syrups and elixirs
TRANSCRIPT
![Page 1: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/1.jpg)
![Page 2: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/2.jpg)
Name: HIRA HASSAN
Roll number: D14M03
NAME: MARRIAM IMTIAZ
ROLL NUMBER: D14M05
![Page 3: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/3.jpg)
Syrups And Elixirs
ASSIGNED BY: MAM MISBAH
![Page 4: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/4.jpg)
Contents:What are syrups?Types of SyrupsComponents of syrupsPreparation of SyrupsInvert SyrupWhat are elixirs?Types of elixirs Components of elixirs Preparation of elixirs
![Page 5: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/5.jpg)
Syrups
![Page 6: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/6.jpg)
Syrups Syrups are concentrated aqueous preparations of a
sugar or sugar substitute with or without flavoring agents and medicinal substances.
Syrups containing flavoring agents but not medicinal substances are called nonmedicated or flavored vehicles (syrups).
![Page 7: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/7.jpg)
Types of Syrups:
1.Simple syrup2.Medicated syrups3.Non-medicated syrups
![Page 8: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/8.jpg)
Simple Syrups:
A simple syrup contains only sucrose and purified water (e.g. Syrup USP). Saturated sugar solution without flavour or medicine
![Page 9: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/9.jpg)
Non-Medicated Syrups
Syrups containing flavoring agents but not medicinal substances are called non-medicated or flavored vehicles (syrups).
![Page 10: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/10.jpg)
EXAMPLES OF NONMEDICATED SYRUPS (VEHICLES)
Cocoa syrup Suspension of cocoa powder in aqueous vehicle sweetened and thickened with sucrose, liquid glucose, glycerin; flavored with vanilla, sodium chloride. Particularly effective in administering bitter-tasting drugs to childrenOrange syrup Sucrose-based syrup uses sweet orange peel tincture, citric acid as the source of flavor and tartness. Resembles orange juice in taste; good vehicle for drugs stable in acidic medium.Raspberry syrup Sucrose-based syrup with raspberry juice about 48% by volume. Pleasant-flavored vehicle to disguise salty or sour taste of saline medicaments
![Page 11: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/11.jpg)
Medicated Syrups:
Syrups containing medicinal substances are called medicated syrups
![Page 12: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/12.jpg)
Medicated Syrups:
![Page 13: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/13.jpg)
Examples of medicated syrup:AnalgesicAnticholinergicAntiemeticAnticonvulsantAntihistamineAntiviralAntitussivesExpectorantBronchodilatorsFecal softener
![Page 14: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/14.jpg)
Components of Syrups:
Most syrups contain the following components in addition to the purified water and any medicinal agents present:
SugarAntimicrobial Preservatives
FlavorantColorants
![Page 15: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/15.jpg)
Sucrose and non-sucrose based syrup
![Page 16: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/16.jpg)
Most syrups contain a high proportion of sucrose, usually 60-80%.Concentrated sugar solutions are quite resistant to microbial growth.
![Page 17: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/17.jpg)
Antimicrobial preservative
Benzoic acid (0.1 to 0.2%)Sodium benzoate (0.1 to 0.2%)
Methyl-, propyl-, and butylparabens (0.1%)Alcohol (15 to 20%)
![Page 18: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/18.jpg)
Preservation:
Syrups can be preserved by1.storage at low temperature2.adding preservatives in the formulation3.by the maintenance of a high concentration of 4.sucrose as a part of the formulation
![Page 19: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/19.jpg)
Flavorant
Synthetic flavorantsNaturally occurring materials
Volatile oilsVanillin
Because syrups are aqueous preparations, these flavorants must be water soluble.
![Page 20: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/20.jpg)
Colorant
The colorant is generally water soluble, nonreactive with the other syrup components, color stable at the pH range and under the intensity of light that the
syrup is likely to encounter during its shelf life.
![Page 21: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/21.jpg)
Preparation of Syrups
Syrups are frequently prepared by one of four general methods.1) solution of the ingredients with the aid of heat,2) solution of the ingredients by agitation without the use of heat, or
the simple admixture of liquid components,3) addition of sucrose to a prepared medicated liquid or to a flavored
liquid, 4) percolation of either the source of the medicating substance or of the
sucrose.
![Page 22: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/22.jpg)
Ⅰ. Solution With the Aid of Heat
Syrups are prepared by this method when it is desired to prepare the syrup as quickly as possible,when the syrup’s components are not damaged or volatilized by heat.
![Page 23: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/23.jpg)
In this method the sugar is generally added to the purified water, and heat is applied until the sugar is dissolved.then other heat-stable components are added to the hot syrup, the mixture is allowed to cool, its volume is adjusted to the proper level by addition of purified water.
![Page 24: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/24.jpg)
If heat labile agents or volatile substances, such as volatile flavoring oils and alcohol, are to be added,
they are generally added to the syrup after the sugar is dissolved by heat,
and the solution is rapidly cooled to room temperature.
![Page 25: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/25.jpg)
Because of the prospect of decomposition by heat,
syrups cannot be sterilized by autoclaving.The use of boiled purified water in the preparation
of a syrup can enhance its permanency, and the addition of preservative agents, when permitted, can protect it during its shelf life.
Storage in a tight container is a requirement for all syrups.
![Page 26: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/26.jpg)
Ⅱ. Solution by Agitation Without the Aid of Heat
To avoid heat-induced inversion of sucrose, a syrup may be prepared without heat by agitation.
On a small scale, sucrose and other formulative agents may be dissolved in purified water and thorough agitated of the mixture.
![Page 27: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/27.jpg)
This process is more time consuming than use of heat, but the product has maximum stability.
Huge glass-lined or stainless steel tanks with mechanical stirrers or agitators are employed in large-scale preparation of syrups.
When solid agents are to be added to a syrup, it is best to dissolve them in a minimal amount of purified water and incorporate the resulting solution into the syrup.
![Page 28: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/28.jpg)
Ⅲ. Addition of Sucrose to a Medicated Liquid or to a Flavored Liquid
Occasionally a medicated liquid, such as a tincture or fluidextract, is employed as the source of medication in the preparation of a syrup.
Many such tinctures and fluidextracts contain alcohol-soluble constituents and are prepared with alcoholic or hydroalcoholic vehicles.
![Page 29: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/29.jpg)
If the alcohol-soluble components are desired medicinal agents, some means of rendering them water soluble is employed.
If the tincture or fluidextract is miscible with aqueous preparations, it may be added directly to simple syrup or to a flavored syrup.
![Page 30: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/30.jpg)
Ⅳ. Percolation
In the percolation method, either sucrose may be percolated to prepare the syrup, or the source of the medicinal component may be percolated to form an extractive to which sucrose or syrup may be added.
This latter method really is two separate procedures: first the preparation of the extractive of the drug and then the preparation of the syrup.
![Page 31: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/31.jpg)
![Page 32: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/32.jpg)
The usual dose of ipecac syrup is 15 ml.
This amount of syrup is commonly used in the management of poisoning in children when the evacuation of the stomach contents is desirable.
Ipecac syrup also has some application as a nauseant expectorant, in doses smaller than the emetic dose.
![Page 33: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/33.jpg)
![Page 34: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/34.jpg)
![Page 35: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/35.jpg)
![Page 36: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/36.jpg)
Inverted sugar syrup
Inverted or invert sugar syrup is a mixture of glucose and fructose; it is obtained by splitting sucrose into these two components
![Page 37: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/37.jpg)
C12H22O11 (sucrose+ H2O (water) → C6H12O6 (glucose+ C6H12O6 (fructose)Hydrolysis is a chemical reaction in which a molecule breaks down by the addition of water. Hydrolysis of sucrose yields glucose and fructose about 85%, the reaction temperature can be maintained at 50–60 °C (122–140 °F).
![Page 38: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/38.jpg)
Shelf life:Invert sugar provides more powerful preserving qualities (a longer shelf life) to products that use it.The shelf life of partial inverts is approximately six months, depending on storage and climatic conditions. Crystallized invert sugar solutions may be restored to their liquid state by gently heating
![Page 39: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/39.jpg)
Elixirs
![Page 40: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/40.jpg)
Elixirs:
Elixirs are, sweetened, flavored, hydro-alcoholic solutions intended for oral use.
![Page 41: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/41.jpg)
Components of elixirs:
Alcohol Sweetening agents
Water Glycerin
Propylene glycol flavourants
![Page 42: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/42.jpg)
Preservatives used for Elixirs:
Elixirs containing more than 10 to 12% of alcohol are usually self-preserving and do not require the addition of an antimicrobial agent.
![Page 43: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/43.jpg)
(1) Preparation of Elixirs
Elixirs are usually prepared by simple solution with agitation and/or by admixture of two or more liquid ingredients.
Alcohol-soluble and water-soluble components are generally dissolved separately in alcohol and in purified water, respectively.
![Page 44: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/44.jpg)
Then the aqueous solution is added to the alcoholic solution to maintain the highest possible alcoholic strength at all times so that minimal separation of the alcohol-soluble components occurs.
When the two solutions are completely mixed, the mixture is made to volume with the specified solvent or vehicle.
![Page 45: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/45.jpg)
Frequently the final mixture will be cloudy because of separation of some of the flavoring oils by the reduced alcoholic concentration.
TalcFilter
![Page 46: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/46.jpg)
Types of Elixirs:
There are two types of Elixirs:1.Medicated elixirs2.Non-medicated Elixirs
![Page 47: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/47.jpg)
Non-Medicated Elixirs:
They are used purely as diluting agents or solvents for drugs containing approximately 25% alcohol, e.g., simple elixir, or low alcohol elixir (containing 8-10% alcohol), High alcoholic elixir (containing 75-78% alcohol)
If a hydroalcoholic vehicle is selected, the proportion of alcohol should be only slightly above the amount needed to effect and maintain the drug's solution.
![Page 48: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/48.jpg)
Nonmedicated elixirs may be useful for(a) the addition of a therapeutic agent to a pleasant-tasting vehicle and
(b) Dilution of an existing medicated elixir
![Page 49: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/49.jpg)
The three most commonly used nonmedicated elixirs were aromatic elixir, compound benzaldehyde elixirisoalcoholic elixir.
![Page 50: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/50.jpg)
Medicated Elixirs:
Elixirs containing therapeutically active compounds are known as medicated elixirs, e.g., Phenobarbital elixir USP, Dexamethasone elixir USP, Chlorpheniramine Maleate elixir USP, Diphenhydramine Hydrochloride elixir USP, Piprazine Citrate elixir, etc.
![Page 52: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/52.jpg)
phenobarbitalExamples of medicated elixirs:
Antihistamine Elixir: Diphenhydramine HCl Analgesic Elixir: acetominophen Cardiotonic Elixir: digoxin Antispasmodic Elixir: hyoscyamine sulfate Sedative Elixir: phenobarbital
![Page 53: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/53.jpg)
Antihistamines elixirs
Antihistamines elixirs are useful primarily in the symptomatic relief of certain allergic disorders.The most common untoward effect is sedation. Other common adverse effects include dryness of the nose, throat, and mouth; dizziness; and disturbed concentration.
![Page 54: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/54.jpg)
Barbiturate sedative/hypnotic elixirs
Barbiturates are administered in small doses in the daytime hours as sedatives to reduce restlessness and emotional tension.
Greater doses may be given before bedtime as hypnotics to release insomnia.
![Page 55: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/55.jpg)
Phenobarbital Elixir
Phenobarbital elixir is formulated to contain phenobarbital 0.4%,which provides about 20 mg of drug per teaspoonful (5mL)of elixir.
![Page 56: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/56.jpg)
Digoxin Elixir
Digoxin is poisonous, and its dose must be carefully determined and administered to each individual patient.
The official elixir contains about 10% of alcohol.
![Page 57: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/57.jpg)
![Page 58: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/58.jpg)
Difference between Syrups And Elixirs:
Syrups1. Alcohol is necessary component2. Less sweet than syrup3. Less viscous than syrup4. Less proportion of sugar5. More stable6. Easy to formulate than syrups7. Less effecting in masking the taste of
madecinal agents8. These are clear formulations9. Can be used for Diabetic patients easily
Elixirs1. Alcohol is not necessary component2. more sweet than elixir3. more viscous than elixirs4. High concentration of sugar5. Less Stable6. Difficult to formulate than elixirs7. More effecting in masking the taste of
madecinal agents8. May not beclear formulations9. Sucrose Syrup can not be used,but if
used exercise care
![Page 59: Syrups and elixirs](https://reader033.vdocuments.mx/reader033/viewer/2022061307/58734f0d1a28ab56378b5d7b/html5/thumbnails/59.jpg)