tb/hiv: impact and opportunities helene gayle, md, mph bill and melinda gates foundation date, 2004
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TB/HIV: Impact and Opportunities
Helene Gayle, MD, MPHBill and Melinda Gates FoundationDATE, 2004
Small and Fujiwara, N Eng J Med 343:189, 2001
The annual risk of TB in HIV infected
approximates the lifetime risk of HIV uninfected
HIV/TB: Profound Effect on Individuals
HIV/TB: Profound Effect on Populations
Kenyon et al., Int J TB Lung Dis 1999;3:4-11
HIV/TB: Profound Effect on Populations
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88 89 90 91 92 93 94 95 96 97 98 99 '00 '01Year
Rat
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r 100
,000
South Africa Kenya Swaziland Malawi
Zambia Namibia Botswana
WHO TB Surveillance Report, 2003
TB/HIV Co-Authorship Network
Medline 97-01Medline 97-01 TB 12,352TB 12,352 HIV 43,455HIV 43,455““Top” 50 authorsTop” 50 authors
Separate Responses
Abernethy and Small, unpublished
A Coordinated Response
C R E A ETo design, implement and evaluate a portfolio of community level trials of new strategies to reduce tuberculosis incidence in populations with high rates of HIV and TB co-infection.
TB/HIV Ultimate Need for New Tools
FIND/TDR for diagnostics ($30M)
Global Alliance for new drug ($25 M)
Aeras for vaccines ($83M)
Reaping the benefitsReaping the benefitsof science of science