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M u t a t i o n Research, 76 (1980) 314--324 © Elsevier /North-Hol land Biomedical Press

S U B J E C T I N D E X

V O L U M E 76 (1980)

Abate , in Salmonel la microsome assay, 38 Acephate , E. coli reverse muta t ion assay,

acceptabi l i ty criteria, 183 5-Acetamido-3-(5-ni t rofuryl)-6H-1,2,4-oxa-

diazine, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 182

4 -Ace tamidophenyl d iazonium borof luor ide , in Salmonel la microsome assay, 42

1 - (4-Acetamidophenyl)-3 ,3-dimethyl t r i - azene, in Salmonel la microsome assay, 40

Ace tophene t id in , in Salmonel la microsome assay, 32

N-AcetoxyoN-acetyl -2-aminof luorene, in Sal- monel la microsome assay, 32

N-Acetoxy-N-myr is toyl -2-amino f luorene, in Salmonel la mic rosome assay, 32

2-Acety laminof luorene , in Salmonel la assay, 32

N-Acety l -p-aminophenol , in Salmonel la mi- crosome assay, 32

Acetylsal icyl ic acid, in Salmonel la micro- some assay, 32

Acrolein, in Salmonel la microsome assay, 32 Acryloni t r i le , carcinogens in drinking water ,

244 --, E. coli reverse muta t ion assay, acceptabil-

i ty criteria, 179 Adipic acid, E. coli reverse muta t ion assay,

acceptabi l i ty criteria, 179 Af la tox in B1, in Salmonella microsome assay,

34 Agar overlay test, E. coli reverse muta t ion

assay, 173 Ainphos-methyl , E. coli reverse muta t ion

assay, acceptabi l i ty criteria, 179 Air pol lutants , ambient , col lect ion, charac-

ter izat ion and testing, 51 , , sources and types, 52

--, characterizing and evaluating mutagen- icity, 63

--, chemical analysis, 58 --, col lec t ion and pre- t rea tment methods , 54 --, mutagenic, 62

Air pol lutants , ( con t inued) --, problems encountered in research, 74 Air pol lut ion, airborne particles, comutagens

and t u m o u r promoters , 160 - - , - - , metabol ic act ivat ion and deact ivat ion,

158 --, biological significance of mutagenic i ty of

airborne particles, 157 --, chemical factors affect ing mutagenic i ty

of airborne particles, 152 --, col lec t ion me thods of airborne particles,

145 --, meteoro logy , physical factors affect ing

mutagenic i ty of airborne particles, 150 --, mutagenic i ty of airborne particles, 143 --, physical factors affect ing mutagenic i ty of

a irborne particles, 145 Aldrin, carcinogens in drinking water, 244 Alkyla t ing agents, direct-acting, mutagen-

icity, e lectrophi l ic i ty and carcinogenici ty, comparisons, 16

, , in Salmonel la microsome assay, 32 Alkyl lead, symptoma to logy of lead intoxi-

cation, 122 Amethop te r in , E. coli reverse muta t ion

assay, acceptabi l i ty criteria, 178 2-Amino-N6-hydroxyadenine , E. coli reverse

muta t ion assay, acceptabi l i ty criteria, 182 2-Amino-4-(5-nitro-2-furyl) thiazole, E. coli

reverse muta t ion assay, acceptabi l i ty cri- teria, 183

3 -Amino-6-[ 2-( 5-nitro-2-furyl )-vinyl ]-1,2,4- triazine, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 180

2-Aminopur ine , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 180

Amosi te , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 182

Animal, metabol ism of isoniazid, 90 --, whole, studies with chromium, 234 Anthophyl l i t e , E. coli reverse muta t ion

assay, acceptabi l i ty criteria, 182 Aroclor 1260, carcinogens in drinking water,

244

315

Aromatic amines, and nitro compounds, in Salmonella microsome assay, 32

Asbestos, E. coli reverse mutation assay, acceptability criteria, 180

Ash, fly, of rice straw, and mutagenicity test, 149

--, --, of wood and peat, and mutagenicity test, 149

Aspirin, in Salmonella microsome assay, 32 Aspon, E. coli reverse mutation assay,

acceptability criteria, 181 Assay, gaseous-exposure, studies on 180

chemicals, metabolizing systems, 4 --, liquid incubation method, studies on 180

chemicals, metabolizing systems, 5 --, microsome-mediated, compounds with

different lipophilic properties, 23 --, plate incorporation, studies on 180

chemicals, metabolizing systems, 4 Atrazine, in Salmonella microsome assay, 38 Automotive exhaust, mutagenicity test, 148 Azaserine, E. coli reverse mutation assay,

acceptability criteria, 179 Azides, in Salmonella microsome assay, 40,

42

Bacteria, repair-deficient, and activities of chromium, 232

--, tests in vitro, mutagenicity of isoniazid, 97

Bacterial, mutagenicity tests, studies on 180 chemicals, various metabolizing systems, 3

Bacteriophages, and activities of chromium, 232

Benomyl, E. coli reverse mutation assay, acceptability criteria, 182

Benz[a]anthracenes, in Salmonella micro- some assay, 38

Benzene, carcinogens in drinking water, 244 --, in Salmonella microsome assay, 32 Benzo[a]pyrene, carcinogens in drinking

water, 244 --, in Salmonella microsome assay, 38, 40 BHC, ~ and ~, carcinogens in drinking water,

244 Bioassay, mutagenicity testing of air pollu-

tants, 62 --, short-term, organic compounds in drink-

ing water, 247 Bis-(2-chlor0ethyl)ether, carcinogens in

drinking water, 244 2,2-Bis(p-chlorophenyl)acetaldehyde, in Sal-

monella microsome assay, 36 2,2-Bis(p-chlorophenyl)acetic acid, in Salmo-

nella microsome assay, 36 2,2-Bis(p-chlorophenyl)ethanol, in Salmo-

nella microsome assay, 36

2,2-Bis(p-chlorophenyl)ethylene, in Salmo- nella microsome assay, 36

2,2-Bis(p-chlorophenyl)ethylene oxide, in Salmonella microsome assay, 38

Bread CH2C12 extract, in Salmonella micro- some assay, 42

Bromacil, E. coli reverse mutation assay, acceptability criteria, 180

10-Bromomethylanthracene, mutagenic compounds in drinking water, 260

7-Bromomethylbenz[a]anthracene, E. coli reverse mutation assay, acceptability cri- teria, 183

4-Bromophenylazide, in Salmonella micro- some assay, 42

1-(4-Bromophenyl)-3,3-dimethyltriazene, in Salmonella microsome assay, 40

p-Bromostyrene oxide, E. coli reverse muta- tion assay, acceptability criteria, 184

tert .-Butylcatechole, in Salmonella micro- some assay, 32

2-sec-Butylphenyl-N-methylcarbamate, E. coli reverse mutation assay, acceptability criteria, 181

Cacodylic acid, E. coli reverse mutation assay, acceptability criteria, 179

Caffeine, E. coli reverse mutation assay, acceptability criteria, 184

--, heritable translocation test in mouse, 211 Calcium chromate, E. coli reverse mutation

assay, acceptability criteria, 182 Cancer, and isoniazid therapy, 102 --, possibility of, evaluation of isoniazid

therapy, 107 --, and tuberculosis, interrelation, epide-

miology of isoniazid, 102 Captafol, E. coli reverse mutation assay,

acceptability criteria, 181 Captan, E. coli reverse mutation assay,

acceptability criteria, 179 -- ,heri table translocation test in mouse,

210 Carbofuran, E. coli reverse mutation assay,

acceptability criteria, 180 Carbon tetrachloride, carcinogens in drink-

ing water, 244 1 -( 2-Carboxyphenyl)-3,3-dimethyltriazene,

in Salmonella microsome assay, 40 1-(3-Carboxyphenyl)-3,3-dimethyltriazene,

in Salmonella microsome assay, 40 1 -( 4 -Carboxyphenyl)-3,3-dimethyltriazene,

in Salmonel!a microsome assay, 42 Carcinogen, metabolism, with human and

experimental animal tissues, 14 Carcinogenic, activity, mutagenicity and

electrophilicity, of direct-acting alkylat- ing agents, comparisons. 16

316

Carcinogenici ty , o f ch romium, 230 --, correlat ion with t ranslocat ion test results

in mouse, 212 - - , o f 1 ,2-d ibromoethane and 1,2-dichloro-

e thane, 282 --, and in vivo mutagenic i ty , correlat ion of

E. coli reverse muta t ion results with, 188 --, of isoniazid, 92 --, micronucleus test, part of test p rogramme,

and predict ion of, le t ter to Editor , 113 --, and mutagenic i ty , of chromium, 227 Carteolol hydrochlor ide , E. coli reverse mu-

ta t ion assay, acceptabi l i ty criteria, 183 CCEO neutral f ract ion, isolated HPLC com-

ponent , mutagenic c o m p o u n d s in drink- ing water , 260

Cell-mediated mutagenic i ty , in Chinese ham- ster cells, 26

Chinese hamster , cells, V79, mutagenic i ty studies, 21

, , , and S. typhimurium strains, studies on 180 chemicals, 1

Chloramphenicol , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 178

Chlordane, carcinogens in drinking water, 244

Chloroace ta ldehyde , in Salmonel la micro- some assay, 34

Chloroacet ic acid, in Salmonel la microsome assay, 34

1-Chloro-2,2-bis(p-chlorophenyl)ethane, in Salmonel la mic rosome assay, 38

1 -Chloro-2,2-bis(p-chlorophenyl)ethylene, in Salmonel la mic rosome assay, 38

1-Chloro- l ,3-butadiene , in Salmonella micro- some assay, 34

2-Chloro- l ,3-butadiene , in Salmonel la micro- some assay, 34

Chlorod i f luoromethane , in Salmonel la mi- c rosome assay, 32

2-Chloroethanol , in Salmonella microsome assay, 34

Chloroe thy lene oxide, in Salmonella micro- some assay, 34

Chloroform, carcinogens in drinking water, 244

p-Chloron i t robenzene , carcinogens in drink- ing water , 244

2-Chloro-4-(5-nitro-furyl)- thiazole, E. coli reverse muta t ion assay, acceptabi l i ty cri- teria, 183

Chloroopyr i fos , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 181

S-[ 6-Chloro-oxazolo( 4,5-b )pyridin-2( 3H)- O-3-y lmethy l ] -O,O-d imethy lphosphoro- thioic acid, in Salmonella mic rosome assay, 38

4-Chlorophenylazide , in Salmonella micro- some assay, 42

1 - (4-Chlorophenyl)-3 ,3-dimethyl t r iazene, in Salmonella microsome assay, 42

2-Chlorophenyl-N-methylcarbamate , E. coli reverse muta t ion assay, acceptabi l i ty cri- teria, 181

1-(4-Chlorophenyl)-3-methyl t r iazene, in Sal- monel la microsome assay, 42

m-Chloros tyrene oxide, E. coli reverse muta- t ion assay, acceptabi l i ty criteria, 184

Chromium, carcinogenici ty , 230 , and mutagenic i ty , 227

--, metabol i sm and general toxic i ty , 229 --, mutagenic i ty , 232 Chrysoti le, particulate, E. coli reverse muta-

t ion assay, acceptabi l i ty criteria, 182 Coal fly ash, mutagenic i ty test, 148 Comutagens, and mutagenic i ty of airborne

particles, 159 Crocidol i te , part iculate, E. coli reverse

muta t ion assay, acceptabi l i ty criteria, 182 Cro toxyphos , E. coli reverse muta t ion assay,

acceptabi l i ty criteria, 182 2-Cyclohexylcarbonyl-( 1,3,4,6,7,11 b )hexa-

hydro-2H-pyrazine-(2,1a) isoquinol ine-4- one, in Salmonel la microsome assay, 32

Cyclopenta [a ]phenanthren-17-one-15,16-di- hydro , in Salmonel la microsome assay, 40

Cyclophosphamide , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 178

--, heri table t ranslocat ion test in mouse, 207

DDD, in Salmonella microsome assay, 38 DDE, in Salmonel la mic rosome assay, 36 DDT, carcinogens in drinking water , 244 --, in Salmonel la microsome assay, 38 Decamethr ine , in Salmonella microsome

assay, 38 Demeton , E. coli reverse muta t ion assay,

acceptabi l i ty criteria, 182 Dexon, E. coli reverse muta t ion assay,

acceptabi l i ty criteria, 179 1,5-Diaminobiuret , E. coli reverse muta-

t ion assay, acceptabi l i ty criteria, 181 2,6-Diaminopurine, E. coli reverse muta-

t ion assay, acceptabi l i ty criteria, 181 Diazinon, E. coli reverse muta t ion assay,

acceptabi l i ty criteria, 180 O,S-Dibenzoyl thiamine HC1, E. coli reverse

muta t ion assay, acceptabi l i ty criteria, 181 1 ,2-Dibromoethane , carcinogenici ty , 282 --, chemical and physical propert ies, 270 --, genotoxic effects, 269 --, metabol ism, 284 --, mutagenic i ty , 272 --, product ion , use and occurrence in envi-

ronment , 270

317

1,2-Dibromoethane, (cont inued) --, reproduction studies, 280 Dicamba, E. coli reverse mutat ion assay,

acceptability criteria, 181 4,4'-Dichlorobenzhydrol, in Salmonella mi-

crosome assay, 38 4,4-Dichlorobenzhydrol acetate, in Salmo-

nella microsome assay, 38 4,4'-Dichlorobenzophenone, in Salmonella

microsome assay, 38 1,1 -Dichloro-2,2-bis(p-chlorophenyl)ethane,

in Salmonella microsome assay, 38 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethyl-

ene, in Salmonella microsome assay, 36 1,4-Dichlorobutene-2, in Salmonella micro-

some assay, 34 3,4-Dichlorobutene-1, in Salmonella micro-

some assay, 34 1,4-Dichloro-2,3-epoxybutane, in Salmonella

microsome assay, 34 1,2-Dichloroethane, carcinogenicity, 282 --, carcinogens in drinking water, 244 --, chemical and physical properties, 270 --, genotoxic effects, 269 --, metabolism, 284 --, mutagenicity, 277 --, production, use and occurrence in envi-

ronment, 270 --, reproduction studies, 280 (2,4-Dichlorophenoxy)-acetic acid, E. coli

reverse mutation assay, acceptability cri- teria, 179

4,4'-Dichloro-~-(trichloromethyl)-benzhy- drol, in Salmonella microsome assay, 36

4,4'-Dichloro~-(trichloromethyl)-benzhy- drol acetate, in Salmonella microsome assay, 36

Dichlorvos, biological data, 299 --, carcinogenicity studies, 303 --, chemical and physical data, 297 --, E. coli reverse mutation assay, accept-

ability criteria, 178 --, genetic toxicity, evaluation, 297 --, metabolites, 303 --, mutagenicity studies, 301 --, in Salmonella microsome assay, 38 Dieldrin, carcinogens in drinking water,

244 1,2:7,8-Diepoxyoctane, mutagenic com-

pounds in drinking water, 260 Diesel exhaust, mutagenicity test, 148 Diethylstilboestrol, in Salmonella micro-

some assay, 32 1,2-Dihydroxy-2,2-bis(p-chlorophenyl)-

ethylene, in Salmonella microsome assay, 38

Dimethylbenz[a]anthracenes, in Salmonella microsome assay, 40

1,1-Dimethylhydrazine, in Salmonella micro- some assay, 42

1,2-Dimethylhydrazine, in Salmonella micro- some assay, 42

2-(2,2-Dimethylhydrazino)-4-(5-nitro-2- furyl)thiazole, E. coli reverse mutation assay, acceptability criteria, 183

Dimethyl nitrosamine, E. coli reverse muta- tion assay, acceptability criteria, 178

3,4-Dimethylstyrene oxide, E. coli reverse mutation assay, acceptability criteria, 184

2,4-Dinitrophenyl-thiocyanate, E. coli reverse mutation assay, acceptability cri- teria, 180

N,N'-Dinitrosoethambutol, in Salmonella microsome assay, 32

Dinoseb, E. coli reverse mutation assay, acceptability criteria, 179

Diphenylhydrazine, carcinogens in drinking water, 244

Disodium methane arsenate, E. coli reverse mutation assay, acceptability criteria, 179

Disulfoton, E. coli reverse mutation assay, acceptability criteria, 180

DNA, reactions with, mutagenicity of isoniazid, 97

--, synthesis, effects of chromium on fidelity of, 232

--, --, mutagenicity of lead, 123 Dominant lethal test, mutagenicity of isoni-

azid, 99 Drinking water, organic compounds, muta-

genic effects, 241 Drosophila melanogaster, activities of chro-

mium, 233 --, mutagenicity of 1,2-dibromoethane, 275 --, mutagenicity of 1,2-dichloroethane, 279 --, mutagenicity of dichlorvos, 302 --, and mutagenicity of lead, 124

Electrophilicity, mutagenicity and carcino- genic activity, of direct-acting alkylating agents, comparisons, 16

Endrin, carcinogens in drinking water, 244 --, E. coli reverse mutation assay, accept-

ability criteria, 179 Epichlorohydrin, in Salmonella microsome

assay, 32 Epoxide 201, 4-methyl-7-oxabicyclo [ 4,1,0 ]-

heptane-3-carboxylic acid, in Salmonella microsome assay, 32

Escherichia coli, mutation by chromium, 232

--, reverse mutation, correlation with results in vivo and carcinogenicity data, 188

--, reverse mutation assay, analysis and data interpretation, 174

318

Escherichia coli, reverse muta t ion assay, ( con t inued )

, , test descript ion, 172 , , test per formance , 176

--, uvrA reverse muta t ion assay, evaluation, 169

Ethion, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 180

E thy lened ibromide , carcinogens in drinking water , 244

Ethylene th iourea , carcinogens in drinking water , 244

--, E. col i reverse muta t ion assay, acceptabil- i ty criteria, 179

Ethyl idene gyromitr in, E. coli reverse muta- t ion assay, acceptabi l i ty criteria, 182

Ethyl methanesulphonate , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 184

--, heri table t ranslocat ion test in mouse, 207 --, in Salmonel la microsome assay, 32 Eukaryotes , and mutagenic i ty of lead, 124 --, screening tests with, on c h r o m i u m muta-

genici ty, 233

Fensul fo th ion , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 179

Fen th ion , E. col i reverse muta t ion assay, acceptabi l i ty criteria, 178

Folpet , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 179

Fonofos , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 180

Formic acid 2-[ 4-(2-furyl)-2-thiazolyl ]hydra- zide, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 183

Formic acid 2-(4-methyl-2- thiazolyl)hydra- zide, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 183

Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazyl]- hydrazide, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 181

Freon 22, in Salmonel la microsome assay, 32

Fura ldehyde semicarbazone, E. coli muta- t ion assay, acceptabi l i ty criteria, 181

Fura l tadone hydrochlor ide , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 181

Furmethano l , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 179

Furosemide [ 4-chloro-N-( 2-furylmethyl)-S- sul famoylanthrani l ic acid], in Salmonella mic rosome assay, 32

Fury l furamide , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 181

Gardona, in Salmonella microsome assay, 38 Gastro-intestinal tract , s y m p t o m a t o l o g y of

lead in toxica t ion , 121

Gene-Tox Program, reports, editorial intro- duct ion, bioassays, 165

D-Glucosamine, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 181

Glycidaldehyde, in Salmonella microsome assay, 32

Haematopoie t ic system, symptoma to logy of lead in toxica t ion , 119

Halo-alkanes, and related halo-compounds , in Salmonel la microsome assay, 34

Halo-olefins, and related halo-compounds , in Salmonella mic rosome assay, 34

Hamster, carcinogenici ty of isoniazid, 96 Hepa to tox ic i ty , in humans, by isoniazid, 87 Heptachlor , carcinogens in drinking water,

244 Heptachlor epoxide , carcinogens in drinking

water , 244 Heterozygotes , t ranslocation, meiot ic confi-

gurations, heri table t ranslocat ion test in mouse, 195

, , semisterile and sterile, heri table trans- locat ion test in mouse, 195

Hexachlorobenzene , carcinogens in drinking water, 244

Host -media ted assay, mutagenic i ty of isoni- azid, 99

Human, data, of cytogenet ics of isoniazid, 101

--, metabol i sm of isoniazid, 88 --, tox ic i ty by isoniazid, 87 Hydrazines, in Salmonella microsome assay,

40, 42 2-Hydrazino-4-( 5-nitro-2-furyl)thiazole, E.

coli reverse muta t ion assay, acceptabi l i ty criteria, 181

N-Hydroxy-N-acetyl -2-aminof luorene , in Sal- monel la microsome assay, 32

N4-Hydroxycyt id ine , E. coli reverse muta- t ion assay, acceptabi l i ty criteria, 181

N-(2-Hydroxyethyl ) -hydraz ine , E. coli reverse muta t ion assay, acceptabi l i ty cri- teria, 179

N-Hydroxy-N-myr is toyl -2-aminof luorene , in Salmonella mic rosome assay, 32

ICPEMC, Commission and Commit tees , compos i t ion and tasks, 223

--, News No. 3, 217 --, Publicat ion, No. 4, isoniazid, retrospec-

tive predict ion, 85 , , No. 5, genetic toxic i ty of dichlorvos,

297 Industrial chemicals, miscellaneous, in Sal-

monel la microsome assay, 32 Injonga CH2C12 extract , in Salmonella mi-

c rosome assay, 42

319

Iodofenphos , in Salmonel la microsome assay, 38

Isixaxa CH2C12 extract , in Salmonel la micro- some assay, 42

Isoniazid, carcinogenici ty , 92 --, cytogenet ics , 9 8 --, ep idemiology, 101 --, metabol ism, 88 --, mutagenic i ty , 97 --, therapy and cancer incidence, 102 ~ , tox ic i ty in humans, 87 --, usage and exposure , 86 2- Isopropophenyl -N-methylcarbamate , E.

coli reverse muta t ion assay, acceptabi l i ty criteria, 179

Isopropyl methanesu lphona te , heri table t ranslocat ion test in mouse, 210

2-Isopropyl-N-methylcarbamate , E. coli reverse muta t ion assay, acceptabi l i ty cri- teria, 181

Joss stick smoke, and mutagenic i ty tes t , 148

Kel thane, in Salmonel la microsome assay, 36 Kepone , carcinogens in drinking water , 244 Kerosene soot , and mutagenic i ty test, 148 Kidney, s y m p t o m a t o l o g y of lead intoxica-

t ion, 121

Lead, chemical and biochemical propert ies, 117

- - embryo tox ic i t y , 126 - - in toxica t ion , gastro-intestinal tract , 121

, haematopoie t i c system, 119 , k idney, 121

- - --, nervous system, 119 - - --, organic lead, 122 - - metabol ism, 122 - - mutagenic i ty , 123 - - s y m p t o m a t o l o g y of in toxica t ion , 118 - - tera togenic i ty , 126 - - toxic i ty , mutagenic i ty and teratogenici ty ,

115 Lindane, carcinogens in drinking water , 244 Lung, tuberculosis and cancer, interrelat ion,

ep idemiology of isoniazid, 102

Magneti te , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 180

Malathion, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 179

Mammalian, cells, cul tured, gene muta t ion by chromium, 233

, , in vitro, mutagenic i ty of lead, 124 --, mutagenic i ty , data, corre la t ion with

t ranslocat ion test results in mouse, 212 --, systems, in vitro and in vivo, mutagen-

icity of 1 ,2-d ibromoethane , 275 , , in vivo, mutagenic i ty o f 1,2-dichloro-

e thane , 280

Mammals, mutagenic i ty of dichlorvos, 302 --, observat ions in vivo, mutagenic i ty of

lead, 124 --, pharmacokine t ic studies of dichlorvos,

299 --, tests, cytogenet ics of isoniazid, 99 Mannitol , E. coli reverse muta t ion assay,

acceptabi l i ty criteria, 179 Marijuana smoke, and mutagenic i ty test, 148 6-Mercaptopurine, heri table t ranslocat ion

test in mouse, 210 Metaboli tes , reactive, ul t imate , characteriza-

t ion by mutagenic i ty tests, 13 Metabolizing systems, studies on 180 chemi-

cals with Salmonel la strains and Chinese hamster cells, 1

Meteoro logy, and mutagenic potent ia l of airborne particles, 150

Methanearsonic acid, monosod ium salt, E. coli reverse muta t ion assay, accept- abili ty criteria, 181

Methomyl , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 182

Methoxychlor , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 179

4-Methoxyphenol , in Salmonella microsome assay, 32

4-Methoxyphenylaz ide , in Salmonella micro- some assay, 42

4 -Methoxyphenyl d iazonium borof luor ide , in Salmonel la microsome assay, 42

1-(4-Methoxyphenyl) -3 ,3-dimethyl t r iazene, in Salmonel la microsome assay, 42

m-Methoxys ty rene oxide, E. coli reverse mu- ta t ion assay, acceptabi l i ty criteria, 184

Methylat ing react ivi ty o f dichlorvos, 300 Methylbenz[a]an thracenes , in Salmonella

mic rosome assay, 40 4-Methylcarboxyphenylaz ide , in Salmonella

microsome assay, 42 3-Methylcholanthrene, mutagenic com-

pounds in drinking water , 260 Methylcholanthrenes , in Salmonel la micro-

some assay, 40 11 -Methylcyclopental [a ] phenanthren-17-

one-15,16-dihydro, in Salmonella micro- some assay, 40

N-Methyl formamide , E. coli reverse muta- t ion assay, acceptabi l i ty criteria, 179

N-Methylhydrazine , E. coli reverse muta- t ion assay, acceptabi l i ty criteria, 178

Methyl methanesulphonate , E. col i reverse muta t ion assay, acceptabi l i ty , 178

--, heri table t ransiocat ion test in mouse, 210 --, in Salmonel la microsome assay, 32

t . . . . N-Methyl-N -nl t ro-N-mtrosoguamdme, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 179

320

N-Methyl-N'-nitro-N-nitrosoguanidine, (con- t inued)

--, in Salmonel la mic rosome assay, 32 4-Methylphenyl d iazonium borof luor ide , in

Salmonella microsome assay, 42 1-(4-Methylphenyl)-3 ,3-dimethyl t r iazene, in

Salmonel la m i c r o s o m e assay, 42 1-(4-Methylphenyl)-3-methyl t r iazene, in Sal-

monel la mic rosome assay, 42 N-Methyl-N-piperazino-acethydrazide, E.

coli reverse muta t ion assay, acceptabi l i ty criteria, 183

Methyls tyrene oxide, E. coli reverse muta- t ion assay, acceptabi l i ty criteria, 184

Metronidazole , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 180

Micronucleus, test, test p rogramme, and predic t ion of carcinogenici ty , let ter to Edi tor , 113

Microorganisms, and mutagenic i ty of 1,2- d ib romoe thane , 272

--, mutagenic i ty of 1 ,2-dichloroethane, 277 --, mutagenic i ty of dichlorvos, 301 Microsome-media ted mutagenic i ty , in Chi-

nese hamster cells, 26 Misonidazole, E. coli reverse muta t ion

assay, acceptabi l i ty criteria, 182 Mi tomycin C, E. coli reverse muta t ion assay,

acceptabi l i ty criteria, 178 --, heri table t ranslocat ion test in mouse, 210 Monocrota l ine , E. coli reverse muta t ion

assay, acceptabi l i ty criteria, 180 Monocro tophos , E. coli reverse muta t ion

assay, acceptabi l i ty criteria, 182 Monuron, E. coli reverse muta t ion assay,

acceptabi l i ty criteria, 179 Mouse, carcinogenici ty of isoniazid, 93 --, heri table t ranslocat ion test, 191

, , description, 194 , , per formance , 205 , , role in testing programme, 213

, testing pro tocol , 196 Mycotoxins , in Salmonel la microsome assay,

34 N-Myris toyloxy-N-acetyl -2-aminof luorene ,

in Salmonel la mic rosome assay, 32 N-Myris toyloxy-N-myris toyl -2-aminof luor -

ene, in Salmonel la microsome assay, 32

/3-Naphthylamine, mutagenic compounds in drinking water , 260

1-Naphthyl-N-methyl-carbamate , E. coli reverse muta t ion assay, acceptabi l i ty cri- teria, 178

Neocarzinostat in , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 182

Nervous system, symptoma to logy of lead in toxica t ion , 119

Neuropa thy , tox ic i ty in humans by isoni- azid, 87

NF-167, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 183

Nickel chloride, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 182

Nifura t rone , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 182

Ni furoxime, E. coIi reverse muta t ion assay, acceptabi l i ty criteria, 182

Nifurpipone, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 183

Niridazole, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 178

Nitr i lotr iacet ic acid, sodium calcium salt, heri table t ranslocat ion test in mouse, 211

4-(4-Nitrobenzyl)pyridine, assay for elec- trophil ic react ivi ty with, studies on 180 chemicals, 5

4-Nit robiphenyl , mutagenic compounds in drinking water , 260

Ni t rof luorene , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 183

--, in Salmonel la microsome assay, 32 5-Nitro-2-furaldehyde, E. coli reverse muta-

t ion assay, acceptabi l i ty criteria, 180 5-Nit ro-2-furanmethandiol diacetate, E. coli

reverse muta t ion assay, acceptabi l i ty cri- teria, 179

Ni t rofuranto in , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 178

Ni t rofurazone , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 178

5-Nitro-2-furonic acid, E. coli reverse muta- t ion assay, acceptabi l i ty criteria, 180

1 -( 5-Nitro-2-furyll idine)-3-N,N-diethylprop- y laminourea HC1, E. coli reverse muta- t ion assay, acceptabi l i ty criteria, 181

1 -( 5 -Nitro-2-furyl )-3-piperidino-propan- 1 - one-semicarbazone-HC1, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 183

1-[ 3-(5-Nitro-2-furyl)-N-2-propenylidine ]- aminohydanto in , E. coli reverse muta t ion assay, acceptabi l i ty criteria, 180

N- [ 4-( 5 -Nitro -2-furyl ) -2 -thiazolyl ]acetamide, E. coli reverse muta t ion assay, acceptabil- i ty criteria, 180

N-[ 4-( 5-Nitro-2-furyt)-2-thiazolyl ]forma- mide, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 182

N-[ 4-( 5-Nitro-2-furyl)-2-thiazolyl ]phenylala- nine, E. coli reverse muta t ion assay, acceptabi l i ty criteria, 183

3-(5-Nitro-2-furyl)-4H-1,2,4-triazole, E. coli reverse muta t ion assay, acceptabi l i ty cri- teria, 181

321

Nitrogen mustard, E. coli reverse mutation assay, acceptability criteria, 178

--, heritable translocation test in mouse, 211 5-Nitro-l-naphthonitrile, E. coli reverse mu-

tation assay, acceptability criteria, 182 1-(3-Nitrophenyl)-3,3-dimethyltriazene, in

Salmonella microsome assay, 42 4-Nitroquinoline N-oxide, E. coli reverse

mutation assay, acceptability criteria, 178 --, in Salmonella microsome assay, 32 N-Nitrosamines, in Salmonella microsome

assay, 34, 36 --, studies in V79 Chinese hamster cells, 21 N-Nitroso-2-sec-butyl-phenyl-N-methylcar-

bamate, E. coli reverse mutation assay, acceptability criteria, 183

N-Nitroso-2-chloro-phenyl-N-methylcarbam- ate, E. coli reverse mutation assay, acceptability criteria, 183

N-Nitrosoethylurea, in Salmonella micro- some assay, 32

N-Nitroso-2-isoproproxyphenyl-N-methyl- carbamate, E. coli reverse mutation assay, acceptability criteria, 183

N-Nitroso-2-isopropyl-N-methylcarbamate, E. coli reverse mutation assay, acceptabil- ity criteria, 183

Nitrosomethylurea, E. coli reverse mutation assay, acceptability criteria, 183

--, in Salmonella microsome assay, 32 N-Nitroso-N-methylurethane, in Salmonella

microsome assay, 32 N-Nitroso-l-naphthyl-N-methylcarbamate, E.

coli reverse mutation assay, acceptability criteria, 182

N-Nitroso-3-tolyl-N-carbamate, E. coli reverse mutation assay, acceptability cri- teria, 183

N-Nitroso-3,4-xylyl-N-methylcarbamate, E. coli reverse mutation assay, acceptability criteria, 183

N-Nitroso-3,5-xylyl-N-methylcarbamate, E. coli reverse mutation assay, acceptability criteria, 183

Noscapine, in Salmonella microsome assay, 32

Ochratoxin A, in Salmonella microsome assay, 34

Opium CH2C12 extract, crude, in Salmonella microsome assay, 42

Opium-smoke condensate CH2C12 extract, in Salmonella microsome assay, 42

Organic compounds, in drinking water, mu- tagenic effects, 241

Organic residues, in drinking water, isola- tion, 252

, , mutagen isolation and identification, 259

Organic residues, in drinking water, (con- tinued)

--, --, reverse osmosis concentrates, 255 --, --, role of disinfection in mutagen forma-

tion, 257 - - , - - , sorption/desorption on XAD and

other resins, 253 Organics, volatile, and non-volatile, mixtures

of, in drinking water, 243 Organochlorine compounds, in Salmonella

microsome assay, 36, 38

Paracetamol, in Salmonella microsome assay, 32

Parathion, E. coli reverse mutation assay, acceptability criteria, 178

--, in Salmonella microsome assay, 38 Parathion-methyl, E. coli reverse mutation

assay, acceptability criteria, 180 Patulin, in Salmonella microsome assay, 34 PCB, carcinogens in drinking water, 244 Penicillic acid, in Salmonella microsome

assay, 34 Permethrine, in Salmonella microsome assay,

38 Pesticides, in Salmonella microsome assay,

36, 38 Phage, RNA, interaction with 1,2-dibromo-

ethane, 272 Pharmaceutical chemicals, miscellaneous, in

Salmonella microsome assay, 32 Pharmacokinetics , studies of dichlorvos in

mammals, 299 Phenacetin, in Salmonella microsome assay,

32 Phenylazide, in Salmonella microsome assay,

42 Phenyl diazonium borofluoride, in Salmo-

nella microsome assay, 42 1-Phenyl-3,3-dimethyltriazene, in Salmonella

microsome assay, 42 1-Phenyl-3-methyltriazene, in Salmonella mi-

crosome assay, 42 N-Phenyl-2-naphthylamine, in Salmonella

microsome assay, 32 Phenyloxirane, in Salmonella microsome

assay, 32 Phorate, E. coli reverse mutation assay,

acceptability criteria, 180 Plants, activities of chromium, 233 --, eukaryotes, and mutagenicity of lead,

124 --, higher, mutagenicity of 1,2-dibromo-

ethane, 274 , 2~9u tagen ic i t y of 1,2-dichloroethane,

--, mutagenicity of dichlorvos, 302

322

cis-Plat inum d ich lo rod iamine , E. coli reverse m u t a t i o n assay, accep tab i l i ty cri teria, 182

Polycycl ic a roma t i c h y d r o c a r b o n s , in Salmo- nella m i c r o s o m e assay, 38

Po tass ium arseni te , E. coli reverse m u t a t i o n assay, accep tab i l i ty cr i ter ia , 180

Po tass ium c h r o m a t e , E. coli reverse muta- t i on assay, accep tab i l i ty cr i ter ia , 182

Praz iquan te l , in Sa lmonel la mic rosome assay, 32

P roca rbaz ine hyd roch l o r i de , he r i t ab le t rans- l oca t ion tes t in mouse , 210

P roka ryo te s , and m u t a g e n i c i t y of lead, 124 --, sc reening tests wi th , on c h r o m i u m mu-

tagenic i ty , 232 P roka ryo t i c assays, a l t e rna te , for organic

c o m p o u n d s in dr ink ing water , 250 1 ,3-Propane su l tone , in Sa lmonel la micro-

some assay, 32 Propani l , E. coli reverse m u t a t i o n assay,

accep tab i l i ty cr i ter ia , 180 2-Propenal , in Sa lmonel la m i c r o s o m e assay,

32 /3-Propiolactone, in Sa lmone l la m i c r o s o m e

assay, 32 P ro t e in pyro lysa te smoke , and m u t a g e n i c i t y

test , 148 PR tox in , in Sa lmone l la m i c r o s o m e assay,

34

Qu in tozene , E. coli reverse m u t a t i o n assay, accep tab i l i ty cr i ter ia , 179

Rat , ca rc inogen ic i ty of isoniazid, 95 R e p r o d u c t i o n s tudies , geno tox ic effects of

1 , 2 - d i b r o m o e t h a n e and 1 ,2-dichloro- e thane , 280

Reverse m u t a t i o n assay, of E. coli uvrA, evalua t ion , 169

Rice s t raw fly ash, and m u t a g e n i c i t y test , 148

RNA, of phage, i n t e r ac t i on wi th 1,2-di- b r o m o e t h a n e , 272

R u b r a t o x i n B, in Sa lmonel la m i c r o s o m e assay, 34

Saccharomyces eerevisiae, act ivi t ies of chro- m i u m , 233

Salmonel la t y p h i m u r i u m , de tec t ing muta - gens in u n c o n c e n t r a t e d d r ink ing water , 25O

--, h o s t - m e d i a t e d assay, m u t a g e n i c i t y of isoniazid, 99

- - m u t a g e n i c i t y of air po l lu tan t s , 63 --, m u t a g e n i c i t y of c o m p l e x mix tu re s of

d r ink ing wa te r organics, 247 --, m u t a t i o n by c h r o m i u m , 232 --, s t rains , and Chinese h a m s t e r cells, s tu-

dies o n 180 chemicals , 1

Sh i reh CH2C12 ex t rac t , in Sa lmonel la micro- some assay, 42

S iduron , E. coli reverse m u t a t i o n assay, accep tab i l i ty cri teria, 181

Simazine , E. coli reverse m u t a t i o n assay, accep tab i l i ty cri teria, 179

Smoke , f rom char red mea t and fish, and m u t a g e n i c i t y test , 148

S o d i u m azide, E. coli reverse m u t a t i o n assay, accep tab i l i ty cr i ter ia , 183

--, in Sa lmone l la m i c r o s o m e assay, 42 Sod ium benzoa t e , E. col i reverse muta -

t ion assay, accep tab i l i ty cri teria, 180 S o d i u m bisulf i te , E. coli reverse m u t a t i o n

assay, accep tab i l i ty cri teria, 182 --, he r i t ab le t r ans loca t ion tes t in mouse ,

211 S o d i u m c h r o m a t e , E. coli reverse muta-

t ion assay, accep tab i l i ty cri teria, 182 S o d i u m 2 , 4 - d i c h l o r o p h e n o x y b u t r a t e , E.

coli reverse m u t a t i o n assay, accept- abi l i ty cri teria, 182

S o d i u m h ippura t e , E. coli reverse muta - t ion assay, accep tab i l i ty cr i ter ia , 180

S o d i u m meta-b isu l f i te , E. coli reverse muta - t ion assay, accep tab i l i ty cri teria, 184

S o d i u m n i t r i t e - t r ea ted pork, he r i t ab le t rans- l oca t ion tes t in mouse , 21 ]

Spo t test , E. coli reverse m u t a t i o n assay, 173 S t a n n o u s chlor ide , E. coli reverse m u t a t i o n

assay, accep tab i l i ty cr i ter ia , 184 Steel welding fumes, and mu tagen i c i t y test ,

148 S ty rene oxide , E. coli reverse m u t a t i o n

assay, accep tab i l i ty cr i ter ia , 184 --, in Sa lmonel la m i c r o s o m e assay, 32 S u k h t e h CH2C12 ext rac t , in Sa lmonel la mi-

e rosome assay, 42 Sulfur mus ta rd , E. coli reverse m u t a t i o n

assay, accep tab i l i ty cr i ter ia , 180

Tea CH2C12 ex t rac t , in Sa lmone l la micro- some assay, 42

T e m e p h o s , in Sa lmonel la mic rosome assay, 38

TEPA, he r i t ab le t r ans loca t ion tes t in mouse , 207

Tera to logy , and tox ic i ty in h u m a n s by isoni- azid, 88

Test , agar overlay, E. coli reverse m u t a t i o n assay, 173

--, bacter ia l mu tagen ic i ty , s tudies on 180 chemicals , var ious me tabo l i z ing sys tems, 3

--, d o m i n a n t lethal , mu tagen i c i t y of isoni- azid, 99

--, f l uc tua t ion , modi f ied , E. coli reverse m u t a t i o n assay, 174

323

Test , ( con t inued ) --, he r i t ab le t r ans loca t ion , in mouse , 191

, , , descr ip t ion , 194 , , , p e r f o r m a n c e , 205

, role in the i r t es t ing p r o g r a m m e , ' 2 1 3

, t es t ing p ro toco l , 196 --, h o s t - m e d i a t e d assay, m u t agen i c i t y of

isoniazid, 99 --, in m a m m a l s , m u t a g e n i c i t y of isoniazid,

99 --, mic ronuc leus , tes t p r o g r a m m e , and pre-

d ic t ion of ca rc inogenic i ty , l e t t e r to Edi- tor , 113

-- organism, and genet ic end p o i n t detec- t ion , E. coli reverse m u t a t i o n assay, 172

, i den t i f i ca t ion and qua l i ty con t ro l , E. coli reverse m u t a t i o n assay, 172

- - screening, wi th euka ryo te s , on c h r o m i u m mutagen i c i t y , 233

, w i th p roka ryo te s , on c h r o m i u m muta - genic i ty , 232

- - shor t - t e rm, and biological s ignif icance of m u t a g e n i c i t y o f a i rbo rne part icles , 157

- - spot , E. coli reverse m u t a t i o n assay, 173 --, t r ea t and plate , E. coli reverse m u t a t i o n

assay, 174 Test ing, a m b i e n t air po l lu tan t s , 51 Tes t ing p r o g r a m m e , role of he r i t ab le t rans-

l oca t ion tes t assay of mouse , 213 T e t r a c h l o r o e t h y l e n e , ca rc inogens in dr ink ing

water , 244 --, in Sa lmone l l a m i c r o s o m e assay, 34 T e t r a c h l o r v i n p h o s , in Sa lmonel la mic rosome

assay, 38 T h i o p h o s , in Sa lmone l l a mic rosome assay,

38 Th io -TEPA, he r i t ab le t r ans loca t i on tes t in

mouse , 207 T o b a c c o smoke , and m u t a g e n i c i t y test , 148 T o b a c c o - s m o k e c o n d e n s a t e CH3OH ext rac t ,

in Sa lmone l l a m i c r o s o m e assay, 42 3 -To ly l -N-me thy l ca rbama te , E. coli reverse

m u t a t i o n assay, accep tab i l i ty cri teria, 180 Tox ico logy , genet ic , eva lua t ion of bioassays,

G e n e - T o x Program, 165 Tradescan t i a , p l an t assay, m u t a g e n i c i t y of

air po l lu tan t s , 63 T r a n s l o c a t i o n he t e rozygos i ty , t es t ing of

male p rogeny , t e s t ing p ro toco l , 197 T rans loca t i on test , he r i t ab le , in mouse , 191 T r e n i m o n , he r i t ab le t r ans loca t ion tes t in

mouse , 207 1 ,3 ,5 -Tr i amino-2 ,4 ,6 - t r i n i t robenzene , E. coli

reverse m u t a t i o n assay, accep tab i l i ty cri- ter ia , 181

Tr iazenes , in Sa lmone l l a mic rosome assay, 40, 42

2 ,4 ,6 -Tr ib romopheny laz ide , in Sa lmonel la mic rosome assay, 42

1 - (2 ,4 ,6 -Tr ib romopheny l ) -3 ,3 -d ime thy l t r i - azene, in Sa lmone l la m i c r o s o m e assay, 42

1 ,3 ,5 -Tr ich lo rbenzene , E. coli reverse muta - t i on assay, accep tab i l i ty cri teria, 179

Tr i ch lo r fon , E. coli reverse m u t a t i o n assay, accep tab i l i ty cr i ter ia , 178

1 ,1 ,1 -Tr ich lo ro-2 ,2 -b i s (p -ch lo rophenyl ) - e thane , in Sa lmone l la mic rosome assay, 38

T r i ch lo roe thy l ene , ca rc inogens in dr ink ing water , 244

--, in Sa lmone l la m i c r o s o m e assay, 34 2 ,4 ,6 -Tr ich lo ropheny laz ide , in Sa lmonel la

m i c r o s o m e assay, 42 1-( 2 ,4 ,6 -Tr i ch lo ropheny l ) -3 ,3 -d ime thy l t r i -

azene, in Sa lmonel la m i c r o s o m e assay, 42

1 -( 2 ,4 ,6 -Tr i ch lo ropheny l ) -3-methyl t r iazene , in Sa lmone l la m i c r o s o m e assay, 42

1 ,1 ,1 -Tr ich lo ropropane-2 ,3 -ox ide , in Salmo- nella m i c r o s o m e assay, 32

1 ,3 ,5 -Tr ich lo ro -2 ,4 ,6 - t r in i t robenzene , E. coli reverse m u t a t i o n assay, accep tab i l i ty cri- teria, 181

T r i e t h y l e n e m e l a m i n e , he r i t ab le t rans loca- t i on tes t in mouse , 206

2 ,2 ,2-Tr i f luoro-N- [ 4-(5-ni t ro-2-furyl) -2- thi - a zo ly l ] ace t amide , E. coli reverse muta- t ion assay, accep tab i l i ty cri teria, 183

Tr i f lura l in , E. coli reverse m u t a t i o n assay, accep tab i l i ty cr i ter ia , 180

Tuberculos is , and cancer , in te r re la t ion , epi- demio logy of isoniazid, 102

T u m o u r , p r o m o t e r s , and mu tagen i c i t y of a i rbo rne part icles , 159

U r b a n air, and mu tagen i c i t y test , 149 U r e t h a n e , E. coli reverse m u t a t i o n a.ssay,

accep tab i l i ty cr i ter ia , 178

V a m i d o t h i o n , E. coli reverse m u t a t i o n assay, accep tab i l i ty cr i ter ia , 181

Vinyl ace ta te , in Sa lmone l la mic rosome assay, 34

Vinyl b r o m i d e , in Sa lmonel la m i c r o s o m e assay, 34

Vinyl ch lor ide , carc inogens in dr ink ing water , 244

--, in Sa lmone l la m i c r o s o m e assay, 34 Viny l idene chlor ide , in Sa lmonel la micro-

some assay, 34 Viny l idene f luor ide , in Sa lmonel la micro-

some assay, 34

Water , dr inking, biological assessment of

324

volat i le and o t h e r k n o w n organic com- pounds , 244

, , m ix tu re s of volat i le and non-vola t i le organics, mu tagen ic i ty , 243

, , m u t a g e n i c i t y of organic residues, 252 , organic c o m p o u n d s , mu tagen i c effects ,

' 241 , , , s h o r t - t e r m bioassays, 247 , -, u n c o n c e n t r a t e d de tec t ing Sa lmonel la

mutagens , 250

Wheat CH2C12 ex t rac t , in Sa lmonel la micro- some assay, 42

X A D eluate , of Miami 1, Seat t le 1 and Phi lade lphia 1, mu tagen i c c o m p o u n d s in d r ink ing water , 260

X y l y l - N - m e t h y l c a r b a m a t e , E. coli reverse m u t a t i o n assay, accep tab i l i ty cr i ter ia , 181

Yeast , act ivi t ies of c h r o m i u m , 233