table of contents journaipf medicine · andropause, testosterone therapy, 880 and quality of life...

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DECEMBER 2000 TABLE OF CONTENTS FROM THE EDITOR Fly-fishing and painting inspire COM Art Director's Homeric odyssey Artist, biographer, and fisherman—Bob Demarest, our Art Director, is a man of many talents. L.K. HENGSTLER AND J.D. CLOUGH 1-MINUTE CONSULT 871 Brief answers to specific clinical questions Should speculations about immune- 873 mediated adverse effects of Lyme disease vaccine deter us from giving it? The vaccine is safe, but should not replace simple common-sense precautions in tick'infested areas. L. S I G AL In postmenopausal women who have had a subtotal (simple) hysterectomy, how much estrogen is enough, and how do you test for deficiency? A standard dosage can be titrated upward according to symptoms. 877 H.L. THACKER MEDICAL GRAND ROUNDS.. Andropause, testosterone therapy, 880 and quality of life in aging men The common wisdom that men do not undergo menopause is being replaced. Testosterone replacement therapy can help. J.E. MORLEY THE CLINICAL PICTURE A 56-year-old man with palpitations 885 Questions and answers on the visible signs of diseases. C.M. RIMMERMAN CONTINUED ON PAGE 868 DEDICATED TO LIFELONG LEARNING JOURNAIP F MEDICINE JOHN D. CLOUGH, MD Editor-in-Chief BRIAN F. MANDELL, MD, PHD Deputy Editor LINDA K. HENGSTLER Editor and Publisher PHILLIP E. CANUTO Executive Editor RAY BORAZANIAN Managing Editor DAVID A. HUDDLESTON Manuscript Editor JESSICA ANCKER, ELS Editorial Services BRUCE M. MARICH Production Manager AMY SLUGG MOORE Patient Education Editor MARY BETH GLAUSER Patient Education Writer JOHN E. PRESSELLO Art Director ROBERT J. DEMAREST Medical Art Director JOSEPH A. PANGRACE Medical Illustrator DAVID R. SCHUMICK Medical Illustrator ERMA RICHARDSON Department Coordinator LOUISA R. PASKERT Editorial Assistant AUDRA BUTDORF BiliingfAccounting/Reprints EDITORIAL ADVISORY BOARD MUZAFFAR AHMAD, MD WILMA FOWLER BERGFELD, MD EMMANUEL L. BRAVO, MD RAY W. GIFFORD, JR, MD WILLIAM R. HART, MD ERIC A. KLEIN, MD FLOYD D. LOOP, MD DOUGLAS S. MOODIE, MD RICHARD H. NODAR, PHD WILLIAM L. PROUDFIT, MD WILLIAM C. SHELDON, MD ERIC J. TOPOL, MD HERBERT P. WIEDEMANN, MD ASSOCIATE EDITORS ALEJANDRO C. ARROLIGA, MD DAVID BRONSON, MD BEN H. BROUHARD, MD MARIE BUDEV, DO WILLIAM D. CAREY, MD WILLIAM A. CHILCOTE, MD BRIAN G. DONLEY, MD GARY FRANCIS, MD KATHLEEN FRANCO-BRONSON, MD STEVEN M. GORDON, MD BRIAN GRIFFIN, MD HITINDER GURM, MD GARY HOFFMAN, MD BYRON J. HOOGWERF, MD MANI S. KAVURU, MD MANDY C. LEONARD, PHARMD ANGELO A. LICATA, MD, D HD DAVID L. LONGWORTH, WD STEPHEN MAHONEY, MD MAURIE MARKMAN, MD ATUL C. MEHTA, MD NEIL B. MEHTA, MD FRANKLIN A. MICHOTA, MD STEVEN NISSEN. MD ROBERT M. PALMER, MD NORMAN B. RATLIFF, MD S. SETHU K. REDDY, MD MARK ROTH, MD DOUGLAS SEIDNER, MD CATHY A. SILA, MD FRANCK SKOBIERANDA, WD HOLLY L. THACKER, MD JAMES THOMAS, MD DONALD G. VIDT, MD WILLIAM S. WILKE, MD MARC WILLIAMS. MD JAMES B. YOUNG, MD ZOBAIR YOUNOSSI, MD CLEVELAND CLINIC FOUNDATION DIVISION OF EDUCATION ANDREW J. FISHLEDER, MD Chairman PHILLIP R. GARD Administrator Hie Cleveland Clinic Journal of Medicine (ISSN 0891 -1150) is published 12 times yearly by The Cleveland Clinic Foundation. STATEMENTS AND OPINIONS expressed in the Cleveland Clinic Journal of Medicine are those of the authors and not necessarily of The Cleveland Clinic Foundation or its Board of Trustees. AUTHOR DISCLOSURES: Current guidelines state that participants in CME activities should be made aware of any affiliation or financial interest that may affect an author's article as well as any discussion of off-labal drug therapies. All authors, except those indicated with an asterisk and a footnote with the article, have disclosed that they do not have a conflict of interest or will not discuss off-label therapies. SUBSCRIPTION RATES: U.S. and possessions: personal $85: institutional $108: single copy/back issue $13. Foreign: $108: single copy/back issue $l 3. Institutional (multiple-reader rate) applies to libraries, schools, hospitals, and federal, commercial, and private institutions and organizations. Individual subscriptions must be in the names of, billed to, and paid by individuals. POSTMASTER ADDRESS CHANGES: Cleveland Clinic Journal of Medicine. NA32,9500 Euclid Avenue, Cleveland, OH 44195 SUBSCRIPTIONS, EDITORIAL, REPRINTS, BILLING/ACCOUNTING AND PRODUCTION: (same address as above) • Phone (216) 444-2661 • Fax (216) 444-9335 • E-mail [email protected] http://www.ccjm.org ADVERTISING: Joseph Dennehy, Director, Sales and Marketing, 120 Castle Ridge Rd, Manhasset, NY 11030 • Phone (516) 365-8640 • Fax (516) 365-0587 CLEVELAND CLINIC JOURNAL OF MEDICINE VOLUME 67 NUMBER 12 DECEMBER 2000 m COPYRIGHT© 2000 THE CLEVELAND CLINIC FOUNDATION PRINTED IN U.S.A. on February 3, 2021. For personal use only. All other uses require permission. www.ccjm.org Downloaded from

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Page 1: TABLE OF CONTENTS JOURNAIPF MEDICINE · Andropause, testosterone therapy, 880 and quality of life in aging men The common wisdom that men do not undergo menopause is being replaced

DECEMBER 2000

T A B L E OF C O N T E N T S F R O M THE E D I T O R

Fly-fishing and painting inspire COM Art Director's Homeric odyssey Artist, biographer, and fisherman—Bob Demarest, our Art Director, is a man of many talents.

L . K . H E N G S T L E R A N D J . D . C L O U G H

1 - M I N U T E C O N S U L T

871

Brief answers to specific clinical questions

Should speculations about immune- 873 mediated adverse effects of Lyme disease vaccine deter us from giving it? The vaccine is safe, but should not replace simple common-sense precautions in tick'infested areas.

L . S I G A L

In postmenopausal women who have had a subtotal (simple) hysterectomy, how much estrogen is enough, and how do you test for deficiency? A standard dosage can be titrated upward according to symptoms.

877

H . L . T H A C K E R

M E D I C A L G R A N D R O U N D S . .

Andropause, testosterone therapy, 880 and quality of life in aging men The common wisdom that men do not undergo menopause is being replaced. Testosterone replacement therapy can help.

J . E . M O R L E Y

THE C L I N I C A L P I C T U R E

A 56-year-old man with palpitations 885 Questions and answers on the visible signs of diseases.

C . M . R I M M E R M A N

CONTINUED ON PAGE 868

D E D I C A T E D T O L I F E L O N G L E A R N I N G

J O U R N A I P F M E D I C I N E

JOHN D. CLOUGH, MD Editor-in-Chief BRIAN F. MANDELL, MD, PHD Deputy Editor LINDA K. HENGSTLER Editor and Publisher

PHILLIP E. CANUTO Executive Editor RAY BORAZANIAN Managing Editor

DAVID A. HUDDLESTON Manuscript Editor JESSICA ANCKER, ELS Editorial Services

BRUCE M. MARICH Production Manager AMY SLUGG MOORE Patient Education Editor

MARY BETH GLAUSER Patient Education Writer JOHN E. PRESSELLO Art Director

ROBERT J. DEMAREST Medical Art Director JOSEPH A. PANGRACE Medical Illustrator DAVID R. SCHUMICK Medical Illustrator

ERMA RICHARDSON Department Coordinator

LOUISA R. PASKERT Editorial Assistant AUDRA BUTDORF BiliingfAccounting/Reprints

EDITORIAL A D V I S O R Y BOARD MUZAFFAR AHMAD, MD WILMA FOWLER BERGFELD, MD EMMANUEL L. BRAVO, MD RAY W. GIFFORD, JR, MD WILLIAM R. HART, MD ERIC A. KLEIN, MD FLOYD D. LOOP, MD DOUGLAS S. MOODIE, MD RICHARD H. NODAR, PHD WILLIAM L. PROUDFIT, MD WILLIAM C. SHELDON, MD ERIC J. TOPOL, MD HERBERT P. WIEDEMANN, MD

A S S O C I A T E EDITORS ALEJANDRO C. ARROLIGA, MD DAVID BRONSON, MD BEN H. BROUHARD, MD MARIE BUDEV, DO WILLIAM D. CAREY, MD WILLIAM A. CHILCOTE, MD BRIAN G. DONLEY, MD GARY FRANCIS, MD KATHLEEN FRANCO-BRONSON, MD STEVEN M. GORDON, MD BRIAN GRIFFIN, MD HITINDER GURM, MD GARY HOFFMAN, MD BYRON J. HOOGWERF, MD MANI S. KAVURU, MD

MANDY C. LEONARD, PHARMD ANGELO A. LICATA, MD, DHD DAVID L. LONGWORTH, WD STEPHEN MAHONEY, MD MAURIE MARKMAN, MD ATUL C. MEHTA, MD NEIL B. MEHTA, MD FRANKLIN A. MICHOTA, MD STEVEN NISSEN. MD ROBERT M. PALMER, MD NORMAN B. RATLIFF, MD S. SETHU K. REDDY, MD MARK ROTH, MD DOUGLAS SEIDNER, MD CATHY A. SILA, MD FRANCK SKOBIERANDA, WD HOLLY L. THACKER, MD JAMES THOMAS, MD DONALD G. VIDT, MD WILLIAM S. WILKE, MD MARC WILLIAMS. MD JAMES B. YOUNG, MD ZOBAIR YOUNOSSI, MD

C L E V E L A N D C L I N I C FOUNDATION DIVIS ION OF EDUCATION ANDREW J. FISHLEDER, MD Chairman PHILLIP R. GARD Administrator

Hie Cleveland Clinic Journal of Medicine (ISSN 0891 -1150) is published 12 times yearly by The Cleveland Clinic Foundation.

STATEMENTS AND OPINIONS expressed in the Cleveland Clinic Journal of Medicine are those of the authors and not necessarily of The Cleveland Clinic Foundation or its Board of Trustees.

AUTHOR DISCLOSURES: Current guidelines state that participants in CME activities should be made aware of any affiliation or financial interest that may affect an author's article as well as any discussion of off-labal drug therapies. All authors, except those indicated with an asterisk and a footnote with the article, have disclosed that they do not have a conflict of interest or will not discuss off-label therapies.

SUBSCRIPTION RATES: U.S. and possessions: personal $85: institutional $108: single copy/back issue $13. Foreign: $108: single copy/back issue $l 3. Institutional (multiple-reader rate) applies to libraries, schools, hospitals, and federal, commercial, and private institutions and organizations. Individual subscriptions must be in the names of, billed to, and paid by individuals.

POSTMASTER ADDRESS CHANGES: Cleveland Clinic Journal of Medicine. NA32,9500 Euclid Avenue, Cleveland, OH 44195

SUBSCRIPTIONS, EDITORIAL, REPRINTS, BILLING/ACCOUNTING AND PRODUCTION: (same address as above) • Phone (216) 444-2661 • Fax (216) 444-9335 • E-mail [email protected] h t t p : / / w w w . c c j m . o r g

ADVERTISING: Joseph Dennehy, Director, Sales and Marketing, 120 Castle Ridge Rd, Manhasset, NY 11030 • Phone (516) 365-8640 • Fax (516) 365-0587

C L E V E L A N D C L I N I C J O U R N A L OF M E D I C I N E V O L U M E 6 7 • N U M B E R 1 2 D E C E M B E R 2 0 0 0 m COPYRIGHT© 2000 THE CLEVELAND CLINIC FOUNDATION PRINTED IN U.S.A.

on February 3, 2021. For personal use only. All other uses require permission.www.ccjm.orgDownloaded from

Page 2: TABLE OF CONTENTS JOURNAIPF MEDICINE · Andropause, testosterone therapy, 880 and quality of life in aging men The common wisdom that men do not undergo menopause is being replaced

DECEMBER 2000

CONTINUED FROM PAGE 866

IM BOARD REVIEW

A 75-year-old woman with a swollen hand and supraclavicular lymphadenopathy What is the cause of this patient's symptoms? A self-test on a clinical case.

G . A . C A R D E N A S , E . G . Z A V A L E T A , AND M . J . G O R E N S E K

A review of pericardial diseases: Clinical, ECG, and hemodynamic features and management Pericardial diseases are common, have multiple causes, and are often misdiagnosed.

S . A I K A T AND S . G H A F F A R I

DEPARTMENTS.

Corrections Index to Volume 67

CME Credit Test

888

INFECTIOUS DISEASE ALERT

Influenza 2000-2001: 898 Coping with vaccine manufacturing delays Delays in production of influenza vaccine are forcing physicians to prioritize who should be vaccinated first.

C . N I E L S E N

903

897 915 919

T h e Cleveland Clinic Journal of Medicine is peer-reviewed and indexed in Index Medicus.

VISIT OUR WEB SITE AT HTTP:/ /WWW.CCJM.ORG

C L E V E L A N D CL IN IC J O U R N A L OF M E D I C I N E V O L U M E 6 7 • N U M B E R 1 2 D E C E M B E R 2 0 0 0

U P C O M I N G FEATURES

Systolic hypertension is still undertreated

CT screening for lung cancer: Ready for prime time?

To treat heart failure, you need a plan

A new treatment for atrial fibrillation

Infertility: What the primary care physician can do

Should brain-tumor patients receive anticoagulation?

Legionnaire disease: Seek and ye shall find

How antiviral therapy is changing HIV patterns

on February 3, 2021. For personal use only. All other uses require permission.www.ccjm.orgDownloaded from