taking ownership of outcomes data...animal sentinels of human disease increased sensitivity canary...
TRANSCRIPT
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TAKING OWNERSHIP OF OUTCOMES DATACAROLYN J HENRY, DVM, MS, DACVIM (ONCOLOGY)
UNIVERSITY OF MISSOURI COLLEGE OF VETERINARY MEDICINE
1DataConference
March 27,2019
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WHAT CAN COMPANION ANIMAL DATA DO FOR US?
Impact points:
Preventative strategies
Research emphasis
Veterinary curriculum
Market identification
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STRATEGIC DATA MINING
Disease surveillance
Sentinel animals
Machine learning and epidemiology
Outbreak detection and prevention
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ANIMAL SENTINELS OF HUMAN DISEASE
Increased sensitivity
Canary in the coal mine
Shortened life span
Asbestos →Mesothelioma
Asymptomatic exposed
Thai dogs with H5N1 strain of avian flu
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DATA SOURCES
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UNIVERSITY OF WASHINGTON CENTER FOR ONE HEALTH RESEARCH
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BANFIELD APPLIED RESEARCH & KNOWLEDGE (BARK)
Data from over 2.5 million dogs and 518,000 cats seen in 2017
State of Pet Health Reports define pet population and disease prevalence
Add in banfield web pic
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STRATEGIC DATA MINING
Disease surveillance
Sentinel animals
Machine learning and epidemiology
Outbreak detection and prevention
Breeding programs and genetic discovery
OFA
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STRATEGIC DATA MINING
Disease surveillance
Sentinel animals
Machine learning and epidemiology
Outbreak detection and prevention
Breeding programs and genetic discovery
OFA
Correlates to human disease
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Translational Medicine
21
Cardiomyopathy
Degenerative disc
disease
Lymphoma
Epilepsy
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18%16%
10%8% 8% 9%
6% 6% 5%
14%
Lymphoma Mast Cell
Tumor
Hemangio-
sarcoma
Osteo-
sarcoma
Mammary Other Soft
Tissue
Sarcoma
Melanoma Oral/Nasal Squamous
Cell
Carcinoma
Other*
Source: Brakke Aug 2002; Burke October 2002; Modiano Lab of the AMC Cancer Research Center; Expert interviews; team analysis
DOG CANCER INCIDENCE
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Translational Medicine
Who is more likely to develop
bone cancer?→
24
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ANNUAL INCIDENCE PER 100,000
65.07.06.0Stomach/Intestines
5.45.07.2Liver and Biliary
1.04.97.9Bone
12.6<1.025.0Melanoma
5.234.790.4Skin (non-melanoma)
HUMANCATDOGTUMORTYPE
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CAUSES OF MORTALITY IN DOGS IN NORTH AMERICA
Breeds with highest proportion of neoplastic disease deaths
Bernese Mountain Dog
Golden Retriever
Scottish Terrier
Bouvier des Flandres
Boxer
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CAUSES OF MORTALITY IN DOGS IN NORTH AMERICA
Breeds with lowest proportion of neoplastic disease deaths
Miniature Pinscher
Miniature Dachshund
Chihuahua
Pekingese
Pomeranian
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REPORTED BREED ASSOCIATIONS WITH CANCER
Golden Retrievers – lymphoma, hemangiosarcoma
Bernese Mtn Dog- malignant histiocytosis; histiocytic sarcoma
Scottish Terriers – bladder cancer
German Shepherd Dogs – hemangiosarcoma; renal cystACa
Greyhounds, Rottweilers, Great Danes – osteosarcoma
Boxers and Pugs – mast cell tumors
Chow Chow – gastric carcinoma
English Springer Spaniel – breast Ca
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GENETIC RESEARCH, TESTING AND BIOREPOSITORIES
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STRATEGIC DATA MINING
Disease surveillance
Sentinel animals
Machine learning and epidemiology
Outbreak detection and prevention
Breeding programs and genetic discovery
OFA
Correlates to human disease
Biorepository access
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BIOREPOSITORY ACCESS
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STRATEGIC DATA MINING
Disease surveillance
Sentinel animals
Machine learning and epidemiology
Outbreak detection and prevention
Breeding programs and genetic discovery
OFA
Correlates to human disease
Biorepository access
Clinical trial networks
COHA
COTC - cancer
Regional
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University of Minnesota
University of California, Davis
Colorado State University
University of Wisconsin
University of Missouri
Auburn University
University of Florida
North Carolina State University
University of Pennsylvania
Cornell University
Tufts University
Ohio State University
Purdue University
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University of Minnesota
University of California, Davis
Colorado State University
University of Wisconsin
University of Missouri
Auburn University
University of Florida
North Carolina State University
University of Pennsylvania
Cornell University
Tufts University
Ohio State University
Purdue University
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Translational Medicine
40
The KC Animal Health Corridor represents 56% of the TOTAL
WORLDWIDE animal health, diagnostics and pet food sales.
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MIDWEST CLINICAL TRIALS CENTER
Veterinary School Collaboration
University of Missouri
Kansas State
Oklahoma State
Iowa State
Increased Access to Trials
Trained Coordinator
Screening Patients
Active Sponsor Solicitation
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LIFETIME STUDIES IN DOGS
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CHALLENGES WITH VETERINARY DATA
Multiple platforms that don’t ‘talk’ to each other
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CHALLENGES WITH VETERINARY DATA
Multiple platforms that don’t ‘talk’ to each other
Silos
Quality control
Loss to follow-up
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We Can Make a Good Team!