summary of the proposed project -...
TRANSCRIPT
1
SUMMARY OF THE PROPOSED PROJECT
1. File No. -
2. (a) Name & location details of the project.
M/s. ASB LABORATORIES PVT. LTD., Plot Nos: 171, 172, 173 & 174, survey no 103, Gadvanthi Village,Humnabad Industrial Area, Humnabad, Bidar District,Karnataka.
(b) Address of Project Proponent for correspondence.
ASB LABORATORIES PVT. LTD., Flot no 102,1st floor ,Elite Residency, Matha Bhuvaneswari,Hi Tech city Mainroad, Khanamet, Madhapur, Hyderabad-500 084.
3. Objective of the Project Establishment of Bulk Drugs and Intermediates manufacturing industry
4. Project details Establishment of Bulk Drugs and Intermediates manufacturing industry
5. Details of major products manufactured (along with by-products)
a) Installed capacity Sl. No.
Name of the Product Quantity (TPM)
Quantity (Kg/day)
1 Biperiden Hydrochloride 1.0 40.0
2 Carisoprodol 1.0 40.0
3 Cetirizine Di-Hydrochloride 5.0 200.0
4 Ciprofloxacin Hydrochloride 0.5 20.0
5 Citalopram HBr 0.1 4.0
6 Clopidogrel Bisulfate 2.0 80.0
7 Enrofloxacin Hydrochloride 0.5 20.0
8 Entacapone 0.5 20.0
9 Fexofenadine Hydrochloride 0.5 20.0
10 Fluconazole 0.5 20.0
11 Hydroxyzine Hydrochloride 0.5 20.0
12 Imatinib Mesylate 0.5 20.0
13 Itraconazole 0.5 20.0
14 Lamivudine 1.0 40.0
15 Lansoprazole 1.0 40.0
16 Levo Cetirizine 1.0 40.0
17 Losartan Potassium 2.0 80.0
18 Mebeverine Hydrochloride 0.5 20.0
19 Meclizine Hydrochloride 0.5 20.0
20 Omeprazole 1.0 40.0
21 Pantoprazole 3.0 120.0
22 Paracetamol 20.0 800.0
23 Pregabalin 3.0 120.0
24 Sertraline Hydrochloride 3.0 120.0
25 Telmisartan 2.0 80.0
26 Tramadol Hydrochloride 0.5 20.0
27 Zidovudine 0.5 20.0
28 Cefuroxime Axetil 1.0 40.0
29 Atorvastatin Calcium 0.5 20.0
53.6 TPM 2144 Kg/day
b) Production at present NA
c) Proposed capacity NA
6. Details of major raw materials (quantity/month).
Details appended as Annexure - 1
2
7. Status of Organization: Government/Semi Government/Public/Private
Private Limited Company
8. Investment (Rs) Rs 9.85 Crores
9. Total labor force 53 people
10. Nature of land (KIADB/ KSSIDC/Revenue /Others)
KIADB industrial area
11. Location and land use details of the area with schematic plan.
Topo map of the project area is submitted.
12. Details of water bodies around the proposed industry.
Gadvanthi Village Nala is at a distance of about 0.66 km towards North & West direction, Humnabad Lake at a distance of about 1.92 km towards South East direction.
13. Nature of soil Soil analysis report is submitted.
14. Distance (if within 50 km) to the nearest
National Park
Sanctuary
Heritage site
Monument
Reserve Forest
Protected Forest
Inter State boundary
None None None None None None None
15. Greenery plan within industrial premises including open area (area % of total area & species proposed).
6879.47 Sqm (34 %)
16. Details of source of water (rivers, lakes, ground, public supply)
KIADB public water supply scheme
17. Water balance Water balance chart is submitted.
a) Total water requirement 82.75 KLD
(i) Domestic 3.6 KLD
(ii) Gardening 6 KLD
(ii) Industrial
Process
Washing/Cleaning
Boiler feed
Cooling tower make-up water
Scrubber
R&D
73.15 24.65 KLD 2 KLD 15 KLD 30 KLD 1 0.5
b) Total wastewater generated 38.4 KLD
(i) Domestic sewage generated 2.4 KLD
(ii) Industrial (m3/day) 36 KLD
Process 29 KLD
3
Washing/Cleaning
Boiler blow-down
Cooling tower make-up water
Scrubber
R&D
2 KLD 2 KLD(Blowdown) 1.5 KLD (Bleed Off) 1 0.5
c) Effluent treatment proposal (a) Domestic Sewage is treated in Septic tank and soak pit.
(b) Industrial Industrial effluent is proposed to be treated in Effluent Treatment Plant with Multiple Effect Evaporator (MEE) followed by RO filtration for treatment, reuse and disposal.
d) Mode of disposal (pond/ river valley/ underground sewer/irrigation/ocean/ others (specify)
a. industrial effluent – Re-used for landscape development, cooling tower make-up water etc.
e) Total area allocated for disposal of wastewater.
NA as the treated wastewater is not disposed on land.
18. a) Details of air pollution sources Boiler & DG set
Processing emission
Griders/crusher
Boiler
Power generators
NA Nil SO2, NOx, SPM SO2, NOx, SPM
b) Details of control equipment Boiler, & DG set – stacks
19. a) Solid waste details (i) Domestic (ii) Industrial (iii) Hazardous
14 kg/day
S.No Description Quantity
1 Ash from Boiler 1.5 TPD
2 Solvent residue 0.3 TPD
3 Evaporation salts 0.65 TPD
4 Process residue 0.23 TPD
Carbon 71 kg/day
Catalyst 0.5 kg/day
Inorganic Residue 32.6 kg/day
5 ETP Sludge 22 Kg/day
6 Municipal Wastes 30 kg/day
7 Detoxified containers 750 nos/year
8 Waste oil 120 Ltrs/year
9 Used batteries 1 No/Year
4
(b) Solid waste disposal methods (i) Domestic (ii) Industrial (iii)hazardous waste)
The domestic wastes are segregated at source, collected in bins and composted. .-
S.No Description Quantity Remarks
1 Ash from Boiler
1.5 TPD Sold to Brick manufactures
2 Solvent residue
0.3 TPD Sent to TDSF/ Cement units
3 Evaporation salts
0.65 TPD Sent to TSDF
4 Process residue
0.23 TPD Sent to Cement units
Carbon 71 kg/day For incineration in boiler
Catalyst 0.5 kg/day Returned to manufacturers
Inorganic Residue
32.6 kg/day
Sent to TSDF/Cement units
5 ETP Sludge 22 Kg/day Sent to TSDF
6 Municipal Wastes
30 kg/day Municipal solid waste disposal/vermin compost bed
7 Detoxified containers
750 nos/year
Sold to authorized vendors
8 Waste oil 120 Ltrs/year
Sent to Authorized Recyclers
9 Used batteries
1 No/Year Sent to Authorized Recyclers
20. Ambient noise level
(A) Source of noise and vibrations DG set
(B) Noise and vibration control measures proposed
Acoustic enclosure is proposed
21. Power requirement indicating source of power supply
1. The total power requirement is 200 KVA which is to be obtained KPTCL through KIADB.
22. Documents submitted:
Environmental Management Plan Submitted
Project report Pre-feasibility Report is Submitted
Clearance of Pollution Control Board
Applied
Clearance approved on site Emergency Plan from the Chief Inspector of factories & Boilers
Submitted
Topographical map of the area Submitted
REIA Submitted
Social commitment plan Submitted
5
ANNEXURE -1 RAW MATERIALS REQUIREMENT
Table .1: - Raw materials requirement
Sl. No.
Product Raw materials Quantity required
kg/batch kg/month kg/annum
1 Biperiden Hydrochloride
Mono Cyclo Penta Diene
33 2,541 30492
Methanol 325 25025 300300
Acetonitrile 30 2310 27,720
1,4 - Dioxane 230 17710 212520
Methyl Magnesium Chloride
275 21175 254100
Di Iso Propyl Ether 850 65450 785400
Piperdine HCl 36 2772 33264
Para Formaldehyde 11 847 10164
Iso Propyl Alcahol 550 42350 508200
Caustic Soda flakes 5 385 4620
Phenyl Magnesium Chloride
180 13860 166320
Iso Propyl Alcahol .HCl (18%)
30 2310 27720
Acetone 30 2310 27720
Activated Carbon 3 231 2772
2 Carisoprodol 2, – Methyl - 2 - n – Propyl propane -1,3
- Diol
100 1000 12000
Toluene 1100 11000 132000
Di Methyl Carbonate
80 800 9600
Methanol 500 5000 60000
S.M.O Powder 40 400 4800
Mono Iso Propyl Amine
95 950 11400
Chloro Form 800 8000 96000
Chloro Form 800 360 4320
Water 800 8000 96000
3 Cetirizine Di-Hydrochloride
Para Chloro Benzophenone
50 5000 60000
Sodium Boro Hydride
3.5 350 4200
Toluene 1545 154500 1854000
Methanol 251 25100 301200
6
Water 2115 211500 2538000
HCl 321.5 32150 385800
Piperzine 60 6000 72000
Tertiory Butyl Ammonium
Bromide
1 100 1200
Caustic Soda Lye 20 2000 24000
Di Chloro Methane 520 52000 624000
2 – Chloro Ethanol 35 3500 42000
Tri Ethyl Amine 43 4300 51600
Di Methyl Form amide
170 17000 204000
KOH 25 2500 30000
Ethyl Acetate 840 84000 1008000
NaCl 7 700 8400
S.M.C.A 45 4500 54000
4 Ciprofloxacin Hydrochloride
Acetophenone 150 750 9000
Ethylene Dichloride 704 3520 42240
NaOH 47 235 2820
Di Chloro Methane 198 990 11880
Di Methyl Sulphate 255 1275 15300
Di Methyl Formamide
325 1625 19500
Potassium Carbonate
10 50 600
DM Water 3970 19850 238200
Cyclo Propyl Amine 30 150 1800
Toluene 115 575 6900
Sodium Carbonate 100 500 6000
C.S.Lye 10 50 600
Hcl 100 500 6000
Acetic acid 7 35 420
Methanol 440 2200 26400
N-Butanol 138 690 8280
Piperzine 172 860 10320
E D T A 100 500 6000
Carbon 4 20 240
5
Citalopram HBr
Magnesium 28 56 672
THF 450 900 10800
PFBB 145 290 3480
DMPAC 120 240 2880
5-cynophthalide 50 100 1200
Toluene 410 820 9840
7
Acetic acid 45 90 1080
Water 318 636 7632
NH4Cl 45 90 1080
HBr 11 22 264
IPA 200 400 4800
Di Hydroxy 65 124 1488
H3PO4 167 334 4008
NH4OP 90 180 2160
6 Clopidogrel Bisulfate
2 – Chloro phenyl glycene
100 2000 24000
H2SO4 130 2600 31200
Toluene 1.95 39 468
Di Chloro methane 0.3 6 72
Liquid Ammonia 70.06 1401.2 16814.4
Na2SO4 55 1100 13200
DM Water 601.5 12030 144360
Methanol 1.97 39.4 472.8
Acetone 0.28 5.6 67.2
L(+)Tartaric acid 77 1540 18480
Thiophene - 2 - ethanol
100 2000 24000
P.T.S.C 165 3300 39600
NaOH 0.15 3 36
T.B.A.B 5.5 110 1320
Acetonitrile 0.15 3 36
KHCO3 177 3540 42480
HCl 0.05 7 12
Ethyl acetate 0.4 8 96
Formaldihyde 0.15 3 36
Ammonia 0.07 1.4 16.8
7 Enrofloxacin Hydrochloride
Q –Acid 25 500 6000
N –Ethyl Piperzine 15.5 310 3720
C.S.Lye 13 260 3120
Acetic acid 15 300 3600
Methanol 120 2400 28,800
n-Butanol 17 340 4080
8 Entacapone Chloroacetyl Chloride
60 540 6480
Toluene 1250 11250 135000
Diethyl amine 42 378 4536
Water 1550 13950 167400
DMF 122 1098 13176
NaCN 22 198 2376
8
3-Methoxy-4-Hydroxy
Benzaldhyde
100 900 10800
NitricAcid 800 7200 86400
3-methoxy-4-hydrxy 5-
Nitro benzaldehyde
90 810 9720
AlCl3 90 810 9720
E.D.C 450 4050 48600
HCl 480 480 5760
Piperdine 20 180 2160
Methanol 325 2925 35100
9 Fexofenadine Hydrochloride
Methyl – 4 – (4 – chloro – 1 –
oxobutyl)2,2-dimethyl phenyl
acetate
140 420 5040
Azocyclonal 100 300 3600
Toluene 750 2250 27,000
Potassium carbonate
40 120 1440
Methanol 120 360 4320
Water 530 1590 19080
Sodium Boro Hydride
9 27 324
Sodium Hydroxide 20 60 720
Ethyl acetate 540 1620 19440
Carbon 5 15 75
HCl 84 252 3024
10 Fluconazole Di fluoro benzene 150 300 3600
Chloro acetyl Chloride
160 320 3840
AlCl3 230 460 5520
Methylene di Chloride
1350 2700 32400
Hcl 300 600 7200
DM Water 3000 6000 72000
I.P.A 1100 2220 26640
Triazole 160 320 3840
Sodium nitrite 37 74 888
Ammonia 50 100 1200
KOH 100 200 2400
1,2,4 – Triazole 160 320 3840
9
Tri methyl sulfoxy iodide
50 100 1200
Methylene di Chloride
1100 2200 26400
Citric acid 25 50 600
11 Hydroxyzine Hydrochloride
4 – Chloro Benz Hydryl Piperzine
60 600 7200
Toluene 348 3480 41760
Tri Ethyl Amine 21 210 2520
HCl 550 5500 66000
2 – (2 – Chloro Ethoxy) Ethanol
55 550 6600
NaOH 48 480 5760
Di Chloro Methane 910 9100 109200
Acetone 470 4700 56400
Water 200 2000 24000
12 Imatinib Mesylate
AP 100 300 3600
DMFDMA 98 294 3528
ANT 250 750 9000
CM 54 162 1944
70% HNO3 105 315 3780
N-butanol 400 1200 13500
IM-II 375 1125 4032
IM-I 1112 336 972
Lye solution 27 81 900
Pd/C 10% 25 75 28800
Methanol 800 2400 2700
IM-Acid 75 225 1368
Thinyl chloride 38 114 4500
Toluene 125 375 3600
IM-IV 100 300 3276
IM-V 91 273 9000
MCL 250 750 1620
NaOH 45 135
Methane sulphonic acid
35 105 1260
13
Itraconazole 1 – (4- Methoxy phenyl) Piperzine
72.5 362.5 4350
P – Nitro Chloro Benzene
59.5 297.5 3570
D.M.F 2740 13700 164400
Potassium carbonate
55 275 3300
10
Water 4760 23800 285600
Palladium Carbon 5.5 27.5 330
Phenyl Chloro Formate
47 235 2820
Toluene 1140 5700 68400
Sodium Bi Carbonate
25.5 127.5 1530
Hydrazine Hydrate 13.5 67.5 810
1,4 - Dioxane 525 2625 31500
Acetic acid 28.5 142.5 1710
Formamide 10.5 52.5 630
2 – Bromo Butane 29.5 147.5 1770
Methanol 3350 16750 201000
Hydrogen Bromide 30 150 1800
Sodium Carbonate 20 100 1200
Cis – Bromo Benzoate
90 450 5400
1,2,4 - Triazole 14 70 840
I.P.A 600 3000 36000
Methane Sulfonyl Chloride
21 105 1260
Triethylamine 18.5 92.5 1110
Potassium Hydroxide
10 50 600
Carbon 8 40 480
14 Lamivudine Α – Menthol 100 1200 14400
Cyclo Hexane 270 3240 38880
Gly Oxalic Acid 40 480 5760
H2SO4 1 12 144
NaHSO3 36 432 5184
HCHO 25 300 3600
Na2CO3 6 72 864
DM Water 1130 13560 162720
2,5-Di Hydroxy-1,4-Di Ethane
34 408 4896
T.E.A 63.5 762 9144
Toluene 555 6660 79920
n-Hexane 264 3168 38016
M.D.C 580 6960 83520
D.M.F 28 336 4032
M.S.A 0.8 9.6 115.2
SOCl2 48 576 6912
Cytosine 39 468 5616
11
H.M.D.S 67 804 9648
15
Lansoprazole Acetic Acid 80 1920 23040
3,5 Lutidine 100 2400 28800
H2O2 2171.7 52120.8 625449.6
Methanol 325 7800 93600
Sulphuric Acid 350 8400 100800
Nitric acid 175 4200 50400
DM Water 450 10800 129600
Methylene chloride 500 12000 144000
MIBK 350 8400 100800
Pottacium carbonate
80 1920 23040
Trifluoroethanol 120 2880 34560
Aceticanhydride 150 3600 43200
Toluene 325 7800 93600
IPA hydrochloride 100 2400 28800
NaOH 108 2592 31104
Carbon 9 216 2592
Sodium sulphate 20 480 5760
Methylene chloride 200 4800 57600
Thionylchloride 75 1800 21600
Acetone 450 10800 129600
Isopropyl alcohol 300 7200 86400
Chloroform 530 12750 152640
n-Hexane 90 2160 25920
Dil Acetic acid 40 960 11520
EDTA 1 24 288
16
Levocetirizine 4-Chloro benzophenone
50 1450 17400
AmmoniumFormamide
95 2755 33060
Methanol 222 6430 77256
Carbon 1 29 348
Water 640 18560 222720
IPA HCl 200 5800 69600
N-Hexane 200 5800 69600
NaOH 78 2262 27144
Methylenechloride 800 23200 278400
L(+) Tartaric Acid 29.4 852.6 10231.2
n- ethyl di isopropyl amine
50 145 17400
12
N – n- bis chloro ethyl -4-methyl
benzene sulfonamide
29 841 10092
Hydrobromic in acetic acid
64 1856 22272
4- hydroxyl benzoic acid
27 783 9396
2-chloro ethanol 13 377 4524
Tri ethyl amine 21 609 7308
toluene 250 7250 87000
2-Chloro sodium acetate
18 522 6264
Koh 10 290 3480
acetone 150 4350 52200
17
Losartan Potassium
2-Cyano-4-Bromo methyl phenyl
100 1600 19200
2 – Butyl-4-chloro-5-formyl imidazole
84 1344 16128
T.B.A.B 11.2 179.2 2150.4
NaOH 40.6 649.6 7795.2
Sodium Boro Hydride
11.2 179.2 2150.4
Methanol 796 12736 152832
DM Water 100 1600 19200
Sodium Azide 84 1344 16128
T.E.A.HCl 150 2400 28800
Toluene 708 11328 135936
n-Methyl Pyrrolidin
137 2192 26304
Water 150 2400 28800
Acetic acid 180 2880 34560
Ethyl acetate 80 1280 15360
Acetone 530 8480 101760
KOH 19 304 3648
Carbon 12 192 2304
18 Mebeverine Hydrochloride
Para methoxy benzaldehyde
100 200 2400
Alpha chloro propionate
100 200 2400
Sodium methoxide (25%)
375 750 9000
HCl 98 196 2352
13
Water 1055 2110 25320
Methanol 150 300 3600
Ethylamine 40 80 960
10% Pd/C 2 4 48
Veratic acid 115 230 2760
Sodium salt of Veratic acid
120 240 2880
Di Bromo butane 600 1200 14400
Toluene 50 100 1200
TEBAC 2 4 48
Sodium Carbonate 63 126 1512
M.I.B.K 150 300 3600
Ethyl acetate 300 600 7200
T.B.A.B 2 4 48
Di Chloro methane 200 400 4800
19 Meclizine Hydrochloride
Meta xylene 90 540 6480
N – Bromo succinamide
90 540 6480
Chloroform 75 450 5400
Benyl peroxide 0.5 3 36
Sodium bi carbonate
60 360 4320
Water 200 1200 14400
Toluene 1260 7560 90720
4 – Chloro Benz Hydryl Piperzine
85 510 6120
Potassium carbonate
60 360 4320
I.P.A HCl 75 450 5400
Iso Propyl Alcohol 365 2190 26280
Methanol 145 870 10440
20 Omeprazole Acetic Acid 90 1260 15120
3,5 Lutidine 100 1400 16800
H2O2 2914.6 40804.4 489652.8
Methanol 1400 19600 235200
Sulphuric Acid 320 4480 53760
Nitric acid 185 2590 31080
DM Water 700 9800 117600
Toluene 2640 36960 443520
DMS 75 1050 12600
NaOH 221 3094 37128
14
Ammonium per sulphate
180 2520 30240
Carbon 20 280 3360
Sodium Sulphate 20 280 3360
Dimethyl formamide
1.6 22.4 268.8
Thionylchloride 65 910 10920
Acetone 210 2940 35280
Mercapto-5methoxy
benzimidazole
75 1050 12600
Catalyst 0.1 1.4 16.8
Dil Acetic acid 40 560 6720
Methylenedichloride
50 700 8400
EDTA 0.1 1.4 16.8
21 Pantoprazole Maltol 100 3000 36000
Di methyl sulphate 105 3150 37800
Potassium carbonate
92 2760 33120
Acetone 2485 74550 894600
Ammonia 230 6900 82800
E.D.C 1352 40560 486720
DM Water 1970 59100 709200
POCL3 60 1800 21600
48% Lye solution 100 3000 36000
H2O2 78 2340 28080
Acetic acid 220 6600 79200
Sodium tungstate 2 60 720
Chloroform 600 18000 216000
25% lye solution 300 9000 108000
Sodium sulphate 10 300 3600
Methanol 350 10500 126000
NaOH 98 2940 35280
Acetic anhydride 120 3600 43200
Sodium sulphate 20 600 7200
SoCl2 60 1800 21600
Benzimidazole 96 2880 34560
M.D.C 1600 48000 576000
NaOCl(3.5-4.2) 1000 30000 360000
Ammonium sulphate
116 3480 41760
Carbon 16 480 5760
15
22 Paracetamol Technical paracetamol
1010 20200 242400
Activated Carbon 35 700 8400
Water 1000 20000 240000
Hydrose 2 40 480
E.D.T.A 0.30 6 72
23 Pregabalin Iso Valaraldehyde 100 3000 36000
Di ethylmalonate 161 4830 57960
Acetic acid 202 6060 72720
Di – N – Propyl amine
55 1650 19800
Hexane 390 11700 140400
Sodium cyanide 48 1440 17280
Ethanol 514 15420 185040
Toluene 2130 63900 766800
DM Water 1052 31560 378720
HCl 240 7200 86400
KOH 166 4980 59760
Methanol 260 7800 93600
Raney nickel 55 1650 19800
I.P.A 565 16950 203400
L(+) Mandallic acid 120 3600 43200
24 Sertraline Hydrochloride
Α – Napthol 100 8100 97200
1,2 – Di Chloro Benzene
300 24300 291600
AlCl3 150 12150 145800
Methanol 1270 102870 1234440
Mono Methyl Amine in
Methanol(25%)
310 25110 301320
Sodium Boro Hydride
11 891 10692
HCl 65 5265 63180
D (-) Mandilic Acid 43 3483 41796
Ethyl Acetate 790 63990 767880
Sodium Sulphate 32 2592 31104
Activate Carbon 6 486 5832
Methanolic HCl (25%)
50 4050 48600
Acetone 10 810 9720
C.S.Flakes 7 567 6804
Lq.Ammonia 25 2025 24300
16
25 Telmisartan Methyl-4-amino-3-methyl benzoic acid
100 2500 30000
SOCl2 102 2550 30600
Methanol 1843 46075 552900
Ammonia 300 7500 90000
Methyl-4-amino-3-methyl benzoate
110 2750 33000
M.D.C 660 16500 198000
NaHCO3 110 2750 33000
Butyryl Chloride 110 2750 33000
DM Water 2900 72500 870000
Hexane 390 9750 117000
HNO3 390 9750 117000
Raney nickel 9 225 2700
Ethyl acetate 120 3000 36000
NaOH 42 1050 12600
Acetic acid 85 2125 25500
N.M.B – I 68 1700 20400
Poly Phosphoric acid
500 12500 150000
Ammonia solution 470 11750 141000
Sodium hydride (60%)
13 325 3900
BPC-II 85 2125 25500
1,2di methoxy ethane
396 9900 118800
26 Tramadol Hydrochloride
Cyclohexanone 180 720 8640
IPA 600 2400 28800
DMA HCl 75 300 3600
Acetone 620 2480 29760
P.formaldehyde 40 160 1920
NaOH 35 140 1680
n-Hexane 450 1800 21600
Water 410 1640 19680
Sodium sulphate 10 40 480
MBA mute brano amisde
105 420 5040
Mg turnings 25 100 1200
Di pormo ethane 135 540 6480
THF 500 2000 24000
AMM Chloride 20 80 960
Methanol 160 640 7680
17
Fuming HNO3 45 180 2160
Toluene 300 1200 14400
C.S.Flakes 35 140 1680
D.M.Water 200 800 9600
IPA 500 2000 24000
IPA HCl (30%) 15 60 720
Carbon 3 12 144
N.Hexane 15 60 720
27 Zidovudine Beta Thymidine 100 300 3600
Trityl Chloride 150 450 5400
1,4 dioxane 1320 3960 47520
T.E.A 560 1680 20160
Toluene 348 1044 12528
DM Water 790 2370 28440
M.D.C 1030 3090 37080
M.S.Chloride 70 210 2520
Methanol 990 2970 35640
28
Cefuroxime Axetil
n-n-Dimethyl Acetamide
477 4770 57240
Cefuroxime Acid 100 1000 12000
Sodium carbonate 15 150 1800
Acetoxy Ethyl Bromide
78 780 9360
Ethyl Acetate 520 5200 62400
DM water 782 7820 93840
Sodium metabisulphite
10 100 1200
Sodium chloride 40 400 4800
Sodium bicarbonate
7 70 840
Hydrochloric acid 9 90 1080
Cyclohexane 456 4560 54720
Acetone 59 590 7080
Carbon 10 100 1200
Methanol 174 1740 20880
29 Atorvastatin Calcium
Ethyl cyano – 3- hydroxyl Butanoite
40 400 4800
Lithium HMDS 20% in THF
340 3400 40800
Tertiary Butyl Acetate
111 1110 13320
HCl 220 2200 26400
Ethyl acetate 300 3000 36000
18
THF 150 1500 18000
Methanol 720 7200 86400
Diethyl methoxy boran
56 560 6720
SBH 7.5 75 900
MDC 750 7500 90000
Sodiumchloride 15 150 1800
Sodium sulphate 10 100 1200
Acetic acid 25 250 3000
Pt ether 570 5700 68400
2,2,dimethoxy propane
120 1200 14400
Methane sulphonic acid
2 20 240
Sodium bicarbonate
37 370 4440
RNC 50 500 6000
Liq.Ammonia 50 500 6000
Cyclohexane 450 4500 54000
Pavulic Acid 6 60 720
Di ketone 50 500 6000
IPA 320 3200 38400
SBC 150 1500 18000
Water 100 1000 12000
Acetonitrile 400 4000 48000
HCl 18 180 2160
Sodium hydroxide 8 80 960
Carbon 4 40 480
Toluene 400 4000 48000
Calcium acetate 18 180 2160