Table 4A. PAG Delta Correlation Gene Networks

ID Molecules in Network Score

Focus

Molecules Top Functions

1

ANXA6, Ap1, B4GALT1, CALM3, Calmodulin, Caspase, CDH22, CNR1, DAPK1, DLEU2, E2f, EGF, F Actin, FCGR2A, GAD1, H19, HBA2, Histone h3, Hsp70, Insulin,

Jnk, NFkB, Ntrk1 dimer, PI3K, Pkc(s), Pld, PLIN, PRKCB1, Ras, RPA2, RUNX1, SHC1, TTK, TXN, UBE2C 44 19

Lipid Metabolism, Small

Molecule Biochemistry, Skeletal and Muscular Disorders

2

AKAP12, ASXL1, CCL27, CKS2 (includes EG:1164), CTCF, DAD1, DUSP5, EEF1G, ELK3, ETV1, HIPK1, HIPK3, HOXB5, ITGB6, KIF23, KRT15, LDB1, NCAN,

PCK2, PLIN, PPARG, PRC1, RACGAP1, retinoic acid, RNF111, SKIL, SMURF2, SOD3, TGFB1, Timp, TNF, TP53, UBE2C, UBE2D3, VEGFA 17 9

Cancer, Cell Cycle, Hematological Disease

3

AKT3, amino acids, beta-estradiol, CBLC, CHGB, CKS1B, COL6A2, COL6A3, EIF4E, glutamic acid, GP5, hydrogen peroxide, IL4, IL6, LGR4, LSM2, LSM4, LSM5, LSM6, LSM7, MTMR7, MX2, NPY1R, PIM2, PLG, PPP5C, PRDX5, RLBP1, SGK3, SLC17A, SLC17A7, SV2B, SYT11,

Timp, TXNIP 17 9

Gene Expression, Cell Death, Nervous System Development

and Function

Network 2

Network 3

PAG Delta Corr Networks

Network 1

Network 1

Table 4B. PAG Saline Correlation Gene Networks

ID Molecules in Network Score

Focus

Molecules Top Functions

1

Akt, ARHGEF4, B4GALT1, Calpain, CASP3, E2f, H19, HMOX1, Hsp27, Hsp70, Insulin, Jnk, LDL, MAP2, Mapk, MAPT, MCM6, NFkB, NFKB2, P38 MAPK, Pdgf, Pdgf Ab,

PDGF BB, PI3K, Pkc(s), PP2A, PPP2R2C, PRDX2, PTN, Ras, RPS14, SERPINF1, Tgf beta, TMOD2, Vegf 31 15

Cell Morphology, Nervous System Development and

Function, Cardiovascular Disease

2

A130040M12RIK, ADARB1, ANXA4, ARL6IP1, ASPM, Caspase, CBR2, CDKN1A, CRISP3 (includes EG:10321), Cyclin A, EG633736, FLNA (includes EG:445353), FOS, FXYD1, GSDMDC1, GZMM, HBA2, HRAS, IFNG, KCNMA1, KCNT1, LOC100043429, LXN, MYC, NAE1, OMG, PARP1, Pka, RPL9 (includes EG:29257), RPS18,

RT1-B, SLC11A1, TOR2A, TTK, YY2 (includes EG:404281) 20 10

Cell Cycle, Cancer,

Connective Tissue Development and Function

3

ACHE, AGT, AP3B2, AP3D1, beta-estradiol, CNP, COLQ, CTNNB1, CTNND2, CTSF, EDIL3, FCGRT, FRK, GBP2, GM2A, GRIP2, H19, KCNMA1, KLK2, KRT5, L-carnitine, LIMA1, MAFF, NRF1, PAK7, PDZD2, PPRC1, PTPRN, RPS13, RPS4X, RPSA, SERPINB9, TGTP, TNF, WWOX 15 8

Immunological Disease, Skeletal and Muscular Disorders, Gene Expression

Network 1

Network 3

PAG Saline Corr Networks Network 2

Table 4C. PFC Delta Correlation Gene Networks

ID Molecules in Network Score

Focus

Molecules Top Functions

1

Ap1, CCNA2, CCNO, Creb, Cyclin A, DNAJA1, DOK1, DUSP9, EGR1, FSTL1, GOSR2, Histone h3, Jnk, MAP3K12, Mapk, MEIS1, Mek, NAPG, NFkB, NSF, P38

MAPK, PCNA, Pdgf, PDGF BB, Pka, Pkc(s), POLE, POLS, PPP1R9A, PRKACA, PTTG1, RPS6KA5 (includes EG:9252), STAT5A, TRIB3, TXNIP 40 19

Cancer, Hematological Disease, Cell Cycle

2

AHCY, APIP, ATP2B2, beta-estradiol, CASP3, CCDC80, DBI, DDX3X, DLG4, DRD2, GARS, GPRASP1, HNRNPC,

HNRNPU, IFIT3, KCNA1, KCNA2, KCNA4, LRCH4, MLF1, NAE1, PEX5L, Pmca, POMC, PPP1R9B, PRKDC, RAB8B, retinoic acid, RPL23A, SNF1LK, SNRP70, TK1, TSPO, YWHAZ, ZFAND6 27 14

Cell Death, Neurological Disease, Organ Morphology

3

2610042L04RIK, ALAD, ASGR2, C12ORF5, CANX, CEBPA, CLDN4, DDIT4, DICER1, EFNA4, EPHA2, ERBB2, ERCC5, FCGRT, FLG, GABARAP, HLA-B, IGF1R, KCNJ4, MYC, PCBP2, PHF17, PMP22, POLD1,

POLE2, PRIM1, RPS21, SERPINI1, SHMT1, TP53, TP63, UBE2C, UBE2V2, UBQLN1, VHL 22 12

Cancer, Respiratory Disease, Cell Cycle

Network 1

Network 3

PFC Delta Corr Networks Network 2

Network 2

Table 4D. PFC Saline Correlation Gene Networks

ID Molecules in Network Score

Focus

Molecules Top Functions

1

Ap1, beta-estradiol, BLR1, CABIN1, CCDC80, CST3, CSTB, CTLA2A, CTSH, CTSL1, DNER, eIF2B, EIF2B4, EIF2B5, EIF2S2, ERN1 (includes EG:2081), GLO1, GLUL,

GSK3A, GSK3B, HPSE, IL4, IL6, LGALS2, MAF, NCK1 (includes EG:29696), NFATC3, NR3C1, NUPR1, Pka, Pkc(s), PSEN1, PSEN2, SLC6A1, SLC6A2 26 12

Cancer, Tumor Morphology, Cellular Development

2

2-mercaptoethanol, ABCB1B, ADRA1A, ADRA1B, ADRA1D, ALDH7A1, ATP2A2, B4GALT1, CCKAR, CCL20, CDC42EP1, CDKN2D, DCN, EDNRB, EGR1, F2, F10, FMO1, GDF15, Gq-coupled receptor, GTF2I, IL1R1, IRS4, ITGB3BP, LHB, NFkB, PDGF BB, PDGFC, PGF,

PPP4C, PRRX1, RLN2, SOCS1, Thyroid hormone receptor, TRIM8 23 11

Cellular Growth and Proliferation, Cardiovascular

System Development and Function, Tissue Morphology

3

ALOX5, ANGPT1, ANP32A, CDH2, CTP, DCN, DNAJB6, EIF4E, ELF3, ELK3, ENTPD4, ERBB2, ETS, FBN1, FOSL1, GNAI1, GPX3, GTP, KRT8, LSM1, LSM2, LSM4, LSM5, LSM6, LSM7, MAP4, MYCN, NFYC, RFC3, RFC4, RPL6, SNRPD3, TGFB1, TNC, WFS1 16 8

Cell Death, Cancer, Organismal Survival

Network 1

Network 3

PFC Sal Corr Networks Network 2

Table 4E. TL Delta Correlation Gene Networks

ID Molecules in Network Score

Focus

Molecules Top Functions

1

ADAM9, Akt, Ap1, APBA2, AR, Calcineurin protein(s), Calpain, CAPN3, Caspase, CEBPD, CENPA, Creb, DNER, EPS15, FRAP1, GTF2F1, HABP4, Insulin, ITGB1, KCNQ1,

LAMB1, MGST1, NFkB, P38 MAPK, PDGF BB, PI3K, Pka, Pkc(s), PP2A, PPP3CB, PRKACA, RELA, STX3, TRIM27, YY1 44 21

Nervous System Development and Function, Tissue Development, Cancer

2

ARFIP1, C1QA, COL4A2, CTBP2, DDAH2, DEFA1 (includes EG:1667), EFEMP2, EHMT1, ELN, ERCC1, ERCC5, HCG 1787519, HINT1 (includes EG:3094), HSPB1, IPO9, JRK, KIF23, MGMT, MMP9, MRPL38, retinoic acid, RPS3, RPS7, RPS9, RPS28 (includes EG:54127),

SERPING1, SMC3, STAG1, TEP1, TGFBI, THBS2, TNFAIP2, TP53, UBE2T, WIZ 26 14

Cardiovascular Disease, Organismal Injury and

Abnormalities, Dermatological Diseases and Conditions

3

AFAP1L2, CD151, CKAP4, COL1A1, EGFR, EVL, F2, FUT8, G-protein gamma, GFER, GNB3, GNG3, GNG4, GNG5, GNG7, GNG10, GNG11, GNG12, GNG13, MTSS1, MYC, NRSN1, PCBP1 (includes EG:5093), PDC, PTPRA, PTPRD, PTPRE, PTPRS (includes EG:5802), RPL35, SAG,

SEMA6A, SERPINH1, SH3BGRL, SRC, TPPP 21 12

Cell Signaling, Cellular Assembly and Organization, Cell-To-Cell Signaling and

Interaction

Network 1

Network 3

TL Delta Corr Networks Network 2

Table 4F. TL Saline Correlation Gene Networks

ID Molecules in Network Score

Focus

Molecules Top Functions

1

Akt, ANGPT2, Ap1, AR, BIRC5, Caspase, CDC20, CEBPD, Creb, Cyclin E, EMI1, GLO1, HBA2, HBXIP, HEY1, Jnk, KCNC1, LITAF, Mapk, MAPK15, MIF, NFkB, Pdgf, PI3K,

PLAUR, PTTG1, RUVBL2, RXRA, SLC12A6, SNURF, SOCS4, STAT5A, TCF19, TMOD2, WASF3 45 20

Cancer, Cell Cycle, Tumor Morphology

2

androstenediol, AREG, ARFGAP3, beta-estradiol, CBR2, CGB, CYP24A1, EGF, ENTPD4, EPB41L1, ERH, FUS, GPD2, GPSM2, GSK3A, GTP, HAS2, HRAS, ID4, IER3,

IL7R, NGFB, NOTCH3, NUMA1, P110, PTGER2, PTGS1, PTTG1, RANBP9, RASD2, RELA, SMC3, SNIP, SRP54, Voltage Gated Calcium Channel 23 12

Cellular Development, Cellular Growth and

Proliferation, Reproductive System Development and Function

3

ABCB11, ACO2, Aconitase, ADAM9, ATP1A2, ATP1B2, AURKB, CABP1, CHI3L1, H3F3A, H3F3B, HBE1, Hd-neuronal intranuclear inclusions, Hd-perinuclear inclusions, HIP1, Histone h3, HTT, IL1B, JUN, LTP, MYST2, NPY, PELP1, PRNP, RNF4, SERP1, SH3D19, SH3GL3,

SLC10A2, SLC39A14, SMARCD1, SMARCD2, SMARCD3, SWI-SNF, TMEM158 21 11

Cell Death, Neurological Disease, Cell Signaling

Network 1

Network 3

TL Sal Corr Networks Network 2

Table 4G. VS Delta Correlation Gene Networks

ID Molecules in Network Score

Focus

Molecules Top Functions

1

2-amino-3-phosphonopropionic acid, Akt, ARF1, ARF5, ARFIP2, ASC2, DAP3, DEFA1 (includes EG:1667), EDF1, EGR1, FOS, GCH1, GDI1, HSPB8, hydroquinone, IDE,

Insulin, Jnk, MAGI1, NFkB, P38 MAPK, Pdgf, Pdgf Ab, PDGF BB, PDGFC, Pkc(s), PRKCG, PSCD2, PTPN6, RORC, SDCBP, SLC2A1, TCR, TGM1, TGM2 32 15

Cell Death, Hematological Disease, Immunological Disease

2

ACTG1, Actin, APP, CAP1, CAP2, CAPRIN1, CCR6, CELSR2, chondroitin sulfate B, CHST11, DAP3, EIF6, EIF4E, ELAVL3, G3BP1, GTP, IL10, ILF3, ILF2 (includes EG:3608), KIF5A, KIF5C, KLC2, NAE1, PHACTR1, PSMA3, PTPRK, retinoic acid, S100A11 (includes

EG:6282), SEPT3, TGFB1, TGFBI, TIA1, TUBB2C, TUSC2, XRN2 29 14

Cellular Development, Cellular Growth and

Proliferation, Hair and Skin Development and Function

3

ABCB1B, C19ORF10, CDH11, CTSH, CUL7, CYFIP2, DDX17, DNAJA1, DNAJA2, ECM1, FBXW8, FSTL1, GAS1, GCLM, Hd-neuronal intranuclear inclusions, HSPA9, HTT, hydrogen peroxide, IL13, LEP, LGALS3BP, MAPK1, MYC, NID1, PDE6G, PLXNB2, PON3, PRDX1, PTP4A2,

SLC25A5, ST3GAL6, SYNGR3, TNF, TP53, YY2 (includes EG:404281) 26 13

Cellular Compromise, DNA

Replication, Recombination, and Repair, Cell Death

Network 1

Network 3

VS Delta Corr Networks Network 2

Table 4H. VS Saline Correlation Gene Networks

ID Molecules in Network Score

Focus

Molecules Top Functions

1

Akt, ALOX12, Ap1, Caspase, CDKN2D, CDT1, CRYAB, CSDE1, E2f, EGR1, GNB1, GRLF1, GSPT1, HABP4, HLA-C, JARID2, Jnk, NEDD4, NFkB, P38 MAPK, Pdgf, PDGF

BB, PI3K, Pkc(s), PRDX2, PRKCG, RANBP1, RBP1, RHOA, SDCBP, SEPT4, SERPINF1, TRAF7, UBE3A, Ubiquitin 50 23

Post-Translational Modification, Organ Development, Cell Death

2

ACHE, AKT1, CAMKK1, CCND1, CCT3, CCT7, CDC42, CDH1, CDKN2D, CDX1, CK1, COLQ, CSNK1G1,

CTNNB1, DUSP14, GLO1, GTPBP4, HNRNPL, INVS, LMO7, MAFF, MCF2, MCF2L, MYO9B, Nectin, NRF1, PISD, PTGDS, PVRL1, PVRL3, RRM1, TMED10, TNF, UCP1, VHL 31 16

Cellular Assembly and Organization, Cell Death, Cell Cycle

3

AHSG, ALPP, ARCN1, BET1L, COPA, COPB1, COPB2, COPE, COPG, COPZ1, CPD, CPT2, GOLGB1, LYPD1, MYC, MYCBP2, MYCN, NEFL, NUCKS1, phosphate, PRPH, RPL19, RPL13A, RPL7L1, RPLP2, RPS7,

ST6GAL1, STX5, TERT, TGFB1, TMED9, USO1, XBP1, ZHX2, ZNF217 19 11

Cellular Development, Cellular Growth and Proliferation, Respiratory

System Development and Function

Network 1

Network 3

VS Sal Corr Networks Network 2