Natalia Zapata ZuluagaU.P.B

The news are related to cell cycle, because the cancers and the reduction of telomeres, are a consequence of cell division.

The cycle control mechanisms are responsible for that daughter cells do not show any mutation, so these control mechanisms have been important point for medical treatment.

The news are related to cell cycle, because the cancers and the reduction of telomeres, are a consequence of cell division.

The cycle control mechanisms are responsible for that daughter cells do not show any mutation, so these control mechanisms have been important point for medical treatment.

Cancer is a disease where cells divide uncontrollably because they are damaged apoptotic mechanisms. These mutated cells grow and serve no function, only consume a very high amount of energy and replicate without control.

The control system of the cell cycle is a biochemical device consists of a set of interactive regulatory proteins: the cyclins and cyclin-dependent kinases, lead and coordinate the basic processes of the cycle as DNA replication and cell division.

Cancer is a disease where cells divide uncontrollably because they are damaged apoptotic mechanisms. These mutated cells grow and serve no function, only consume a very high amount of energy and replicate without control.

The control system of the cell cycle is a biochemical device consists of a set of interactive regulatory proteins: the cyclins and cyclin-dependent kinases, lead and coordinate the basic processes of the cycle as DNA replication and cell division.

G2 checkpoint: We evaluated the integrity, damage or unreplicated DNA, they are sufficient nutrients in the medium to continue the process of division. It is most common point where it stops the cycle if there are any problems.

Metaphase checkpoint: verify that the chromosomes are aligned at the metaphase properly before entering anaphase. This item protects against loss or gain of chromosomes.

G2 checkpoint: We evaluated the integrity, damage or unreplicated DNA, they are sufficient nutrients in the medium to continue the process of division. It is most common point where it stops the cycle if there are any problems.

Metaphase checkpoint: verify that the chromosomes are aligned at the metaphase properly before entering anaphase. This item protects against loss or gain of chromosomes.

The control points are:

G1 checkpoint: It starts the process that initiates the S phase

The control points are:

G1 checkpoint: It starts the process that initiates the S phase

EP 0332991, a small molecule synthesized by Pfizer is exceptionally selective for CDK4 and CDK6. Dr. Chen-Kiang says, "Since the program of gene expression is coupled to the cell cycle, we hypothesized that inhibition of gene expression CDK4/CDK6 remains scheduled for early G1, while avoiding gene expression time scheduled for other cell cycle phases "

EP 0332991, a small molecule synthesized by Pfizer is exceptionally selective for CDK4 and CDK6. Dr. Chen-Kiang says, "Since the program of gene expression is coupled to the cell cycle, we hypothesized that inhibition of gene expression CDK4/CDK6 remains scheduled for early G1, while avoiding gene expression time scheduled for other cell cycle phases "

Any alteration in the enzymes that act at checkpoints, can reach the generation of cancer cells.

For example, CDK4 and CDK6 active cells in the first G1 phase to the later stages where the cell divides in two. In many cancers types, these two enzymes are over-expressed, ensuring continued growth.

Any alteration in the enzymes that act at checkpoints, can reach the generation of cancer cells.

For example, CDK4 and CDK6 active cells in the first G1 phase to the later stages where the cell divides in two. In many cancers types, these two enzymes are over-expressed, ensuring continued growth.

The researchers discovered a botezomib which hold the G1 phase, it causes the cell to lose a protein called IRF4, a essential factor for the survival of myeloma cells, and won several pro-apoptotic proteins.

"These findings demonstrate for the first time the genes survival and apoptosis are regulated by cell cycle in cancer cells, and suggest new molecular targets for intervention," Dr. Chen-Kiang

The researchers discovered a botezomib which hold the G1 phase, it causes the cell to lose a protein called IRF4, a essential factor for the survival of myeloma cells, and won several pro-apoptotic proteins.

"These findings demonstrate for the first time the genes survival and apoptosis are regulated by cell cycle in cancer cells, and suggest new molecular targets for intervention," Dr. Chen-Kiang

 

Telomeres are sequences at the end of eukaryotic chromosomes.

-They protect chromosomes and prevent the degradation of DNA- Preventing fusion with other chromosomes- Facilitate duplication without losing end

Telomeres are sequences at the end of eukaryotic chromosomes.

-They protect chromosomes and prevent the degradation of DNA- Preventing fusion with other chromosomes- Facilitate duplication without losing end

These have the feature to become shorter with increasing cell division, so are considered markers of biological and cell aging.

These have the feature to become shorter with increasing cell division, so are considered markers of biological and cell aging.

In the study the researchers obtained blood samples from 5.243 women age 42 to 69 years, and measured the longitus their telomeres.

In the study the researchers obtained blood samples from 5.243 women age 42 to 69 years, and measured the longitus their telomeres.

They obtained the result that a high level of phobic anxiety is a risk factor with shorter telomeres.

Therefore this study wants to make a directly relationship with premature aging and phobic anxiety, although this study can't prove cause and effect or problem came first, the anxiety or shorter telomeres.

They obtained the result that a high level of phobic anxiety is a risk factor with shorter telomeres.

Therefore this study wants to make a directly relationship with premature aging and phobic anxiety, although this study can't prove cause and effect or problem came first, the anxiety or shorter telomeres.

 

The modification in the cell cycle, may be the answer for the cure of cancer, because it will prevent bad cells reproduce indiscriminately giving the doctors a chance that the disease does not develop further and therefore be able to remove the tumor.

The modification in the cell cycle, may be the answer for the cure of cancer, because it will prevent bad cells reproduce indiscriminately giving the doctors a chance that the disease does not develop further and therefore be able to remove the tumor.

The repair of damaged organs could be achieved through the modification of this cycle, because if we could accelerate the process to create good new cells we could improve the quality of life for many patients. But in this case would have to consider how to stop this process when no longer needed, because otherwise we could lead to cancer.

The repair of damaged organs could be achieved through the modification of this cycle, because if we could accelerate the process to create good new cells we could improve the quality of life for many patients. But in this case would have to consider how to stop this process when no longer needed, because otherwise we could lead to cancer.

Understand processes such as aging and growth are intimately related issues with the cell cycle, because depending on how is this cycle will be able to see macroscopic signs.

Molecular medicine has become the new approach to treatment, so any improvement on this, a great knowledge brought

Understand processes such as aging and growth are intimately related issues with the cell cycle, because depending on how is this cycle will be able to see macroscopic signs.

Molecular medicine has become the new approach to treatment, so any improvement on this, a great knowledge brought

- MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 208 p. 55 – 58

- CICLO CELULAR Y DUPLICACIÓN DEL ADN [Genomas Sur]. Argentina. Márquez Silvia, Ifrán Sergio Daniel, Zabala Enrique. [ July 15 / 2012 ] http:/genimasur.com/lecturas/Guia12a.htm -STOPPING AND STARTING CANCER CELL CYCLE WEAKENS AND DEFEATS MULTIPLE MYELOMA [ Weill Conell Medical Collage ] NEW YORK June 21, 2012 [ July 15 / 2012 ] http://weill.cornell.edu/new/releases/wcmc/wcmc_2012/06_21_12.shtml

- ANXIETY LINKED TO SHORTENED TELOMERES, ACCELERATED AGING [Science Daily] July 11, 2012 [ July 17 / 2012 ] http://www.sciencedaly.com/releases/2012/07/120711210102

- MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 208 p. 55 – 58

- CICLO CELULAR Y DUPLICACIÓN DEL ADN [Genomas Sur]. Argentina. Márquez Silvia, Ifrán Sergio Daniel, Zabala Enrique. [ July 15 / 2012 ] http:/genimasur.com/lecturas/Guia12a.htm -STOPPING AND STARTING CANCER CELL CYCLE WEAKENS AND DEFEATS MULTIPLE MYELOMA [ Weill Conell Medical Collage ] NEW YORK June 21, 2012 [ July 15 / 2012 ] http://weill.cornell.edu/new/releases/wcmc/wcmc_2012/06_21_12.shtml

- ANXIETY LINKED TO SHORTENED TELOMERES, ACCELERATED AGING [Science Daily] July 11, 2012 [ July 17 / 2012 ] http://www.sciencedaly.com/releases/2012/07/120711210102