stanford cancer immunotherapy and blood & marrow ... · professor of medicine (blood and marrow...

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Friday, April 20, 2018 8:00 AM – 5:20 PM to Saturday, April 21, 2018 8:00 AM – 2:35 PM Frances C. Arrillaga Alumni Center McCaw Hall Stanford, CA Update on Current Advances in BMT and Cancer Immunotherapy A Continuing Medical Education Conference Presented by the Department of Medicine and the Division of Blood & Marrow Transplant at the Stanford University School of Medicine Sponsored by the Stanford University School of Medicine Register online at cme.stanford.edu/BMT Stanford Cancer Immunotherapy and Blood & Marrow Transplant Symposium

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Page 1: Stanford Cancer Immunotherapy and Blood & Marrow ... · Professor of Medicine (Blood and Marrow Transplantation) Crystal Mackall, M.D. Professor of Pediatrics (Hematology/Oncology)

Friday, April 20, 20188:00 AM – 5:20 PM

toSaturday, April 21, 2018

8:00 AM – 2:35 PM

Frances C. Arrillaga Alumni CenterMcCaw HallStanford, CA

Update on Current Advances in BMT and Cancer

ImmunotherapyA Continuing Medical Education Conference Presented by the Department of Medicine and the Division of Blood & Marrow Transplant at the Stanford University School of Medicine

Sponsored by the Stanford University School of Medicine

Register online at cme.stanford.edu/BMT

Stanford Cancer Immunotherapy and Blood & Marrow

Transplant Symposium

Page 2: Stanford Cancer Immunotherapy and Blood & Marrow ... · Professor of Medicine (Blood and Marrow Transplantation) Crystal Mackall, M.D. Professor of Pediatrics (Hematology/Oncology)

Conference Information

STATEMENT OF NEEDThis CME activity seeks to fulfill the need in the transplant and cellular therapeutics community to increase and improve knowledge as well as management skillset in performing stem cell transplantation and cellular therapeutics to optimize patients’ clinical outcomes. The conference will utilize lectures, debate and panel discussion to achieve the educational objectives.

TARGET AUDIENCEThis national conference is designed to meet the educational needs of:

• Physicians practicing in hematology, oncology, and internal medicine• Physicians Assistants• Nurse Practitioners• Nurses

LEARNING OBJECTIVESAt the conclusion of this activity, learners will be able to:

• Review the difference of transplant-related mortality/morbidity and chance of disease relapse in myeloablative regimen, in reduced intensity regimen and in non-myeloablative regimen in order to determine the best treatment options for your patients presenting with myelodysplastic syndrome.

• Utilize Stanford guidelines on the criteria for ICU transfer of critically ill post-transplant patients.

• Determine the different pathways involved in the pathogenesis of Graft-Versus-Host Disease (GVHD) and use them as a guide for choosing different classes of treatment in individual patients.

• Analyze the pros and cons of different donor sources based on current clinical data in order to determine which sources to use with your patients.

• Review the application of high-throughput sequencing (HTS) to monitor minimal residual disease after transplant and in managing disease relapse.

• Review the outcome data using CD-19 targeting CAR T-cells from different institutes, and be familiar with the guidelines in managing therapy-related complications.

ACCREDITATIONThe Stanford University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATIONThe Stanford University School of Medicine designates this live activity for a maximum of 11.25 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The California Board of Registered Nursing recognizes that Continuing Medical Education (CME) is acceptable for meeting RN continuing education requirements as long as the course is certified for AMA PRA Category 1 CreditTM (rn.ca.gov). Nurses will receive a Certificate of Participation following this activity that may be used for license renewal.

COMMERCIAL SUPPORT ACKNOWLEDGEMENT This CME activity is supported in part by educational grants. A complete list of commercial supporters will be published in the course syllabus.

FACULTY DISCLOSUREThe Stanford University School of Medicine adheres to ACCME Criteria, Standards and Policies regarding industry support of continuing medical education. Disclosure of faculty and their commercial relationships will be made prior to the activity.

REGISTRATIONRegistration fee includes course materials, certificate of participation, continental breakfast, and lunch.

Register online with a Visa or Master Card by visiting cme.stanford.edu/BMT. If you prefer to pay by check or need assistance, please call (650) 497-8554 or email [email protected]. Be sure to register with an email address that you check frequently. Your email address is used for critical information, including registration confirmation, evaluation, and certificate.

CANCELLATION POLICY Cancellations received in writing no less than 30 days before the course will be refunded, less a 20% administrative fee. No refunds will be made on cancellations received after March 21, 2018. Please send cancellation requests to [email protected].

Stanford University School of Medicine reserves the right to cancel or postpone this program if necessary; in the event of cancellation, course fees will be fully refunded. We are not responsible for other costs incurred such as non-refundable airline tickets or hotel penalties.

CONFERENCE LOCATIONFrances C. Arrillaga, Alumni Center – McCaw Hall 326 Galvez Street, Stanford, CA 94305(650) 723-2021

PARKING, MAPS & DIRECTIONSFor driving directions , maps and parking at Arrillaga Alumni Center please visit: https://alumni.stanford.edu/get/page/resources/alumnicenter/directions

VISITING STANFORD AND ACCOMMODATIONSNearby Hotels:Sheraton Palo Alto Hotel (650) 328-2800The Westin Palo Alto (650) 321-4422Please contact the hotel directly to secure a reservation.http://visit.stanford.edu/plan/lodging

CONTACT INFORMATIONFor questions about the conference, please contact Rodney D. Jackson, CME Conference Coordinator at (650)724-2288 or [email protected].

Stanford Center for Continuing Medical Education1520 Page Mill Road, Palo Alto, CA 94304Phone: (650) 497-8554 • Email: [email protected]: cme.stanford.edu

Stanford University School of Medicine is committed to ensuring that its programs, services, goods and facilities are accessible to individuals with disabilities as specified under Section 504 of the

Rehabilitation Act of 1973 and the Americans with Disabilities Amendments Act of 2008. If you have needs that require special accommodations, including dietary concerns, please contact the CME Conference Coordinator.

ATTENDEE TYPE FEES FEESEarly Bird Rate After March 20, 2018

Physician $475.00 $650.00Nurse/Allied Health Professionals $350.00 $475.00

Page 3: Stanford Cancer Immunotherapy and Blood & Marrow ... · Professor of Medicine (Blood and Marrow Transplantation) Crystal Mackall, M.D. Professor of Pediatrics (Hematology/Oncology)

Please register early – space is limited

FRIDAY, APRIL 20, 20188:00-8:35 Registration and Breakfast

8:35-8:40 Introductory RemarksLaura Johnston, M.D. and Wen Kai Weng, M.D., Ph.D.

8:40-8:50 Welcome: 30 Years of Stanford BMTRobert Negrin, M.D.

8:50-9:15 The Intensity of Conditioning in Myeloid Malignancy: Myeloablative vs Reduced Intensity vs Non-MyeloablativeFrederick R. Applebaum, M.D.

9:15-9:40 Targeting the Stem Cell Niche with Antibody: Allogeneic Transplant in Children with Severe Combined Immunodeficiency (SCID)Judith Shizuru, M.D., Ph.D.

9:40-10:05 Graft Manipulation: Making of a Safer Transplant

10:05-10:30 Understanding the Biology of GVHDRobert Negrin, M.D.

10:30-10:45 Coffee Break

10:45-11:10 The Struggling and Triumphant Story of CMV Management in Allogenic TransplantJanice Brown, M.D.

11:10-11:35 Cell Therapy with In-Vitro Engineered T Regulatory Cells to Modulate GVHDMaria Grazia Roncarolo, M.D.

11:35-12:00 Inducing Organ Transplant Tolerance with Hematopoietic CellsSamuel Strober, M.D.

12:00-12:25 The Intestinal Microbiome and Its Clinical ImplicationAmi Bhatt, M.D., Ph.D.

12:25-1:10 Lunch

1:10-1:30 Managing the Criticall Ill Patients: The ICU ProjectPatricia Jenkins, R.N., B.S.N., M.P.H.

1:30-1:55 Building an Allogeneic Transplant Model Using Cutaneous T-Cell LymphomaWen-Kai Weng, M.D., Ph.D.

1:55-2:20 Young Adult ALL: A Lesson LearnedLori Muffly, M.D., M.S.

2:20-2:45 Hematopoietic Cell Transplantation in HemoglobinopathiesAlice Bertaina, M.D.

2:45-3:00 Coffee Break

3:00-3:25 State of the Art in Multiple MyelomaPaul Richardson, M.D.

3:25-3:50 Teaching a Young Dog New Tricks: The Story of BTK InhibitorDavid Miklos, M.D., Ph.D.

3:50-4:15 Harness the Power of Graft-Versus-Tumor EffectRobert Lowsky, M.D.

4:15-5:20

5:20-6:30

The Debate: Double Cord vs Haploidentical vs Unrelated DonorModerator: Laura Johnston, M.D.Case Scenario Laura Johnston, M.D.Double Cord Blood Stem Cells Nelson Chao, M.D. Haploidentical Donor Andrew Rezvani, M.D. Unrelated Donor Frederick R. Applebaum, M.D. RebuttalPanel Discussion Frederick R. Applebaum, M.D., Nelson Chao, M.D., and Andrew Rezvani, M.D.

Wine and Cheese ReceptionArillaga Center

SATURDAY, APRIL 21, 20188:00-8:40 Registration and Breakfast

8:40-8:50 Introduction for Day 2Laura Johnston, M.D. and Wen Kai Weng, M.D., Ph.D.

8:50-9:20 CD19-CAR for Adult B Cell Malignancy: Efficacy and SafetyDavid Maloney, M.D., Ph.D.

9:20-9:50 CARs for Leukemia: Antigen Evasion and Targeting CD22Terry J. Fry, M.D.

9:50-10:20 CD19-CAR for DLBCL and BeyondDavid Miklos, M.D., Ph.D.

10:20-10:40 Coffee Break

10:40-11:10 CD19-CAR for Pediatric B-ALL: State of the FieldKara Davis, D.O.

11:10-11:40 CARs for Brain Tumors: Seattle ExperienceMichael Jensen, M.D.

11:40-12:10 AML and CD123Elizabeth Budde, M.D., Ph.D.

12:10-1:20 Lunch

1:20-1:50 CARs Associated Neurotoxicity: Emerging InsightsCameron Turtle, M.B.B.S., Ph.D., F.R.A.C.P., F.R.C.P.A.

1:50-2:20 Next Generation CAR T CellsCrystal Mackall, M.D.

2:10-2:35 Closing Remarks

*Opportunities for Q&A will be provided at the conclusion of each presentation.

ProgramProgram (Subject to change)

Everett Meyer, M.D., Ph.D.

Page 4: Stanford Cancer Immunotherapy and Blood & Marrow ... · Professor of Medicine (Blood and Marrow Transplantation) Crystal Mackall, M.D. Professor of Pediatrics (Hematology/Oncology)

Stanford Cancer Immunotherapy and Blood & Marrow Transplant Symposium 2018 Update on Current Advances in BMT and Cancer Immunotherapy

Register online at cme.stanford.edu/BMT

Faculty All faculty members and conference planners are from Stanford University School of Medicine (unless otherwise noted).

COURSE CO-DIRECTORSCourse DirectorLaura Johnston, M.D.Associate Professor of Medicine (Blood and Marrow Transplantation) Division of Blood and Marrow Transplant

Course Co-DirectorWen-Kai Weng, M.D., Ph.D. Associate Professor of Medicine (Blood and Marrow Transplantation) Division of Blood and Marrow Transplant

STANFORD FACULTYAlice Bertaina, M.D.Associate Professor of Pediatrics

Ami Bhatt, M.D.Assistant Professor of Medicine (Hematology) and Genetics

Janice Brown, M.D.Professor of Medicine, Blood and Marrow Transplantation

Kara Lynn Davis, D.O.Assistant Professor of Pediatrics (Hematology/Oncology) at Lucile Packard

Patricia Jenkins, R.N., B.S.N., M.P.H. Nurse Manager, Stanford BMT

Robert Lowsky, M.D.Professor of Medicine (Blood and Marrow Transplantation)

Crystal Mackall, M.D.Professor of Pediatrics (Hematology/Oncology) and of Medicine

Everett Meyer, M.D., Ph.D. Assistant Professor of Medicine (Blood and Marrow Transplantation)

David Miklos, M.D., Ph.D. Associate Professor of Medicine (Blood and Marrow Transplantation)

Lori Muffly, M.D., M.S.Assistant Professor of Medicine (Blood and Marrow Transplantation)

Robert Negrin, M.D.Professor of Medicine, Division Chief, Stanford BMT

Andrew Rezvani, M.D.Assistant Professor of Medicine (Blood and Marrow Transplantation)

Maria Grazia Roncarolo, M.D.George D. Smith Professor of Pediatrics (Stem Cell Transplantation) and Medicine (BMT)

Judith Shizuru, M.D., Ph.D.Professor of Medicine (Blood and Marrow Transplantation)

Samuel Strober, M.D.Professor of Medicine (Immunology and Rheumatology)

GUEST FACULTYFrederick R. Applebaum, M.D.Executive Vice President, Deputy Director Fred Hutchinson Cancer Research Center Professor, Medical Oncology Division University of Washington School of Medicine

Nelson J. Chao, M.D.Professor of Medicine, Duke University Chief, Division of Cell Therapy in the Department of Medicine

Terry J. Fry, M.D.Head, Hematologic Malignancies Section Investigator, National Cancer Institute Pediatric Oncology Branch

Michael Jensen, M.D.Professor of Pediatrics, University of Washington School of Medicine Director of the Ben Towne Center for Childhood Cancer Research, SCRI

David Maloney, M.D., Ph.D.Professor of Medicine, Division of Oncology, University of Washington Medical Director, Cellular Immunotherapy – Leonard and Norma Klorine Endowed Chair for Clinical Research

Paul Richardson, M.D.R.J. Corman Professor of Medicine, Harvard Medical School Dana Farber Cancer Institute

Cameron Turtle, M.B.B.S., Ph.D., F.R.A.C.P., F.R.C.P.A.Associate Professor of Medicine, University of Washington School of Medicine