StabilisAmpicillin sodium - sulbactam sodium

Tradename

Alfasid TurkeyAmpibac ColombiaAmpibactam VenezuelaAmpictam EgyptAmpiplus Romania, Saudi ArabiaAmpisid TurkeyAmpixim VenezuelaBacimex SpainBegalin GreeceBethacil ItalyCinclox IndiaCombicid TurkeyDarzitil ArgentinaDuobaktam TurkeyDuocid TurkeyGalotam SpainLibractam ChileLoricin ItalyPrixin ArgentinaRanpisul MexicoRetarpen SpainSabect EgyptSulamp ColombiaSulbacter VenezuelaSulbaksit TurkeySulbin EgyptSulcid TurkeySumitan Colombia, VenezuelaSynerpen EgyptUltracillin EgyptUnacid GermanyUnacim FranceUnasyn Austria, Chile, Ecuador, Italy, Poland,

Saudi Arabia, Spain, United States ofAmerica

Unictam EgyptXilbac Peru

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Stability in solutions

20 mg/ml 24°C 24 258

20 mg/ml 5°C 60 258

Stability of mixtures

20/10 mg/ml 25°C Palonosetron hydrochloride : 25 µg/ml 4 2214

20 mg/ml 24°C Aztreonam : 10 mg/ml 24 258

20 mg/ml 5°C Aztreonam : 10 mg/ml 84 258

Compatibility

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlAmifostine : 10 mg/ml 3

Ampicillin sodium - sulbactam sodiumAmikacin sulfate 3549

Ampicillin sodium - sulbactam sodium : 30 mg/mlAmiodarone hydrochloride : 6 mg/ml 1611

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlAmphotericin B cholesteryl sulfate complex : 0.83 mg/ml 921

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlAnidulafungin : 0.5 mg/ml 1982

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlAztreonam : 40 mg/ml 99

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlBivalirudin : 5 mg/ml 1713

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlCeftolozane / tazobactam : 10/5 mg/ml 3828

Ampicillin sodium - sulbactam sodiumCiprofloxacin lactate 1500

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlCisatracurium besylate : 0.1 & 2 mg/ml 299

Ampicillin sodium - sulbactam sodium : 15 mg/ml 4440Ampicillin sodium - sulbactam sodium : 20/10 mg/mlCisatracurium besylate : 5 mg/ml 299

Ampicillin sodium - sulbactam sodium : 2 & 15 mg/mlDiltiazem hydrochloride : 5 mg/ml 198

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Ampicillin sodium - sulbactam sodium : 20/10 mg/mlDocetaxel : 0.9 mg/ml 1754

Ampicillin sodium - sulbactam sodium : 20/10 mg/ml 1415Ampicillin sodium - sulbactam sodium : 45 mg/mlDiltiazem hydrochloride : 5 mg/ml 198

Ampicillin sodium - sulbactam sodium : 20 mg/ml 4507Ampicillin sodium - sulbactam sodium : 20/10 mg/ml 301Ampicillin sodium - sulbactam sodium : 30 mg/mlCiprofloxacin lactate : 2 mg/ml 285

Ampicillin sodium - sulbactam sodiumCiprofloxacin lactate 3529

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlDexmedetomidine : 4 µg/ml 1712

Ampicillin sodium - sulbactam sodium : 45 mg/mlDiltiazem hydrochloride : 1 mg/ml 198

Ampicillin sodium - sulbactam sodium : 15 mg/mlEnalaprilate : 0.05 mg/ml 1315

Ampicillin sodium - sulbactam sodiumErythromycin lactobionate 3674

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlEtoposide phosphate : 5 mg/ml 1410

Ampicillin sodium - sulbactam sodium : 30 mg/mlFamotidine 397

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlFenoldopam mesylate : 80 µg/ml 1803

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlFilgrastim : 30 µg/ml 244

Ampicillin sodium - sulbactam sodium : 60 mg/mlFluconazole : 2 mg/ml 496

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlFludarabine phosphate : 1 mg/ml 492

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlFosfomycin : 30 mg/ml 4055

Ampicillin sodium - sulbactam sodium : 45/22.4 mg/mlGallium nitrate : 1 mg/ml 91

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlGemcitabine hydrochloride : 10 mg/ml 1423

Ampicillin sodium - sulbactam sodiumGentamicin sulfate 3520

Ampicillin sodium - sulbactam sodiumGentamicin sulfate 3643

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlGranisetron hydrochloride : 0.05 mg/ml 182

Ampicillin sodium - sulbactam sodium : 30 mg/mlHeparin sodium : 50 UI/ml 317

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlHetastarch : 60 mg/ml 1721

Ampicillin sodium - sulbactam sodium : 30 mg/mlIdarubicin hydrochloride : 1 mg/ml 491

Ampicillin sodium - sulbactam sodium : 30 mg/mlInsulin : 0.2 UI/ml 129

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Ampicillin sodium - sulbactam sodium : 20/10 mg/mlIsavuconazonium sulfate : 1.5 mg/ml 3829

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlKetoprofene : 3.2 mg/ml 1847

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlLansoprazole : 0.55 mg/ml 1625

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlLinezolid : 2 mg/ml 1925

Ampicillin sodium - sulbactam sodium : 30 mg/mlMorphine sulfate : 1 mg/ml 406

Ampicillin sodium - sulbactam sodium : 15 mg/mlNicardipine hydrochloride : 0.1 mg/ml 1490

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlOndansetron hydrochloride : 1 mg/ml 334

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlPaclitaxel : 1.2 mg/ml 248

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlPalonosetron hydrochloride : 50 µg/ml 2214

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlPemetrexed disodium : 20 mg/ml 1953

Ampicillin sodium - sulbactam sodium : 30 mg/mlPethidine hydrochloride : 10 mg/ml 406

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlPlazomicin sulfate : 24 mg/ml 4145

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlRemifentanil hydrochloride : 25 & 250 µg/ml 59

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlSargramostim : 10 µg/ml 335

Ampicillin sodium - sulbactam sodium : 200 mg/mlSugammadex : 100 mg/ml 3372

Ampicillin sodium - sulbactam sodium : 50 mg/mlTacrolimus : 1000 µg/ml 479

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlTedizolid phosphate : 0.8 mg/ml 3827

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlTelavancin hydrochloride : 7.5 mg/ml 3254

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlTelavancin hydrochloride : 7.5 mg/ml 3254

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlTeniposide : 0.1 mg/ml 905

Ampicillin sodium - sulbactam sodium : 30 mg/mlTheophylline : 4 mg/ml 317

Ampicillin sodium - sulbactam sodium : 20/10 mg/mlThiotepa : 1 mg/ml 249

Ampicillin sodium - sulbactam sodium : 10/20 mg/mlTramadol hydrochloride : 0,4 mg/ml 2002

Ampicillin sodium - sulbactam sodium : 1/0.5 >> 250/125 mg/mlVancomycin hydrochloride : 2 mg/ml 1674

Ampicillin sodium - sulbactam sodium : 1/0.5 >> 50/25 mg/mlVancomycin hydrochloride : 20 mg/ml 1674

Ampicillin sodium - sulbactam sodium : 250-125 mg/mlVancomycin hydrochloride : 20 mg/ml 1674

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Route of administration

References

Type Publication3 Journal Trissel LA, Martinez JF.

Compatibility of amifostine with selected drugs during simulated Y-site administration.Am J Health-Syst Pharm 1995 ; 52: 2208-2212.

59 Journal Trissel LA, Gilbert DL, Martinez JF, Kim MC.Compatibility of remifentanil hydrochloride with selected drugs during simulated Y-site administration.Am J Health-Syst Pharm 1997 ; 54: 2192-2196.

91 Journal Lober CA, Dollard PA.Visual compatibility of gallium nitrate with selected drugs during Y-site injection.Am J Hosp Pharm 1993 ; 50: 1208-1210.

99 Journal Trissel LA, Martinez JF.Compatibility of aztreonam with selected drugs during simulated Y-site administration.Am J Health-Syst Pharm 1995 ; 52: 1086-1090.

129 Journal Smythe M, Malouf E.Visual compatibility of insulin with secondary intravenous drugs in admixtures.Am J Hosp Pharm 1991 ; 48: 125-126.

182 Journal Trissel LA, Gilbert DL, Martinez JF.Compatibility of granisetron hydrochloride with selected drugs during simulated Y-site administration.Am J Health-Syst Pharm 1997 ; 54: 56-60.

198 Journal Gayed AA, Kheshary PR, Hinkle RL.Visual compatibility of diltiazem injection with various diluents and medications during simulated Y-site injection.Am J Health-Syst Pharm 1995 ; 52: 516-520.

244 Journal Trissel LA, Martinez JF.Compatibility of filgrastim with selected drugs during simulated Y-site administration.Am J Hosp Pharm 1994 ; 51: 1907-1913.

248 Journal Trissel LA, Martinez JF.Turbidimetric assessment of the compatibility of taxol with 42 other drugs during simulated Y-site injection.Am J Hosp Pharm 1993 ; 50: 300-304.

249 Journal Trissel LA, Martinez JF.Compatibility of thiotepa (lyophilized) with selected drugs during simulated Y-site administration.Am J Health-Syst Pharm 1996 ; 53: 1041-1045.

258 Journal Belliveau PP, Nightingale CH, Quintiliani R.Stability of aztreonam and ampicillin sodium-sulbactam sodium in 0.9% sodium chloride injection.Am J Hosp Pharm 1994 ; 51: 901-904.

285 Journal Elmore RL, Contois ME, Kelly J, Noe A, Poirier A.Stability and compatibility of admixtures of intravenous ciprofloxacin and selected drugs.Clin Ther 1996 ; 18: 246-255.

299 Journal Trissel LA, Martinez JF, Gilbert DL.Compatibility of cisatracurium besylate with selected drugs during simulated Y-site administration.Am J Health-Syst Pharm 1997 ; 54: 1735-1741.

301 Journal Trissel LA, Gilbert DL, Martinez JF, Baker MB, Walter WV, Mirtallo JM.Compatibility of parenteral nutrient solutions with selected drugs during simulated Y-site administration.Am J Health-Syst Pharm 1997 ; 54: 1295-1300.

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317 Journal Kershaw BP, Monnier HL, Mason JH.Visual compatibility of premixed theophylline or heparin with selected drugs for IV administration.Am J Hosp Pharm 1993 ; 50: 1360-1362.

334 Journal Trissel LA, Tramonte SM, Grilley BJ.Visual compatibility of ondansetron hydrochloride with selected drugs during simulated Y-site injection.Am J Hosp Pharm 1991 ; 48: 988-992.

335 Journal Trissel LA, Bready BB, Kwan JW, Santiago NM.Visual compatibility of sargramostim with selected antineoplasic agents, anti-infectives, or other drugs duringsimulated Y-site injection.Am J Hosp Pharm 1992 ; 49: 402-406.

397 Journal Fong PA, Ward J.Visual compatibility of intravenous famotidine with selected drugs.Am J Hosp Pharm 1989 ; 46: 125-126.

406 Journal Smythe MA, Patel MA, Gasloli RA.Visual compatibility of narcotic analgesics with selected intravenous admixtures.Am J Hosp Pharm 1990 ; 47: 819-820.

479 Journal Min DI, Brown T, HWang GC.Visual compatibility of tacrolimus with commonly used drugs during simulated Y-site injection.Am J Hosp Pharm 1992 ; 49: 2964-2966.

491 Journal Turowski RC, Durthaler JM.Visual compatibility of idarubicin hydrochloride with selected drugs during simulated Y-site injection.Am J Hosp Pharm 1991 ; 48: 2181-2184.

492 Journal Trissel LA, Parks NPT, Santiago NM.Visual compatibility of fludarabine phosphate with antineoplastic drugs, anti-infectives, and other selected drugsduring simulated Y-site injection.Am J Hosp Pharm 1991 ; 48: 2186-2189.

496 Journal Lor E, Sheybani T, Takagi J.Visual compatibility of fluconazole with commonly used injectable drugs during simulated Y-site administration.Am J Hosp Pharm 1991 ; 48: 744-746.

905 Journal Trissel LA, Martinez JF.Screening teniposide for Y-site physical incompatibilities.Hosp Pharm 1994 ; 29: 1010-1017.

921 Journal Trissel LA, Gilbert DL, Martinez JF.Incompatibility and compatibility of amphotericin B cholesteryl sulfate complex with selected other drugs duringsimulated Y-site administration.Hosp Pharm 1998 ; 33: 284-292.

1315 Journal Halpern NA, Colucci RD, Alicea M, Greenstein R.Visual compatibility of enalaprilat with commonly used critical care medications during simulated Y-site injection.Int J Pharm Clin Pharmacol Ther Tox 1989 ; 27: 294-297.

1410 Journal Trissel LA, Martinez JF, Simmons M.Compatibility of etoposide phosphate with selected drugs during simulated Y-site injection.J Am Pharm Assoc 1999 ; 39: 141-145.

1415 Journal Trissel L.A, Gilbert D.L, Martinez J.F, Baker M.B, Walter W.V, Mirtallo J.M.Compatibility of medications with 3-in-1 parenteral nutrition admixtures.JPEN 1999 ; 23: 67-74.

1423 Journal Trissel LA, Martinez JF, Gilbert DL.Compatibility of gemcitabine hyrochloride with 107 selected drugs during simulated Y-site injection.J Am Pharm Assoc 1999 ; 39: 514-518.

1490 Journal Halpern NA, Colucci RD, Alicea M, Greenstein R.The compatibility of nicardipine hydrochloride injection with various ICU medications during simulated Y-siteinjection.Int J Pharm Clin Pharmacol Ther Tox 1989 ; 27: 250-254.

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1500 Journal Melonakos TK.Ciprofloxacin-ampicillin sulbactam incompatibility.Ann Pharmacotherapy 1996 ; 30: 87.

1611 Journal Chalmers JR, Bobek MB, Militello MA.Visual compatibility of amiodarone hydrochloride injection with various intravenous drugs.Am J Health-Syst Pharm 2001 ; 58: 504-506.

1625 Journal Trissel LA, Saenz C, Williams YW, Ingram D.Incompatibilities of lansoprazole injection with other drugs during simulated Y-site coadministration.Int J Pharm Compound 2001 ; 5: 314-321.

1674 Journal Trissel LA, Gilbert DL, Martinez JF.Concentration dependency of vancomycin hydrochloride compatibility with beta-lactam antibiotics during simulatedY-site administration.Hosp Pharm 1998 ; 33: 1515-1522.

1712 Journal Trissel LA, Saenz CA.Compatibility screening of Precedex during simulated Y-site administration with other drugs.Int J Pharm Compound 2002 ; 6: 230-233.

1713 Journal Trissel LA, Saenz CA.Compatibility screening of bivalirudin during simulated Y-site administration with other drugs.Int J Pharm Compound 2002 ; 6: 311-315.

1721 Journal Trissel LA, Williams KY, Baker MB.Compatibility screening of Hextend during simulated Y-site administration with other drugs.Int J Pharm Compound 2001 ; 5: 69-72.

1754 Journal Trissel LA, Gilbert DL, Wolkin AC.Compatibility of docetaxel with selected drugs during simulated Y-site administration.Int J Pharm Compound 1999 ; 3: 241-244.

1803 Journal Trissel, LA, Saenz CA, Ogundele OB, Ingram D, Baker MB.Compatibility of fenoldopam mesylate with other drugs during simulated Y-site administration.Am J Health-Syst Pharm 2003 ; 60: 80-85.

1847 Journal Anacardo R, Perilli O, Bartolini S, Gentile MM, Mazzeo P, Carlucci G.Physicochemical compatibility between ketoprofen kysine salt injections (Artrosilene®) and pharmaceuticalproducts frequently used for combined therapy by intravenous administration.J Pharm Biomed Anal 2003 ; 32, 6: 1235-1241.

1925 Journal Trissel LA , Williams KY, Gilbert DL.Compatibility screening of linezolid injection during simulated Y-site administration with other drugs and infusionsolutions.J Am Pharm Assoc 2000 ; 40: 515-519.

1953 Journal Trissel LA, Saenz CA, Ogundele AB, Ingram DS.Physical compatibility of pemetrexed disodium with other drugs during simulated Y-site administration.Am J Health-Syst Pharm 2004 ; 61: 2289-2293.

1982 Journal Trissel LA, Ogundele AB.Compatibility of anidulafungin with other drugs during simulated Y-site administration.Am J Health-Syst Pharm 2005 ; 62: 834-837.

2002 Journal Abanmy NO, Zaghloul IY, Radwan MA.Compatibility of tramadol hydrochloride injection with selected drugs and solutions.Am J Health-Syst Pharm 2005 ; 62: 1299-1302.

2214 Journal Ben M, Trusley C,Kupiec T.C, Trissel L.A.Palonosetron hydrochloride compatibility and stability with three beta-lactam antibiotics during simulated Y-siteadministration.Int J Pharm Compound 2007 ; 11, 6: 520-524.

3254 Journal Housman S.T, Tessier P.R, Nicolau D.P, Kuti J.L.Physical compatibility of telavancin hydrochloride with select i.v. drugs during simulated Y-site administration Am J Health-Syst Pharm 2011 ; 68: 2265-2270.

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3372 Journal Hanci V, Ali Kiraz H, Ömür D, Ekin S, Uyan B, Yurtlu B.S.Precipitation in Gallipoli: Sugammadex / Amiodarone & Sugammadex / Dobutamine & Sugammadex / Protamine.Rev Bras Anestesiol 2013 ; 63, 1: 163-166.

3520 Manufacturer Cidomycin - Summary of product Chracteristics.Sanofi 2011

3529 Manufacturer Ciprofloxacin – Summary of Product CharacteristicsHospira 2013

3549 Manufacturer Amikacine B Braun - Résumé des caractéristiques du produit.B Braun 2012

3643 Manufacturer Gentamicin sulphate (Cidomycin®) - Summary of Product CharacteristicsSanofi 2015

3674 Manufacturer Erythromycin lactobionate - Summary of Product CharacteristicsPanPharma 2016

3827 Poster Ghazi I.M, Hamada Y, Nicolau D.P.Compatibility of tedizolid phosphate with selected intravenous drugs via simulated Y-site conditions.ASHP Midyear 2015 2015

3828 Poster Thabit A.K, Hamada Y, Nicolau D.P.Ceftozolane/tazobactam physical compatibility during simulated Y-site administration.ASHP Midyear 2015 2015

3829 Poster So W, Kim L, Thabit A.K, Nicolau D.P, Kuti J.L.Compatibility of isavunazonium sulfate during simulated Y-site administration.ASHP Midyear 2015 2015

4055 Journal Monogue M, Almarzoky Abuhussain S, Kuti J, Nicolau D.Physical compatibility of fosfomycin for injection with select i.v. drugs during simulated Y-site administration.Am J Health-Syst Pharm 2018 , 75, 1:36-44

4145 Journal Asempa T.E, Avery L.M, Kidd J.M, Kuti J.L, Nicolau D.P.Physical compatibility of plazomicin with select i.v. drugs during simulated Y-site administration.Am J Health-Syst Pharm 2018 ;75,14:1048-1056

4440 Journal Omotani S, Aoe M, Esaki S, Nagai K, Hatsuda Y, Mukai J, Teramachi H, Myotoku M.Compatibility of Intravenous Fat Emulsion with Antibiotics for Secondary Piggyback Infusion.Ann Nutr Metab 2018 ; 73: 227-233.

4507 Journal Ross E, Salinas A, Petty K, Her C, Carpenter J.Compatibility of medications with intravenous lipid emulsions: Effects of simulated Y-site mixing.Am J Health-Syst Pharm 2020 ;77,23:1980-1985

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Dictionary

Antibiotic InjectionTradename Stability in solutionsContainer MoleculeConcentration TemperatureStorage Length of timeBiosimilar Conflicting dataReferences Polyvinyl chlorideSodium chloride 0,9% Not specifiedHour Stability of mixturesSolvent CompoundGlass CompatibilityCompatible Glucose 5%Chemical instability IncompatibleImmediate precipitation NaCl 0,9% or Glucose 5%Parenteral nutrition (with lipids) Immediate turbidityParenteral nutrition (binary mixture) Unspecified incompatibilityNone Specific solventPrecipitation after 4 hours Ringer’s lactate solutionRoute of administration IntravenousIntramuscular ReferencesDictionary

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