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Slide 2 Slide 3 Slide 4 Slide 5 Slide 6 Table 1 The role of microRNAs in cancers microRNAsTumorigenesis miR-9Neuroblastoma miR-10bBreast cancer miR-15, miR-15aLeukemia, pituitary adenoma miR-16, miR-16-1Leukemia, pituitary adenoma miR-17-5p, miR-17-92Lung cancer, lymphoma miR-20aLymphoma, lung cancer miR-21Breast cancer, cholangiocarcinoma, head & neck cancer, leukemia, cervical cancer, Pancreatic cancer miR-29, miR-29bLeukemia, cholangiocarcinoma miR-31Colorectal cancer miR-34aPancreatic cancer, Neuroblastoma miR-96Colorectal cancer miR-98Head & neck cancer miR-103Pancreatic cancer miR-107Leukemia, pancreatic cancer miR-125a, miR-125bNeuroblastoma, breast cancer miR-128Glioblastoma miR-133bColorectal cancer miR-135bColorectal cancer miR-143Colon cancer, cervical cancer miR-145Breast cancer, colorectal cancer miR-146Thyroid carcinoma miR-155Breast cancer, leukemia, pancreatic cancer miR-181, miR-181a, miR-181cLeukemia, glioblastoma, thyroid carcinoma miR-183Colorectal cancer miR-184Neuroblastoma miR-196a-2Pancreatic cancer miR-221Glioblastoma, thyroid carcinoma, Pancreatic cancer miR-222Thyroid carcinoma miR-223Leukemia miR-301Pancreatic cancer miR-376Pancreatic cancer let-7, let-7a, let-7a-1, let-7a-3Lung cancer, colon cancer Mol Cancer. 2007; 6: 60. Published online 2007 September 25. doi: 10.1186/1476-4598-6-60. Copyright 2007 Cho; licensee BioMed Central Ltd. Slide 7 Slide 8 Slide 9 Slide 10 Slide 11 Slide 12 Slide 13 Slide 14 Slide 15 Slide 16 Slide 17 Let-7g impairs proliferation and enhances cell death. Kumar M S et al. PNAS 2008;105:3903-3908 2008 by National Academy of Sciences Slide 18 Let-7g-induced tumors maintain overexpression and target suppression. Kumar M S et al. PNAS 2008;105:3903-3908 2008 by National Academy of Sciences Slide 19 Let-7g suppresses tumorigenesis in vivo. Kumar M S et al. PNAS 2008;105:3903-3908 2008 by National Academy of Sciences Slide 20 K-RasG12D substantially rescues let-7g-mediated tumor suppression. Kumar M S et al. PNAS 2008;105:3903-3908 2008 by National Academy of Sciences Slide 21 Let-7g suppresses tumor initiation in an autochthonous NSCLC model. Kumar M S et al. PNAS 2008;105:3903-3908 2008 by National Academy of Sciences Slide 22 Slide 23 miR-26a is amplified in glioma. Huse J T et al. Genes Dev. 2009;23:1327-1337 2009 by Cold Spring Harbor Laboratory Press Slide 24 miR-26a-expressing murine gliomas (P/26a). Huse J T et al. Genes Dev. 2009;23:1327-1337 2009 by Cold Spring Harbor Laboratory Press Slide 25 miR-26a facilitates gliomagenesis in vivo. Huse J T et al. Genes Dev. 2009;23:1327-1337 2009 by Cold Spring Harbor Laboratory Press Slide 26 miR-26a represses PTEN expression in murine gliomas. Huse J T et al. Genes Dev. 2009;23:1327-1337 2009 by Cold Spring Harbor Laboratory Press Slide 27 Slide 28 Slide 29 Slide 30