spatio-temporal dynamics, fish farms and pair-approximations
DESCRIPTION
Spatio-temporal dynamics, fish farms and pair-approximations. Maths2005 The University of Liverpool Kieran Sharkey, Roger Bowers, Kenton Morgan. DEFRA funded. Investigate epidemiology of three fish diseases IHN (Infectious Haematopoietic Necrosis) VHS (Viral Haemorrhagic Septicaemia) - PowerPoint PPT PresentationTRANSCRIPT
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Spatio-temporal dynamics, fish farms and pair-approximations
Maths2005
The University of LiverpoolKieran Sharkey, Roger Bowers, Kenton Morgan
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DEFRA fundedInvestigate epidemiology of three fish diseasesIHN (Infectious Haematopoietic Necrosis)VHS (Viral Haemorrhagic Septicaemia)GS (Gyrodactylus Salaris)
Collaboration between:Liverpool University Veterinary Epidemiology GroupLiverpool University Applied Maths DeptLancaster University Statistics DeptStirling University Institute for AquacultureCEFAS – Defra funded Laboratory
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The symmetric pair-wise model and Foot&Mouth disease
Application to fish farms
Overview of non-symmetric model
Results from non-symmetric model applied to fish farm data
Outline
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The Symmetric Pair-wise model
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A
D
B
C
A B C D 0 0 0 10 0 1 10 1 0 01 1 0 0
A
B
C
D
Contact Network
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2001 Foot&Mouth Outbreak
Total ban on livestock movement
Route of transmission assumes to be local & symmetric
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S I
][][
][][][
][][
IgR
IgSII
SIS
N
ISnSI
]][[][
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S S
I
][2][ SSISS
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d[SS]/dt = -2[SSI]
d[SI]/dt = ([SSI]-[ISI]-[SI])-g[SI]
d[SR]/dt = -[RSI]+g[SI]
d[II]/dt = 2([ISI]+[SI])-2g[II]
d[IR]/dt = [RSI]+g([II]-[IR])
d[RR]/dt = 2g[IR]
Pair-wise Equations
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Triples Approximation
A
B
C
A
B
CA
B
CA
B
C+
][
]][[][
B
BCABABC
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Disease transmission between fish farms
Slides in this section provided by Mark Thrush at CEFAS
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Disease transmission matrix
Nodes
• Fish Farms• Fisheries• Wild populations
Routes of transmission
• Live fish movement• Water flow• Wild fish migration• Fish farm personnel &
equipment
?
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Nodes
Fish farms
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Nodes
Fish farms
Fisheries
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Nodes
Fish farms
FisheriesWild fish(EA sampling sites)
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AvonTest
Thames
Itchen
Stour
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AvonTest
Thames
Itchen
Stour
Route 1: Live Fish Movement
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Route 2: Water flow (down stream)
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Route 2: Water flow (down stream)
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General pair-wise
model
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Contact network: eg
0 1 11 0 00 1 0
G =
Gs0 1 01 0 00 0 0= Ga
0 0 10 0 00 1 0
=
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S I
S I
S I
S→I
S←I
S↔I
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A
B
CA
B
CA
B
C+
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Some results from the model
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Nodes
Fish farms
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3576
1714
829
32
16
0
65 65 0
65 65 8
65 0 0
8 0 0
0 0 0
0 0 0
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Infectious Time Series
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Infectious Time Series
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Infectious Time Series
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Susceptible Time Series
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Summary
The symmetric pair-wise equations can be generalised to include asymmetric transmission.
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Summary
The non-symmetric model can give significantly different predictions to the symmetric model.
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Summary
The non-symmetric model is closer to stochastic simulation than the symmetric model on one non-symmetric network.