structure of tenascin-c · 2012-03-14 · structure of tenascin-c tenascin-c is an extracellular...

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Structure of Tenascin-C Tenascin-C is an extracellular matrix (ECM) glycoprotein that is composed of 210-400 kDa subunits consisting of four domains. One subunit has a TA domain at the N-terminal end, then an epidermal growth factor-like sequence domain (EGF-like domain), a fibronectin type Ⅲ (FNⅢ) repeat domain, and a fibrinogen-like domain at the C-terminal end. There is an alternatively spliced domain in the FNⅢ domain, and it generates some types of variants of Tenascin-C. The subunits form a trimer by twisting at the N-terminal coiled domain and form a hexamer by a disulfide bond, in tissue. E GF-like domain Fibronectin type III domain Fibrinogen-like domain TA domain 1 2 3 4 5 A1 A2 A3 A4 B AD2 AD1 C D 6 7 8 Alternatively spliced domain

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Page 1: Structure of Tenascin-C · 2012-03-14 · Structure of Tenascin-C Tenascin-C is an extracellular matrix (ECM) glycoprotein that is composed of 210-400 kDa subunits consisting of four

Structure of Tenascin-C

Tenascin-C is an extracellular matrix (ECM) glycoprotein that is composed of 210-400 kDa subunits consisting of four domains. One subunit has a TA domain at the N-terminal end, then an epidermal growth factor-like sequence domain (EGF-like domain), a fibronectin type Ⅲ (FNⅢ) repeat domain, and a fibrinogen-like domain at the C-terminal end. There is an alternatively spliced domain in the FNⅢdomain, and it generates some types of variants of Tenascin-C.The subunits form a trimer by twisting at the N-terminal coiled domain and form a hexamer by a disulfide bond, in tissue.

E GF-like domain F ibronectin type III domain F ibrinogen-likedomain

TAdomain

1 2 3 4 5 A1 A2 A3 A4 B AD2 AD1 C D 6 7 8

Alternativelyspliced domain

Page 2: Structure of Tenascin-C · 2012-03-14 · Structure of Tenascin-C Tenascin-C is an extracellular matrix (ECM) glycoprotein that is composed of 210-400 kDa subunits consisting of four

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