www.granulox.deSastoMed GmbH

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Patent licensed fromSangui Biotech GmbH

Granulox is a dressingand therefore reimbursablePZN 9505753www.granulox.de

Support wound healing, save costs

Haemoglobin spray

1 spray can = 30 applications

4. Granulox relieves your budget

“The wound had persisted for several years. After a few weeks of Granulox treatment, the wound had closed.” Nesat Mustafi, Woundambulance, Hospital Frankfurt North-West. Chronic wounds, in particular, can become a permanent cost factor. Granulox demonstrably accelerates healing. The shortened wound healing time allows marked savings to be achieved in the prescription of further dressing materials.

Weeks N = 72, p < 0.001

0%

+20%

+40%

21 3 4 5 6 7 8 9 10 11 12 13

Mean relative wound reduction

Group 2(Comparator-group)

Group 1(Granulox)

With Granulox:53% average reduction in wound sizeafter 13 weeks

-40%

-20%

-60%

-80%

The results

3. Granulox accelerates wound healing

“It’s simple, it’s effective and there are no undesirable effects!“Prof. Dr. med. Arenberger, Charles University, PragueA clinical trial by Karls University, Prague proves: Wounds heal significantly faster with Granulox, treatment times are shortened by an average of 50%. (Arenbergerova et al, 2013)

Start of treatment After 2 weeks After 8 weeks After 15 weeksEnd of treatment

Patient: 43 years, male, venous crural ulcer for 8 years, place of treatment: die pflegezentrale [The Care Agency], Duisburg

Granulox is a haemoglobin spray to support the healing of chronic wounds.

Reimbursable Granulox is officially licensed as a medical device class III.Due to its proven efficacy and cost saving potential according to recent pharmaeconomic studies Granulox is reimbursable in most of the European countries.

Easy application Application of the red Granulox spray can be adapted to the usual rhythm of dressing changing (i.e. every 1-3 days, depending on the wound phase).

30 applications per spray can

One spray of 1-2 seconds is normally sufficient to cover a wound area of 2 x 3 cm.

1. Thoroughly rinse the wound with a physiological solution within the scope of routine wound cleaning.

2. Spray with Granulox from a distance of 5 to 10 cm.

3. Cover the wound with a breathable/non-occlusive wound dressing.

Mechanism of action

“At last, not just the nth new PU foam, but a genuine innovation!”Anita Mysor, Wundmanagement MysorInsufficient oxygen supply to wounds has long been recognised as a central problem in wound healing. Granulox is the first product to solve this problem, thereby decisively accelerating wound healing.

“As a natural transporter substance, haemoglobin allows oxygen diffusion to the wound base.”Prof. Dr. med. Risse, Hospital DortmundHaemoglobin is able to bind oxygen and then release it again. When sprayed onto the wound, the water-soluble, red haemoglobin spray is uniformly distribu-ted in the exudate, binds oxygen from the surrounding air and transports it to the wound base, from where it diffuses into the cells. This process repeats itself continuously and without using up haemoglobin. In this way, large quantities of oxygen can be brought to the wound base.

2. Granulox combats hypoxia

The oxygen supply of the cells is increased, the hypoxia reduced.The wound situation improves and wound healing is accelerated.

“In the absence of other wound healing inhibitory factors local hypoxia is the central problem of an impaired wound healing.”Kröger et al, Woundmanagement 05/2012Increased oxygen requirement, but poor oxygen supply. The need for oxygen is particularly high in all phases of wound healing because of increased metabolic activity. The primary disease (CVI, pAOD, diabetes) leads to inadequate oxygen supply via the vascular system (hypoxia). Even Oxygen from the outside cannot reach the wound base, because the wound exudate forms a diffusion barrier.

1. Hypoxia prevents wound healing

Ingredients: 10% carbonylated haemoglobin; 0.7% phenoxyethanol; 0.9% sodium chloride; 0.05% N-acetylcysteine; to 100 ml with water.Side effects: No side effects are known.Interactions: Do not use with locally-acting drugs such as antibiotics. Action impaired by: disinfectants and proteolytic (enzymatic) debridements.Contraindications: For safety reasons, Granulox should not be used on infected wounds or during pregnancy. Sufficient data is not yet available to evaluate these cases.Storage: Long periods of non-use: refrigerator, 2°C - 8°C. On days of use: room temperature, max. 25°C.On daily use it may also be stored for up to 6 weeks.