelaide, Australia. Other Professional Experiences and Memberships: Membership:

American Society for Virology

International Society of antiviral therapy

Reviewership:

Cellular and Molecular Neurobiology, (Springer Link Publishers) PLos ONE (Public Library of Science) Neurotoxicology (Elsevier Publishers) Clinical and Experimental Pharmacology and Physiology (Blackwell Science publishers) Journal of Animal Physiology and Animal Nutrition, (Blackwell Science publisher) Pharmaceutical Biology (Informa Health Care) Journal of Food Science and Technology, (Springer Link Publishers) Toxicology Mechanisms and Methods, (Informa Health Care)

Grants Review: Reviewer - The National Pork Board – Research Grants related to Porcine Diseases, USA.

Research Support:

Current:

2013–2018: NIH/NIGMS, Centers of Biomedical Research Excellence (CoBRE), ”Neutrophil-mediated acute lung injury in influenza virus pneumonia.”, Role: PI, $850,000

Past:

2007-2009: Microbiology Vaccine Initiative grant, Singapore. Development of a recombinant vaccine

against H5N1 avian influenza viruses. Role: Co-investigator. Amount: US $ 210,000, 2 years

2008 – 2012: National Medical Research Council (NMRC), Singapore. Title. Adaptation of human

influenza A virus in a mouse model for understanding the molecular pathogenesis of influenza

pneumonitis. Role: Co-PI. Amount: US $ 400,000, 3 Years

2011–2012: Agency: Center for Veterinary Health Sciences, Seed grant, USA.

Title. Combination drug therapy against influenza Pneumonia”. Role: PI, Amount: US $ 15,000, 1 Year

Selected Publications:

1. Audrey-Ann L, Narasaraju T, Tan KB, Wang S, Phoon MC, Vincent T.K. Chow. Caspase-1-deficient mice are more susceptible to influenza pneumonitis. European Journal of Inflammation. 2014 in press

2. Narasaraju TA, Edwin YY, H.H. Ng, Audrey A, Phoon MC, Vincent TK Chow. Therapeutic effect of combining hepatocyte growth factor and oseltamivir in amelioration of influenza pneumonitis. Current Molecular Medicine. 2014 Accepted

3. Anandi NM, Narasaraju T Prashant R, perumalsamy R, Tan KB, Wang S, Bevin Engelward, Vincent T.K. Chow. In vivo and in vitro studies on the roles of neutrophil extracellular traps during secondary pneumococcal pneumonia after primary pulmonary influenza infection. Frontiers in Immunology. 2013;4:56.

4. Ng HH, Narasaraju TA, Sim MK and Vincent TK Chow. Doxycyline treatment attenuates acute lung injury in mice infected with highly virulent influenza H3N2 virus: involvement of matrix metalloproteases. Experimental and Molecular Pathology. 2012; 92:287-95.

5. Ivan FX, Rajapakse JC, Welsch RE, Rozen SE, Narasaraju T, Xiong GM, Chow VT. Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines and chemokines. Functional & Integrative Genomics. 2012; 12:105-17.

6. Bhaskaran M, Dong Xi, Yang W, Huang C, Narasaraju T, Weiqun Shu, Chunling Zhao, Xiao X, More S, Breshears M, and Liu L. Identification of microRNAs changed in the neonatal lungs in response to hyperoxia exposure. Physiological Genomics. 2012; 44:970-80.

7. Narasaraju T, Edwin Y, Ramar perumal S, Ng HH, Poh WP, Audrey-Ann L, Phoon Meng C, van Rooijen N and Chow VT. Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis. American Journal of Pathology. 2011; 179:199-210.

8. Li R, Lim A, , Phoon MC, Narasaraju TA, Jowin K.W. Ng, Wee Peng, Poh, Meng Kwoon Sim, Vincent T. Chow and Sylvie Alonso. Attenuated Bordetella pertussis protects against highly pathogenic Influenza A Viruses by dampening the Cytokine Storm. Journal of Virology, 2010; 84:7105-13.

9. Narasaraju TA, H.H. Ng, Phoon MC and Vincent TK Chow. MCP-1 Antibody Treatment Enhances Damage and Impedes Repair of the Alveolar Epithelium in Influenza. American Journal of Respiratory Cell and Molecular Biology. 2010; 42: 732-43.

10. Wei Peng P, Narasaraju TA, Phoon MC, Macary P, Wong SH, Lu J, Koh DR and Vincent TK Chow. Characterization of cytotoxic T-lymphocyte epitopes and immune response to SARS coronavirus spike DNA vaccine expressing the RGD integrin-binding motif. Journal of Medical Virology, 2009; 81: 1131- 9.

11. Narasaraju T, Sim MK, Ng HH, Phoon MC, Shanker N, Lal SK, Chow VT. Adaptation of human influenza H3N2 virus in a mouse pneumonitis model: insights into viral virulence, tissue tropism and host pathogenesis. Microbes and Infection. 2009;11: 2-11.

12. Chen J, Chen Z, Chintagari NR, Bhaskaran M, Jin N, Narasaraju TA and Liu L. Alveolar Type I Cells Protect Rat Lung Epithelium from Oxidative Injury. Journal of Physiology. 2006; 572: 625-38. *Comment on this paper J. Physiol. 2006;572:609-10.

13. Chintagari NR, Jin N, Wang P, Narasaraju TA, Chen J and Liu L. Effect of Cholesterol Depletion on Exocytosis of Alveolar Type II Cells. American Journal of Respiratory Cell and Molecular Biology. 2006; 34:677-87.

14. Narasaraju TA, Nili Jin, Zhongming Chen and Liu L. Role of Insulin like growth factor system during the repair after hyperoxia mediated lung injury. Journal of Cellular Biochemistry. 2005, 97: 984-98.

15. Jin N, Narasaraju TA, Kuttiputi N, Chen J, Liu L. Differential expression of GABAA receptor pi subunit in cultured rat alveolar epithelial cells. Cell and Tissue Research. 2005; 321: 173-83.

16. Maiti S, Dutta SM, Baker SM, Zhang J, Narasaraju TA, Liu L, and Chen G. In vivo and in vitro oxidative regulation of rat sulfotransferase IV (AST IV). Journal of Biochemical and Molecular Toxicology. 2005 19: 109-18.

17. Gou D*, Narasaraju TA*, Chintagari NR, Jin N, Wang P, Liu L. Gene silencing in alveolar type II cells using cell-specific promoter in vitro and in vivo. Nucleic Acids Research 2004; 32:e134. (*

co-first authors). 18. Zhongming Chen, Chen J, Narasaraju TA and Liu L. Identification of novel markers for alveolar

epithelial cells. Biochemical and Biophysical Research Communications 2004, 2; 319:774-80.

19. Jiwang C, chen Z, Narasaraju TA and Lin Liu. Isolation of highly pure alveolar epithelial type 1 and type 2 cells from rat lungs. Lab Investigation. 2004, 84:727-35.

20. Abonyo BO, Gou D, Wang P, Narasaraju TA, Wang Z, Liu L. Syntaxin 2 and SNAP-23 Are Required for Regulated Surfactant Secretion. Biochemistry. 2004;43: 3499-506.

21. Singh, T. K., Abonyo, B., Narasaraju, T and Liu, L. Reorganization of cytoskeleton during surfactant secretion in lung type II cells: a role of annexin II, Cell Signal. 2004;16: 63-70.

22. Narasaraju TA, li Jin Reddy RN, Zhongming Chen and Liu L. Protein nitration during hyperoxia mediated lung injury: a possible role of myeloperoxidase. American Journal of Physiology, Lung Cell Molecular Physiology 2003; 285:L1037-45.

23. Abonyo, B.O, Wang PC, TA Narasaraju, William H Rowan III, David H. McMillan, Un-Jin Zimmerman and Liu, L. Characterization of a-SNAP in alveolar type II cells: implications in lung surfactant secretion. American Journal of Respiratory Cell and Molecular Biology. 2003; 29, 273-282.

24. Anand. T, Narasaraju TA, Vishnu. C, Venkateswar Rao. L, Sharma. G. Development of Dot-ELISA for the detection of human rotavirus and comparison with RNA-PAGE. Letters in Applied Microbiology. 2001; 32:176-180.

25. Anand T, Narasaraju TA, Linga Venkateshwar Rao, Gita Sharma. Symptomatic Rotavirus infection subgroups, serotypes and electropherotypes in Hyderabad, India. Indian Journal of Medical Research. 2000; 112:1-4.

26. Narasaraju TA, Ayyagari naga Vijayalakshmi, Tamatam Anand, Linga Venkateshwar Rao, Gita Sharma. Protective role of quercetin during influenza induced oxidative stress. Asia Pacific Journal of Clinical Nutrition 2000; 9: 314-317.