strategies and tools for the environmental laboratory ... · strategies and tools for the...

Strategies and Tools for

the Environmental

Laboratory

Improving Operational

Efficiency and Return on

Invested Capital

Agilent Technologies, Inc.

Craig Marvin

GPD Solutions Business Manager

June 11, 2013

1

Today’s Challenges Expecting More from Less

• Increasing cost of ownership

• Trace analysis in complex matrices

Business Challenges

• Less time for method development

• Limited technical experience

Resource Allocation

• Demands for higher throughput

• Quicker return on capital investment

Optimizing Efficiency

Laboratory Strategies

2 July 2013

Presentation Overview


3

Cost of Operation - Helium Availability

Reducing Maintenance & Enhancing Performance

Rapid Deployment for Quicker Financial Returns

July 2013

Market Situation The most common carrier gas for GC is in short supply!

Unreliable supply of helium worldwide and increasing prices have

laboratories seeking alternative carrier gas solutions


4 July 2013

Carrier Gas Decision Tree Method Translation or Helium Conservation

Consider migration to H2 Consider migration to N2 He Conservation

GC/MS specific H2

considerations

Is the customer willing to convert

to alternative gasses?

Is the Application based on

GC or GC/MS?

Does the current GC method

have more than enough resolution?

No

No

Yes

Yes

GC/MS GC


5 July 2013

Carrier Gas Savings CalculatorChange values in gray boxes to calculate savings for your operating parameters

Method:

Column:

Gas Flow Conditions

He Carrier Flow (mL/min): 1.5

He Split flow (mL/min): 190

Gas Saver Flow (mL/min): 20

Gas Saver On (min): 3

Run Time(min.): 15

Gas Volume in Cylinder (L): 8000

Runs per Day: 30

He Cylinder Cost ($): 300

N2 Cylinder Cost ($): 60

Parameter No ConservationWith

Conservation

Daily He Usage (L) 276 25

He Cylinder Life (days) 29 320

Daily N2 Usage (L) 0 21

N2 Cylinder Life (days) 0 376

Yearly He Cost ($) 3,774 342

Yearly N2 Cost ($) 0 58

Yearly Total Gas Cost ($) 3,774 400

Savings vs. No Gas Saver ($) 0 3,374

Typical Split GC method

30m x 0.25mm x 0.25um

Helium Savings Calculator Extend supply and lower cost using conservation techniques

• Helium Conservation

– Helium cylinder life extended to

~12 months

– Greatly reduces annual gas costs

• Additional Benefit

– Reduces dependence on Helium

deliveries

– Ensures business continuity


6 July 2013

www.agilent.com/helium/update

System Maintenance

Greatest disruption to workflow and productivity


7

System venting and disassembly of MS source

Manual cleaning requires expertise

Reassembly and system re-equilibration

System offline for full day of operation

July 2013

Self-Cleaning Ion Source Using H2 to Clean to MS Source

5 0 1 0 0 1 5 0 2 0 0 2 5 0 3 0 0 3 5 0 4 0 0 4 5 0 5 0 0

0

5 0 0 0

1 0 0 0 0

1 5 0 0 0

2 0 0 0 0

2 5 0 0 0

3 0 0 0 0

3 5 0 0 0

4 0 0 0 0

4 5 0 0 0

5 0 0 0 0

5 5 0 0 0

6 0 0 0 0

6 5 0 0 0

7 0 0 0 0

7 5 0 0 0

m / z - - >

A b u n d a n c e

A v e r a g e o f 1 . 9 6 9 t o 1 0 . 0 4 6 m i n . : E I - b a c k g r d - r e p 0 . D \ d a t a . m s

9 1 . 0

5 5 . 0

1 3 3 . 1

1 7 8 . 1

2 1 5 . 1

2 5 2 . 2

2 8 9 . 1

3 2 6 . 2 3 6 0 . 2 4 0 2 . 3 4 4 0 . 3 4 7 6 . 3

Very Dirty Source:

Background

Spectrum

50,000

5 0 1 0 0 1 5 0 2 0 0 2 5 0 3 0 0 3 5 0 4 0 0 4 5 0 5 0 0

0

5 0 0 0

1 0 0 0 0

1 5 0 0 0

2 0 0 0 0

2 5 0 0 0

3 0 0 0 0

3 5 0 0 0

4 0 0 0 0

4 5 0 0 0

5 0 0 0 0

5 5 0 0 0

6 0 0 0 0

6 5 0 0 0

7 0 0 0 0

7 5 0 0 0

m / z - - >

A b u n d a n c e

A v e r a g e o f 1 0 0 . 0 0 9 t o 1 1 0 . 0 2 7 m i n . : E I - b a c k g r d - r e p 3 . D \ d a t a . m s

7 8 . 14 5 . 1 2 0 6 . 9 2 8 1 . 11 3 4 . 9 3 5 5 . 1 4 4 5 . 52 4 1 . 61 6 8 . 1 3 2 0 . 6 3 8 8 . 9 4 7 7 . 9

After Cleaning

with H2

50,000

5 0 1 0 0 1 5 0 2 0 0 2 5 0 3 0 0 3 5 0 4 0 0 4 5 0 5 0 0

0

2 0

4 0

6 0

8 0

1 0 0

1 2 0

1 4 0

1 6 0

1 8 0

2 0 0

2 2 0

2 4 0

m / z - - >

A b u n d a n c e

A v e r a g e o f 1 0 0 . 0 0 9 t o 1 1 0 . 0 2 7 m in . : E I - b a c k g r d - r e p 3 . D \ d a t a . m s

7 8 . 1

4 5 . 1 2 0 6 . 9

2 8 1 . 1

1 3 4 . 9 3 5 5 . 1

4 4 5 . 52 4 1 . 61 6 8 . 1 3 2 0 . 6 3 8 8 . 9 4 7 7 . 9

Expanded scale

50


8 July 2013

Cleaning Restores Analyte (OFN) Detection Comparable to manual cleaning?

4 . 1 0 4 . 1 2 4 . 1 4 4 . 1 6 4 . 1 8 4 . 2 0 4 . 2 2 4 . 2 4 4 . 2 6 4 . 2 8 4 . 3 0 4 . 3 2 4 . 3 4 4 . 3 6 4 . 3 8

1 4 0 0 0 0

1 4 2 0 0 0

1 4 4 0 0 0

1 4 6 0 0 0

1 4 8 0 0 0

1 5 0 0 0 0

1 5 2 0 0 0

1 5 4 0 0 0

1 5 6 0 0 0

1 5 8 0 0 0

1 6 0 0 0 0

1 6 2 0 0 0

1 6 4 0 0 0

1 6 6 0 0 0

1 6 8 0 0 0

1 7 0 0 0 0

1 7 2 0 0 0

1 7 4 0 0 0

1 7 6 0 0 0

1 7 8 0 0 0

T i m e - - >

A b u n d a n c e

I o n 2 4 1 . 0 0 ( 2 4 0 . 7 0 t o 2 4 1 . 7 0 ) : O F N - p r e c o n d - 0 - r e p 0 0 . D \ d a t a . m s

4 . 1 0 4 . 1 2 4 . 1 4 4 . 1 6 4 . 1 8 4 . 2 0 4 . 2 2 4 . 2 4 4 . 2 6 4 . 2 8 4 . 3 0 4 . 3 2 4 . 3 4 4 . 3 6 4 . 3 8

0

5 0 0

1 0 0 0

1 5 0 0

2 0 0 0

2 5 0 0

3 0 0 0

3 5 0 0

4 0 0 0

4 5 0 0

5 0 0 0

5 5 0 0

6 0 0 0

6 5 0 0

7 0 0 0

7 5 0 0

T im e - - >

A b u n d a n c e

T I C : O F N - p o s t c o n d - 1 - p r e t u n e - r e p 0 2 . D \ d a t a . m s

S:N > 50 pk-pk

> 200 rms

S:N ≈ 1 pk-pk

> 2 rms

Very dirty

source before

cleaning

After cleaning

with H2


9 July 2013

App. optimized

consumables

Pre-Configured Analyzers Increasing the Value Proposition

Application

report

System with

application setup

w/o Analyzer

Familiarization

Common

Components Factory Configured with Chemical Testing

Field Verification

Std. HW, SW Customer

Configured Analyzer Solution


10 July 2013

Focus your team on analyses; not method development!

http://www.agilent.com/about/newsroom/lsca/imagelibrary/images/lsca_98.jpg

http://www.sisweb.com/art/sge/gccol.jpg

The Value of Analyzers and Application Kits Reduce the time required for system deployment

…Faster Application Startup with a Quality Method

Sample

Ready

Order Fulfillment

Standard Installation &

Familiarization

Customer Method Development

and Validation

Agilent Method

Development

Application checkout

Analyzer Installation &

Familiarization

Customer Method

Validation

Order Fulfillment

Agilent Analyzers

End User Configured

Order

Placement


11 July 2013

Sample

Ready

Analyzers of Interest Environmental Laboratory Focus

GC/MS/MS Solutions

• Polycyclic Aromatic Hydrocarbons (PAHs)

• Pesticides & Environmental Pollutants

GC/MS Solutions

• Pesticides

• Volatiles and Semi Volatiles

• Polycyclic Aromatic Hydrocarbons (PAHs)

GC Solutions

• Greenhouse Gases


12 July 2013

Analyzer Value to Customers Helping you enhance your competitive advantage

Alleviate Resource Pressure

Guaranteed Method

Optimized Performance

Advanced Technologies

Quicker Deployment and Return


13 July 2013

Thank you Let’s Continue the Conversation


14 July 2013

2013.06.18

Q&A

Question 1.

• Should end users, or the scientists in the lab, be looking to

validate the results that they have obtained using a certain

instrument?

• And do you think that, if they have used another instrument,

they would be likely to get different results? Because we are

sometimes talking about very trace amounts of material, or

very low volumes of samples. So what is your

recommendation when it comes to validating results?

2013.06.18

Question 2.

• The next point I wanted to bring up was around sample prep.

What are some of the trends that you're seeing in sample

prep now, and how can it help with minimizing some of the

current problems.

2013.06.18

Question 3.

• Can you elaborate a little bit more on how you clean the ion

source using hydrogen?

2013.06.18

Question 4.

• What is Agilent’s approach to field testing?

2013.06.18

Contact

Craig Marvin

[email protected]

2013.06.18

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