stephen doig fracs (orth) june 2016
TRANSCRIPT
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Stephen Doig FRACS (Orth) June 2016
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There are no conflicts of interest to declare except I do do knee arthroscopy I am over 55 (just).
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My esteemed opponent will try to convince you that knee arthroscopy is purely a vehicle for making orthopaedic surgeons rich and is of no clinical benefit to the patient
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Used widely for many years Debridement and lavage Efficacy has been questioned and much more
so recently
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2012-13, 33682 admissions for knee arthroscopy > age 55
560/100K population Varies from 185 to 1319 264 in ACT to 980 in SA Economics is variable Does not always reflect socioeconomic status
Makes no comment about under or over treating
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1. Moseley JB. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2002;347:81–88. [PubMed]
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3 groups Sham Lavage Debridement
Showed no difference between the groups
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Multiple criticisms 97% male All veterans ( equivalent to Workcover) Non validated outcome measures Outcome measures changed during the study Multiple statistical flaws 44% of eligible patients refused to participate
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Some have questioned the decision of NEJM to publish this in light of the multiple flaws present
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A Randomized Trial of Arthroscopic Surgery for Osteoarthritis of the Knee
Alexandra Kirkley, M.D., Trevor B. Birmingham, Ph.D., Robert B. Litchfield, M.D., J. Robert Giffin, M.D., Kevin R. Willits, M.D., Cindy J. Wong, M.Sc., Brian G. Feagan, M.D., Allan Donner, Ph.D., Sharon H. Griffin, C.S.S., Linda M. D'Ascanio, B.Sc.N., Janet E. Pope, M.D., and Peter J. Fowler, M.D.*
N Engl J Med 2008; 359:1097-1107September 11, 2008DOI: 10.1056/NEJMoa0708333
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Much more rigorous Validated outcome measure Only Grade 3 or 4 (Kellgren-Lawrence) Marked joint space narrowing Osteophytes Sclerosis
Other exclusion criteria were inflammatory or postinfectious arthritis, previous arthroscopic treatment for knee osteoarthritis, more than 5 degrees of varus or valgus deformity, previous major knee trauma, Kellgren–Lawrence grade 4 osteoarthritis in two compartments (the medial or lateral compartments of the tibiofemoral joint or the patellofemoral compartment) in persons over 60 years
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Concluded arthroscopy did not work in this group
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Vocal opponents of arthroscopy in OA State that many surgeons say that it works in their
hands, implying that this is false State that the evidence does not support arthroscopy
Multiple journal articles (Med J Aust 2012; 197 (7): 364-365.)
Editorial in MJA, advocating using glucosamine instead
Furthermore, recommend TKR if conservative treatment fails, rather than arthroscopy
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The problem is that these articles have lead to ....
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Knee arthroscopy hospital admissions 55 years and over
The Commission recommends to the MBS Review Taskforce that, given the lack of clinical evidence for the efficacy of knee arthroscopy for people with degenerative changes in the knee that the relevant MBS item(s) be amended to remove knee arthroscopy for this group.
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Despite the fact that these studies did not support this conclusion
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Ten-Year Survivorship After Knee Arthroscopy in Patient With Kellgren-Lawrence Grade 3 and Grade 4 Osteoarthritis of the Knee
J. Richard Steadman et al, J arthroscopy and related Surgery, 2013: 1-6
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81 knees, all recommended to have TKR All Grade 3-4 All had scope, 10 year FU 62% had TKR at mean 4.4 years (1-9.6) Grade 4 is 5 times more likely to fail 40% delayed TKR by at least 10 years
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Blood Coagul Fibrinolysis. 2015 Nov 7. [Epub ahead of print]
Arthroscopic knee debridement can delay total knee replacement in painful moderate haemophilic arthropathy of the knee in adult patients.
Rodriguez-Merchan EC1, Gomez-Cardero P.
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27 patients, average age 28 Ongoing pain Arthroscopy and debridement, FU 7.5 years Knee society score from 39-66 (pain), 36-52
(function) 1 had TKR at 12.5 years
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Krych, Sports Med Arthrosc Rev. Mar2013;21: 1.
Van der Bekerom, J Knee Surg. 2007;20:271-6.
Aaron, JBJS Am, 2006 May; 88(5): 936-43.
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- Probably does not improve pain or ability to
function compared to placebo (sham surgery) - Probably leads to little or no difference in pain or ability to function compared to lavage - May improve pain compared to washout - May not lead to any difference in pain or ability to function compared to closed needle joint lavage
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Authors' conclusions: There is 'gold' level evidence that AD has no
benefit for undiscriminated OA (mechanical or inflammatory causes).
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Three RCTs were included with a total of 271 patients. They had different comparison groups and a moderate risk of bias. One study compared AD with lavage and with sham surgery. Compared to lavage the study found no significant difference. Compared to sham surgery placebo, the study found worse outcomes for AD at two weeks (WMD for pain 8.7, 95% CI 1.7 to 15.8, and function 7.7, 95% CI 1.1 to 14.3; NNTH=5) and no significant difference at two years. The second trial, at higher risk of bias, compared AD and arthroscopic washout, and found that AD significantly reduced knee pain compared to washout at five years (RR 5.5, 95% CI 1.7 to 15.5; NNTB=3). The third trial, also at higher risk of bias, compared AD to closed-needle lavage, and found no significant difference.
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Three RCTs were included with a total of 271 patients. They had different comparison groups and a moderate risk of bias. One study compared AD with lavage and with sham surgery. Compared to lavage the study found no significant difference. Compared to sham surgery placebo, the study found worse outcomes for AD at two weeks (WMD for pain 8.7, 95% CI 1.7 to 15.8, and function 7.7, 95% CI 1.1 to 14.3; NNTH=5) and no significant difference at two years. The second trial, at higher risk of bias, compared AD and arthroscopic washout, and found that AD significantly reduced knee pain compared to washout at five years (RR 5.5, 95% CI 1.7 to 15.5; NNTB=3). The third trial, also at higher risk of bias, compared AD to closed-needle lavage, and found no significant difference.
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Studies from 1993, 1996 and the Moseley study 2002
All assessed as moderate risk of bias Conclusion notes that Moseley was at odds
with multiple published studies Most compared with lavage, which nobody
does
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The logical corollary to this line of thinking is that if the patient has failed conservative treatment then the patient either puts up with it or has
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Moderate to severe OA alone is not helped Isolated MFC lesions may be helped if
conservative treatment fails Recommends conservative treatment to start
with Recommends that surgical discretion and
informed consent is essential
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Why do surgeons still do arthroscopy? The cynics would say money But there may be other reasons including
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Looked up last 10 patients having TKR preceded by arthroscopy
5M, 5F Age at scope 67 (53-76) Age at TKR 74 (56-83) Delay of TKR 7 years, delay of symptoms 6
years All had Grade 4 changes at arthroscopy Many had other pathology as well, MMT, CMP
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Arthroscopy from 2009
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TKR in 2016
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All but 1 would be refused funding for arthroscopy under new guidelines
All had had conservative treatment prior to arthroscopy
All would be recommended for TKR under the new guidelines
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Discussion with multiple other surgeons yields same experience, which correlates with the commentary given by Harris et al
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This patient has had 4 scopes over last 20 years
Grade 4 PFJ changes at first scope Continued to play A grade cricket Last scope before this one 7 years ago
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The new guidelines will result in 2 possible scenarios
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A huge untreated cohort of patients
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An order of magnitude increase in the number of TKRs performed.
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Both outcomes are disastrous From the patient’s point of view From an economic point of view From an ethical and moral point of view
However, it will save money in the short term due to the decline in arthroscopy
But it will be much more expensive in the long term
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Arthroscopy has a specific valuable place in the treatment of knee arthritis
It is not for all patients There is good evidence that it is of value in
many patients Removing a tool such as this in the surgeon’s
armamentarium on economic grounds is simply wrong
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