structure and circuits of the basal ganglia · basal ganglia nucleus caudatus, putamen, globus...
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STRUCTURE AND STRUCTURE AND CIRCUITS OF THE BASAL CIRCUITS OF THE BASAL GANGLIA GANGLIA
Rastislav DrugaRastislav Druga
Institute of Anatomy, 1st and 2nd Medical FacultyInstitute of Anatomy, 1st and 2nd Medical Faculty
2012
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Basal gangliaBasal ganglia Nucleus caudatus, putamen, globus pallidus (pallidum Nucleus caudatus, putamen, globus pallidus (pallidum
externum, pallidum internum), nc.subthalamicus, externum, pallidum internum), nc.subthalamicus, substantia nigra (compacta, reticulata). substantia nigra (compacta, reticulata).
amygdala, claustrumamygdala, claustrum
Nucleus caudatus + putamen = striatumNucleus caudatus + putamen = striatum Putamen+ globus pallidus (pallidum Putamen+ globus pallidus (pallidum
externum, pallidum internum) = nucleus externum, pallidum internum) = nucleus lentiformislentiformis
Amygdala ( limbic system)Amygdala ( limbic system) ClaustrumClaustrum
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Topography of the basal Topography of the basal gangliaganglia
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Dorsal striatum, Ventral striatum (nc. Accumbens)
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Dorsal pallidum, Ventral pallidum
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Striatum dorsale a striatum Striatum dorsale a striatum ventraleventrale
Striatum ventrale = nc. accumbens and adjoining Striatum ventrale = nc. accumbens and adjoining part of the nc. caudatus a putamenpart of the nc. caudatus a putamen
22 % volume of striatum22 % volume of striatum Reward centrum Reward centrum Striatum ventrale – significantly activated in the Striatum ventrale – significantly activated in the
process of addictive behavior (alkohol, nikotin, process of addictive behavior (alkohol, nikotin, drogy, gambles, sex)drogy, gambles, sex)
Projections from orbitofrontal and cingular cortex Projections from orbitofrontal and cingular cortex and from limbic systand from limbic systeem (hippocampus, amygdala) m (hippocampus, amygdala)
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1 – 3 caudate nc.
2 – ventral striatum
4 – putamen
5 – globus pallidus
6 - amygdala
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Striatal compartments – matrix, striosomes
Enk+ AChE-
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A-projecting neurons, GABAergic , 80 %
B – cholinergic neurons, 1 %
C and D - GABAergic interneuons
Striatal neurons
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Medium spiny neuronsMedium spiny neurons, projecting neurons (globus pallidus, substantia , projecting neurons (globus pallidus, substantia nigra), GABAergic, 80 %nigra), GABAergic, 80 %
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STRIATUM - STRIATUM - afferent connections afferent connections
cortex,cortex, thalamus, amygdala, substantia nigra thalamus, amygdala, substantia nigra (p. compacta, Dopamin), rapheal nuclei (p. compacta, Dopamin), rapheal nuclei (serotonin)(serotonin)
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PM area 6M I area 4
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Anterograde Anterograde intraaxonal intraaxonal transporttransport
Cortex – Cortex – striatumstriatum
PM + M I - PM + M I - putamenputamen
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RetrogradeRetrograde
IntraaxonalIntraaxonal
TransportTransport
Assoc. Assoc. Cortex-Cortex-
Nc. Nc. caudatuscaudatus
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Assoc. Assoc. Cortex – Cortex – nc. nc. caudatuscaudatus
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Amygdalo – Amygdalo – striatal striatal projectionsprojections
Amygdala-Amygdala-
Projects to Projects to
the Ventral the Ventral striatumstriatum
(Nc. (Nc. Accumbens)Accumbens)
Hippocampal formation –
project to the ventral striatum
Parahippocampal gyrus and orbitofrontal cortex -
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Cortico – striatal projections - summaryCortico – striatal projections - summary
Limbic structures
Functionally different sectors of the striatum
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Distribution of corticostriatal neurons in cortical layers
Large dots – striatum
Small dots - thalamus
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Nigro-striatal Nigro-striatal projectionsprojections
DopaminergicDopaminergic
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Distribution of dopaminergic terminals (SNc) on MSNeurons
Dopamin – usnadňuje přenos na kortiko-striatických synapsích
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Raphe nuclei –Raphe nuclei –
Striatum Striatum /pallidum/pallidum
SEROTONIN
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THALAMOSTRIATAL PROJECTION
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THALAMIC NEURONS PROJECTING TO THE STRIATUM (CAUDATE NUCLEUS)
VAmc
MD
IL (PF)
Pulvinar
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DORSAL STRIATUMDORSAL STRIATUM - -efferent connections efferent connections globus pallidusglobus pallidus (GPe,GPi), (GPe,GPi),
subst. nigrasubst. nigra (p. reticulata) (p. reticulata)
Putamen Putamen – globus pallidus – globus pallidus
Caudate nucleusCaudate nucleus – subst. nigra – subst. nigra(pars reticulata)(pars reticulata)
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Striatal efferents Pallidal afferents and efferents
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Striato-nigral Striato-nigral projectionsprojections
Putamen –
s. Nigra
weak proj.
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Caudate nc. – subst. Nigra
Strong projection
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GLOBUS PALLIDUSGLOBUS PALLIDUSafferent connections:afferent connections: Striatum ( Pe, Pi), Nc.subthalamicus (PeStriatum ( Pe, Pi), Nc.subthalamicus (Pe, Pi, Pi))
efferent connnections :efferent connnections : Pallidum externum - Pallidum externum - Nc. Subthalamicus Nc. Subthalamicus
Pallidum internum - Pallidum internum - Thalamus (VA, IL,Hb), Reticular formationThalamus (VA, IL,Hb), Reticular formation
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Projections rfrom the subthalamic nucleus to the pallidum
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Projections from the Subthalamic nucleus to the globus pallidus (excitatory, glutamatergic)
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Pallidum internum projects to the thalamus ! (W.J.H.Nauta and W.R. Mehler 1966)
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Circuit of the Circuit of the basal gangliabasal ganglia
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CIRCUIT OF THE BASAL GANGLIA (Nauta – Mehler 1966)
CORTEX-STRIATUM – PALLIDUM – THALAMUS (VA) - CORTEX
VA
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Limbic circuit Prefrontal circuits
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CIRCUIT OF BASAL GANGLIA (Nauta –Mehler CIRCUIT OF BASAL GANGLIA (Nauta –Mehler circuit, 1966)circuit, 1966)
OKRUH BAZÁLNÍCH GANGLIÍOKRUH BAZÁLNÍCH GANGLIÍ
Neocortex – striatum – globus pallidus – Neocortex – striatum – globus pallidus – thalamus (VA) – neocortexthalamus (VA) – neocortex – cortical projections – cortical projections to the brain stem and to the spinal cordto the brain stem and to the spinal cord
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A = direct pathway – stimulates motor activities ( P-substance, dynorphin)
B = indirect pathway – depression of motor activity (Enkefalin)
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Circuit of basal ganglia - Direct and indirect pathway
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Direct and indirect pathwaysDirect and indirect pathways of basal gangliaof basal ganglia
Direct pathway : Direct pathway : cortexcortex … …(+)(+) striatum … (-) pallidum internum/subst. striatum … (-) pallidum internum/subst.
nigra … (-) thalamus … nigra … (-) thalamus … (+) (+) cortex cortex (increases the (increases the activity of the thalamus and the excitation of cerebral activity of the thalamus and the excitation of cerebral cortex = cortex = increased motor activityincreased motor activity))
Indirect pathway :Indirect pathway : cortex … cortex … (+)(+) striatum … (-) pallidum externum … (-) striatum … (-) pallidum externum … (-)
subthalamic nc. … subthalamic nc. … (+)(+) pallidum internum … pallidum internum … (-) thalamus … (-) thalamus … (+)(+) cortex cortex (decreases activity of the (decreases activity of the thalamus and the excitation of cerebral cortex = thalamus and the excitation of cerebral cortex = decreased motor activitydecreased motor activity))
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Circuits of the ventral striatum (nc. accumbens) and Circuits of the ventral striatum (nc. accumbens) and ventral pallidum ventral pallidum
Ventral striatumVentral striatum
Afferent connectionsAfferent connections Limbic cortexLimbic cortex VTA (medial part of the VTA (medial part of the
SNc - dopamine)SNc - dopamine)
Efferent connectionsEfferent connections Ventral pallidumVentral pallidum Substantia nigraSubstantia nigra
Ventral pallidumVentral pallidum
Afferent connectionsAfferent connections Ventral striatumVentral striatum
Efferent connectionsEfferent connections Thalamus (MD)Thalamus (MD)
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SyndromsSyndroms of the basal ganglia I. of the basal ganglia I.
HypokinesiaHypokinesia Akinesia – impairment in the iniciation of movementAkinesia – impairment in the iniciation of movement Bradykinesia – reduction in velocity and amplitudeBradykinesia – reduction in velocity and amplitude Parkinson disease (tremor at rest, flexed posture, Parkinson disease (tremor at rest, flexed posture,
paucity of limb and facial movements)paucity of limb and facial movements) Decrease in production of DopamineDecrease in production of Dopamine Loss of dopaminergic neurons within Loss of dopaminergic neurons within
substantia nigrasubstantia nigra (pars compacta). (pars compacta). L-Dopa will cross BBB (after amination in brain is L-Dopa will cross BBB (after amination in brain is
converted to Dopaminconverted to Dopamin
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Syndroms Syndroms of the basal ganglia II. of the basal ganglia II.
HyperkinesiaHyperkinesia Choreiform movementsChoreiform movements – irregular dancelike movements – irregular dancelike movements
of the limbs and in facial muscles – loss of striatal medium of the limbs and in facial muscles – loss of striatal medium spiny neurons, decrease in the size of the striatum, gliosis – spiny neurons, decrease in the size of the striatum, gliosis –
Huntington disease Huntington disease (major affective (major affective psychiatric disorders, partly hereditary)psychiatric disorders, partly hereditary)
Hemiballism – uncontrolled (dangerous) flingting Hemiballism – uncontrolled (dangerous) flingting movements of limbs – vascular lesion in the movements of limbs – vascular lesion in the subthalamic nucleus subthalamic nucleus
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Different role for striatal dopamineDifferent role for striatal dopamine Low levels of dopamineLow levels of dopamine = strong inhibitory output of the = strong inhibitory output of the
BG to the thalamocortical system (paucity of movements, BG to the thalamocortical system (paucity of movements, cognitive, emotional behavior, cognitive, emotional behavior, Parkinson diseaseParkinson disease))
High levels of dopamineHigh levels of dopamine = low activity of the inhibitory = low activity of the inhibitory output of the BG to the thalamocortical system (a facilitation output of the BG to the thalamocortical system (a facilitation of movements and cognitive/ behavioral actsof movements and cognitive/ behavioral acts
Dopaminergic neurons (SNcDopaminergic neurons (SNc) show ) show phasic phasic activations activations following the encounter the animal with novel stimuli following the encounter the animal with novel stimuli particularly with presentation of primary reward. Such particularly with presentation of primary reward. Such activation leads to a spatially release of dopamineactivation leads to a spatially release of dopamine
Dopamine release enable or facilitate the output of a Dopamine release enable or facilitate the output of a particular population of striatal neurons (to the GP and SNr)particular population of striatal neurons (to the GP and SNr)
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Function of the striatum – inhibition ?
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LESIONS AND STIMULATIONS OF THE LESIONS AND STIMULATIONS OF THE
STRIATUMSTRIATUM (an inhibitory structure)(an inhibitory structure) LESIONS – LESIONS –
hyperactivity hyperactivity drive to run forward, drive to run forward,
regardless of obstacles regardless of obstacles (without to avoid the (without to avoid the obstacle)obstacle)
stereotyped approaching stereotyped approaching and following of persons, and following of persons, objectsobjects
TremorTremor Choreic - like movementsChoreic - like movements
STIMULATIONS –STIMULATIONS – hypoactivityhypoactivity Arrest of voluntary Arrest of voluntary
movements and speechmovements and speech Short confussion and Short confussion and
amnesiaamnesia Sleep – like effectSleep – like effect Rejecting of foodRejecting of food Inhibition of agressive Inhibition of agressive
behaviorbehavior
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Functions of the striatumFunctions of the striatum
THE DORSAL STRIATUMTHE DORSAL STRIATUM The selection of motor and behavioral processes The selection of motor and behavioral processes
appropriate for a particular contextappropriate for a particular context The release of desired and the supression of The release of desired and the supression of
unwanted movementsunwanted movements Important for stimulus – response behaviorImportant for stimulus – response behavior
THE VENTRAL STRIATUMTHE VENTRAL STRIATUM (nc. Accumbens) (nc. Accumbens) The learning and execution of reward-related The learning and execution of reward-related
movements and activities. The ventral striatum is movements and activities. The ventral striatum is activated in reward situations.activated in reward situations.
Reward= smoking, alcohol, drugs, sex, economic rewardReward= smoking, alcohol, drugs, sex, economic reward
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The reward related striatum
Red and purple colour
Haber et al. 2006
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Thank youThank you
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The dorsal striatum and the ventral striatumThe dorsal striatum and the ventral striatum
The ventral striatumThe ventral striatum = nucleus accumbens and = nucleus accumbens and adjacent caudate nucleus and putamenadjacent caudate nucleus and putamen
The reward- related striatum is defined also by The reward- related striatum is defined also by projections from orbitofrontal and anterior cingular projections from orbitofrontal and anterior cingular cortex and by projections from limbic structures cortex and by projections from limbic structures (hippocampus, amygdala)(hippocampus, amygdala)
22 % of the striatum22 % of the striatum The nc. accumbens may play an important role in The nc. accumbens may play an important role in
behaviors related to addiction (alcohol, nicotine, behaviors related to addiction (alcohol, nicotine, drugs)drugs)
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Circuits of the ventral striatum and Circuits of the ventral striatum and
pallidum IIpallidum II Limbic cortex, amygdala –Limbic cortex, amygdala – Ventral striatum -Ventral striatum - Ventral pallidum / subst. Nigra -Ventral pallidum / subst. Nigra - Thalamus (mediodorsal nc.) –Thalamus (mediodorsal nc.) – Prefrontal cortexPrefrontal cortex
Circuit might be crucial for the learning and Circuit might be crucial for the learning and executionof reward – related behaviorexecutionof reward – related behavior
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NOS-positive neuronsNOS-positive neurons
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Circuit of the basal ganglia