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SSM Health Spinal Causes and Management 1 Richard A Covert MD, MPH Medical Director - SSM Health Comprehensive Back Pain Program Neuroscience Institute

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Page 1: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

SSM HealthSpinal Causes and Management

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Richard A Covert MD, MPHMedical Director- SSM Health Comprehensive Back Pain Program

Neuroscience Institute

Page 2: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Disclosures

• I am employed by the SSM Medical Group• Nothing to disclose• I am not reimbursed for any lectures, articles, medication

usage, etc.• I have no financial relationships in any imaging,

rehabilitation or other 3rd party providers, nor any investments in products

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Page 3: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Overview

• Epidemiology of Back Pain• Causes of LBP

– Multiple sources– Top 3 Dx’s seen in the Back Pain Program

• Treatment Approach• Outcomes of SSM Program

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Page 4: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Epidemiology

• Prevalence/yr 25-28%1,2

• Prevalence/lifetime is 79-84% 1,2

• # ED Visits/yr in US 2015 136.9 million (all causes) • 3.5 million are for back pain (2.6%) as 10 cause of visit

– Men 15-64 -> 1.23 M ED visits– Women 15-64 -> 1.68 M ED visits– Adults ≥ 65 -> 600,000 ED visits 3

• ED visits for Chronic Disorders (ICD-9 Codes) LBP 20 Dx• Spinal Disorders (720-724) -> 4.28 million visits• Sprains/Strains of Back (846,847) -> 2.08 million visits

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Page 5: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Financial Burden of Back Pain

• Most Common Cause of Disability in adults (18-64y/o)• Accounts for 40% of all Missed Workdays (AAOS)• #2 Reason for OP visits to doctors• Hosp Admission for Back Pain as 1⁰ Dx 1.7% (663,402) 2008

– Financial Cost $9.52 B (2008) => $11.17 B (2019) 4

• Hospital LOS for Pts. With Back Problems = 2.3 days longer– Financial Cost $25.97 B (2008) => $30.05 B (2019)4

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Page 6: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Common Causes of LBP

• Mechanical Low Back Pain

• Sprains/Strains• Degenerative Disc

Disease• Herniated Discs• Spinal Stenosis

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• Skeletal Deformities (Scoliosis, Kyphosis, Lordosis)

• Spondylolisthesis• Compression

Fractures (traumatic, osteoporotic)

• Myofascial Pain/Fibromyalgia

Page 7: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Less Common Causes of LBP

• Kidney Stones• Aortic Aneurysms• Tumors• Infections• Facet Cysts• Ankylosing Spondylitis

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Page 8: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Risk Factors for LBP

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Page 9: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Risk Factors for LBP

• Age – Impacts Discs, Muscle Elasticity, Injury Recovery, Spinal Stenosis, Bone Loss, Balance

• Poor Fitness – Weak Core Muscles, Loss of Flexibility, Strength, Endurance

• Pregnancy – Especially 3rd Trimester due to Weight Gain, Ligamentous Laxity, Decreased Core Strength

• Obesity – Increases Loading of Spine with Decreased Core Strength• Genetics• Occupational Stresses – Excess Activity or Desk Work• Sports / Hobbies – Biking, Golf, Back Packing, Gymnastics, Football• Smoking

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Page 10: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Distribution of Back Disorders by Age

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• Disc Herniation• Degenerative Disc Disease• Spinal Stenosis

Page 11: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Most Common Problems @ Back Clinic

• Mechanical Low Back Pain• Spinal Stenosis• Sacroiliitis• Piriformis Syndrome

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Page 12: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Structures of the Lumbar Spine

• Muscles• Discs• Vertebrae• Ligaments• Facet Joints• Spinal Cord• Nerve Roots

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Page 13: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

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Spinal Causes of Pain

Page 14: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Video of Spinal Structures

• Spinal Anatomy

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Page 15: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Mechanical Low Back Pain

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Normal Motion

Zygotebody.com

Page 16: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Mechanical Factors

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• Flexibility – Limit Mobility of Hips, Pelvis → Incr. Stress to spine– Tight Hamstrings– Tight Hip Flexors– Tight Calf Muscles– Tight Piriformis / Gluteal Muscles

• Lack of Core Muscle Strength – decr. Spine Stabilization– Abdominals – Paraspinals– Hip Abductors

• Leg Length Discrepancy• Pelvic Asymmetry

Page 17: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Symptoms of Mechanical Low Back Pain

• Aching/Stiffness in low to mid back• Tightness/Spasm• Limited ROM• Pain with Bending• Pain upon arising from chairs or bed• Occasional Hamstring Pain but NO Radicular Symptoms down

the legs• Pain with Fatigue• Pain can be bilateral or unilateral

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Page 18: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Treatment of Mechanical LBP

• Stretching of key muscle groups (Hamstrings, Hip Flexors, Gluteals)

• Strengthening of Core Muscles, Legs and Hips• Massage to break up old Adhesions• Heat/Ice• Myofascial Release• Aerobic Fitness

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Page 19: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

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Useful Stretches for Mechanical LBP

Page 20: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Sacroiliac Joint Anatomy

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Page 21: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

SI Dysfunction

• Symptoms and Signs– Unilateral Pain

• Sharp or dull• Waxes and Wanes• Can vary sharply with position (arising from a chair, twisting, sex)• Aggravated by prolonged standing (go to a bar)• Refers Sx down the buttocks, thigh or groin (mimics sciatica without

lower leg Sx)

– Localized Tenderness

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Page 22: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

SI Dysfunction

• Clinical Exam– Pelvic Asymmetry

• Leg Length Discrepancy• Muscle Spasm• Pelvic Rotation due to muscle imbalance, falls, MVA’s, etc.• Ligamentous Laxity from pregnancy, repeated mobilization of the joint

– Local Tenderness over Sciatic Notches– (+) Gaenslen’s Test (hip thrust)– (+/-) Patrick FABER test– Limited Mobility of the SI region on forward flexion

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Posterior View of Iliac Crests and Sciatic Notches

Page 23: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

SI Dysfunction

• Contributing Factors– Tight Hip Flexors and Quads– Tight Lower Back Muscles– Tight Hamstrings– Weak Core Muscles and Weak Gluteal Muscles– Pregnancy– Obesity with Increase Shear Forces

• Unilateral Sacralization or Lumbarization of L5 or S1 (Bertolotti’sSyndrome)

• DJD• Ankylosis Spondylitis and other autoimmune diseases

23Zygotebody.com

Page 24: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Treatment of Sacroiliitis

• Treatment– Physical Therapy to address muscle strength, flexibility, pelvic rotation– Correction of Leg Length discrepancy with heel lifts, orthotics– Pillow behind or between knees when sleeping– Medications

• NSAID’s• Muscle relaxers for spasm• Avoid Narcotics• Gabapentin, Amitriptyline, Duloxetine have no benefit

– Injection into SI joint under fluoroscopy

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Page 25: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Spinal Stenosis

• What is it?• What causes it?• What are typical symptoms?• What treatments are available?

– Therapy – Medication– Injections– Surgery

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Page 26: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Risk Factors• Age > 50 • Congenital Stenosis (Short

Pedicles)• Scoliosis• Bulging or Herniated Discs• Thickened Ligaments (Lig. Flav.)• OA / Spondylosis• Traumatic Injuries to vertebrae6

Prevalence by Age7

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Page 27: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Symptoms of Spinal Stenosis• Numbness or tingling in a foot or leg• Weakness in a foot or leg • Pain or cramping in one or both legs when you stand for long

periods of time or when you walk, which usually eases when you bend forward or sit (Shopping Cart Sign)

• Back pain

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Page 28: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Imaging

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Page 29: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Treatment of Spinal Stenosis• Non Surgical

– PT to address Mechanical Issues– Medications

• NSAID’s• Gabapentin (Neurontin)• Pre-Gabalin (Lyrica)• Duloxitine (Cymbalta)• Venlafaxine (Effexor)• Amitriptyline / Nortriptyline• Medrol Dosepak

– Injections• ESI• Transforaminal Steroids

• Surgical– Laminectomy– Foraminotomy– Decompression with Fusion– Insertion of Spacers

• Indications for Surgery– Bowel / Bladder control issues– Intractable pain– Inability to Ambulate– Progressive Weakness– Increasing Numbness

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Page 30: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Spinal Stenosis

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Page 31: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Back Pain Program Outcomes

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5.26

2.322.94

0.00

1.00

2.00

3.00

4.00

5.00

6.00

PHQ9-Init PHQ9-Exit PHQ9 Net

PHQ 9 Outcomes

0-4 Minimal Depression

5-9 Mild Depression

33.18%

15.18%18.00%

0.00%

5.00%

10.00%

15.00%

20.00%

25.00%

30.00%

35.00%

ODI-Init ODI-Exit ODI net

ODI Outcomes

Depression and Disability ChangesScoring Range 0 to 100 %Scoring Range 0 to 27

21-40% mod. Dis.

0-20% Min. Dis.

Page 32: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Back Pain Program Outcomes

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15.29

7.588.32

0.00

2.00

4.00

6.00

8.00

10.00

12.00

14.00

16.00

18.00

FABQa-Init FABQa-Exit FABQa-Net

FABQa Outcomes9.32

5.54

3.82

0.00

1.00

2.00

3.00

4.00

5.00

6.00

7.00

8.00

9.00

10.00

FABQw-Init FABQw-Exit FABQw-Net

FABQw Outcomes

Fear Avoidance Behavior Changes for Personal Activity and Work

Scoring Range 0 to 24 points (Threshold > 15) Scoring Range 0 to 42 points (Threshold >34)

Page 33: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Thanks for your time and attention!

Thanks for Staying Awake after Lunch!

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Page 34: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

CannabisUpside DownsideMay Help Reduce Neuropathic Pain (CB1 receptors in Brain)10

Lung Disease if Smoked

Improved Sense of Wellbeing Pancreatitis

Better Appetite Cannabinoid Hyperemesis Syndrome

Relaxation - Sleep Acute Cognitive Impairment - short term use

Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term Cognitive Deficits in Younger Persons

CBD legal in most states (THC legal in 23 states and DC) (see Wikipedia)

Exacerbation of Psychosis/Schizophrenia/Agitation

CBD (Epidiolex) approved for 2 types of Sz disorders Cannabinoid W/D syndrome

Adverse Effects on Fetus if user is pregnant

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Research Limitations: No Double Blind Studies of THC, Conc. Of THC varies from 5% to 90%, Dose of THC or CBD/CC varies among suppliers, format of delivery is variable (drops, inhalation, creams, oils) so pharmacokinetics is variable, purity of preparations is variable (No USP control), No Guidelines for dosing 9

Page 35: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

Cannabinoid Alleged Benefits

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Page 36: SSM Health · Cannabinoid Hyperemesis Syndrome. Relaxation - Sleep: Acute Cognitive Impairment - short term use. Anti-Inflammatory Effect (CB2 receptors on immune cells) Long Term

CBD is the Greatest Thing!

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Use Common Sense Don’t believe everything you read on the WebJust be careful – start low… go slow