18O

PET and Molecular Imaging Products

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Spectra Gases, Inc.

3434 Route 22 West

Branchburg, NJ 08876 USA

tel: 1-908-252-9300 or 1-800-932-0624

fax: 1-908-252-0811

Spectra Stable Isotopes

9108A Guilford Rd

Columbia, MD 21046 USA

tel:800-338-9959 or 410-740-7381

fax:410-740-1328

www.spectrastableisotopes.com

Our Philosophy

At Spectra, innovation is not just a word. . .it is a passionate

pursuit and foundation for our success. We believe in

continuously improving existing products by creating better

chemicals and gases and enabling emerging technologies with

unique specialty chemicals, gases and services.

Position Statement

Spectra is the global leader in next generation fine chemicals and high

purity gases for the research, medical, fiber optic, semiconductor,

environmental, laser, lighting, and high purity gas handling equipment

markets.

From the Beginning—A Technological Leader with Customer Focus

Spectra was founded in 1980 to meet the needs of researchers for the

excimer laser market. We grew quickly as excimer laser applications

became widespread and found great acceptance in Lithography and

laser vision correction (Lasik). Over the years, we have grown to

become a leading supplier in next generation fine chemicals, including

highly enriched isotopes, and high purity gases for the research,

medical, fiber optic, semiconductor, environmental, laser, lighting, and

high purity gas handling equipment markets throughout the world. As

we continue to grow, Spectra’s mission is to focus on providing cutting-

edge solutions to meet our customers’ ever-changing needs.

Spectra Stable Isotopes (SSI) is a division of Spectra, founded in 1980,

and is a major producer of stable isotope labeled biochemicals,

synthons, and stable isotope specialty gases. Spectra is the world’s

largest manufacturer of deuterium, helium-3, and stable isotope labeled

biochemicals.

As a part of the SSI division, our purification systems and separation

technology represent some of the most advanced processes in the

world, including the world’s longest continuous cryogenic distillation

columns located at Spectra’s ICON (Isotopes of Carbon Oxygen and

Nitrogen) Facility at the Los Alamos National Laboratory.

It is not surprising that SSI is uniquely positioned to provide some of

the highest quality 18O enriched water anywhere in the world.

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Spectra Stable Isotopes

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NO NO

NO

NO NO

18O2H2

Your most reliable source for High Enriched18O water:

• Atom Enrichment, > 98% 18O

(normalized)

• Assured by a c-GMP-based program

• Processed in Class 10,000 and Class

100 Environment

• Packaged in an FDA Registered Facility

Guaranteed Quality Through:

• Sterile water filtration

• Containers and closures sterilized

• Lot sampling

• ISO 9001:2000 Quality System

18O2

18O2

18O2

H218O

H218O

H218O

Nitric oxide gas is

distilled and separated.

Enriched isotopes of

oxygen are extracted.

Oxygen-18 gas is

hydrolyzed with

ultra-pure hydrogen.

18O water is produced

from the reaction of

hydrogen and oxygen.

i

i

+

i

Efficient Production Process

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Superior Quality

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Cryogenic Distillation

• Used Water

Recycling

• Used Water

Remediation

• Mannose Triflate

• 18O2 Gas

• 2.5% O2 / 15N2 Gas

• 82Kr

• 124Xe

• Other Precursors and

Standards

Other PET Related Products

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• Higher enrichments

• Lower production costs

Cryogenic Distillation Process

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