systems biology approaches to understanding glutathione metabolism
DESCRIPTION
Systems Biology approaches to understanding glutathione metabolism. Dr Najl Valeyev. Centre for Molecular Processing. University of Kent. Edinburgh. 29 September 2010 . Different types of Systems. Electronic circuits design. Weather. Stock market. Aircraft flight controllers. - PowerPoint PPT PresentationTRANSCRIPT
Systems Biology approaches tounderstanding glutathione metabolism
29 September 2010
Dr Najl Valeyev
Edinburgh
University of Kent
Centre for Molecular Processing
WeatherElectronic circuits design
Aircraft flight controllers Stock market
Different types of Systems
Causative knockouts of “functional” parts
Lazebnik Y, Cancer Cell. 2002 Sep;2(3):179-82
Linking parts with “disease” phenotypes
Family classification according to Phenotype
Idealised Cell as a System
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The Complexity Problem
Science or Art ?
The Complexity Problem
Major Modelling Principle
TrueObject
Knowledge 1 Knowledge 2
Knowledge 3 Knowledge 4
TrueObject
Model 1 Model 2
Model 3 Model 4
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Comparison of experiments with simulations
Experiments Model predictions
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Stochastic interactions between models and experiments
should lead to deterministic conclusions
to test and evaluate the structure of the assumed intracellular interactions with the pathways
to identify inconsistent hypotheses and design experiments to clarify the properties of signalling pathways
to provide advanced interpretation of the experimental data
to developed an integrative model of fimbriation