takgene bc

presents

Functional properties of Thermostable lactic acid-

forming bacteria (B. coagulans)

Dr. Maryam Tajabadi Ebrahimi

Iranian Society of Probiotic and

Functional Food

2

Takgene BC Takgene.com

1014 micro-organisms, >400 differentes species

stomach

Jejunum

Ileum

Colon with appendix

Duodenum

102 to 103

<105

104 to 107

109 to 1012

Lactobacilli

Streptococci

Lactobacilli

Enterobacteria

Enterococcus

Faesalis

Bacteroides

Bifidobacteria

Peptococcus

Raminococcus

Clostridia

Lactobacilli 3 Takgene BC

Takgene.com

4


5


2. Moreover, we also consume

antibacterial substances ranging

from vinegar to antibiotics

1. The changing food habits and

lifestyle force us to take processed and

sterile food, which affects our access

to, and colonization, by certain type of

bacteria.

6


400+ Species

of Prpbiotics

In Your Body

7

8


9

“Death sits in the bowels; a bad digestion is the root of all evil” - Hippocrates, ca. 400 BC


First described by Metchnikoff in 1908“Live microbial food ingredients that alter the microflora and confer health benefit”

WHO definition(2001): “Live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host”

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Probiotic

Prebiotic

0

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97

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Awareness of the terms are moving into "mainstream"… with 3 of 5 consumers now aware of the term probiotics

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Probiotic Supplements

11 Takgene BC

Takgene.com

Probiotic Functional foods

Dairy Non-Dairy

12 Takgene BC

Takgene.com

Dairy 38%

Bakery&cereal 23%

Beverage 12%

Meat, Fish&egg 7%

Soya Products 6%

Fat& Oil 8%

Other 6%

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L. sporogenes (Bacillus coagulance)

Contain a large number of viable lactobacilli that retain viability

during preparation in pharmaceutical dosage forms and during

storage before consumption.

The spores are thermostable as against viable L. acidophilus cells which may not withstand spray drying.

Survive in gastric secretions and bile of the upper digestive

tract and reach the intestine safely.

Settle in the digestive tract and produce enough lactic acid and

other antagonistic substances to inhibit the growth of

pathogenic bacteria.

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Takg

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BC

Takg

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com

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Takg

ene

BC

Takg

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com

Bacillus coagulans has been added by

the EFSA to their Qualified

Presumption of Safety list approved

for as GRAS by the U.S. Food and

Drug Administration's Center

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Takg

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BC

Takg

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com

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• Maturation of mononuclear phagocytes toward both

macrophage and dendritic cell

• T helper cell differentiation

• Generating T regulatory cells

• Cell wall & metabolites modulate inflammatory

processes

• Induction of IL-10,

• Possible treatment of inflammatory bowel diseases

• Adjunct therapy for relieving symptoms of rheumatoid

arthrite

Bebsons et al. World J Gastroenterol 2012 April 28; 18(16): 1875-1883

Mandel et al. BMC Complementary and Alternative Medicine 2010, 10:1

Jensen et al. BMC Immunology 2010, 11:15

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• Improve bowel movement

• Defecation frequency

• Increase number of intestinal bifdobacteria

• Decrease intestinal clostridium perfringens

• Improvements in GSRS abdominal pain

• Concentrations of intestinal ammonia, indole and p-cresol

decreased

• Improved abdominal pain and bloating in patients with

IBS

Phalguni Dutta et al. Tropical Medicine and International Health

Kal man et al., BMC Gastroenterology 2009

Larysa Hun et al., Postgraduate Medicine, 2009

Katsutoshi Ara, et al., 2002, Microbial Ecology in Health and Disease

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• Decrease in serum insulin levels

• hs-crp,

• Uric acid

• Reduces levels of lipid profile

• Increase of glutathione

• Increase of TAC Z. Asemi et al., Clinical Nutrition, 2013 Z. Asemi et al., Lipid, 2013 Shakeri et al., Lipid, 2014 Tajabadi Ebrahimi et al., 2014, Ann Nutr Metab

22


• Screening for Aflatoxin binding

• Alanin transferase (ALT)

• Aspartat aminotransferase (AST)

• Alkalin transferase (ALP)

23

Control Aflatoxin B1 Aflatoxin B1+ B. Coagulance


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• Take care of microbiota

• Probiotic can improve healthy

microbiota

• B. coagulance is heat resistant

probiotic

- Immune modulation

- Metabolic status in diabetic patients

- Gut health


25


(Dr. Michael L. McCann)

“Probiotics will be medicine

in the 21st century what antibiotics

and microbiology were in the 20th”

26


takgene bc

Food

bc takgene bc

com15 takgene bc takgene

sterile food

changing food habits

probiotic supplements

health benefit

improved abdominal pain

com16 bacillus coagulans