Chapter 15

Chapter 23, 24 and 25 (Glycogen metabolism, Pentose pathway)Chapter Objectives

1. Describe the steps involved in the breakdown of glycogen with the enzymes used in each step.

2. Where is glycogen stored in the body? What is the difference between the 2 sites

3. Explain the regulation of the phosphorylase enzyme in terms of both allosteric regulation. Explain the signal transduction pathway.

4. How does the synthesis of glycogen differ from the degradation?

5. Explain the regulation of Glycogen synthase.

6. How do insulin and epinephrine/glucagon affect regulation of glycogen metabolism?

7. What are the goals of the pentose phosphate pathway, explain.

Important Terms and ComparisonsGlycogen phosphorlyaseGlucose 6 phosphatase

Glucaogon and epinephrine

Insulin

Protein kinase

Transferase

Debranching and branching enzymes

Phosphoglucomutase

Glycogen synthase

UDP glucose