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0 20 40 60 80 100 120 0 20 40 60 80 100 120 concentration ( ethidium Fascaplycin Cisplatin Oxaliplatin Echinomycin Doxorubicin Supplementary figure S1.

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Supplementary figure S1. Supplementary figure S2. A. B. DNA replication %. DNA replication %. NU. EB+NU. EB. ctl. 20’ 60’. 20’ 60’. 20’ 60’. 20’ 60’. cdc45. RPA. PCNA. MCM3. Supplementary figure S3. A. B. DNA replication %. Supplementary figure S4. % DNA replicated. - PowerPoint PPT Presentation

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Page 1: Supplementary figure S1

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0 20 40 60 80 100 120

concentration (µM)

% f

luo

resc

ence ethidium

Fascaplycin

Cisplatin

Oxaliplatin

Echinomycin

Doxorubicin

Supplementary figure S1.

Page 2: Supplementary figure S1

0102030405060708090100

time (min)

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A B

Supplementary figure S2.

DN

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ep

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ati

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%

DN

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20 40 60 90 120EB 25µM + NU 100µMNU 100µMEB 25µM

ctl

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10

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30

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Time (min)

Supplementary figure S3.

cdc45

RPA

PCNA

MCM3

ctl EB NU EB+NU20’ 60’ 20’ 60’ 20’ 60’ 20’ 60’

A

B

DN

A r

ep

lic

ati

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%

Page 4: Supplementary figure S1

Supplementary figure S4.

0 25 45 60 90 1200

20

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time (min)

Cisplatin

Oxaliplatin

Fascaplycin

DMSO

% DNA replicated

Page 5: Supplementary figure S1

Supplementary figure S5.

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Page 6: Supplementary figure S1

Supplementary figure S6.

℗-MCM2

- 5 20 60

Cdc45

RPA

MCM7

Page 7: Supplementary figure S1

Supplementary figure S7.

Ctl 90’ EB 90’ 30’

DNA

DHCC

Supplementary figure S8.

DNA

Lamin B3

CTL10min 10min 45min45min

EB 50µM


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