t cell development ? ? ? ?? ? ?. role of the thymus in t cell development required for t cell...
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![Page 1: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/1.jpg)
T Cell Development
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![Page 2: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/2.jpg)
![Page 3: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/3.jpg)
Role of the thymus in T cell development
• Required for T cell development– Neonatal thymectomy– Nude mice
• Shapes T cell repertoire– Transplant experiments
![Page 4: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/4.jpg)
Shaping the T cell repertoire
![Page 5: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/5.jpg)
What are thymocytes doing?
• MigratingMigrating
• Contacting stromal cells
• Changing phenotype
• Expressing TCRs
• Undergoing selection
![Page 6: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/6.jpg)
![Page 7: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/7.jpg)
What are thymocytes doing?
• Migrating
• Contacting stromal cellsContacting stromal cells
• Changing phenotype
• Expressing TCRs
• Undergoing selection
![Page 8: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/8.jpg)
Thymocyte:stromal cell interactions
![Page 9: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/9.jpg)
What are thymocytes doing?
• Migrating
• Contacting stromal cells
• Changing phenotypeChanging phenotype
• Expressing TCRs
• Undergoing selection
![Page 10: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/10.jpg)
T Cell Development in the Thymus
![Page 11: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/11.jpg)
What are thymocytes doing?
• Migrating
• Contacting stromal cells
• Changing phenotype
• Expressing TCRsExpressing TCRs
• Undergoing selection
![Page 12: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/12.jpg)
T Cell Development in the Thymus
![Page 13: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/13.jpg)
![Page 14: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/14.jpg)
![Page 15: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/15.jpg)
What are thymocytes doing?
• Migrating
• Contacting stromal cells
• Changing phenotype
• Expressing TCRs
• Undergoing selectionUndergoing selection
![Page 16: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/16.jpg)
T and B cell receptors
![Page 17: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/17.jpg)
• Based on specificity of TCR• Produces “central tolerance” to self antigens• Produces T cell repertoire biased toward self
MHC + peptide specificities• Consists of 3 levels of selection
– Positive Selection– Negative Selection– Death by neglect
Thymic Selection
![Page 18: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/18.jpg)
Positive selection
![Page 19: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/19.jpg)
Positive selection
![Page 20: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/20.jpg)
Positive selection
![Page 21: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/21.jpg)
Negative selection
![Page 22: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/22.jpg)
Thymic Selection
![Page 23: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/23.jpg)
![Page 24: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/24.jpg)
CD4/CD8 lineage commitment
![Page 25: T Cell Development ? ? ? ?? ? ?. Role of the thymus in T cell development Required for T cell development –Neonatal thymectomy –Nude mice Shapes T cell](https://reader036.vdocuments.mx/reader036/viewer/2022062320/56649d775503460f94a596d2/html5/thumbnails/25.jpg)