supplementary figures for genesis of two most prevalent prop1 gene variants causing combined...
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B. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from Europe except Portugal and Spain. BTRANSCRIPT
![Page 1: Supplementary Figures for Genesis of Two Most Prevalent PROP1 Gene Variants Causing Combined Pituitary Hormone Deficiency in 21 Populations Petra Dusatkova](https://reader036.vdocuments.mx/reader036/viewer/2022082501/5a4d1b867f8b9ab0599bcd40/html5/thumbnails/1.jpg)
Supplementary Figures for
Genesis of Two Most Prevalent PROP1 Gene Variants Causing Combined Pituitary
Hormone Deficiency in 21 Populations
Petra Dusatkova et al.
Supplementary Figure 1. Plots of observed haplotypes among patients with c.
[301_302delAG] in the PROP1 gene from all studied countries (A), from Europe except
Portugal and Spain (B), from Iberian Peninsula (C), from Argentina, Dominican Republic
and partly Brazil (D), from Jamaica, Panama and partly Brazil (E) and from healthy
European individuals derived from Hapmap (F).
The colours are displayed as follows: bright red represents LOD≥2 and D'=1, shade of red LOD≥2 and D'<1,
brightly pink LOD<2 and D'>0.5 and white LOD<2 and D'< 0.5. Numbers in each cell represents D' in percents. If
D'=1, no number is present in the respective cell.
![Page 2: Supplementary Figures for Genesis of Two Most Prevalent PROP1 Gene Variants Causing Combined Pituitary Hormone Deficiency in 21 Populations Petra Dusatkova](https://reader036.vdocuments.mx/reader036/viewer/2022082501/5a4d1b867f8b9ab0599bcd40/html5/thumbnails/2.jpg)
A. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from all studied countries.
A
![Page 3: Supplementary Figures for Genesis of Two Most Prevalent PROP1 Gene Variants Causing Combined Pituitary Hormone Deficiency in 21 Populations Petra Dusatkova](https://reader036.vdocuments.mx/reader036/viewer/2022082501/5a4d1b867f8b9ab0599bcd40/html5/thumbnails/3.jpg)
B. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from Europe except Portugal and Spain.
B
![Page 4: Supplementary Figures for Genesis of Two Most Prevalent PROP1 Gene Variants Causing Combined Pituitary Hormone Deficiency in 21 Populations Petra Dusatkova](https://reader036.vdocuments.mx/reader036/viewer/2022082501/5a4d1b867f8b9ab0599bcd40/html5/thumbnails/4.jpg)
C. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from Iberian Peninsula.
C
![Page 5: Supplementary Figures for Genesis of Two Most Prevalent PROP1 Gene Variants Causing Combined Pituitary Hormone Deficiency in 21 Populations Petra Dusatkova](https://reader036.vdocuments.mx/reader036/viewer/2022082501/5a4d1b867f8b9ab0599bcd40/html5/thumbnails/5.jpg)
D. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from Argentina, Dominican Republic and partly Brazil.
D
![Page 6: Supplementary Figures for Genesis of Two Most Prevalent PROP1 Gene Variants Causing Combined Pituitary Hormone Deficiency in 21 Populations Petra Dusatkova](https://reader036.vdocuments.mx/reader036/viewer/2022082501/5a4d1b867f8b9ab0599bcd40/html5/thumbnails/6.jpg)
E. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from Jamaica, Panama and partly Brazil.
E
![Page 7: Supplementary Figures for Genesis of Two Most Prevalent PROP1 Gene Variants Causing Combined Pituitary Hormone Deficiency in 21 Populations Petra Dusatkova](https://reader036.vdocuments.mx/reader036/viewer/2022082501/5a4d1b867f8b9ab0599bcd40/html5/thumbnails/7.jpg)
F. Plots of observed haplotypes among patients with c.[301_302delAG] in the PROP1 gene from healthy European individuals derived from Hapmap.
F
![Page 8: Supplementary Figures for Genesis of Two Most Prevalent PROP1 Gene Variants Causing Combined Pituitary Hormone Deficiency in 21 Populations Petra Dusatkova](https://reader036.vdocuments.mx/reader036/viewer/2022082501/5a4d1b867f8b9ab0599bcd40/html5/thumbnails/8.jpg)
Supplementary Figure 2. Plot of observed haplotype among patients with c.[150delA] in the PROP1 gene from all studied countries. The colours are displayed as follows: bright red represents LOD≥2 and D'=1, shade of red LOD≥2 and D'<1, brightly pink LOD<2 and D'>0.5 and white LOD<2 and D'< 0.5. Numbers in each cell represents D' in percents. If D'=1, no number is present in the respective cell.