studying multiple neural representations at once in autism
TRANSCRIPT
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Felipe PegadoMD, PhD
Laboratoire de Psychologie CognitiveAix-Marseille Université, France
Studying multiple neural representations at oncein autism and controls
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Autism abnormalities
Social
High sensory
Low sensory
voicesfaces
loudnessgabor
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DSM-5: ASD- Autism Spectrum Disorders
• A. Persistent deficits in social communication and social interaction across multiple contexts
• B. Restricted, repetitive patterns of behavior, interests, or activities
• C. Present in the early developmental period D. Significant impairment in social, occupational areas.
• E. These disturbances are not better explained by intellectual disability or global developmental delay.
B4. Hyper‐or hypo‐reactivity to sensory input or unusual interest in sensory aspects of environment; (such as apparent indifference to pain/heat/cold, adverse response to specific sounds or textures, excessive smelling or touching of objects, fascination with lights or spinning objects).
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Typical studies
posterior & anterior
mPFCPrecuneus-PC TPJ
mentalizing network
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Studying multiple brain representations at once
Congruent Incongruent
H. Op de BeeckKU Leuven
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Congruent reaction Incongruent reaction
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For me
this is
appropriate
But what do
‘most people’
think?
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« Self-reference » task « Social norm » task
versus
Behavioral task validation
Similarity of response patterns
blo
cks
Within-subjects: r = 0.65 vs 0.67; t(43) = −0.3*** Between-subjects: r = 0.33 vs 0.50; t(43) −7.1; p < 0.0001
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posterior & anterior
mPFC
Low-Level
Sensory
High-Level
Sensory
Precuneus-PC TPJ
Hierarchical Brain Areas
High-Order
Cognition
mentalizing network
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Separate GLMs :
visual, audio and congruency GLMs
Visual GLM- Duration & onset for visual stimuli (0-2.5 sec)- Conditions: 12 visual stimuli
Auditory GLM- Duration & onset for auditory stimuli (0.6-1.3 sec)- Conditions: 8 auditory stimuli
Congruency GLM- Duration & onset : 0.6 - 4.5 sec- 2 Conditions: congruent vs incongruent
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Studying multiple brain representations at once
congruency
3 GLMs: MVPA
Pegado et al, Frontiers 2018
Pegado et al, Sci Rep 2018
RSA
RSA
congruency
congr
incongr
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22 High-Functioning Autism (HFA) vs
22 matched Typically Developing (TD)
ASD
N = 22
Matched TD
N = 22
T-statistic P-value
Age 22.5 (+/- 4.09) 22.8 (+/- 2.94) T(42) = 0.34 P = 0.74
IQ 108.6 (+/- 14.5) 112.4 (+/- 15.4) T(42) = 0.84 P = 0.40
SRS-A 63.0 (+/- 13.0) 49.0 (+/- 8.0) T(42) = 4.28 P = 0.0001
Groups’ matching
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HFATD
Sub
ject
nu
mb
erSimilarity of visual valence ratings across participants
HFATD
Similarity of auditory valence ratings across participants
Sub
ject
nu
mb
er
Behavioral ratings
*** T(42) = -4.78; p < 0.0001
** T(42) = -2.83; p = 0.007
Variability across subjects
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TD HFA
Similarity of congruency judgementswithin and between participants
(inside the scanner)
Behavioral ratings
within-subject correlations (TD: r = 0.51 vs ASD: r = 0.54; T(42) = -0.59; p = 0.56).
** between-subject correlations (TD: r = 0.26; ASD: r = 0.19; T(42) = 2.62; p = 0.01).
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pix lux val anim
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HFA show more low-level visual information in PC
1- Pixelwise 3- Visual Valence2- Luminance1
1 12
1
12
1
121 12
1
12
0.5
1
0
0.5
1
0
0.5
1
0
-0.5
1
0.5
01 121 12
4- Animacy
Precuneus-PC
models
Partial correlations
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F0 val emo gen
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4- Voice Gender1- FundamentalFrequency (F0) 2- Auditory Valence 3- Emotion
1
8
1 8
1
81 8
1
8
1 8
1
8
1 8
1
0.5
0
1
0.5
0
-0.5
1
0.5
0
1
Temporal Voice Area- TVA
F0 val emo genmodels
Partial correlations
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Subject 1
…
Subject 2 Subject 3
Variability across subjects
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TD HFA
sub
ject
s
TD HFA
Functional Connectivity
Betweenbrainregions
Betweensubjects[all 8 ROI]
n.s.
n.s.
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sub
ject
s
TD HFA
Betweensubjects[Only TVA]
Functional Connectivity
** group difference
T(36) = 2.76;
p = 0.009
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HFA show more uniqueness of neural patterns
and functional connectivity in the Voice Area
Voice Area (TVA)
behavioral judgments of auditoryvalence...
and those of auditory congruency werealso more idiosyncratic in HFA
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High Functioning Autism
Social
High sensory
Low sensory
voicesfaces
loudnessgabor
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Financial Support
Open science
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- Striking similar neural representations among HFA and TD adults at all hierarchical levels, including low and high level sensory processing and higher-order social processing.
- The only exception is a high-level area (Precuneus) carrying more low-level information (pixel information) in HFA.
- At the individual-subject level, one brain region showed more interindividual variability in the HFA group, both for neural representations and functional connectivity: the Temporal Voice Area (TVA).
- This larger neural idiosyncrasy in HFA matches with the increased behavioral idiosyncrasy, both for valence ratings of auditory stimuli (outside the scan) and for the congruency of these vocalizations with visual contexts (inside and outside the scanner).
idiosyncrasy in the functioning of high-sensory areas relevant for social understanding could underlie the idiosyncrasy in social behavior in HFA.
Summary