stefan pilz - vitamin d und krebs
DESCRIPTION
Prof. Dr. Stefan Pilz: Sonne, Sonnenschein-Vitamin D und Krebs. Forschungsergebnisse zu Vitamin D und seine Wirkung bei Prävention und Therapie verschiedener Krebsarten. Vortrag beim "Vitamin D-Update 2013" in der Charité BerlinTRANSCRIPT
Wirkung von Vitamin D bei Krebserkrankungen
Stefan PilzDepartment of Internal Medicine, Division of Endocrinology and
Metabolism, Medical University of Graz, AustriaDepartment of Epidemiology and Biostatistics, EMGO Institute for Health
and Care Research, VU University Amsterdam, The Netherlands
OUTLINE
Sunlight (ultraviolet-B) exposure and cancer
Vitamin D deficiency and cancer risk
Outlook and conclusions
Anti-cancer effects of vitamin D
Vitamin D treatment and cancer
Sunlight (ultraviolet-B) exposure and cancer
Vitamin D and sun
Reichrath J. British Journal of Dermatology, 2009; 161: 54-60
Cancer and sunlight
Cancer Res 1:191-195, 1941 Apperly FL
Cancer and sunlight
Apperly FL. Cancer Res 1:191-195, 1941
Solar radiation and colon cancer
Int J Epidemiol 1980; 9:227-231
UV-B and cancer mortality
Cancer 2002;94:1867-1875
OUTLINE
Sunlight (ultraviolet-B) exposure and cancer
Vitamin D deficiency and cancer
Outlook and conclusions
Anti-cancer effects of vitamin D
Vitamin D treatment and cancer
Vitamin D and melanoma
Vitamin D and melanoma
„…there was no evidence for a
nything other than a
beneficial effe
ct for h
igher (vita
min D) levels“
Vitamin D and cancer
47,800 men4,286 incident cancers2,025 cancer deaths
Largest study in this field
Follow-up (years)
1086420
Cu
mu
lati
ve S
urv
ival
1.00
0.99
0.98
0.97
0.96
0.95
0.94
Q4 (High)Q3Q2Q1 (Low)
25-hydroxyvitamin D (ng/ml)
(N=95)
HR 0.49 (0.28-0.88)(fully adjusted model)
Pilz S et al, Cancer Epidemiol Biomarkers Prev 2008; 17: 1228-1233
Vitamin D and cancer mortality
Data from 3299 patients referred for coronary angiography and followed up for 7.7 years
Vitamin D and colorectal cancer
Non-linear dose-response meta-analyses on circulating 25-
hydroxyvitamin D and risk of colorectal cancer
Vitamin D and colorectal cancer
Dose-response meta-analyses of total (dietary + supplemental) vitamin D intake and risk of colorectal and colon cancer
OUTLINE
Sunlight (ultraviolet-B) exposure and cancer
Vitamin D deficiency and cancer
Outlook and conclusions
Anti-cancer effects of vitamin D
Vitamin D treatment and cancer
Anticancer effects of vitamin D
684-700
Anticancer effects of vitamin D
JNCI J Natl Cancer Inst (1992) 84(17): 1355-1357
OUTLINE
Sunlight (ultraviolet-B) exposure and cancer
Vitamin D deficiency and cancer risk
Outlook and conclusions
Anti-cancer effects of vitamin D
Vitamin D treatment and cancer
Vitamin D and cancer incidence
Lappe J, et al. Am J Clin Nutr 2007;85:1586-91
A 4-year, population based, double-blind, randomized, placebo controlled trial among healthy postmenopausal women (n=1179) receiving 1400-1500 mg calcium/d (Ca-only), calcium plus 1100 IU vitamin D/d (Ca + D), or placebo
** P=0.01 *** P=0.005
RR 0.40**RR 0.23***
Entire study cohort Free of cancer at 1 years of intervention
WHI-Study
WHI-Study
OUTLINE
Sunlight (ultraviolet-B) exposure and cancer
Vitamin D deficiency and cancer risk
Outlook and Conclusions
Anti-cancer effects of vitamin D
Vitamin D treatment and cancer
Conclusion
Sunlight (ultraviolet-B exposure), which increases vitamin D synthesis in the skin, is associated with reduced cancer risk
Vitamin D exerts various anti-carcinogenic effects
Observational and interventional studies have partially but not consistently shown an association of a poor vitamin D status with increased cancer risk
Whether vitamin D supplementation is effective in the prevention and treatment of cancer remains to be further evaluated in large-scale randomized controlled trials but the promising data on vitamin D regarding cancer and various other health outcomes strongly argue that it is reasonable to prevent and treat vitamin D deficiency
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