Targeted Alpha Therapy

Maria BettiDirector

European Commission Joint Research Centre Directorate Nuclear Safety

and Security

Prostate Cancer Incidence

1.1 million men worldwide

WHO, GLOBOCAN 2012

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Prostate Cancer Mortality

307,000 deaths

6.6% total men deathsWHO, GLOBOCAN 2012

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Targeted Therapy

Selective killing tumor cells

Limited side effects (healthy tissue)

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High energyHigh ionisation density

Clinical Testings

Before treatmentDec. 2014

After 4 treatmentsSept. 2015 

Complete response

Life expectation considerably

increased

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Secure supply of 225Ac (IAEA TCP) - Production

Case Study 1 – Argentina

Training

Know-How transfer

Hosting staff at JRC

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Case Study 2 – South AfricaKnowledge Transfer in the Hospitals

Education to use of radio isotopes

Building capacity to treat prostate cancer

Establishing Regional Training Centre in Africa

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225Ac‐PSMA617: Pretoria experience

1 x225Ac‐PSMA

(10 MBq)

Case Study 2 – South Africa

April 2017PSA = 2280 ng/ml

July 2017 PSA = 205 ng/ml

Follow-up Clinical trials

Specific Regulations

Pharmaceutical Industry Involvement

Looking forward to the future2017‐09‐21 9

THANK YOU

2017‐09‐21 10