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is published twice each month byThe Journal of Immunology

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VOL. 196 | NO. 7 | April 1, 2016 | Pages 2911–3214

IN THIS ISSUE2911 Watching Wnt in FA See article p. 2986

Going beyond GWAS in T1D See article p. 3043Smoking Out POU2AF1 Lung Protection See article p. 3159Allografts Don’t Want Your Help See article p. 3180

PILLARS OF IMMUNOLOGY2913 Promiscuity Promotes Tolerance

Diane Mathis and Christophe Benoist

2915 Pillars Article: Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Mirrors the PeripheralSelf. Nat. Immunol. 2001. 2: 1032–1039Jens Derbinski, Antje Schulte, Bruno Kyewski, and Ludger Klein

BRIEF REVIEWS2923 Human CD56bright NK Cells: An Update

Tatiana Michel, Aur�elie Poli, Angelica Cuapio, Benjamin Briquemont, Gilles Iserentant, Markus Ollert,

and Jacques Zimmer

CUTTING EDGE2933 Cutting Edge: Engineering Active IKKb in T Cells Drives Tumor Rejection

C�esar Evaristo, Stefani Spranger, Sarah E. Barnes, Michelle L. Miller, Luciana L. Molinero, Frederick L. Locke,

Thomas F. Gajewski, and Maria-Luisa Alegre

ANTIGEN RECOGNITION AND RESPONSES2939 T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced

MHC Class I LevelsGiorgia Rota, Kristina Ludigs, Stefanie Siegert, Aubry Tardivel, Leonor Morgado, Walter Reith, Aude De Gassart,

and Greta Guarda

On the cover: H&E staining on the small intestine indicates milder pathologic injuries in the recipient mice deficientfor T-bet (cover) than the wild-type counterparts (Fig. 1G) after allogeneic T cell–replete hematopoietic cell

transplantation. Fu, J., Y. Wu, H. Nguyen, J. Heinrichs, S. Schutt, Y. Liu, C. Liu, J. Jin, C. Anasetti, and X.-Z. Yu.2016. T-bet promotes acute graft-versus-host disease by regulating recipient hematopoietic cells in mice. J. Immunol.196: 3168–3179.

The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists,

Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852, Phone: 301-634-7197, Fax: 301-634-7829. Subscription terms:New subscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscriptions for pricesand details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/membership). The American Association of Immunologists, Inc., is not responsible for undeliverable issues. Replacement issues

can be obtained, if available, at the regular price of single issues (see http://www.jimmunol.org/pdf/single_issue_purchase.pdf).Reprints of individual articles are available only from authors. Periodicals postage paid at Rockville, MD 20852, and at additionalmailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes 60 days in

advance to The Journal of Immunology, Subscription Department, 1451 Rockville Pike, Suite 650, Rockville, MD 20852.Copyright � 2016 by The American Association of Immunologists, Inc.

Journal ofTh e

ImmunologyTable of Contents

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AUTOIMMUNITY2947 Pathogenic Function of Herpesvirus Entry Mediator in Experimental Autoimmune Uveitis by Induction of

Th1- and Th17-Type T Cell ResponsesYukimi Sakoda, Tomohiko Nagai, Sizuka Murata, Yukari Mizuno, Hiromi Kurosawa, Hiromi Shoda, Naoyuki Morishige,

Ryoji Yanai, Koh-Hei Sonoda, and Koji Tamada

CLINICAL AND HUMAN IMMUNOLOGY2955 Anticommensal Responses Are Associated with Regulatory T Cell Defect in Autoimmune

Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy PatientsIivo Hetemaki, Hanna Jarva, Nicolas Kluger, Hanna-Mari Baldauf, Sini Laakso, Eirik Bratland, Eystein S. Husebye,

Kai Kisand, Annamari Ranki, Part Peterson, and T. Petteri Arstila

2965 Vitamin D [1,25(OH)2D3] Differentially Regulates Human Innate Cytokine Responses to Bacterial versusViral Pattern Recognition Receptor StimuliNatascha Fitch, Allan B. Becker, and Kent T. HayGlass

IMMUNE REGULATION2973 Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling

during Th17 DifferentiationLindsay L. Jones, Rajshekhar Alli, Bofeng Li, and Terrence L. Geiger

2986 Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the WntSignaling PathwayMathieu Sertorio, Surya Amarachintha, Andrew Wilson, and Qishen Pang

2995 Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of ExperimentalAutoimmune EncephalomyelitisDaniel Radtke, Sonja M. Lacher, Nadine Szumilas, Lena Sandrock, Jochen Ackermann, Lars Nitschke, and Elisabeth Zinser

3006 HIV Skews the Lineage-Defining Transcriptional Profile of Mycobacterium tuberculosis–Specific CD4+ T CellsCatherine Riou, Natalie Strickland, Andreia P. Soares, Bjorn Corleis, Douglas S. Kwon, E. John Wherry,

Robert J. Wilkinson, and Wendy A. Burgers

3019 Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 InhibitionYoshihiro Ueda, Naoyuki Kondo, Madoka Ozawa, Kaneki Yasuda, Takashi Tomiyama, and Tatsuo Kinashi

IMMUNOGENETICS3032 Restoration of ATM Expression in DNA-PKcs–Deficient Cells Inhibits Signal End Joining

Jessica A. Neal, Yao Xu, Masumi Abe, Eric Hendrickson, and Katheryn Meek

3043 Systematic Evaluation of Genes and Genetic Variants Associated with Type 1 Diabetes SusceptibilityRamesh Ram, Munish Mehta, Quang T. Nguyen, Irma Larma, Bernhard O. Boehm, Flemming Pociot, Patrick Concannon,

and Grant Morahan

IMMUNOTHERAPY AND VACCINES3054 Shortened Intervals during Heterologous Boosting PreserveMemory CD8 TCell Function but Compromise

LongevityEmily A. Thompson, Lalit K. Beura, Christine E. Nelson, Kristin G. Anderson, and Vaiva Vezys

3064 Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by StrategicSelection of Envelope ImmunogensAnn J. Hessell, Delphine C. Malherbe, Franco Pissani, Sean McBurney, Shelly J. Krebs, Michelle Gomes,

Shilpi Pandey, William F. Sutton, Benjamin J. Burwitz, Matthew Gray, Harlan Robins, Byung S. Park, Jonah B. Sacha,

Celia C. LaBranche, Deborah H. Fuller, David C. Montefiori, Leonidas Stamatatos, D. Noah Sather, and

Nancy L. Haigwood

3079 Clearing Persistent Extracellular Antigen of Hepatitis B Virus: An Immunomodulatory Strategy To ReverseTolerance for an Effective Therapeutic VaccinationDanming Zhu, Longchao Liu, Dan Yang, Sherry Fu, Yingjie Bian, Zhichen Sun, Junming He, Lishan Su, Liguo Zhang,

Hua Peng, and Yang-Xin Fu

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INFECTIOUS DISEASE AND HOST RESPONSE3088 Macrophage Galactose-Type Lectin-1 Deficiency Is Associated with Increased Neutrophilia and

Hyperinflammation in Gram-Negative PneumoniaChristopher N. Jondle, Atul Sharma, Tanner J. Simonson, Benjamin Larson, Bibhuti B. Mishra, and Jyotika Sharma

3097 Clinical Isolates of Pseudomonas aeruginosa from Chronically Infected Cystic Fibrosis Patients Fail ToActivate the Inflammasome during Both Stable Infection and Pulmonary ExacerbationKelsey E. Huus, Julie Joseph, Li Zhang, Alex Wong, Shawn D. Aaron, Thien-Fah Mah, and Subash Sad

3109 Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenesMichelle G. Pitts, Tanya Myers-Morales, and Sarah E. F. D’Orazio

INNATE IMMUNITY AND INFLAMMATION3117 MLN4924, a First-in-Class NEDD8-Activating Enzyme Inhibitor, Attenuates IFN-b Production

Hui Song, Wanwan Huai, Zhongxia Yu, Wenwen Wang, Jing Zhao, Lining Zhang, and Wei Zhao

3124 Mouse Cytomegalovirus Infection in BALB/cMice Resembles Virus-Associated Secondary HemophagocyticLymphohistiocytosis and Shows a Pathogenesis Distinct from Primary HemophagocyticLymphohistiocytosisEllen Brisse, Maya Imbrechts, Karen Put, Anneleen Avau, Tania Mitera, Nele Berghmans, Omer Rutgeerts, Mark Waer,

Marisa Ninivaggi, Hilde Kelchtermans, Louis Boon, Robert Snoeck, Carine H. Wouters, Graciela Andrei,

and Patrick Matthys

3135 Human SR-BI and SR-BII Potentiate Lipopolysaccharide-Induced Inflammation and Acute Liver andKidney Injury in MiceIrina N. Baranova, Ana C. P. Souza, Alexander V. Bocharov, Tatyana G. Vishnyakova, Xuzhen Hu, Boris L. Vaisman,

Marcelo J. Amar, Zhigang Chen, Yana Kost, Alan T. Remaley, Amy P. Patterson, Peter S. T. Yuen, Robert A. Star,

and Thomas L. Eggerman

3148 Mincle Activation and the Syk/Card9 Signaling Axis Are Central to the Development of AutoimmuneDisease of the EyeEllen J. Lee, Brieanna R. Brown, Emily E. Vance, Paige E. Snow, Phyllis B. Silver, David Heinrichs, Xin Lin,

Yoichiro Iwakura, Christine A. Wells, Rachel R. Caspi, and Holly L. Rosenzweig

MUCOSAL IMMUNOLOGY3159 POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes

Haixia Zhou, Angelika Brekman, Wu-Lin Zuo, Xuemei Ou, Renat Shaykhiev, Francisco J. Agosto-Perez, Rui Wang,

Matthew S. Walters, Jacqueline Salit, Yael Strulovici-Barel, Michelle R. Staudt, Robert J. Kaner, Jason G. Mezey,

Ronald G. Crystal, and Guoqing Wang

TRANSPLANTATION3168 T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice

Jianing Fu, Yongxia Wu, Hung Nguyen, Jessica Heinrichs, Steven Schutt, Yuejun Liu, Chen Liu, Junfei Jin,

Claudio Anasetti, and Xue-Zhong Yu

3180 CD4 T Cell Help via B Cells Is Required for Lymphopenia-Induced CD8 T Cell ProliferationKatayoun Ayasoufi, Ran Fan, Robert L. Fairchild, and Anna Valujskikh

TUMOR IMMUNOLOGY3191 Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA

Leticia Corrales, Seng-Ryong Woo, Jason B. Williams, Sarah M. McWhirter, Thomas W. Dubensky, Jr.,

and Thomas F. Gajewski

NOVEL IMMUNOLOGICAL METHODS3199 Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific

AntibodiesJos�ee Golay, Sylvie Choblet, Justyna Iwaszkiewicz, Pierre C�erutti, Annick Ozil, S�everine Loisel, Martine Pugni�ere, Greta Ubiali,

Vincent Zoete, Olivier Michielin, Christian Berthou, Jean Kadouche, Jean-Pierre Mach, and Martine Duonor-C�erutti

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CORRECTIONS3212 Correction: Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node

Homing: Effects of Ozone ExposureMoyar Qing Ge, Blerina Kokalari, Cameron H. Flayer, Sarah S. Killingbeck, Imre G. Redai, Alexander W. MacFarlane, IV,

Jin W. Hwang, Anisha Kolupoti, David M. Kemeny, Kerry S. Campbell, and Angela Haczku

3213 AUTHOR INDEX

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