tb spine -management challenge
DESCRIPTION
TB SPINE -MANAGEMENT CHALLENGE. Unit 3 Presentation Presenter: Dr. Mapala Moderator: Dr Musuku. INTRODUCTION. Evidence of spinal TB dates back to Egyptian times and has been documented in 5000-year-old mummies. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/1.jpg)
TB SPINE -MANAGEMENT CHALLENGE
Unit 3 PresentationPresenter: Dr. Mapala
Moderator: Dr Musuku
![Page 2: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/2.jpg)
INTRODUCTION• Evidence of spinal TB dates back to Egyptian times and has
been documented in 5000-year-old mummies.• In 1779, Percival Pott published the first modern description
of spinal deformity and paraplegia resulting from spinal TB.• According to WHO(2006), about one third of the world’s
population is infected by Mycobacterium TB, and 9 million individuals develop TB each year.
![Page 3: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/3.jpg)
• Spinal tuberculosis (often called Pott's disease) is by definition, an advanced disease, requiring meticulous assessment and aggressive systemic therapy.
• It is usually secondary to lung or abdominal involvement and may also be the first manifestation of tuberculosis.
![Page 4: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/4.jpg)
• Skeletal involvement of Tb has been reported to occur in approximately 10% of all patents with extra-pulmonary tuberculosis, -and half of these patients develop infection within the spinal column.
• It is much more prone to develop neurological manifestation, paraplegia of varying degree.
• The palpation of spinous process in routine clinical examination is the most rewarding clinical method -and is an invaluable measure for early recognition.
![Page 5: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/5.jpg)
• Vertebral TB is the most common form of skeletal TB and accounts for 50% of all cases of skeletal TB.
• Almost 50% are from paediatric group.• Neurological complications are the most crippling
complications of spinal TB ( Incidence : 10 to 43%).
![Page 6: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/6.jpg)
![Page 7: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/7.jpg)
![Page 8: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/8.jpg)
Pathogenesis • In children, the main route of infection of spinal tuberculosis
is through hematogenous spread from a primary site of infection, which is often unknown.
• A concomitant active pulmonary disease is present in <50% of the cases.
• The mycobacterium is deposited via the end arterioles in the vertebral body adjacent to the anterior aspect of the vertebral end plate.
• Thus, the anterior portion of the vertebral body is most commonly involved.
![Page 9: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/9.jpg)
• While the infection is developing, the cortex is disrupted and the infection may spread up and down,- stripping the anterior and posterior longitudinal ligaments and the periosteum from the front and sides of the vertebral bodies.
• This results in loss of the periosteal blood supply and distraction of the anterolateral surface of the vertebrae.
• Extension of the infection into the adjacent soft tissue to form paravertebral or epidural masses is commonly observed.
• The end may result in neurological complications such as spinal cord compression
![Page 10: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/10.jpg)
• Tissue necrosis and breakdown of inflammatory cells result in a paraspinal abscess.
• Progressive necrosis of bone leads to a kyphotic deformity and Gibbus formation
• The infection then spreads to the adjacent vertebral bodies under the longitudinal ligaments.
• Non-contiguous (skip) lesions are also seen occasionally . • In children, vertebral destruction is more severe because most
bone is cartilaginous
![Page 11: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/11.jpg)
History
Presentation depends on :• Stage of disease,• Site• Presence of complications such as neurologic deficits, abscesses, or sinus tracts.
• Average duration of symptoms at the time of diagnosis is 3 – 4 months.
• Back pain is the earliest & most common symptom.• Constitutional symptoms include fever and weight loss.• Neurologic symptoms (50 % of cases).
![Page 12: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/12.jpg)
Presentation • In spinal TB, onset of symptoms is usually insidious and
disease progression is slow. • The usual presentation consists of pain overlying the affected
vertebrae, low-grade fevers, chills, weight loss, and nonspecific constitutional symptoms of varying duration.
• Paraplegia can be the first sign of spinal disease.-Varying degrees of weakness, nerve-root compression and sensory involvement can occur.
• Duration of symptoms prior to diagnosis ranges from 2 weeks to several years.
![Page 13: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/13.jpg)
• Neurologic abnormalities can include:- spinal cord compression with paraplegia, paresis, impaired sensation, nerve root pain, or cauda equina syndrome.
• Cervical spine tuberculosis is a less common presentation is characterized by neck pain and stiffness.
![Page 14: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/14.jpg)
Physical examination of the spine • Localised tenderness and paravertebral muscle spasms,• Kyphotic deformity,• Cold abscess swelling / sinus tract• Cervical spine TB is a less common presentation,
-characterized by neck pain & stiffness with dysphagia / stridor more common in lower cervical spine involvement.
![Page 15: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/15.jpg)
![Page 16: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/16.jpg)
SPINAL TUBERCULOSISDIAGNOSIS
LAB STUDIES• Mantoux / Tuberculin skin test ( purified protein derivative
{PPD})• ESR may be markedly elevated (neither specific nor reliable).• ELISA : for antibody to mycobacterial antigen-6 , sensitivity of
60 – 80%.• PCR : sensitivity of 40% only.
-The amplified M tuberculosis direct test is an isothermal transcription-mediated amplification that targets RNA.
![Page 17: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/17.jpg)
Microbiology studies to confirm diagnosis :• Ziehl-Neelsen staining:
-a quick and inexpensive method.• Obtain bone tissue or abscess samples to stain for acid-
fast bacilli (AFB), & isolate organisms for culture & drug susceptibility.
• Culture results are available only after a few weeks.
-Positive only in 50% of cases.
![Page 18: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/18.jpg)
RADIOLOGICAL DIAGNOSIS1. PLAIN RADIOGRAPH2. CT SCAN3. MRI SPINE4. BONE SCAN
• TB bacilli are rarely found in CSF, therefore imaging plays pivotal role in suggesting the diagnosis.
![Page 19: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/19.jpg)
PLAIN RADIOGRAPH• More than 50% of bone has to be destroyed before a lesion
can be seen on X-ray.This process takes approximately six months.
• The classic X-ray triad in spinal tuberculosis is -primary vertebral lesion, -disc space narrowing and -paravertebral abscess.
• Skip lesions as involvement of non contiguous vertebrae (7 – 10 % cases).
![Page 20: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/20.jpg)
DEFORMITIES:1. Anterior wedging2. Gibbous deformity.3. Vertebra plana = single collapsed vertebra .
![Page 21: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/21.jpg)
• The best diagnostic modality for spinal TB is MRI.• MRI is more sensitive than radiography and more specific
than CT in the diagnosis of spinal TB. • The anatomical pattern revealed by MRI, particularly the soft
tissue and disc involvement, -yields greater specificity.
• MRI can also provide the diagnosis of TB of the spine 4-6 months earlier than conventional methods, -offering the benefits of earlier detection and treatment.
![Page 22: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/22.jpg)
• MRI allows for the rapid determination of the mechanism for neurologic compression and can distinguish between bone and soft tissue lesion (tuberculoma).
• MRI is able to give precise information regarding the level of cord compression -and is thus helpful for surgical planning in patients requiring surgical decompression
![Page 23: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/23.jpg)
• The CT scan is useful in demonstrating bony sclerosis and destruction, especially in the posterior elements, which are difficult to assess by conventional radiography.
• It is also a useful technique in guiding percutaneous biopsy. • However, the CT scan is inferior to the MRI exploration in the
exhibition of soft tissue masses, discs involvement and spinal cord compression.
![Page 24: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/24.jpg)
BONE SCAN • Increased uptake in up to 60 per cent patients with active
tuberculosis.• >= 5mm lesion size can be detected.• Avascular segments and abscesses show a cold spot due to
decreased uptake.• Highly sensitive but nonspecific.• Aid to localise the site of active disease and to detect
multilevel involvement.
![Page 25: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/25.jpg)
![Page 26: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/26.jpg)
1. Paradiscal Lesions :• Most common pattern of spinal tuberculosis.• It is adjacent to the I/V disc leading to a narrowing of the disc
space.• Disk space narrowing is caused either by destruction of
subchondral bone with subsequent herniation of the disc into the vertebral body or by direct involvement of the disc.
• MR imaging shows low signal on T1-weighted images and high signal on T2-weighted images in the endplate, narrowing of the disc, and large paraspinal and sometimes epidural abscesses.
![Page 27: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/27.jpg)
![Page 28: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/28.jpg)
2. Anterior Lesions :• The anterior type is a subperiosteal lesion under the ALL.• Pus spreads over multiple vertebral segments, stripping the
periosteum and ALL from the anterior surface of the vertebral bodies.
• The periosteal stripping renders the vertebrae avascular and susceptible to infection.
• Both pressure and ischemia combine to produce anterior scalloping.
![Page 29: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/29.jpg)
• Collapse of the VB & diminution of the disc space is usually minimal & occurs late.
• This lesion is relatively more common in thoracic spine in children.
• MR imaging shows the subligamentous abscess,preservation of the discs, and abnormal signal involving multiple vertebral segments representing vertebral tuberculous osteomyelitis.
![Page 30: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/30.jpg)
![Page 31: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/31.jpg)
3. Central Lesions :• Centred on the vertebral body.• Disc is not involved.• Infection starts from the center of the vertebral body; reaches
there through Batson’s venous plexus or through posterior vertebral artery.
• Vertebral collapse can occur, producing a vertebra plana appearance.
• MR imaging shows a signal abnormality of the vertebral body with preservation of the disc.
DD: The appearance is indistinguishable from that of lymphoma or metastasis.
![Page 32: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/32.jpg)
![Page 33: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/33.jpg)
4. Appendicial type :• Isolated infection of the pedicles & laminae (neural arch),
transverse processes, & spinous process.• Uncommon lesion (< 5%).• Occur in isolation or in conjunction with the typical
paradiscal variant• Radiographically, they appear as erosive lesions,
paravertebral shadows with intact disc space.• Rarely, present as synovitis of facet joints.
![Page 34: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/34.jpg)
![Page 35: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/35.jpg)
Paravertebral abscess :• With collapse of the vertebral body, tuberculous granulation
tissue, caseous matter, and necrotic bone accumulate beneath the anterior longitudinal ligament.
• Gravitate along the fascial planes and present externally at some distance from the site of the original lesion.
• In thoracic region, the longitudinal ligaments limit the abscess, or may reach the anterior chest wall in the parasternal area by tracking via the intercostal vessels.
![Page 36: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/36.jpg)
![Page 37: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/37.jpg)
![Page 38: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/38.jpg)
DIFFERENTIAL DIAGNOSIS
• The differential diagnosis of the tuberculous spine includes:1.SPINAL INFECTIONS- pyogenic, brucella & fungal.2.NEUROPATHIC spine3.NEOPLASTIC commonly lymphoma/ metastasis4.DEGENERATIVE• No pathognomonic imaging signs allow tuberculosis to be
readily distinguished from other conditions. • Biopsy is definitive.
![Page 39: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/39.jpg)
COMPLICATIONS OF SPINALTUBERCULOSIS
• Neurological complications paraplegia and spinal deformity are the most dreaded complications of tuberculosis of spine.
• Neurological complications develop in the active or healed stage of the disease.
• The sequelae of these two complications affect the quality and span of life.
• Cold abscess• Sinuses• Secondary infection• Fatality
![Page 40: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/40.jpg)
PATHOLOGY OF TUBERCULOUSPARAPLEGIA
• Bony disorders :Sequestra , Internal Gibbus
• Infarction of Spinal Cord :Endarteritis, Periarteritis or thrombosis of tributary to ASA.
• Changes in Spinal Cord :Thinning (Atrophy), Myelomalacia
![Page 41: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/41.jpg)
TUBERCULOUS SPINE WITH PARAPLEGIA• Incidence : 10 – 30 %• Dorsal spine most common• Motor functions affected before / greater than sensory.• Sense of position & vibration last to disappear.
![Page 42: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/42.jpg)
SEDDON’S CLASSIFICATION OFTUBERCULOUS PARAPLEGIA:
GROUP A (EARLY ONSET PARAPLEGIA) -Paraplegia associated with active disease : During the active phase of the disease within first 2 years of onset.
• Pathology can be inflammatory edema, granulation tissue, abscess, caseous material or ischemia of cord.
GROUP B (LATE ONSET PARAPLEGIA)-Paraplegia associated with healed disease :
• Usually after 2 years of onset of disease.• Can be due to recrudescence of the disease or due to
mechanical pressure on the cord.• Pathology can be sequestra, debris, internal gibbus or stenosis
of the canal.
![Page 43: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/43.jpg)
BASIC PRINCIPLES OFMANAGEMENT
• The treatment goals of spinal tuberculosis are to- eradicate the infection, -ensure a good recovery from any neurological deficits and -cure the disease with minimum residual spinal deformity
• Early diagnosis• Expeditious medical treatment• Aggressive surgical approach
![Page 44: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/44.jpg)
• Conservative treatment, including:- chemotherapy and -orthopedic immobilization, remains the cornerstone of the management of spinal tuberculosis in children.
• Neurological deficit due to Tb of spine is reversible in majority of cases-especially if decompression is done promptly.
• Good fusion and stabilization can prevent pain and late deformity.
![Page 45: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/45.jpg)
SURGICAL INDICATIONS :
• No sign of neurological recovery after trial of 3-4 weeks therapy• Neurological complications develop during conservative
treatment• Neuro deficit becoming worse on drugs & bed rest• Recurrence of neurological complication• Prevertebral cervical abscess with difficulty in deglutition &
respiration• Advanced cases
- Sphincter involvement, flaccid paralysis or severe flexor spasms
![Page 46: TB SPINE -MANAGEMENT CHALLENGE](https://reader035.vdocuments.mx/reader035/viewer/2022062218/568166e6550346895ddb236e/html5/thumbnails/46.jpg)
Thank you