systems medicine & copd
DESCRIPTION
Grazie per aver scelto di utilizzare a scopo didattico questo materiale delle Guidelines 2011 libra. Le ricordiamo che questo materiale è di proprietà dell’autore e fornito come supporto didattico per uso personale. Systems medicine & COPD. Alvar Agustí. Data-free lecture (almost). - PowerPoint PPT PresentationTRANSCRIPT
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Grazie per aver scelto di utilizzare a scopo didattico questo materiale
delle Guidelines 2011 libra.Le ricordiamo che questo materiale è di proprietà
dell’autore e fornito come supporto didattico per uso
personale.
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Alvar Agustí
Systems medicine & COPD
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Data-free lecture(almost)
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Galas DJ, Hood L. IBC 1 (6):1-4, 2009
Systems medicine: basic hypothesis
• Diseases arises as a consequence of one or more biological networks in the relevant organ that have become disease-perturbed through genetic and/or environmental pathogenic changes.
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Barabasi AL. N Engl J Med 357 (4):404-407, 2007
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The human disease network
Goh et al. PNAS104 (21):8685-8690, 2007
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The disease gene network
Goh et al. PNAS104 (21):8685-8690, 2007
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Goh et al. PNAS104 (21):8685-8690, 2007
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Goh et al. PNAS104 (21):8685-8690, 2007
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Vestbo et al. ERJ 31 (4):869-873, 2008 Regan EA et al. COPD 7 (1):32-43, 2010
http://www.cancold.ca
http://www.cscc.unc.edu/spir/
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Unbiased Biomarkersfor the Prediction
of Respiratory DiseaseOutcomes
Synergy
Airway Disease PRedicting Outcomes through Patient
Specific Computational Modelling
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High throughput technology Bioinformatics
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Genetic network GWAS
ncRNAmiDNA
miRNAEpigenetics
Innate inmunity
Ageing
Bioenergetics
Repair
Oxidative stressAcquired immunity
Biological network
Clinical phenotypesIntegrated carePersonalized medicine Guidelines network
Intermediate pathophenotypesDiagnostic biomarkersTherapeutic targets
Genetic markersRisk assessment
Life-styleModifiable factors
COPD
CVD
CancerMyopathty
OsteoporosisMetab Syn.
Clinical network
Environmental network
Pollution
Allergens
DietSmoking
Temperature
Infections
Agusti A , Vestbo J AJRCCM 2011
Systems medicine & COPD
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N=30.000.000 individuos(Medicare)
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Traditional medicine
Reactive = centered around diseases
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P4 Medicine
P4= centered on health
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