Sunday, October 1411:30 Registration and poster mounting13:00 Welcome: Otmar D. Wiestler 13:15 Welcome lecTURe Elaine Fuchs

Skin stem cells in homeostasis and cancer

Session 1 Leukemic STem ceLLS AND micro- eNviroNmeNT

Chair: Andreas Trumpp

14:15 Tariq Enver Genetic and epigenetic sources of hetero-geneity in childhood leukaemia

14:45 Shahin Rafii Angiocrine factors-derived from tumor-

specified vascular niche induce and maintain tumor initiating cells

15:15 Coffee break 15:45 Markus Müschen

oncogene signaling and negative feedback in leukemia

16:15 Catriona Jamieson malignant progenitor reprogramming:

Biologic and therapeutic implications16:45 Paul Frenette

Neural regulation of stem cell and cancer cell migration

17:15 David Lyden Tumor-derived exosomes educate bone

marrow progenitor cells to a pro-metastatic phenotype

17:45 Welcome reception

Monday, October 1509:00 Greeting address Philipp U. Heitz German Academy of Sciences leopoldina

Session 2 STem ceLLS oF SoLiD TumorS AND meTASTASiS

Chair: Varda Rotter

09:15 Thomas BrabletzemT, microRNAs and cancer stem cells

09:45 Michael Clarke Deregulation of stem cell self-renewal pathways in cancer

10:15 Coffee break 10:45 Andreas Trumpp circulating metastasis-initiating cells in

breast cancer 11:15 Thea Tlsty

cellular conversations that control malignancy

11:45 Luis Parada Genetic mouse models of glioma: Trans-

lational tools for therapeutic development

12:15 Lunch break 13:15 Gregory Driessens (short talk)

Defining the mode of tumor growth by clonal analysis

13:30 Beatriz Aranda-Orgilles (short talk)Regulation of stem cell self-renewal, differentiation and transformation by the ubiquitin-proteasome system

13:45 Michael Shen Stem cells and the origin of prostate cancer14:15 Owen Witte

Stem cells in prostate cancer initiation and progression

14:45 PoSTeR SeSSioN

16:30 KeYNoTe lecTURe Philip Beachy

Sonic hedgehog-expressing basal stem cells are the cell-of-origin for bladder cancer

17:30 Meet-the-speakers dinner, DKFZ

Tuesday, October 16

Session 3 BrAiN Tumor STem ceLLS

Chair: Michael Platten 09:00 Jürgen Knoblich Using Drosophila as a model system for

tumorigenesis and cancer stem cells09:30 Ana Martin-Villalba

The role of cD95 in tumor initiation and tumor progression

10:00 Hai-Kun Liu (short talk)Genetic dissection of self-renewal and differentiation in normal and malignant brain stem cells

10:15 Coffee break

10:45 KeYNoTe lecTURe Ronald McKay Stem cell technologies & human functional

genomics

11:45 PoSTeR AWARD

12:00 Lunch break

Session 4 reProGrAmmiNG AND STem ceLL PATHWAYS

Chair: Anthony Ho

13:15 Marius WernigUpdates on induced neuronal cell reprogramming

13:45 Jochen Utikal (short talk)induced pluripotency and cancer cells

14:00 Varda RotterThe role of p53 in the life of stem cells

14:30 Coffee break 15:00 Mariano Barbacid

cancer initiating cells in non-small-cell lung carcinoma

15:30 Joachim Wittbrodtexclusive multipotency in post-embryonic neural stem cells of the fish retina

16:00 KeYNoTe lecTURe Hans Clevers Wnt signaling, lgr5 stem cells and cancer

17:00 Farewell reception

Venue

German cancer Research centercommunication centerim Neuenheimer Feld 280D-69120 Heidelberg, Germanyphone: +49 (0) 6221 42-0www.dkfz.de/Scc2012

Conference office

Dagmar JarekRenate KimGerman cancer Research centerim Neuenheimer Feld 280D-69120 Heidelberg, Germanyphone: +49 (0) 6221 42-2841fax: +49 (0) 6221 42-2840e-mail: Scc2012@dkfz.de

Sponsored by

Heinrich F. C. Behr-Stiftung, Heidelberg

Speakers

mariano Barbacid, madridPhilip Beachy, StanfordThomas Brabletz, Freiburg michael F. clarke, StanfordHans c. clevers, UtrechtTariq enver, londonPaul S. Frenette, New Yorkelaine Fuchs, New Yorkcatriona Jamieson, San DiegoJürgen A. Knoblich, ViennaHai-Kun liu, HeidelbergDavid c. lyden, New YorkAna martin-Villalba, HeidelbergRonald mcKay, Baltimoremarkus müschen, San Franciscoluis F. Parada, DallasShahin Rafii, New YorkVarda Rotter, Rehovotmichael m. Shen, New YorkThea Tlsty, San FranciscoAndreas Trumpp, HeidelbergJochen Utikal, Heidelbergmarius Wernig, StanfordJoachim Wittbrodt, Heidelbergowen Witte, los Angeles

organizers

Joe B. Harford, BethesdaRon mcKay, BaltimoreAndreas Trumpp, Heidelbergotmar D. Wiestler, Heidelberg

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a 7th International Heinrich F. C. Behr-Symposiumoctober 14 – 16, 2012German cancer research center (DkFZ), Heidelberg

STem ceLLS AND cANcer

2012

DKFZ main building

Main entrance

Communication Center

from B37 / A656 / Main station