scitek.com.au

SOLUTIONS FORMEDICINAL CANNABIS PRODUCTION

Selected International References

REFERENCES PROVIDED BY HEIDOLPH NORTH AMERICA

3

Heidolph

Heidolph magnetic stirrers include leading safety standards and features for superior ease of use and reduced cost of ownership. The design is splash proof with sealed electronics to protect from corrosive fumes and spill accidents.

Magnetic Stirrers with heating

The Heat-On attachments are suitable to replace oil baths and heating mantles in your lab and reduce the risk of fire hazards. Moreover, the attachments minimize the messy oil clean-ups that result from changing oil or removing flasks from an oil bath!

Highlights:• A separate ON/OFF switch for the heating function prevents unintentional heat-up. The button illuminates clearly for a visual indicator • High temperature warning light to alert users of high hotplate temperatures even when switched off or malfunction• Analogue or digital speed setting from 100 to 1,400 rpm and temperature setting up to 300C• 145mm Kera-Disk hotplate with 800 watt heating power.

™

The Hei-Torque range offers the newest generation drives in either Value or Precision models with torque from 100 to 400Ncm. All units are well sealed for operation in fume hoods. The glass touch screen controller is intuitive and allows precise control as well as programming (Precision model) of all parameters.

Overhead

• Constant speed even under changing loads• Sealed housing, glass panel with magnetic Smart-Knob, IP54 rated• New generation motor offers maximum power at minimum noise• Large range of accessories and impellers

Heat-On attachments

Preparation

Highlights:

Cleanup, Purification & Concentration Heidolph

Asahi

R&D Chemical Reactors

Asahi is a cutting edge glass manufacturing specialist who supplies chemistry and pharma research, as well as industry, with state of the art scientific glassware.

Asahi produce reactors from small 300 ml benchtop to industrial scale of up 1,000l. Process temperatures range from -90C to +230C temperature under full vacuum to 0.5 bar pressure. During production, Asahi employs unique glass re-formating technology, which ensures unmatched process performance of AG! vessels thanks to thinner glass in the reactor area and strengthened flange areas.

All glass double-wall or triple-wall reactors are available withoptional patented ring baffle to improve temperaturehomogeneity. Volumes are available from 300 ml to 20l.

Each benchtop or pilot system is capable to hold a wide range of reactor vessels without the need to fully disassemble the reactors or replace top lids. Vessel changes can be done in less than 5 minutes.

Patented Ring BafflesPatented ring baffles direct the heat transfer fluid flow to prevent “cold spots” and ensure turbulent heat transfer fluid flow for best possible heat transfer and reactor performance. It is common for our reactors to achieve reactor ramp times 40% faster than non-baffled reactors from other brands.

Extraction, Winterisation & Filtration

4

AG! Vessel with

Ring Baffles

Ordinary Jacketed

Vessel

even thermal distribution (HTF)<AG! Vessel with Ring Baffle>

localized heating<Standard Jacketed Vessel>

Optional Integrated FiltrationOur filter reactors feature customised filter inserts to enable direct filtration of product from the reactor vessel without the need to transfer into external filtration vessels.

Heidolph

Rotary Evaporators - Benchtop

shorter process times than other brands • New innovative product feed and vent valves which eliminate the need for grease sealing and prevent glass damage• Unmatched leak rate for purest product and highest boiling point solvent compatibility• FDA compliant media wetted parts• Long-life vacuum seal allows years of operation without replacement• Non-stick vapour tube with patented clamping sleeve eliminates broken glass tubes• Designed for 10+ year lifetime

2• Class leading 2,200 cm surface area condensers for 40%

Scitek is the first certified Heidolph Premium Distributor on the southern hemisphere. This is a factory endorsement is only given after stringent criteria are met – all of which set with the aim to ensure class-leading quality of service, response times, repair turnaround times and stock availability. Scitek is proud to support your Heidolph purchases with 3 years factory backed warranty.

They are suitable for standard distillation, for complex distilling processes as well as for automatic continuous distillation.

The Heidolph rotary evaporators of the Hei-VAP series are forming the ideal basis for intelligent and safe evaporation on your laboratory.

Rotary Evaporators - IndustrialThe Heidolph large scale evaporators of the Hei-VAP Industrial series are for large volume work in 20l flasks or continuous evaporation of virtually unlimited volumes. The unit is fully enclosed in safety glass, PPMA and sheet metal housings making it the safest large scale evaporator on the market. The patented flask handling system allows true one-person operation.

• IP 54 rated large glass touch-screen control panel for all process parameters• 20L flask with patented EASY-LOCK loading and unloading technology• Protective receiver cassettes for waste flasks • Automated filling and lifting of bath Continous process with Distimatic module

Continous Evaporation - DistimaticSave time and production cost by distilling large volumes in a continuous fully automated system.

• Fully automated continuous distillation of largest volumes• Save time and labour to reduce production cost• Sensor and timer based operation

The Distimatic system refills the evaporation flask with precursor, automatically discharges waste solvent and automatically harvests your concentrated product.

It is compatible with our benchtop and industrial series rotary evaporators and can be fitted to most other brands (*without product harvest function).

5

Highlights:

Highlights:

Highlights:

Cleanup, Purification & Concentration

Thin Film and Short Path Evaporators

• Various wiper materials to suits your temperature requirements• Wiper and wiper mechanism options compatiblewith concentrated acid work• DN 60 as standard and DN 100 tube size for high throughput applications• Custom feed vessel assemblies• Turnkey systems with temperature control, condenser cooling, chemistry high vacuum pumping and control technology

Thin film and short path evaporators are perfect for evaporation of heat sensistive or high boiling point products. The large evaporation surface area further increased through the wiper action allows feed rates up to 3 kg/h with very high boiling point products. Process temperatures are commonly up to 300C and pressure below 0.001 mbar.

Highlights:

Asahi

6

Salvis

Vacuum Drying Oven VC20 & VC50The SalvisLab Vacucenter is the optimal solution for oxidation-sensitive substances and thermally instable products. It provides precise thermal conditions in dust-free vacuum atmosphere. These characteristics enable highly successful SalvisLab Vacucenter applications for a wide range of laboratory applications in areas such as pharmaceuticals, food products and cosmetics. The SalvisLab Vacucenter is renowned for its compact form factor, reliability and durability.

Final Purification

Product Drying

UV VIS Spectroscopy

Analytik Jena

7

UV Vis spectrophotometers belong to the basic equipment in pharmaceutical laboratories. The double beam systems

of the Specord series are well known for their high quality and robustness. In combination with the comprehensive range

of accessories available, they are a must in routine testing applications.

Progress towards better health requires international cooperation in the establishment of international standards for

biological and pharmaceuticals. The Specord spectrophotometers are compliant to the strict regulations of all

international pharmacopeia and to the requirements of the Departments of Health and Human Services.

Research and Development

• Screening of Active ingredients

• Purity control

• Test of bio availability

• Incoming goods inspection

• Control of chemical substance

• Control of contamination

• Quality control of products

• Control of the

concentration of

active ingredients

• Purity control

• Dissolution tests

Specord Plus

• Precision

The Specord plus offers highest precision and total reliability of measurement results

Application Highlights:

Highlights:

• Durability

Analytik Jena is the only manufacturer worldwide that offers a long term 10yr warranty for the optical components

of the device

• Flexibility

An extensive range of accessories guarantees flexibility and efficiency for all routine or special applications

• User-Friendliness

The generously sized sample chamber and easily accessible durable radiation sources are a novelty in respect of

functionality and instrument design.

• Intelligence

The modular software package WinAspect is the basis for the intelligent control of the Specord and allows intuitive

and precise operation

Crop and Product Quality Testing

8

Sample Preparation and Heavy Metals Analysis

Analytik Jena

One of the most significant standards introduced

by the United States Pharmacopeia (USP) has

been new methodology for determining

elemental impurities and contaminants in drug

products and dietary supplements. These new

methods have been going through a review and

approval process for several years, and, a recent

announcement by the USP has indicated that

these new chapters will be implemented on

January 1, 2018.

The new methods will address the limitations of the

current methods, extending the list of analytes,

reducing the maximum permitted exposure limits

and taking into account the route of exposure.

The use of closed vessel sample digestion and

modern instrumental techniques is also introduced

to ensure the accurate recovery and

determination of individual analyte concentrations.

Chapter and ICH Q3D Chapter and ICH Q3D specify maximum limits for elemental impurities permitted in drug products,

drug substances, active ingredients and excipients.

Medicinal cannabis manufacturers should be concerned about the content of all heavy metals in their final product,

because all cannabis is grown for ingestion of some form. However, a few that stand out because they're so dangerous

are arsenic, cadmium, cobalt, copper, lead and mercury. Heavy metals, depending on their concentrations, can have

a wide range of effects on the human body. Everything from headaches, nausea, to organ failure, and cancer in cases

of prolonged or extreme exposure. Because cannabis is often combusted, there are increased respiratory risks as well.

If any cannabis product that contains heavy metals and is ingested, the heavy metals mimic other essential elements

and replace them in bones and in other cellular processes. In short, these metals bind with sites which were not originally

intended for them and, in the process, they remove the original metals from their natural binding sites. This is what

causes the malfunctioning of cells and, ultimately,

toxicity. Heavy metals also cause oxidative stress,

which greatly increases free radicals in the body,

causing further damage.

Medicinal cannabis manufacturers therefore

need the ability to test for heavy metals because

medical marijuana patients are using marijuana

to improve their health, not make it worse.

Medical marijuana patients often have

compromised immune systems, which can make

them especially susceptible to harm from heavy

metals.

Analytik Jena provides a complete solution from

sample preparation to final analysis in their

Topwave microwave digestion system and the

Plasma spectrometers; PQ9000 and PQMS.

Crop and Product Quality Testing

ICP OES PQ9000

Highlights:

9

The PQ9000 ICP OES from Analytik Jena combines

the latest technology and a revolutionary small

design to give you the right results all the time for

all your metals analysis.

Analytik Jena

• High Resolution Optics

Unique resolving power for unconditional

confidence in results

ICPMS PQMS

Highlights:

• ADD10 — All-Digital Detection System

10-orders linear dynamic range

• V Shuttle Torch

Intelligent torch design for comfortable high

end functionality

• Dual View Plus

Flexible plasma views for most comprehensive

applicability

• High Frequency Generator

Absolute plasma power for compelling long

term performance

When you need better limits of detection, the PQMS

ICPMS from Analytik Jena is the answer. The system

offers detection limits from sub part per trillion.

• Eco Plasma

Robust plasma performance with half the Argon gas

• iCRC — Integrated Collision Reaction Cell

Interference-free analysis plus BOOST technology

• ReflexION

3D focussing ion mirror for unsurpassed sensitivity

• HD Quadrupole

True 3MHz quadrupole provides superior mass

separation

Crop and Product Quality Testing

10

Topwave is one of the best systems for microwave

assisted pressure digestion. It provides a wide range

of applications, ranging from routine lab and quality

control applications through to special applications

under extreme conditions. It is the instrument of

choice for digestion prior to metals analysis.

Analytik JenaSample Digestion

• Extremely versatile digestion system

• Meets all the requirements of

modern digestion technology

• Ensures maximum operation safety

due to the Self Check System (SCS)

• Intelligent design for straightforward

operation and safety

• Documents all digestion parameters of each sample

• Minimum number of consumables

• Contactless pressure and temperature measurement for all samples

Topwave

Highlights:

NMReady-60Pro

NanalysisCrop and Product Quality Testing

The NMReady-60PRO is the next generation of compact NMR spectrometers from Nanalysis. This dual-channel spectrometer was designed to improve workflow forcustomers that require high performance and high throughput. The NMReady-60PRO can be tuned to acquire spectra for twoconventional spin active nuclei. This is means to enhance the characterisation of a broad range of natural and synthetic products.

SUPERIOR PERFORMANCE • 60 MHz (1.4 T)• Standard 5mm NMR tubes• Dual mode nuclei acquisition (e.g. 1H/13C)• less than 1.0 Hz (20 ppb) at FWHM• Pulse Program Control

INNOVATIVE DESIGN• All-in-one compact enclosure• Large 10 " LCD display (4:3 ratio)• Touchscreen usable with gloves on/off

SUPREME USABILITY• Easy-to-use on-board acquisition and processing software• Good connectivity (i.e. Ethernet, WIFI, USB)• Network access for printing, data retrieval, or Internet based customer service• Secure login & user profiles available

Highlights:

Huber

Dynamic Temperature Control Systems

• Temperatures from -120 C to +425 C• Pilot ONE controller with 5.7” touchscreen and chart functions• TAC, self-optimising true adaptive control• Adjustable circulation pump• Powerful remote control access• Onboard system diagnostics for remote support

.

Chillers

For more than 20 years, the Huber Unistat range of dynamic thermo-regulators have been leading fluid based temperature control technology . Unistats are the ideal solution for fast and precise thermal control of externally connected applications such as chemical reactors.

In comparison to other circulators, the Unistats offer rapid temperature change performance and a wide operating temperature range without fluid change which is achieved through hermetical seal of the heat transfer fluid circuit.

There are over 60 models to choose from with cooling powers from 0,7 to 130 kW.

Huber Unichillers offer better efficiency, stable pressure and performance delivery with a constant cooling water temperature compared to traditional tap water cooling.

Chillers also reduce water consumption and help conserve the environment whilst lowering operating costs.

Unichillers are suitable for the removal of heat from chemical processes, cooling technical plants, vacuum instrumentation or as a central cooling water supply for laboratories.

Highlights:

Exceptionally compact and powerful, Ministats have been the smallest cooling circulators in the world sin- ce 1976. Their compact form allows them to be placed in small spaces, e.g. in a laboratory fume hood.

MiniStat

• Ultra compact• Air-cooled and water-cooled models• External PT100 sensor available• Variable pump speed to adjust to your process• Temperatures from -45 C to +200 C

• Cooling capacity of 280W to 50,000W• Heating elements optional • Air-cooled and water-cooled models.• Immersion coolers & flow-through chillers

11

Temperature Process Control

Highlights:

Highlights:

SP-1Our SP-1 stand alone solvent purifier is a complete system built from highest quality components such as Swagelok and has the capacity to handle up to seven (7) different solvents. The system delivers 2 ppm anhydrous solvent using a safe and reliable process.

It uses low pressure nitrogen gas to force solvent through various filter materials that remove moisture and impurities from the solvent, delivering moisture free solvent for your application cleanly and safely.

Our complete system comes with everything you need to start drying solvents. All you have to do is connect high purity nitrogen or argon, a power supply for the vacuum pump and you are ready to go.

• • Fume extraction at dispensing point• Unique collection flasks for inert atmosphere solvent dispense with septa for solvent use

Fully enclosed purification column system to protect against spills and allow targeted fume extraction

LC Technologies

Our SPBT-1 bench top solvent purifier is a compact yet complete system for safely drying solvents and was specifically designed to fit on a bench top or in a fume hood.

The system comes complete with a small 5 litre solvent keg that can be easily disconnected and refilled. Since this small keg only holds 5 litres it commonly removes the requirement of storing the solvent in a bulky fire cabinet.

SPBT-1

This point-of-use-system is perfect for small or singleuse solvent applications. It is a small package, buthas the same purification capacity as our largerunits (800 litres) and uses the same high qualitycomponents. Our SP-1 has merely beenrepackaged to fit into a small space.

12

Highlights:

Anhydrous Solvent Purification

Our benchtop freeze dryers have been designed to meet the needs of the most demanding research laboratories. Each system can be configured to meet your present and future needs. Condenser refrigeration packages of -55°C, -75°C, -85°C and -105°C can meet the demands of both aqueous or aqueous-solvent based formulations.

BenchTop Pro

• • Available in 3, 8 and 9 litre configurations• Direct chamber, flask and/or rack drying capabilities• Programmable PLC-based Omnitronics™ controller with unique functions such as email alerts • One touch system auto-start and one touch auto-stop• Remote user and technician access unmatched system support• Unique self test function to assist with trouble shooting

Compact bench-top design

This is the smallest process development of small pilot batch freeze dryer on the market. If offers simlar high performance technology as much larger floor standing models. The shelves are actively cooled for on-shelf freezing of your sample enabling true one-process drying. It offers the convenience of a tray dryer in a benchtop unit.

AdVantage Pro

• Convenience of a tray dryer in a benchtop unit• Actively cooled and heated shelves for true one-process drying• Intellitronics™ controller with a full-color touch-screen display• Available with up to three (3) usable product drying shelves• Optional pneumatic stoppering system available to stopper vials• Six-liter ice condensing capacity

SP Scientific

The fully programmable touchscreen Intellitronics™ Controller offers users many unique functions such as Ethernet remoteaccess and email communication. Monitor your cycle from anywhere and receive email notification of important events.

13

Freeze Drying

Highlights:

Highlights:

LyoStar3The Lyostar 3 ipharmaceutical process development professionals. It provides unmatched capabilities in terms of performance, process accuracy, reliability and unique ease-of-use features,

s designed to meet the highest needs of

that are unmatched by any other freeze dryer.

The LyoStar features Type T thermocouple-controlled shelf temperature accuracy of +/- 0.5°C or better and vacuum control within 0.1% of set-point.

It`s robust 5.5 hp cascade refrigeration system enables shelf pull down from ambient to –40°C in less than 25 minutes, and the ultra-reliable scroll compressors feature just 3 moving parts.

LyoStar3 is available with our unique and patented Praxair ControLyo™ Nucleation on Demand Technology. ControLyo™ Nucleation uses a patented depressurisation method to force simultaneous product nucleation. It is currently the only production validated controlled ice nucleation technology on the market.

Production Freeze DryersSP Scientific is your one-stop-shop for clinical and production freeze dryers. They offer a wide range of production tools to suit every application. SP Scientific offers patented technology including our ControLyo™ Nucleation.

Freeze Dryer Options available include:

Single chamber and double chamber design

• Bulk and stoppering

• 10 kg to 1,500 kg batch capacity

• steam sterilisable (SIP) and clean in place (CIP)

• auto-locking SIP doors

• Redundant system components

• Batch reporting (CFR 21 P122 compliant)

• Allen Bradley and Siemens controllers

• Patented ControLyo™ Nucleation

• Aseptic production systems

• Unique PAT tools including wireless temperature

sensors, TDLAS laser moisture measurement and

many more

•

SP Scientific

Our patented SMART technology puts the experience of the world's top lyophilisation experts into an easyto-use cycle development tool. SMARTS eliminates the common trial-and-error approach and replaces it with reproducible measurements and auto-tuning. Case studies have shown development cost and time savings as high as 78%.

This is an innovative line-of-sight tunable diode laser system for in-situ real time measurement of water vapour flow. This measurement gives a better understanding of drying rates and allows precise process endpoint determination.

With the recent acquisition of PennTech SP we can now also offer a full range of pharmaceutical automation technologies including automatic freeze dryer loading and unloading, vial washing and many more.

LyoFlux

SMART Freeze Drying

14

Freeze Drying

Hybrid Pumps RC 6

Highlights:• Oil changes typically reduced 90% or more • Reduced internal corrosion, even when working with corrosive vapours

Vacuum Gauges

Vacuubrand

The RC 6 chemistry-HYBRID pump is a combination of a two-stage rotary vane pump and a two-stage chemistrydiaphragm pump for optimized corrosion resistance. The diaphragm pump maintains the oil reservoir under vacuum in order to keep the partial pressures of solvent vapours at levels below their condensation points. Therefore the RC 6 chemistry-HYBRID pump has a much higher solvent vapour pumping capability and resistance to aggressive gases than conventional rotary vane pumps.

State-of-the-art vacuum gauges with high resistance to chemicals, reliability in rugged applications and operator-friendly interfaces.

The Pirani vacuum sensors VACUU·VIEW extended and VSP 3000 feature an exceptional chemical resistance and robustness compared with conventional Pirani sensors (with metallic filament) as its wetted parts are made of special plastics and ceramics.

For the monitoring of your vacuum processes in the rough and fine vacuum range, the vacuum gauges VACUU·VIEW and DCP 3000 are perfect.

15

Typical applications for chemistry diaphragm pumps include evacuating chemically aggressive gases and vapours from equipment such as rotary evaporators, vacuum drying ovens and centrifugal concentrators. Their construction with fluoropolymers makes them very resistant to chemical vapours from inlet to exhaust and very tolerant to condensates. Chemistry diaphragm pumps are oil-free and have vastly reduced service demands compared with oil-sealed rotary vane pumps. Pumping stations can be fitted with optional catchpots, emission condensers and vacuum control solutions.

Chemistry Pumps and Pumping Units

Highlights:• Pumping Speed from 1m3 to 10 m3/h• Ultimate Vacuum from 70 mbar to 1.5 mbar• Options with inlet / outlet catchpots and emission condensers• Single and dual channel systems• Manual, two point and variable speed vacuum control• VARIO systems with automatic boiling point detection and tracking to save users from process babysitting

Chemistry Vacuum

Sydney Head OfficeUnit 1, 12 Chaplin DriveLane Cove NSW 2066Phone: 1800 023 467

Victoria OfficeUnit 24, 1 Kingston RoadHeatherton, VIC, 2302Phone: 1800 023 467

Queensland OfficePhone: 0434 382 300

Western Australia OfficePhone: 0428 878 164

General Email: contact@scitek.com.au

Sales: sales@scitek.com.au

Service: service@scitek.com.au

International Calls +61 2 9420 0477

Desi

gn: S

tefa

n W

olli

n, e

-stu

dio

.de

Calls within Australia 1800 023 467