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Page 1: Supplementary table 1. Supplementary table 2 Supplementary table 3

Supplementary table 1

Page 2: Supplementary table 1. Supplementary table 2 Supplementary table 3

Supplementary table 2

Page 3: Supplementary table 1. Supplementary table 2 Supplementary table 3

Supplementary table 3

Page 4: Supplementary table 1. Supplementary table 2 Supplementary table 3

Supplementary table 4

A.

B.

Page 5: Supplementary table 1. Supplementary table 2 Supplementary table 3

VALIDATED hsa-miR-155 TARGETS

AGTR1

AICDA

BCL2

CSF1R

CTLA4

CUX1

ETS1

FGF7

IKBKE

IL13RA1

INPP5D

IRAK3

JARID2

MYD88

RIPK1

RNF123

SKI

SLA

SOCS1

SPI1

WEE1

Supplementary table 5

Page 6: Supplementary table 1. Supplementary table 2 Supplementary table 3

Supplementary table 6

Page 7: Supplementary table 1. Supplementary table 2 Supplementary table 3

Supplementary Fig. S1

A. B. C.

Page 8: Supplementary table 1. Supplementary table 2 Supplementary table 3

Flag-TRF1

actin

MG132

siTR

F1

- + +-control miR-155

1.00 2.55 1.13 2.05

2mgWB a-TRF1

MG132 siTR

F1

- + +-control miR-155

Flag-TRF1 end. TRF1

actin

20mgWB a-TRF1

1.00 1.38 0.52 0.71 0.18end. TRF1/actin

*

B.

C.

A.

con. m

iRNA

mir-155

antag

o-miR-155

con. si

RNAsiT

RF10

20

40

60

80

100

120

TRF1

mRN

A le

vels

nor

mal

ized

to a

ctin

(con

.miR

NA

set “

1”)

n=3n=3

n=3

n=3

n=3

p=0.3p=0.2 p=0.012

Supplementary Fig. S2

Flag-TRF1/actin

Page 9: Supplementary table 1. Supplementary table 2 Supplementary table 3

Supplementary Fig. S3

miR-155 signature low: n=593

miR-155 signature high: n=606

ER positive tumors

Page 10: Supplementary table 1. Supplementary table 2 Supplementary table 3

Supplementary Fig. S4

B.A.

miR

-155

a-m

iR-1

55

cont

rol

6000

5000

4000

3000

2000

1000

0

7000

8000

TRF1

fluo

resc

ence

inte

nsity

(a.f.

u)

1312±30.52n=602N=41

1051±31.08n=512N= 40

1464±37.79 n=508 N= 31

p<0.0001

p<0.0001

cont

rol

miR

-155

anta

go-

miR

-155

TRF1 TRF1/DAPI

anta

go-

miR

-155

MBA

-MD

-468

U 2

-OS

D.C.

miR

-155

a-m

iR-1

55

cont

rol

2000

4000

6000

8000

10000

12000

14000

16000

18000

20000

POT1

fluo

resc

ence

inte

nsity

(a.f.

u)

1199±101.7n=1199N=35

p=0.119

p=0.071

1552±86.24

n=1552 N= 37

985±101.4n=985N= 30

cont

rol

miR

-155

anta

go-

miR

-155

POT1 POT1/DAPI

5000

1000

10000

miR

-155

a-m

iR-1

55

cont

rol

TRF2

fluo

resc

ence

inte

nsity

(a.f.

u)

150001619

±54.45n=1173N=48

p=0.4

p=0.065

1584±41.40

n=1267N= 48

1694±51.07n=1050N= 48

cont

rol

miR

-155

anta

go-

miR

-155

TRF2 TRF2/DAPI

Page 11: Supplementary table 1. Supplementary table 2 Supplementary table 3

TRF2

mRN

A le

vels

norm

alize

d ve

rsus

acti

n

con-trol

miR-155

0

0.5

1

1.5

2

2.5

3

n=3 n=3

p=0.2

con-trol

miR-155

0

0.5

1

1.5

2

2.5

3

TRF1

mRN

A le

vels

norm

alize

d ve

rsus

acti

n

n=3n=3

p=0.2

con-trol

miR-155

0

10

20

30

40

50

60

70

80

miR

-155

leve

lsno

rmal

ized

vers

us R

NU

46

n=3

n=3

p<0.0001

cont

rol

miR

-155

con-trol

mir-155

0

20

40

60

80

100

120

TRF1

pro

tein

leve

lsno

rmal

ized

vers

us a

ctin n=3

n=3

p=0.01

A. B.

D.C.

E.

TRF1

actin

Supplementary Fig. S5

telo

mer

e le

ngth

(a.f.

u.)

A

B

C

1591± 30.72

N=42n=3823

1916± 37.47N=39

n=3521

p<0,0001

2000

10000

12000

14000

16000

4000

6000

8000

0

cont

rol

miR

-155

cont

rol

miR

-155

0

20

40

60

80

100 > 4000 1500-40000-1500A

B

C

telo

mer

e a.

f.u in

tesi

sty

cate

gorie

s (%

)

Page 12: Supplementary table 1. Supplementary table 2 Supplementary table 3

cont

rol

miR

-155

0

10

20

30

40

50

60

p=0.035

N=3n=50

N=3n=50

TIF

freq

uenc

y(2

< TI

Fs; %

)

0

25

50

75

100

125

150

miR

-155

leve

ls, n

orm

lized

to R

NU

46

(con

set

“1”

)

cont

rol

miR

-155

cont

rol

miR

-155

TRF1actin

cont

rol

siTRF

1

01020304050607080

TIF

freq

uenc

y3<

TIF

s; %

)

p=0.05

N=3n=81

N=3n=93

Supplementary Fig. S6

A.

B. C. D.

Page 13: Supplementary table 1. Supplementary table 2 Supplementary table 3

cont

rol

siTR

F1

05

10152025303540

n=1370

n=1533N=17

N=20

p= 0,03

frag

ile te

lom

eres

(%)

Supplementary Fig. S7

A.

cont

rol

miR

-155

0

5

10

15

20

25

30

35

40N=40

n=3084

N=40n=3098

p=0,003

frag

ile te

lom

eres

(%)

B.

C. D.

0102030405060

Chart Title

N=25n=1974

N=25n=1906

p= 0,04

frag

ile te

lom

eres

(%)

-

+

-

-

+

+ Aphidicolin

con.miRNA

antago-miR-155 antago-miR-155

0

2

4

6

8

10

-

+

-

-

+

+ Aphidicolin

con.miRNA

p=0.05

N=26n=2134

N=21N=1542

telo

mer

ic s

ister

ch

rom

atid

fusi

ons

(%)


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