stretchable micropatterns and microfluidic systems · stretchable micropatterns and microfluidic...
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Stretchable Micropatterns and Microfluidic Systems
Stephen A. Morin Department of Chemistry,
Nebraska Center for Materials and Nanoscience, University of Nebraska – Lincoln
Brightlights Nanocamp, June 15th 2015
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2
Inspiration
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3 Weiner and Addadi Annu. Rev. Mater. Res. 2011 41, 21.
Biomineralization • Controlled
Nucleation • Manipulation
(transport) • Deposition in
three dimensions • Cellular machinery Dynamic, Adaptive,
Complex
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Research Thrusts
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“Stretchable” Chemical Pattern
50 mm
Bowen, J.J.; Taylor, J.; Morin, S.A.* Submitted.
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Controlled Deformations
6
• Strain (s):
𝜎 =∆𝐿 + 𝐿
𝐿
• Uniaxial and biaxial strain (on order of 1.5 to 2) investigated.
• Manual devices. • Electromechanical devices.
(1.5X playback)
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Uniaxial Deformation: Decreased Molecular Density
7
• Change in area: 6,200 mm2 (49%) • Decrease in fluorescence intensity
enables estimate of change in molecular density of: 16%
• Complete recovery of original intensity not achieved due to photo-bleaching of the fluorophore.
• Key: Capability enabled by Poison’s ration (~0.5).
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Manipulation of Droplets
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Hydrophilic moities Nucleate droplets, Release Strain
• Strained hydrophilic pattern used to heterogeonously nucleate droplets.
• Relaxation of elastomer organizes droplets.
• Geometry can then be manipulated.
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Research Thrusts
9
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10 https://www.youtube.com/watch?v=33YdIe5JABA
3D Printing: A Makers Revolution
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Approach - Solid Object Printing & Soft Lithography
• Master: 3D Printer
o Acrylonitrile butadiene styrene (ABS) master
o Flexibility in the fabrication of complex (three-dimensional) designs
** Thickness of the layer depends on the surface it has to seal against
• Compression based reversible sealing
• Seal against arbitrary substrates
• Independent of the channel design
• Reversible sealing technique
12 A. Konda, J. M. Taylor, M. A. Stoller, and S. A. Morin Lab Chip 2015, 15, 2009.
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Manual
Semi-automatic
Sealing via Compression
• Flow rates: upto 300 mL/min
• Stability: >72 hrs
• Temperature: 100 oC
A. Konda, J. M. Taylor, M. A. Stoller, and S. A. Morin Lab Chip 2015, 15, 2009.
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Reconfigurable Fluid Pathways
14 A. Konda, J. M. Taylor, M. A. Stoller, and S. A. Morin Lab Chip 2015, 15, 2009.
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Sealing on Rough/Uneven Substrates & 3D Objects
15 A. Konda, J. M. Taylor, M. A. Stoller, and S. A. Morin Lab Chip 2015, 15, 2009.
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Other applications of Microfluidics
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Soft machine “gripper”
3D Printed Mold
2cm
EcoflexTM
Sylgard 184TM
F. Ilievski et al. Angew. Chem. Int. Ed. 2011, 50, 1890.
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Soft machine “gripper”
F. Ilievski et al. Angew. Chem. Int. Ed. 2011, 50, 1890.
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Soft machine “walkers”
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Shepherd, R.F. et al. P. Natl. Acad. Sci. USA 2011, 108, 20400-20403.
PN 1
PN 2
PN 3
PN 4
PN 5
pneumatic tethers (5)
quadruped mold
• Soft lithography is used to construct systems of pneu-nets.
Crawling – 24 + 3 m/s Undulation – 13 + 0.6 m/s
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Soft machine “walkers”
20
Shepherd, R.F. et al. P. Natl. Acad. Sci. USA 2011, 108, 20400-20403.
PN 1
PN 2
PN 3
PN 4
PN 5
pneumatic tethers (5)
quadruped mold
• Soft lithography is used to construct systems of pneu-nets.
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Display using microfluidics
Morin, S.A. et al. Science 2012, 337, 828-832.
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Acknowledgments