CALIFORNIA TUMOR TISSUE REGISTRY

"Soft Tissue Tumors"

Study Cases, Subscription A

April, 2007

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

LomaLinda University Sebool of Medicine 11021 Campus f\yenue, AH335 Lorna Linda, California 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: C!!r@linkline.com

2

Tar:cet audience: Practicing pathologists and pathology residents.

Goal: To acquaint the participant with the histologic features of a variety of benign and

malignant neoplasms an<j tumor· like conditions.

Objectives: The participant will be able to re<:ognize morphologic feature$ of a variety of benign

and malignant neoplasms and tumor-like conditions and relate those processes to pertinent references in the medical literature.

Edutational methods and media: Review of representative glass slides with associated histories. Feedback on consensus dia1:noses from participating pathologists. Listing of selected references from the medicallitenoture.

Principal faeultv: Donald R. Chase, MD

CME Credit: Loma Linda University School of Medicine designates this continuing medical

education activity for up to 2 hours of Category I o f the Physician's Recognition Award of the American Medical Association.

CME credit is offered for the subscription year only.

Accreditation: Loma Linda University School of Medicine is accredited by lhe Accreditation

Council for Continuing Medical Education (ACCME) to sponsor continuing medical education for physicians.

Study Cases, Apri12007, Subscription A

Contributor: Hrag Marganian, M.n. Case No.1 - April2007 A Anaheim,CA

Tissue from : Left hip Accession #30244

Clinical Abstract: This 77 year old woman present with a right hip mass, near the site of a hip replacement done

twelve years earlier.

Gross Pathology: The 8 x 6.5 x 2 em specimen had a variegated tao cut surface with areas of hemorrhage and foci

of fatty tissue.

Contributor: Mark Janssen, M.D. Case No. 2 - April 2007 A Anaheim,CA

Tissue from: Skin of right upper back Accession #30220

Clinical Abstract: A 48 year old man had notice a nodule on his right upper back for about 3 years.

Gross Pathology: A skin ellipse covered a 3.5 x 3.5 x 2.3 em homogeneous white tao nodule.

Special Studies: CD34: SIOO, SMA:

Strongly positive Negative

SNdy Cases, April 2007, Subscription A 3

Contributor: Sheldon Miller, M.D. Case No.3 - April2007 A Oxnard,CA

Tissue from: Left buttock Accession #30367

Clinical Abstract: A 49 year old woman noted a large mass on her left buttock. No other personal or family

history is available.

Gross Pathology: A 12 x 4 x 4 em irregular specimen showed fatty tissue with intervening strands of white

fibrous tissue

Contributor: AJbert Garib, M.D. Case No.4 - April 2007 A Huntington Beach, CA

Tissue from: Right knee Accession #30143

Clinical Abstract: A 36 year old man noted a mass on his right knee.

Gross Pathology: The I 0 gram oval mass was 4.5 x 3 x 2.4 em. The cut surface showed a thin-walled capsule

surrounding gelatinous yellow material.

Special Studies: SIOO: Strongly positive

4 Study Cases, April2007, Subscription A

Contributor: Jin Mei, M.D. Case No. 5 - April 2007 A Hangzhou, China

Tissue from: Supraclavicular region Accession #30331

Clinical Abstract: A 31 year old man presented with a left supraclavicular mass, noted for about 10 days.

Gross Pathology: The 4 x 2.8 x 2 em encapsulated nodule had a gray-yellow cut surface.

Contributor: Arthur Koehler, M.D. Su.n Valley, CA

Tissue from: Right thigh

Clinical Abstract: This 36 year old woman noted a mass in her right thigh.

Gross Pathology: The resection specimen wa~ 9 x 5 x 3.5 em.

Special Studies: SlOO: Strongly positive Desmin, keratin: Negative

Sludy Cases, April 2007, Subscription A

Case No. 6 - April2007 A

Accession #30335

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Contributor: Kenneth Frankel, M.D. Ca.se No. 7 - April2007 A GJendale, CA

Tissue from: Retroperitoneum Accession #29186

Clinical Abstract: This 65 year old man was found to have a large retroperitoneal mass.

Gross Pathology: The 9,200 gram specimen was 41 x 35 x 14 em. The cut surface was homogeneous yellow­

brown, without lobulation or nodularity.

Contributor: Robert Zuch, M.D. Case No. 8 - April 2007 A Baldwin Park, CA

Tissue from: Right knee Accession 1#30395

C linical Abstract: A 40 year old man complained of a large mass surrounding his right knee.

Gross Pathology: The specimen consisted of a 10 em aggregate of ragged brown-tan friable tissue fragments.

Special Studies:

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Positive: Pancytokeratin, CK7, EMA, Vimentin Negative: CD20, SIOO, SMA, MSA, Desmin Cytogenetic analysis: Translocation t(X; 18) (p 11.2;q 11.2)

Gain of a derivative X chromosome Additional material on the short arm (p) of chromosome I Loss of one chromosome 18

Study Cases, April2007, Subscription A

Contributor: uster Thompson, M.D. Case No.9 - April2007 A Woodland Hills, CA

Tissue from: Neck Accession #30374

Clinical Abstract: A 69 year old man presented with a 2-3 year history of a slowly enlarging mass in the posterior

neck. The mass was soft and mobile to palpation.

Gross Pathology: The resected mass was well circumscribed but not encapsulated.

Special Studjes: CD34: positive

Contributor: Walid Salahi, M.D. Case No. 10 - Apri12007 A VanNuys, CA

Tissue from: Right forearm Accession #30152

Clinical Abstract: This 60 year old man noted a mass on his right forearm.

Gross Pathology: The 4.8 x 4 x 3.2 em encapsulated ovoid mass had a solid tan whorled cut smface.

Special Studies: Negative: Positive:

HMB45, SIOO, Keratin SMA, vimentin, desmin

Study cases, April 2007, Subscription A 7

CALIFORNIA TUMOR T ISSUE REGISTRY

SOFT TISSUE PATHOLOGY

Minutes - Subscription A

April, 2007

SUGGEST ED READING (Gener:ol Topics from Recent Literature):

Olsen SH, Thomas 00 and Lucas DR. Cluster Analysis o('lmmunohistochemical Profiles in Synovial Sarcomn, Malignant J'eripheral Nerve Sheath Tumor, and Ewing Snrcomn. Mod P111ho! 2006; 19:659-668.

Shimada K, Sakamoto Y, et aL Prognostic Factors At\er Distal Pancreatectomy with Extended Lymphadenectomy tor Invasive Pancreatic Adenocarcinoma of the Body and Tail. Surg 2006; 139:2.88-295.

Morton OL, Thompson JF, et aL Sentinel-Node Biopsy or Nodal Observation in Melanoma. N Eng/ J Mcd 2006; 355:1307-13 17.

RomanS, Lin Rand Sosa JA. Prognosis ofMeduUary Thyroid Carcinoma. Demographic, Clinical and Pathologic Predictors of Survival in 1252 Cases. Cancer 2006; 107:2 I 34-2142.

Haider K, Shahid RK, et al. Exrrapulmonary SmaU Cell Cancer. A Canadian Province's Experience. Cancer 2006; 107:2262-2269.

California Tumor Tissue Registry c/o: Department of Pathology and Human Anatomy

Lorna Linda University .School of Medicine 11021 Campus Avenue, AH 335 Loma Linda, Calitbmia 92350

(909) 558-4788 FAX: (909) 558-0188

E-mail: ctl(@linkline.com Web site & Case of the Month: www.cttr.org

Case 1:

Case 2:

Case 3:

Case 4:

Case 5:

Case 6:

Case 7:

Case 8:

Case 9:

FILE DIAGNOSES

(Preferably submitted on website at www.cttr.org. Click "subscriptions", then S\lbmit answers".)

CTTR Subscription A

Ischemic fasciitis (atypical decubital fibroplasia), hip T-YlSOO, M-76130

Dermatofibrosarcoma protuberans, back T-YilOO; M-88321

Diffuse neurofibronia, buttock T-Y1600, M-95400

Myxoid neurofibroma, knee T-Y9200, M-95400

April, 2007

Benign mesenchymal spindled neoplasm, likely variant of cellular schwannoma, supraclavicular T -08220, M-95600

Schwannoma with degenerative changes (ancienrschwannoma), thigh T-Y9100, M-95600

W cll-differemiated liposarcoma, retroperitone)lm T-Y4600, M-88513

Synovial sarcoma, biphasic, knee T-Y9200, M-80003

Spindle cell lipoma, neck T-Y0600, M-91501

Case 10:

2

Pleomorphic leiomyosarcoma, forearm T-Y8500, M-88903

CTI'R, April 2007 "Minutes" (Subscription A)

Case No. t, Accession No. 30244

Apphcim COrange County Mpdical Centerl - Benign reactive process Baldwin Parle <Kaiser Pennancntol • Ischemic fasc:ii!is (4) ~ - lschemic fasciitis ~ .. Soft tissue. hip, fibrous dssue with fibrinoid necrosis Glendale • Atypicul decubo<al fibroplasia liaywurd!Frcmont .. Ischemic fascihis l.on• Beach (Lone Beach VA !iOSJ!i!all - Ischemic fascii!is (2} Los Angeles - Hemangioc:ndotheHoma ofuncmain mali1J1ant pocc:orial

April2007

Monterey Pcninsuln <Community tlospitgl of Monterey J>coinsulgl • Oe.'imoid fibrom•nosis vs. dcgcncnuivc stromal change ~ • Angiofibroma Oaklpnd (Alameda County Mcdiql Center> - Ischemic fa.sciitis Sacramcntp CUC payis Medical Center) .. hchemic fascihis San Diego .. Ischemic fasejitis San Diego <Nuval Medical Centql .. Ischemic fasciitis San Diego CUCSD> • Ischemic fasciit is Som• Barb&m - Ofxaniring h<motoma Snnh1 Rosn CSanUl Rosa Memorial Hospitnl> - (schcmic C.'lsciitis (2); Fa.iciitis wich necrosis (I) Sonoma (Sonoma Valley HpspitaJl • Fibroma WOO<fland Hills • Ischemic fasciins (a<ypicul d<wbi<al fibroplosiu) Alub!l!!la (Qu!)[ist Medjcal Center) • lschcmic fAsciitis Colorado Ft. Colljns · Foreign body tissue reaction Florida <Mynroc: Regional Medical Center) - Fibroma Georsia. 0(.yatur • Ischemic fasciitis Georaia (Wellstar Kcnnesaonc HO$Qilall • Ischemic fasciltis !l!jnois. Burr Ridge • ExtnLSkeletal osteo$nr<:oma (I); Ischemic fasciitis (I) Illinois (Hc;tnland Regional Medical Ceotcrl · Ischemic fosciitis (aoypic•l decubi!lol fibroplasias) lllinois(lgyola VnivcrsityafOlicasol • Ischemic fasciitis lndj:ma (Howard Regional Medical Center) - Bur5ld cyst Kon•as (Cytocheck Lab9nnory. LLC) - Tendon sheath libroma (I); Reactive process ( I) Kguycky lUnjversjty of Lovisvillel .. Proliferative fasciitis vs.. ischemic fosciitis MorvJand {Northwest Hosnjtol) • Ischemic fasciic'iS Maryland <Univcrsjly of Mqaland) - Hyalinizing angiectatic tumor vs. aggressive nngiomyxomu vs. is.chcmie fasciids Massachugns CBc:ycrly ti()Spitall • Ischemic fasciitis Ma~!Hlcbuscus. Penbody • Foreign body gronulomn MP.uach\!Sj:1ts ITuOt=Ncw Enoland Medieal Centsrl · Ischemic fa.ciitis Michigan (Oakland HospltqD - lschcmic fasciitis Michjgat~ cpatholpgy Seryices of Wcsl Mjchjgan) • Non-s~cific intlammotion and necNsis Minncsot1\ <Fairview Ridges Hospitall - Ischemic fasciitis M jssouri CM issouri Delta Medical Center) • lschemic faseiitis Montana (forrosic Science Pivisjon) • Ischemic fa.sci itis Nebraska <Creighton Univmirvl • Benign reactive synovitu New Mexico Albuc~ - Orgoniz.ing hcmorrhugc. frll necrosis, fibroma. reactive proliferation non-neoplastic vs. JUXto anicular

myxoma New yprk <Nassau Univqsjly Medical CeQ!srl - Ischemic fiasciids New York lStony Brook Un!yersitv Hospitg!l - Ischemic fascii lis New Yoric (SUNY Oownstptc MedjcaJ Center) - Ischemic fascihis Noah Caro!jna <Mountajn Afcu Pathology) • Granular cell tumor Objo (McCylloush-Hydc Mcmoriol Hospital\ · Atwical decubital flbroplasiaslfascii!is Pennsvlvanj11 <Drcxd Uniymjtv College> - Nodular fasciitis Pmm:ylvanjn Clehjgh Valley Hospitall. - Ischemic f.asciitis f>cnnsy1vanh' CMt Njuany Medical Center} • A()'l>ical decubital fibroplasias (isdtcmic 19$cih:is) Puqto Rico <Univqsitv ofPueno Rjcol - IJChe:mie fasciitislp:scudotumor Soytb Dakotu (UCM Residents) · Ganglion Texas. Crvs1al Beach - Benign ronncctive tissue growth possibly u eho1tdroid lip0111a Texas. Houuon - Organi?.ing fibrin and fibrosis (hcma!oma) Tcxos LubWck • Angiofibromo TeaM IProPaohl · Musculoaponeurotic fibroma!oSis Texas (St. Lukes Enjscopal Hospitnll - Reactive, pseudOC\lmor Texgs. Sugar Land • Ischemic fasciitis \Vastungtop CSeanle VA Mctdjcal Crntcrl - Reactive fibroproJifcnll ive process Wc;st y irniojq <Greenbrier Valley Medical Center) - Ossifying fibromyxoid tumor

GrrR. Apnl2007 .. Mmultt" (Subscriplion A) 3

Wisconsin. Madison .. Reactive granulation tissue (proliferative fasci itis) Wisconsin CMeriter Hospital> - Reactive synovlal changes Australia fNortb Queensland Pathology Group> - Synovial reaction to fa i19(1 joint prosthesis Australia CRoval Hoban Hospital) - Ischemic f-a~i itis Australia (Royal Prince Alfred t Jospjtal> - Ischemic fusc-iitis Austra!ja (Sulliyan Nicolaides Pathology) - Ischemic fasciitis Brazil ll:nboratorio Anatomia Pathologica Ectiologial - Ischemic fasC-ii tls Canada (Pa.<:gua Hospjtall - lsohemic fasci'itis Canada <University Hospital of Shcrbrookcl • Ischemic fas.ciitis India. Kamataka - Grandular myxoma Janan (Asashi General Hospimll - De$mOplastic fibroblostoma Japan <Kvoto Univcrsitv Hospilall - .Ischemic fasciitis Oman <Khoula Hosnitall .. Ischemic fasciitis Oatar <Hamad Medical Comonuionl - Ischemic fasciitis Saudj Ambia (King Fnhad National Guard Hospirall • Fibromatosis United Kingdom (Oxford Study Group) - lscbemic fasciitis

Case I - Diagnosis: Ischemic fasciitis (atypical decubital fibrQp1asia), hip

T-Yl500, M-76130

Case I - References: Deligdisch L. Ischemic Fasciitis. A Juxta-Skoletql fibrobiMtic Proli foration with a Prodile<:rion for Elderly Patients. Mod Pathol

1993; 6( I ):69-72. Kendall BS, Liang CY, Lancaliter KJ, et aL Ischemic Fasci itis. Rcpon of a Case '"ith Fine Needle Aspiration Findings. Acta Cyro/

1997; 41(2):598-602. Tsui·JK and Wong· NL. Fine Needle Aspiration Cytology of Pseudosarcomatous Rcacrive Proliferative Lesions of Soft Tissue. Acta

Cy/012002; 46(6): I 049-1055. Washing D and Zaher A. Pathologic Quiz Case. A 76-Year-Old Debilitated Woonan with a Right Thigh Mass. Ischemic Fasciitis

(Atypical DecubitOI Fibroplasia). Arch Pat loot Lau Med 2004; 128( I 0): 139-1 40. lla.sian H, Joyce M. Bauer T, ct al. Decubital Ischemic Fasc.iitis. Clinical, Poihologic; imd MRI Features of Pseudosarcoma. AJR Am

J Roentgeno/2006; 187(5): 1338·1341. Scanion R, Kelehan P, Flannelly G, ct at. Ischemic Fasciitis. An Unusual Vulvovaginal Spindle Cell Lesion. !nt J Gynecol Pmhol

2004: 23(1):65-67.

Case No. 2, Accession No. 30220

Anaheim <Orange Countv Me.dica1 Cemerl - Dennatotibrosarcoma protubcrans Baldwin Park <Kaiser Pennanentel - DFSP ( I); Solitary fibrous tumor (3) Chico - Dennatoflbrosarcoma protubcrans Clovis • Skin, back. dermatofibrosarcoma protuberans Glendale - Dennatofibrosarcoma protub~ans Havward/Fremopt - Spindlo lipoma Long Beach (kong Beach VA Hospital) - Dennotofibrosarcoma protuberans (2) Los Angeles - Neurofibroma Monterey Peninsula <Community Hospical of Monterey Peninsula) - Solitruy fibrous tumor Oakland - DFSP Oakland (Alameda Countv Medicnl Cepter} - Oennntofibrosarcoma protubcrans Sacromento CiJC Dayjs Mcs! jcal Center> - Dennatofibrosarcoma protuberans San DjegQ - Ocnnatofibrosarcoma protuberans San Diego (Naval Medical Cenrerl - Oennatofibrosarcoma procuberans San Diego <UCSD) - Dennatofibrosarcoma protubc..-ans Sruna Barbara - Dennatofibrosai'coma protubcrans. S;.nta Rosa (Santa Rosa Memorial Hospital) - Dennatofibrosarcoma prot\lbernns {3) Sonoma <Sonoma Valley Hospiral> - Dennaiofibrosarcoma protubc:rans Woodland Hills - oe.nnOIOfibroSarcoma protubcrans Ahtbama <Baptist Medical Centef) - Dennatofibrosarcoma protuberans Arkansas fUniVcrsitv Of Arkansas for Medical Science~> - Oermatotibrosarcoma protubcrans, back Colorado F1. Collins - Solitary fibrous tumor Florida (Munroe. Regjonal Medic-.tl Center) - Dc..'mlatofibrosarcoma proruberans Goorgja. Decatur - DcnnatOfibrosarcoma protubernns

Apri12007

4 CITR, April 2007 '"Minutes·· (Subs<:ription t\)

Georgia OVcllstnr Kennesronc HospjtAil - Dermotofibrostucoma protubmms Illinois Burr Ridsc • Dermatofibrosarcoma prorubmns {2) Illinois (Heartland Regional Medico! Center) • Dermatofibrosarcoma protuberans !lljnois (Loyola Unjycrsity ofChicogo> • Denmttotibrosarcoma protubcruns !ndjnno <Howard Regional Medicgl Center) - Dennatotibrosarcoma protuberans KMsas !C'VIocheclc l,aboratorv. !.!.C) • Solitary fibrous rumor (I); Neurilemmoma ( I) Kenruckv fUnjymity of l..ooisvillcl • Solitary fibrous rumor Marvland CNonhwqt Hospital) - Dcnnatofibrosarcomn protubcrans Marvland CUnjyershy ofMarvlandl .. Denna[ofibrosarooma pron~bc:rons MOSf3chusctts Clleyc.r!y Hospital) • Oenrtntofibrosarcoma protubcro.ns MpstBchuscns Pe bocJy - Derrnotofibrosa.rcoma prorubcrans Mi!JS!!ohuse!ts ITufls-Ncw England Mc:dical Ccntcrl - Dermatofibrosarcoma protubcrans Mjcbi•an (Oakland tlomitall • Dc:nnatofibrosan:oma proruber.lns Mjchjgan <Pathofoay Sqyice:.c; of West Michigan) - Dermatofibrosarcoma protubcran.s MinnesOta Cfajrvjcw Ridges HosWJ.n.l.l • Dcnnatolibrosurcoma protubc.rans Mjssouri <Missouri Qclta Medical Censer) - Dennrttot1brosarcomo prot\lbc:rans Momana CForensic Scjeoce pi vision) - Dermatofibrosarcoma prOt\lbcrons Nc;bwka CCreiehtoo Univcrsi1Vl • Dennatofibroslli'COma prorubcrans New Mcxiw Albuouergoo • Dmnatofibrosan:oma pro<ut>erans New York CNnssau Unjversitv Medical Center) - Oc:nnotofibrosarcoma protuberaos New York CStony Brgok Uni ysrs jrv Hospitall - Dcnnotofibrosarcomo protuberans New York CSUNY Downstate Medical Center) • D<:nnutofibrosarcomu l)rotuberans Nooh Carolina CMountain Area Pathology) - Myxoma Qhjo(Mceullougb.J1ydc Mcmorjal Hospital\ · Drnnatofibrosarooma protuberans Pennsylvania (Drexel Universirv College> - Solitary fibrous rumor Pqm,y!vania CLchjgh Vollev Hospj(l!l - Dermawflbrosnrcoma prorubcrans ~cnnsylypnia CMt Njuany ModicnJ Ccmcrl - Spindle ce ll lipoma Putrto Rico CUnjCt§ity of J)uerto Rico> • Detmatofibrosnrcoma pi'Otub.;nms Squ1h Dakora (LCM Residents) • Oc:nnatofibrosarcoma prorubcrans Texas. CMtal llqch . Hemangioma spindle cell TeMs. Houston - Ocnnatofibrosarcoma protubcrans Il;xos Lubbock • Dermatofibrosarcoma prorubernn$ Texgs CProPathl .. 0crn'lntofibro.sarcoma protubcruns Tcxgs <St. Lukes Epi$copal Ho~nitpll • Dcnnatoflbrosurcoma protuher:ms Texas, Sugar Land • Dermatofibrosarcoma Wa<hington !Scau!c VA Medical Ccmtql - Ne<>plastic fibroproliferotivc process, focally invasive, dermatofibrosarcoma protuber.lns Wen Virginia <Yrtenbricr VaHey Medical Ccntcxl • Nodular fasciitis Wjwonsin. Madjsgn .. DamatofibtOSDtComa prorubcmns Wjsconsin CMeritcr Hospital) • DcrmatOfibrosaroomu prorubertli'IS Auturnlia (Nonh Ouccpsland Pmhology Group) - Dcrmotofibrosurcomn pron1b<.-rans Australia CRoyn! Hobart Hospital> • Dennatofibros&rcoma protubcrons Augralia <Roval Prince Alfred HospjJoll • Dermatofibrosarcoma protubaans Au.stralia <Sullivan Njcolaides PethoJosv> - Denniltofibrosarcoma protubmms Brpzjl Cloboracorio Anmomia Patholoaica Ectjologia) • Dermatofibrosarcoma protuberons Cpnuda CPasguo tlosniJA!1 - Dennatofibrosarcomn protuberans Canuda fUnivcrsily Hospital of Shtrb(()oke) - Dcnnnlolibrosarcoma pro1uberans lnd ja. Kamataka • Renal cell carcinoma lawn !Asas!Jj Geoml Hospilllll • i!J<tr.lpleural solitary fibrous rumor IJman (Kl'!lto Uniym;j'Y Hosoita!l • Dermatofibrosarcoma proruberan• Onum fKhoula f-lo~mhnl) - Dermatofibrosarcoma procubcrans Omgr fHamad MedjCB! Co!J!()rat jonl .. Dermatofibro:mrcoma protubcruns Saydj Ambia fKjns Fnhad Nationol Guprd Hospitoll .. Dennatofibros8rcoma protuberons Uojted Kinedom <Oxford Study Group) - Dermatofibrosarcoma protubcrans

Case 2- Diagnosis: Dennatofibrosarcoma protubcrans, bock

T-YIIOO, M-8832 1

Case 2 • References: SadCI H, Tsunemi Y. Ohtuski M, « al. Gene Mutation Analysis in Five Cases ofDennatofibrosarcorna Protuber.lns Usin& Fonnalin·

Fixed, Pamffin·Embcdded Tissues. Acta Denn Yenereo/ 2005; 85(3}:221·224. Dominguc-.t:-Mnlo.gon H) Valdez-Carrillo Mdcl C, er al. OennatofibronH:. and Oenn:uofibrosarcomo Pl'()tUl>ernns. A Comparative

Uhrostructur•l Study. U/trastru,•t Pmho/2006; 30(4 ):283-291.

CITR. April2007 "Minutes" (Subscription A)

Gu W, Ogose A. Kawa,hima H, er al. Congenital Dermatofibrosarcoma Protuberans with· Fibrosarcomatous and Myxoid Change. J Cli11 Pat hoi 2005; 58(9):984-986.

Domanski HA. FNA Diagnosis of Dennatotibrosarcoma Protuberans.- Diagn Cytopatlzol 2005; 32(5):299-302. Mend..,hall Wm, Zlotecki RA and Scarborough MT. Dermatofibrosarcoma Protulx:rans. Cancer 2004; I 0 1(11 ):2503-2508. McArthur G. Molecularly Targeted Treatment for Dcnnatofibrosarcoma Protuberans. Semin Oncol 2004; 32:30-36.

Case No. 3, Accession No. 30367

Anahpim <Onmgs:: COunty ModiC{\ I Center) - Neurofibroma Baldwin Park (Kaiser Pennanentel - Spindle cell lipoma (4) Chico - Neurofibroma wltl1 fatty infiltration (vs. hamonoma) Clovis - Buttock, neurofibroma, diffuse Glendale - Diffuse neurofibroma HaywardfJ':remont - Neural tibrolipoma vs. spi11dle lipoma Long Beach <Lqng Beach VA Hospitatl - AngjomyolipOma (2) Los Angeles - Neurilemoma Monterey Penins-ula <Community Hospital ofMontere>• Peninsula) • Angiomyolipoma Oakland - Spindle cell lipoma Oakland (Alameda County Medical Ccnu, .. ,-) · Diffuse neurofibroma Sacramento (UC Davis Medical Center) - Fibrolipomatous hamartoma San Ojcgo • Spindle: cell lipoma San Diego fNaval Medical Center) - Atypic-.al fibrous lipomatous tumor San Diego <UCSO> - Lipoma, spindle cell type Santa Barbara - Angi61iponla Santa Rosa <Santa Rosa Memorial Hospital) - Lipoma/hamartoma (I); Lipoma (2) Sonoma·(Sonoma Valley Hospiral) - Spindle cell lipoma Woodlansl Ji jlls - Spindlecell lipoma Alabama <Baptist Medical Cenlcrl - Neurofibroma Arkansas <Universitv Arkan·sas for Medic·aJ Sciences) - Neurofibroma, diffuse type, buttock. Colorado. Ft. CoWos - Neurofibroma Florida <Munroe Regional Medical Center} - Neurofibrolipoma Georgia. Decatur .. Neurofibroma, diffuse georgia (Wellsror Kennestone Hospital) - Spindle celt lipoma Illinois, Burr Ridge - Angiolipoma (I); Spindle cell lipoma ( I) Illinois <Heanland Regional Medical Center} - Fibrolipomu Illinois <Loyola University of Chicago) - Lipoma Indiana (Howard Regional Medical Center) - Angiolipoma Kansas.CCvtoeheck laboratorv. LlCl - Angiomyolipoma (I ); Lipoma ( I) Kentucky (University of Louisville) - Benign lipoma variant. favor ncun_>fibrolipoma Marvland <North\\1est Ho!initafl - Lipoblastie-nerve sheath rumor ·Man· land CUnivcrsitv of Maryland)- Gliomangiomatosis Massachusetts CBeverlv HosnitaJl - Neurofibroma Masoo·useus. Peabody - Superficial fibromatosis Massachusetts Cfufts-New England Medical Center} - Fibrolipoma Michigan (Oakland Hospimll - Angiolipoma Michigan (Pathology Services of \Vest Michigan) - Lipoma_ Minnesota ffajrvjew Rjdgg Hc>Suiln!l - Diffuse neurofibroma Missouri·(Missouri Delta Medical Center} - Fibrolipomn Montana <Forensic Science Division) - Spindle cell lipoma Nebraska fCrejghton Unjyersjrvl - Spindle cell lipoma New Mexico. Albuquerque - Myxoid liposarcoma New York <Nassau University Medical Ccnt<...-r) • Myolipoma New York (Stony Bmok Universitv Hospitall . Fibrolipoma New York <SUNY Downstate M¢djcal Centq l - Atypical lipomatous tumor North CaroJina CMoumain Area Pathology) - Schwnnnoma Ohio CMcCu11ough-Hyde Memorial Hosnitall - Plexifonn neurofibroma PenosyJvnnia fDr¢JSCI Unjvers jly College) - Spindle cell lipoma Pennsylvania (Lehigh Valley Hospitall - Spindle cell lipoma Pennsylvania (Mt f\,;ittany Medical Center) • Jntramuscular lipoma Puerto Rioo (Universitv of P'Uerto Ricol - Diffuse neurofibroma/spindle cell lipoma Soyth p akotn fLCM Re$jdeQ!S) - Spindle cell lipoma

Apri12007

6 CITR, Apri12007 "Minutes" (Subocription A)

Texu. C'Nml Beach · Atypical lipomatous tumor Tc•V· Houston - Neurofibrolipoma Texas Lubbock - Spindle eelllipoma Tcxns CProPathl - Spindle cell lipoma Thus CSt Lukes Episcopal tlo$piu•ll - Neurofibroma, diffuse Texus. Sugar Land - N~urolibro~na Wl\§hjnoton (Seanlc VA Mcdjcal Center) - Ncoplostie lihroproliferativc process in tot, low grade groW1h, spindle cell lipoma West Virginia (Greenbrier Vulk:v Medical Center) - Atypical lipomatous tumor Wjmnsin Madison - Fibrolipomalspindlc cell lipoma Wjmnsin (Meriter Hospi111l - Spindle cell lipoma Allll!!lliq CNonh Oueendans! Pathology Group) • Lipomntosis of buttock Au,otralja (Roval Hoban Hospjm!l - Diffuse neurofibroma Austrulia CRoyaJ Prince Alfred Ho§pital) - Diffuse type neurofibroma AliJtrplia <Sullivan Njcolajdt'S Pgthologyl - Spindle cell lipoma Brozil (Laboratorio Ana1omju Pathologico EctiologW,) .. Diffuse neurol'ibromu Cuoodp (Pasqua Hospital> · Diffuse neurofibroma Canada fUnivg~isv HnsniLpl of' Shcrbrooke> - Lipomlt !ndja. Kamotaka - Pleomorphic adenoma with ossificalion Japan CAsa,~i General Homjcall . Angiotipoma JiMD CKvo1o Univqsirv Homj1all - Diffuse neurofibroma Oman (Khoula Hospital! - Spindle cell lipoma Oatur (tlamad Medical Comorotjonl - Neurofibroma Saudj Arubja CKing Fahad Nationol Guard Hospitu!) .. AnKiolipoma United Kingdom (Oxford Study G1·ouo> • Plexifonn nCUI'Ofibroma

Casc 3 • Diagnosis: Diffuse neorofibroma, buuock

T-Y1600, M-95400

Di«ctors Note: Diffuse neurofibroma may incorporate fat and be<:ausc of spindled cells, may mimtc spindle cell lipoma. The location, however, is helpful in their distinction. (drc)

Case 3 - References: Sinha R, Paul R, Sen l, et al A SolitOJ)' Huge Neurofibroma of the Soft Palate. L Ull)'"gol Oto/2002 11 6(8):637-638. Goldberg NS and Collins FS. The Hunt for !he NcurofibromB!osis Gene. Arch Dmnato/ 1991; 127(11). 1705-1707. Atlas of Tumor PothiJ/ogy, 17tirrl Series Fasclde 24 Tumors of !he PcriphCflll Nervous S)'stcm by Sehei!llauer, Woodrutl' and

Ertanson PH.D. Annod forces Institute of Pathology, WashingtOn D.C. 1997. Chapter 8, Ncurofibtoma 117-216. van Zuur~:n EJ and Pos""' AN. Diffuse Ncurofibtoma on the Lower Back. JAm A cad Dermato/2003; 48(6):938-940. Houori H. Vacuolated Cells in Neurofibroma. An inununohistochemical Study. J Cw.an Patho/20S; 3Z(2):1SS-161. Vai-B<.•rnal JF and Gonzfllez-Vela MC. Cutaneous Lipomatous Neurolibroma. CharacH:rizatiOr\ lllld Frequency. J Cmnn Pmhol

200S; 32(4):274·279.

Case No. 4, Accession No. 30143

Anobdm rOrange County Mcdjcal Center) . Myxoid neurofibroma Baldwjn Park (Kajsg Peongnentc) · Myxoid nC\Irofibromu ~ • Neurofibroma ~ * Neurofibroma, kne~;: Glcodn!c - Ncurofibromo Hayward!Frc:mont - Neurolibroma Lont Beach (Long Beach YA 11osphal\ - Neurofibroma with myxoid degencrotion (2) Los Angeles - Juxtaanicular myxoma Momcrsy Peninsula <Communjrv Hc»~ital of Monterey Psojnsulal - Myxoid neurofibroma ~ • Ncurofibrorno OnkJnod (Alameda County Medical Center> • Myxoid neurofibroma Sncrnmcoto cue Davis Mcdjcu! Center) - Net~rotibroma San Dicgu - Ncuronbroma Sun Diego (Naval Medicul Center> . Neurofibroma S11n Diego !UCSDl • Neurofibroma Sp.ou1 Barbara - Neurofibroma

C'TTR, Apnl Z007 "Minutes" (Sub,.;nplion A)

April2007

1

Sama Rosa !Santa Rosa Manoria!Hospilall • Neurofibroma (>) Sonoma <Sonoma Valley HosnitaD • Myxoid neurofibroma Wogdland Hills - Neurofibroma Ai•bam• CBa!l!ist Medical Center> - Neurofibroma Arkwas <Uniyersity of Arkansas for Mcs!ica! Sciences\ • Neurilemmoma, knee Colorado, Fl. Collins - Myxoid schwannoma E!orjda (Munroe Regional Medjepl Center> - Myxoma Oeor'Sja. PO£ptur - Neurofibroma Goorgiu CWcllstar Kenncstonc Hosnl!all • Neurofibroma lll!noj•, Burr Ridge - Schwan noma (2) !lljoqjs (Heartland Regjonal Medical Ccntc:r) - Myxoid schwannoma llljnojs <Loyola Univcrsitv of Chicago) • Neurofibroma lndjona <Howard Re2ional Medjul Ce:tuer) - Neurofibrom• Kanw !Cvtocheck laboratPfY L!.CI - Myxoid neurofibroma (2) Kenrudsy CUoivqsjt:v of Louisville) - Myxoid neurofibroma Mgry!ond <Northwest Hosoitall • NC\lrofibroma Mgrvlnnd CUniversiry o(Marvlandl • Neurofibroma Mossnchuseus <Beverly Hospital) - Atypical lipomatous rumor Mns~nchu~c:tts . Peabody - Neurofibroma, knee Mnss!lchusetts CTufL'i-New Eng!ond Medjgll Canc.r) - Neurofibromu Mjchj~on !Onkland Hosoitnll • NcuroObroma Mjchjgun CPnthology Services o f\Vcs' Mjchigaol - Myxoma Mjnncyotu {fairview Ridges HospiJo!) - Intraneural neurofibroma M jssouri ( M jssouri Delta Medical Center) - Schwannoma Moncana (forensic Science Divjsion) • Myxoid neurofibroma Ncbmska (Creighton UnivertiM - Nc:urofibroma New Mexico Albyguqooe • Schwannoma with dcgeneratiw changes vs. neurofibroma Nc:w York CNassau Uniwt!ity Mcdjcp! Center> - Neurofibroma New York CStonv Brook Univmitv tlomito!l - Myxoid neurofibroma New York fSVNY pownsuuc Msdjcal Center) - Neurofibroma Nonb Carolina (Mountain Arc.1 Patboloavl - Ang.iosarcoma Ohjo CMcCullough.Hyde Memprjnl Ho;mjtu!) - Ncuilcmmoma J>cnnsylvania (Drexel Unjycrrsity CoJ!cgcl • Sporadic neurotibromu. J>ennsylvonjp <Lehigh Valley Hosphall .. Neurofibroma Ps:nnsylynnia !Mt Niuany Medjca! Center> - Myxoid neurofibroma Pucno Rico <University o( PuL-no Rjcol - Myxoid schwannoma Sou!h pokota !LCM Residents) - Neurilemmoma (schwannoma) TCJ5&.1· Crystal Beach - Benign neural rumor. neurofibroma. traumatic neuroma Tcxa.~. Houston - Neurofibroma Tcxos Lubbcxk - Neurilc:mmomo Texas CProPathl - Neurilemmomn Icxgs (St. Lukes Episconal Ho~njto!l - Neurofibroma. myxoid Tc.us. Sugar Land - JuxUHlrticulsr myxoma WQShjngton (Seattle VA Medical Ccmcr> - Neurofibroma (? Re.'lctive process wifh underlying ubnom1al gene response) West Virginia <Greenbrier Valley Modjcnl Center) - Juxtu-orticulor myxoma Whscoosin Madison - Neurofibromn \Vj&ccmsi11 (Mcritq HosoitaJ) - Neurofibroma Austmlig (North Queensland Pathology Group) - Myxoid net~rofibroma Auilll!li• !Royal !iob;!n HOSpi!all • Neurofibroma Auumua <Royal Prince Alfted Hosphan • Solitary neurofibroma AuSJmHa <Sullivan Nicolaides Pathology) - Mpoid nc:urofibroms Bmljl <Laboratorio Anatomio Pptbo!osicp Estjologial - Myxoid neurofibroma CanadA <Pasqua Hosnjtall • Neurofibroma Con•da !Unjversitv Hospi1al ofShcrbrpokcl - Neurofibroma (myxoid type} lndjo. Kamotuka - Lipid rich scrtoli cell tijmor, ovary Jnpun (Aso.shi General Hospitlll) • Ncurotibroma Ji!nfin (Kyoto University Hospimll .. i>lexifonn neurofibroma Oman IKhoula Hospi!al\ - Ntt~ro!ibromu Onw Ilia mad Medical Coroorutjonl • Neurilemmoma v.itb degcncra1ivc chonges (3); Neurofibroma (2) Snudj Arabja fKjng Fa had National Gynrd Hospital> - Soft !issue myxoma United Kjngdom <Oxford Srudy Qmun) • Myxoid neurofibroma

C!TR. April 2007 "Mtnu!cs'' (Subscrip!ion A)

Case 4 -.Diagnosis: Myxoid neurofibroma, knee

T-Y9200, M-95400

Case 4 - Refen:nces: FelSch JF, Laskin Wh, and Mieuincn M. Nerve Sheath Myxoma. A Clinicopmhologic and Immunohistochemical Analysis of 57

Morphologically Distincth·c, S-100 Protein •nd AFAP-PO$tive, Myxoid Peripheral Nerve Shcnth Tumo"' with A Predilection for the Extremities and • High local Recurrence Rate. Am J Surg Patho/2005; 29(12):1615-1624.

Dhouib RS, Drlss M, Sassi S, et ol. Myxoid Tumor of Son Tissue. Pnthologica (Italy) 2006; 98(3):175· 177. Gmyrek RF. Beer R. Silvers ON. et al. Periungual Myxoid Neurofibroma. Cut/.r2002; 69(1):54·56. Kottler VB, Conway RM, Schlotzc:r-Schrchardt U, et ol. Isolated Neurofibroma of the Orbit with Extensive Myxoid Changes. A

Clinicopathologic Sntdy lnculding MRI and Electron Microsoopic Findings. Orbit (Netherland•); 2004; 23(1):59-64.

Case No. S, Accession No. 30331

Anaheim <Orange: Coun()r Medical Center) · Nodular fa.sciilis !laldwjn Parle IKoiser Pennanentel - Nodular fasciitis (3); Neurofibroma (myxoid) ( I) Chico • Nodular Kaposi's sarcoma vs. nodular fasciltls Clovis • Supraclavicular, spindle cell lesion, suspect K.S., need IHC Glend;tlc - Cellular schwannomo Hpvwnrd!Fremouc - MPNST with squamous differentiation Long Beach /Long Beach VA Ho.witoll • Nodular fascii tis (2) los Anseles - Synovial so.rcoma Monterey Pc:njosula !Community Hospital of Monterey Pcninsulnl - Nodular fa.,ciitis vs. DFSP Oakland • Nodular fasciitis Oakland !Aiamsd3 Coumy Medigl Center) - Vasoprolifetorion Sacramento CUC Dayis Medical Ceotql - Schwannoma San Qjego - Nodular fnsciitis San Dicso (Naval Medical Center) - Nodular fasciiris San Djcsp CUCSPl - Nodular fa~ciitis Santa Bprbara - Kaposi's stu(:Otl'IO San111 Rosa !Soma Rosa Memorial Hospi1111l - Synovial sarcoma (3) Sonoma !Sonomg Valley Hospital) • MPNST malignant peripheral nem: $heath tUITI()C' Woodland Jijlls • Solitary fibrous tumor Alabama IBaptj« Medical Center) • Solitory fibrous tumor Arkansns CUnivcajtY of Mnnsas for Mcdicpl Sciences> - Ectopic hamanomatous 'hytnOml .. neck Colomdo. Ft. Collins - Nodular fOsciiris Florida (Munroe Regional Medico! Center) - Kaposi's sarcoma Georgia. Decatur - Kapo$i's sarcoma Gcorgjn <Wel!stqr Kennestone tlospjtnll - KapOsi's so.rcorna Jllinojs. Burr Rjdvo · Nodular fesci itis ( I); Hemangiopericytomo ( I) Illinois CHeanlan4 Regional MediC!! I Centcrl • Kaposi fonn neoplasm, NOS Illinois (Loyola University ofChiqgol- Ectopic hamanonunous thymoma Indiana CHowprd Regional McdjCI)I Cc:nterl • Kaposi's sarcomu Kansas !Cvtocbeck laboralorv. lLCl - Nodulor fasciitis (I); Fibroma (I) Kenrucky fUnivcrsjtv of boujsvillcl - Nodular faseiitis Marvland Wonhwc:;t Hosnitall ~ Kttposi's sarcoma Marvlend Nnjvc;rsitv of Maryland! • Kaposi's sarcoma vs. HPC Massncbusens C!leyer!v Hospitall • Spindle cell lipoma MassncbUi~etts. Pcqbody · Neurofibroma, supraclavicular Ma.~ashuseus <Tufts-New England Medjc:al Center) - Kaposi's sarCCIIlla

MichiK!IIl !Oakland Hosojtall • Schwannoma Michigan (Pathology Services ofWs;st Michjganl - Low grade ~'pindlc cell rumor Minnesota (fairyjcw Ridacs Hosnjtun· - Ectopic hamurtomatous thy-mOIUIJ MiS$00d CMiSS9!!ri Deha Medical Center) • Fibrosarcoma Montana CForcnsjc Science Division) - Ectopic hamartomatous thymoma Nehraskq rCreicluon Unjys.Tsitv) • Solitwy fibrous rumor ~cw Mcx1co. Albuaucroue · Carcinosarcoma New York CNassou Univmity Mcdjcal Cr:ntql . Hemangioendothelioma New York (Stony Brook Unjversity Hospital> . Spindle epithelial rumor with rhymic.Jikc: differentitltion

CTIR, April2007 .. Minutes"' (Subscription A)

April2007

9

New York CSUNY oownstate Medical Center> • Myoflbrobla;nic rumor vs. neurosan:oma, low grade North Corolinp <Mountain Area Pathology) - Leiomyosarcoma Ohio CMcCyl!oyah-Uvdc Memorial Hospital) • Hemangiopericytomo Pennsylwnja (0rcxc1 University College) - Hcmangiopcricytoma Pcmmlvanja !Lehjah Valley Hospjh!l) - Nodular fasciitls Pcnnsylyanja !Mt Njuany Medical Center) • Cellular fibrous histi«ytoma Pumo Rjso Nnjvcn:ity of Pueno Rico> - Nodular fasciitis Soyth Dakota tlCM BesKJe;nt.1l - Neurofibroma Texas Crvstq! Beach ~ Nodular fasciiris Tcxa.~ Houston • Fibromatosis Texas. Lubbock - Neurilemmoma Texas (Prol'oth\ .. Kaposi 's sarcoma Texos l$1. Lukes Episcopal Hosnita1) - Schwannoma Texqs. Sugqr Land - Ee10pic hamartomatous thymoma Wushing1on <Scottie VA Medical Center) - Atypical reoccive fibroprolifcrutive process, nodular rnsciitis Wcsl Vjrgjnia <Greenbrier Vallev Medjcal CcnLcrl • Dcnuutofibrosurcoma prOiuberancc. Wisconsin Mndjspo • Solitary fibrous tumor Wisconsjn CMcritcr Homitall • Ectopic tJ1ymoma Austrgljn <Noah OueCflslllfld Pathology Group) ~ Nodular t3sclitb Australia CRoyol Hobart Ho~pital> • Cellular schwannomll Australia CRoya! rrincc Alfred Hospital> • EctOpic hnmanomotous chymoma AIJS!ralia !Sum van Nicoloides Pathology) - Solitary fibrous tumoc-Brazjlll&b9£1!orio Anotomia Pathologies Ectiol!!!!ial - Cellular schwannoma (I); Pcrincurioma ( l ) Canada CPosqyo Hospita1l • Schwannoma Canada IVnjvrnily Hosoital ofSherl!roo!sel - Kaposi sarccma lndja. Karnqwlla • Low gnlde malignant phyilodcs Jaoan CAsgshj General Hospital) • Nodular fasciitis Japan CKyoto UniversiD' Hospi1aJ> - Ectopic hamartoma1ous 1hymoma Patar CHamad Medical Comoration> - Lc:iomyoma Saudi Arabia CKjns Eohad Na1jopnl Guard Hosoital> • Kaposi sarcoma United Kingdom (Oxford Stt~dy Group) - Solitary fibrous tumor

Cusc 5 • J)IMgMsls: Benign mesenchymal spindled neoplasm, likely variant of cellular schwannoma, supraclavicular

T-08220, M-95600

Case 5 - Re !Crences:

Kurtkaya-Yapicitt 0 , Scheithauo:r B and Woodruff JM . The Pathobiologic Spectrum ofSchwannomas. llistol Hlstopotho/2003: 18(3):925-934.

Casadei GP. Schcithauer BW, Hirose T, et al. Cellular Schwannoma. A Clinicopethologic. DNA Flow Cytomcmc, and Proliferotion Morl<er Study of 70 Patients. <Ancer 1995; 7S(S): 1109-1119.

Lodding P, Kindblom LG, Angcrvall 1.., et al. Cellular Schwannomo. A Clinicopathologic Srudy of29 Cases. Vlrcho"'" Arclr A Pathol Annt HIStopotho/1990; 416(3):237-248.

Sehgal VN, Gupta RL, Bhatia A, et al. Solitary Cellular Schwannoma (Neurilemmoma) Showing Malignant Changes. Evaluotion Through Magnetic Rcsonacc lmagina (M.R.I.), Surgical Intervention, and HiStopathology. J Dermato/1999; 26(3): 189·195.

Case No. 6, Accession No. 30335

Anaheim COrongc; County Medical Center) . Hyolinizcd and thrombosed schwannorna Boldwin Pork CKojscr Pcnnanentel - Schwannoma (4) !J1ks1 · Schwannoma !dsciJ - Angioneurofibroma, thigh Glendale • Schwannoma with degenetative changes Haywardlfrsmont • Neurilemmoma Lon• Beach llono Beach VA Hospita!l - Schwannoma with degcncnttivc change (2) Los An&eiC$ • Extra•kcletal myxoid cbondrosarcoma Monterey Pspjntyla <Communitv HO$!?ita) of Montag Peninsula) - Sehwannoma with hyalinized vessels QUiaasl • Neurofibroma Oakland (Afqmed• Cpyn!y Medical Center) - SchwllflnOina SacrumenJQ CUC pavjs Medical Ccmerl • Schwan noma

April 2007

10 ClTR . . ~pril2007 " Minui<S" (SubiCription A)

San Diego - Ancient schwannoma San Diego {N1wal Medieal Center) - Ancient schwannom<l San.Diego IUCSDl - Schwnnnoma Sanm Barbai-a - Neurofibroma Santa Rosa <Snnw Rosa Memorial Hosnitan • Ancient schwannoma (I): Schwnnnoma with degenennive changes (1 ); Benign nerve sheath rumor (schwannoma) (I) Sonoma (Sonoma VaJiev Hospita)) .. Schwannoma Woodland Hills - Schwannoma Alabama (Baptist Medical Center) - Malignant peripheral nerve sheath tumor Arkan~n..~ (lJniversitv of Arkansas for Medical .Scicnccs) - Schwan noma with deg~1erative changes-, lhigh C-olorado. Ft. Collins - Extra skeletal chondr.osarcoma Florida<Munroc Regional Medical Center) - Schwannoma Georgia Decatur - SChwannoma Georgio (Wellstnr Kenne.~tone Hospital) - Schwannoma Illinois. Burr Ridge - MPNST ( I); Schwannoma ( I) Illinois (Heortland Regional Medical Center) - -Schwann(Jma Illinois <Loyola University ofChieago) • Schwannomn Indiana (Howard Regional McdjcQ! Center) • Lymphangioma Kansas ICvtocheck Laboratorv. LLC) - Myofibroblastic tumor vs. schwannoma ( I); Mixed tumor (I ) Kentucky <Unjyersitv of Louisville) · Ossifying fibromyxoid tumor Marvland <Nonhwcst HosojtaD - Schwannoma Marvland !University of Marvland) - Ancient sehwannoma Ma.~ispctru~eus (Beverlv Ho.spitall .. Schwannoma Massachusetts. Peabody - Plexifonn neurofibroma. thigh Massachusetts ITufts-New England Medical Genter> · Schwannoma Mjchjgun <Oakland Hospital) • Schwann·oma Michigmi (Pntbologv Ss:ryic:e.._ of West Michigan) • Liposarcoma Minnesota (fairview Ride.es HospitnD - Sch\VUnnOtn!). Missouri <Missouri 'Delta Medical Center) · Schwannoma Montana fforensjc Scje11ce Division) - Schwannoma NCbraslCa (Creighton Universirvl - Schwannoma New Mexico A1buguerouc .. Schwannoma New .. York (Nassau University Medical Center) .. SchwannOmil New York (Stony·Brogk Unlve~irv Hospital) - Schwannoma New York·<SUNY Downstate Mt?dical c&nttrr) - Asian schwannoma Nol'lll Cal'olina (Mountain Area Pathology} - Angiosarcoma Ohio <McCullough-Hyde Memorial Hospitall • Schwannoma Pennsylvania (Drexel Univen.;rv College> - Ancient schwannoma Pennsylvania <Lehigh Valle\' Hospital> • Schwannoma PcmnsylvSLnia (Mt Niuri.ny Medical Center) .. Ancient schwnnnoma Puerto Rico <Un-iversity ofPusrto Ricol - Ancient schwannoma South Dakota ILCM Residents\ - Ancient schwannomn Texas Crvstal Beach • Lesion possible synovial origin wirh hyalinization of vessels and foci of ossification. li'kely benign Texas. tloustori . Neu.rofibroma Texas Lubbock * Neurilemmoma Texas <ProPath) - Schwannoma Texas <S!. Lukes E.pi~copal Hospital) • Schwannoma Texas Sugar. Lund - Schwannoma Wqshjngton <Seattle VA Medical Center) - Schwannomn West Virginia <Greenbrier Valley Medica) Center) • Schwan noma Wisconsin. Madison - Neun1cmm¢mQ Wisconsin (Meriter Hosnitall .. Schw'ttnnoma Aystr.1lia <North Ouee.lsland Patllology .Groupl * Non·ossifying varian! of ossifying fibrornyxoid tumor Australia ( Row) Hoban Hosnitnl) - Degenerate s-chwannoma Australia lRoval Prince Alfred Hospital) - Schwannoma Auslralia <Sullivan Nicolaides Pathology) - Schwannomn Brazil <Laboratorio Anatomia Pathologica Ectiologia) .. Schwannoma with cystic changes Canada <Pasqua "Hospitall - Schwannoma Canada <Universirv Hospical of Shcrbrooke> - Schwannoma !ndjn. Kamntnka - Non-Hodgkin lymphoma (malignant histiocytosis) Japan (Asashi General Hosnita1l - Ancienl schwnnnoma Japan fKyoto Universitv Hospital) - Scbwannoma, ancient or cysdc Oatar (Hamad Medical Cornordtionl • Schwannoma

C.T fR. April 2007 .. Minutes" (SubscripLion A) II

Saudi Ambia CKjog- fahad National Guard Hospjtal> - Sthwannoma United Kingdom (Oxford Study Group) ·• Schwonnoma

Case 6 -Diagnosis: Schwannoma with degenerative changes (ancient schwannoma), thigh

T-Y9100, M-95600

Case 6 - References: Argenyi ZB. Bnlogh K and Abraham AA. Degenerative ("Ancient") Changes in Benign Cutaneous Schwannoma A Light

Microscopic, Histochemical and lmmunohistoc.hemical Srudy. J Curan Parhol I 993; 20(2): 148-I 53. M ikami Y Hidaka T, Akisada T, et al. Malignant P<'ripheral Nerve Sheath Tumor Ari:sing in Benign Ancient Schwannoma. A Case

Report with an Immunohistochemical Study. Parlwllnt 2000; 50(2): 156- I 61. Bondy PC, Block RM and Green J. Ancient Schwan noma oft he Submandibular GJa.,d, A Case Report. Ear Nose Throat J 19%;

75(12}:781 -783. Klijanicnko J, Caillaud IM and Lagace R. Cytohistologic Correlations in Schwannomas (Neuilemmomas). Including "Ancient",

Cellular, antl Epithelioid VariontS. Diagn Cytoparho/,2006; 34(8):517-522. Karn M, Ozkan M, Sak SO, et al. Giant Ancient ~chwannoma of the Post<."lior Mediastinum Cytologically Misdiagnosed a.~ a

Malaignant Tumour. A Case Report. Acta Chir· Be/g_(Belgium) 2002; 102(6): 464-466. Giglio M, Giasotto V. Medica M. et al Rerroperitoneal A11ciwt Schwan noma. Case· Report and .-\oalysis of Clinico-Radiological

Findings. Ann Urol (Paris) 2002; 36(2): 104-106. Strouhal o and Nemeckovn A. Polcopathological Find of a Sacral Neurilemmoma from Ancient Egypt. Am J Phys Anthropo/ 20()4;

125(4):320·328.

Case No. 7, Acce.ssion No. 29186

Anahejm (Orange County Medical Center) - Atypical lipomat.ous tumor/well-differemiated liposarcoma Baldwin Park (Kaiscrl'ennanente) - Well-differentiated liposarcoma, sclerosing type (4) Chico - Wel l ~differentiated liposatcoma ~ - Rcrroperitoncal liposarcoma Glendale - Well-differentiated liposarcoma Hayward/Fremont - Well differentiated liposarcoma Long Beach (Long Beach v A ~lospim!l - Liposarcoma, well-differentiated (I); Well-differentiated, liposarcoma (I) Los Angeles - Myxoid liposarcoma Monterey Peninsula <Communirv Hospital of Monrerev J>eninsula) - Well-differentiated lip<>Silrcoma Oakland - Liposarcoma Oaklond (Alameda Countv Medical Center) - Well-differentiated liposarcoma Sacramemo CUC Davis Medical Centetl - Well-dflft•rentiated liposarcoma SaJ' Diego - Well-di l~"erenciated I iposurcoma San pjego {Nitval Medical Genter> - We11-diffcrcntia(cd liposarcoma San Diego CUCSO) - At)1>ical lipomatous tumor / lipomatous type lipo~arcoma Santa Barbara - Liposarcoma Santa Rosa (Santa Rosa Meinorial Hospitall - Liposarcoma ( I); Myxoid liposarcomat (2) Sonoma (Sonoma Valley Hospita1l · 'Veil-differentiated liposarcoma with myxoid change Wood1and'Hills - Myxoid liposarcoma Alabama (Bantist Medjcal Center> - Myxofd liposarcoma Arkansas CUniveisity of Arkansas for Medical Sciences) .. Wcll-differcntiatod Hposat"COma, retropcritoneum Colorado Ft. Collins .. Myxoid liposarcoma Florida (Munroe Regional Medical Center) - Well-differentiated liposarcomts Georg.in. Decatur - Well-differentiated liposarcoma Qeornja (Welh.1ar Kcnnestone Ho5j?itall · Liposarcoma Illinois. Burr Ridge • Pleomorphic lipoma (I); Myxoid liposarcoma ( I ); Pleomorphic lipoma ( I) Jllinois (Heartland Re.giorlal Medical Center) - Well-differentiated liposarcoma Illinois (Loyola Univ<..-rsicy of Chicagol .. Myxoid liposarcoma Indiana (Howard Regional Medical Center) - Atypical lipommous tumor Kansas <Cvtocheck Laborntorv, LLC) - Low grade liposarcoma (2) Kentucky fUojversjty of Louisville) - Well-differentiated liposarcoma Marvland (Northwest Hospital> - Well-differentiated liposarcoma Man•land CUniversity of Maryland> - Myxoid lipOsarcoma Ma;;;sachusens fB·everly HosnjtaD - Well-differentiated liposarcoma Massachuseus. Peabody - Well-differentiated liposarcoma, rcrropcritoncal ·Massachusetts ITufts-Ncw England Medical Center) - Well-differentiated liposarcoma

April2007

12 C'lT R. April 2007 "Minutes" (Subscription A)

Michigan (Oakland Hospital) · Well·diO'"-n:ntialcd liposarcoma Mjchjsan tp;uhoJogy Services of West MjchjgADl • WcU·differcntilled liposarcoma MinnCS9(p IFajrvinv Ridges Hospital) - Liposarcoma. well--differentiated Mjmuri CMissoori Delta M«f!Cl!l Ccnlcr\ • Alypicallipoma MonttuJ& <Forensic Science Division) • Wcll~ifferentiated liposarcoma Nebrn.<ka ICrcigbton UnjversiM . Well·diffcrc:nlialcd liposan:oma New Mexjoo. Albuquerque - Well-differentiated liposarc-oma New y ork <Nas~au University Medical Ccnts.r> - Pleomorphic lipoma New York CStgoy Brook Universi()' Hosnhall - Prc<lomina•uly wcll-diffcrcntilltl:(l liposnrcomo New York CSUNY Do\~11Sl!!te M,;;djcnl Center> • Wcll-diffc;.Tentitucd li1>0surcorna North Cnroljna (MounUlin Area Palholoayl • Liposarcoma (wcll-differcnlialod) Ohio <McCullough-Hyde Memorial Hosnitall - Liposarcoma Penmylygnja CDrexcl Universi1y College> .. Well·differc.ntiated liposarcoma Pennsylyanja (Lehigh Val lev Hospital\ • Al)'picallipomatous nooplasm/well-differentialed liposarcoma Pennsylvania lM1 Njttan'' Medical Cmterl ~ Atypical lipomatous tumor Pueno Rk;o IUnivem!V ofPucno Rjcol • Well.<fiffermriatcd liposarcoma South Dako1o !LCM Residents\ • Wctl-differentiatcd liposarcoma Tex;u Cwal Beaoh · Liposarcoma, low grudo Texas Houston - Wcll-<iiffcrt'11tiotcd liposurcoma Tcxns. Lubbock - Well~itfercntiatcd liposarcoma Texas fProPqtbl - Myxoid liposarco1na Texas ($t Lukes Episcopal Hosnjta!) - Well-differentiated lipasa.rco•no Texns Sugur Lund ~ Well-differentiutc:d liposarcoma Wa1hjnaton (Seattle VA Medical Cemcrl - Ncopla~aic libroproliferativc process in fot. atypicallipoma/wcll-diiTcrcntiatcd

1ipos3rcoma Ws;st Virginia £Greenbrier Valley Medjegl C&ntcrl - Liposarcoma. low 3radc Wjsconsjo. Madison • Wcll-diffcronliatcd liposarcoma (81ypicallipomatoustumor) Wignsio CMcritg HomitaJl - WeiJ .. diffcrentiatcd lipc>saTComa Aumpl!o (Ngnh Qyscnsland Patholooy Group) • Myxoid liposa=mq Aus1rnlio CRoyal Hobart Hosoitall • Well·difl'erentiatcd !iposareome Austrnljn fRoyal Prince Alfred Hospital) .. Wc:ll·di!Terenti;ued liposarcoma Au~trn!lo (Sullivan Nicolaides Pathology) - Well-differentiated liposarcoma Bpgj l fLnhonnorio Anafomia Pathologjcn Ectjologia) - Well·diffcrtnti(Ued liposarcoma Qnoru.tn (J)usouo Hospital) - Sclerosing wcll-diflt't'entiated liposarcoma Conadq (University Ho::.pilal ofSherbrookc) - liposurcoma (wcll-diffcrcnriuled $Ch:WS:ing type) lndjo. Kpmytuka · Myxoid lciomyomn lung Japan CA:tasbj General Hospital) - Myxoid liposarcoma Jap3n <Kyoto Um~rsity Ho!ipiUl1) - Uposarcoma, myxoid Oatar IHomod Medical Comon!liog) • Atypicallipomalou.s ll!mor ("ell.<fiffcrenrialcd liposareoma) Snudj Ambjn I King l'ahad National Guar!l HOS>il•ll • \Ve!l·diffcrenliotcd liposorcoma Unitc:d Kjnodom COafon! Srudy Group) • Wcll.<fiffcrentiated liposarcoma

Cue ? ·Diagnosis: Well-differentiated liposarcoma, retroperitoneum

T-Y4600, M-885 13

Directors Note: Sowcallcd atypica! lipoml'IIOUS "ncopla..o;;ms'' when they occur in the retroperitoncum arc dcsigruucd ''liposar¢:omas". (drc)

Case 7 • References: Inoue K. Higoki Y and Yoshida H. Giant Rc«roperiloneal Lipo!M'COO!a fmJ Uro/2005; 12(2):220.222. Nauhous SJ. Bony P, Clark MA. et al. Suflical Maru~g<-menl of Primary and Rc:cum:m R<:lroperitooeal Liposarcoma. BrJ Smg

200S; 92(2):246-252. Monjozcb A, Scanlon C and Levine EA. Intussusception Secondary 10 McUlslasis rrom a Low-Grode Rctrop<>riloocol Liposarcoma.

Am Surg 2004: 70(9): 775-778. McCollum OJ, Burke JJ, Childs AJ, ct al. Rolroperiloncal Liposarcoma Weishing Over One Hundred Pounds wilh Review oflhe

l. iiCI'Oiure. Gyneco/ Onco/2006; 103(3): I 152-11 54. Fobi'C~Oui llcvin E, Coindre JM , Somcrhauscn Ndc S. et a!. Retroperitoncol LipOS(Ircomns. Follow-Up Annlysis of OcdiffCn:ndation

Aflcr Clinicop111hologie ReexaminMion of 86 Liposarcomas and Malignnn1 Fibrous Histioe)1omos Cancer 2006: 106( I 2):2725-2733.

C'fl'R. Apnt 2007 "Minu<es" (Subscripllon A) 13

Case No. 8, Accession No. 30395

Anaheim (Or.J.noe Coumy Medical Center) • Synovial sarcoma Baldwjn Pqrk lKaisq Pqmpncntcl • Synovial sarcoma {4) ~ • Biphasic synovial sarcoma Q.lUi:; • Synovial sorcoma, knee G!smdnlc - Biphasic synovial san;oma liayward!Fremonr - Synovia.! sarcoma Long Beach /Lono Be,1ch VA Hospital) - Synovial sarcoma (2) Los Ange.Jcs - Synovial sarcoma Monterey Peninsula <Communjty HCb"'Wtal ofMpnterey Peninsula> - Synovial sarcoma ~ - Synovial sarcoma Oakland <Alameda County Medical Center) • Synovial sarcoma, bipha.~ic SncJ11mc:nto fUC Davil Modica! Cemer) - lliphnsic synovial sarcoma Siin Diego - Biphasic synoviol stu·coma Sno Diego CNaynJ Metfjcql Ccmcrl - Synovial sarcoma Snn Ojcgo (UCSDl • Synovial sarcoma Sqma Barbara - Monophasic synovial sarcoma Santa RP$1 !Santa Rosa Memorial Hosoioall - Synovial !oarcoma (3) Sonoma !Sonoma Valley Hqspitall - Biphas;c synovial sarcoma WOO<! land Hills - Synovial sarcoma, biph1>$ic Alabama <Baptist McsJjcgl Csntql - Monophasic: synovial sarcoma Arknnsa.s CUniversityoCArkgnsas for Medical Scicncgsl - Synovial sarcoma, knee Colorado. Ft Collins - Monophasic synovial sarcomu florjda <Munroe Regionnl Modi<:nl Center} • Synovial sarcoma Gconia. Decatur • Synovial sarcoma Gcomia CWeUs[ar K~nnes;1one Hosnittlll - Synovial sarcoma Illinois Burr Ridge • Synovial sarwma (2) llljoojs <Hcanland Regjonol Medical Center! - Synovial sarcoma, biphasjc llljnojs <Lovola Univmjty ofCbicagol - Synovial sarcoma lndjana fHo~'!fd Regional Mc:djcal Center) - S)Tiovial sarcoma Kugsns fCvtochcck Labomtorv. LLC\ - Biphasic synovial sarcoma (2) KcnJucky (University of Loujsvillel - Monophasic $ynovial sarcoma Maryland <Nonhwest HomWill - Synovial sarcomo MnrvJand CUniversi!v of Mnrvlqndl - Synovia) sarcoma, biphasic Massachusetts CBeverly Hospital> - Synovial sarcoma Manachuse<'.s. Pcabodv - Biphasic synovial sarcoma. kncc Mp<srhuset« <Tufts-New England Medical Cenrru • Biphasic synovial sarcoma Mjcbjcan (Qaldand HO!!JjJa!l - Synovial sarcoma Mjchigan £Pathology Servicq of West Mjchjgan) .. Synovial sarcoma M jnnesma <Fairvjew Rjdgct Hospjtall • Synovial sorcomo Mjssouri CMjssourj Oelto Msdjcol Center) .. Synovial sorcoma Montnna (forensic Science Djyjsionl - Synovial sorcomo Nebraska <Creighton Uojyersjtyl - Synovial sarcoma New Mexjco. Albugueroue .. Synovial sarcoma, bipha.sic New Vorl< <Nassau Univmjrv Medical CentCI') - Synovial sarcoma New York <Stony Brook Uojymitv Howitall - Biphuie syno\i.al san:oma New Yoric <SUNY Oownstgur Medical Center) • Monophasic synovial sarcoma Noah Carolina CMounrojn Area Patho1ogvl - Myxoid liposarcoma Ohjo fMcCullouell-Hydc Memorial Hospjroll • Synovinl sarcoma Pennsylvania <Drexel University College) · Synovial sarcoma Pennsylvania (Lehigh Vq!!cy liospitill) - Biphasio synovial surcoma Pennsylvania (Mr Nitranv Mcxlicql Center) - Biphosic $ynovial sarcoma Pyeno Rico (Univepity of Pusrto Rico) - Biphasic synovial sarcoma Soy1h DalsO!a fLCM Resjdgusl - Synovial sarcoma TC!JSas. Crvstal Beach - Biphasic synovial sarcoma Texn,-~. Hous.lon - Synovial sarcoma Texgs t ubbock - Monophasic synovial sarcom:~ Texas <Pro Path) • Synovial snrcoma Tcxils <St. Lukes Episcopal Hnspjto!) - Synoviol surconm 'lJ:xus:. Sugar Land - Synoviol surcoma Woshjngton CScaulc VA M\.-djcal Cen1erl - Synovial sorcorna Wcsl Vjrginia (Greenbrier Volley Medical CetJLerl .. Synovial sarcoma

April 2007

14 CTTR. April2007 "Minutes' (SuiKI:ription A)

Wisconsjo Madison - Synovial snrcoma Wjsconsjn lMeriter Ho:,nitaD . SynoviOS."lrCOma Australia (North Queensland Ppthology Group) - Biphosic synovial sarcoma Auslnllia (Roval Hoba!l HospjJPil - Biplwic synovial SA~<:oma Australia rRoval Prince Alfred Hospitall - Synovial sarcoma Austrnlio (Sullivan Nicolaides Padtology) • Synovial snrcoma Brazil <Laboratorio Amuomia Pothologica Ecliologia) - Biphasic synovial stLrc:oma Cana4a cra.gua Ho<pjta!l - Synovial san:oma Canada (Universitv Hospi10l ofSherbrookel - Synovi<><~arooma (biphasic type) India Knmntaka • Inflammatory myofibrobhtstic rumor/GJS·r cxtruintestinal Japan IApshi Genml Homita)) · Synovial sarcomtl Jaoon CKyp1o UnivmilV HospjJall - Synovial san:oma, biphasic Oatar fHnmgd Medical Comomtjgol - Sarcoma witll epithelioid features or malignant pcriphera1 nerve sheath rumor Saudi Arubia (Kina fnhad Nat!onaJ Guprd 11osoitaD . Synovial sarcoma United Kjngdom (Oxford Study Group) · Synovial sarcoma

Case 8 • Diagnosis: Synovial sarcoma, biphasic, knee

T-Y9200, M-80003

Case 8 - References: Sanl8virra S. Synovial Saroomu. A Clinicoporhological S1udy of 31 Cases. Arch Orthop Trauma Sw·g 1992 ; I I I (3): 155- I 59. Buck P, Mickelson MR and Bonfiglio M. Synovial Sarcoma A R~view of33 Cases. Clm Orthop Relat Res 1981; 156:211 ·215. louis OS, Hankin FM and Hankin RC. Synovial Cell San;oma. A Case Repon wilh a Commenl on 21 Years ofTreatmcnl. J Hand

S1111: 1986; I 1(4):578-581. Menendc:z LR, Brien E and Brien WW. Synovio.l Sarcoma. A Clinicoparholo&ic Srudy. Ortlrop Rev 1992; 21 (4):465-471 , Morrison C. Wakely PE Jr and Ashman CJ. Cystic Synovial Sarcoma- Ann Diogn Patho/ 2001; 5(1 ):48-56.

Case No. 9, Accession No. 30374 Apri12007

Anaheim (Orange County Mcdjcnl Center) . Solitary fibrous tumor Baldwin l'ark fKaiscr Pennancntcl - Spindle celllipo1na (4) Chico - Spindle. cell lipoma Clovis - Ocnnarofibrosan:oma prorubcnlns (myxoid "'·myxofibroma) Glendale - Spindle cell lipoma Hayward/Fremont • Solitary fibrous tumor long Bcgch flong Beach VA l!ospilall - Soli181)' fibrous rumor (2) Monterey Peninsula CCommunj1y Homital gfMonrerey Peninsula) - Solirary fibrous rumor Oak lang - Nerve shcurh rumor Ooklan<j (Alameda Countv Medical Ccn)er) - Spindle cell lipoma Sacrnmen1o lUC Oayjs Medical Center) • Spindle cell lipoma San Dim - Solirazy fibrous rump; Son Diego CNavaJ Medical Center) · Spindle cell lipOma San Diego CUCSPl - Spindle cell lipomo San111 Barb111'8 - Hcm•ngiopcricyloma San1a Rosa !Soma Rosa Memorial Hospiroll - Solirory fibrous nodule (3) Sononm (Sonoma VaJicv Hospitgll · Neurofibroma Wood lund Hills - Spindle cell lipoma Alabamg CR3ptis.t Msdjeal Cental - Spindle celllipomo Ar!cansas fUniversi!Y of Arlcan•M for Mes!kal Sciencnl - Spindle cdllipoma, poslen<>< nc:ck Colorado, fl . Collin! - Spindle ceil lipoma Florida <Munroe Resjonal Medical Center} · Neuro"tihrorna vs. fibrous histiocytoma Georgia, !)ecarur - Spindle cell lipoma Illinois, Burr Rjdge - Hcmangiocndorhelioma (I); Soli181)' fibrous rumor wilh myxoid change (I) lllinojs <Heartland Regional Mcdjcal Ccntt.Tl . Spindle cell lipoma Illinois <Loyola UniytGjjty of Chjcpgo> - SPT Indiana <Howard Regjonal Medical Cen!erl - Low grade fibrosarcoma KansasfCytochs:cll !.aborato<y. LLQ - Soli18Cyfib..,... rumor(!): Neurofibroma(!) Kcnrucky CUnivcrsjty orlouisyillel - Spindle cell lipoma Maryland (Northwcsl Hospira)) . Spindle cell lipoma Maryland CUnivmj!Y of Marylondl - Solilory fibrous rumor

CTTR, Apri1 2007 "Minules .. (Subseriplion 1\) IS

Massachusetts (Beverly Hosoitall • Spindle cell lipoma Massachusetts PeabOdy - Dermatofibrosarcoma proruerans. neck Massacbuseus !TuAs-New England Medjcal Center) - Epithelioid hemaJlgioendothel iom~ Michigan (Oakland Hospital) . Spindle cell lipoma Michigan (Pathology Services of West Michigan) - Ma~tocytoma

Minnesota <Fairview Rjdges Hosp\1!lll · Spindle cell lipoma Missouri (Missouri Delta Medical Center) - Liposarcoma vs. solitary fibrous rumor Montana (forensic Science Division) - Solitary fibrous tumor Ncbrn.skn <Creighton Uniymitvl - Spindle cell lipoma New Mexico Albuquerque • Spindle ccll lipomn New York (Nassau Universitv Medical Center) - Myofibrobla~toma. mammary type New York (Stony Brook UniverSity Hospitall - Spindle cell lipoma New York (SUNY Downstate Medical Genter) .. Spindle cell lipoma vs. solitary fibrous tumor North Cqrolina (Mountain Area Pathology> - Malignant fibro\ls·histiocytoma (myxoid) Ohio l!ylcCuilough-Hydc Memorial Hospitall · Low gr.odc tlbromyxoid sarcoma Pennsylvania (Drexel Universitv College) - Dermatofibrosarcoma protuberans Pennsylynoja CL&hjgh valley liQSpjw!l - Solitary fibrous tumor Pennsylvania lMt Nittany Medical Cent(.'T) - Spindle cell lipOma Pueno Rico lUniversirv of Puerto Rico) . Solitary fibrous rumor/glomus tumor/ht..111anglopcricytoma South Dakota CLCM Re.~ idents) - Dennatofibrosarcomn protuberans Texas. Crvstal Beac-h - Granular cell tumor Texas. Hous£On · Hemangiopericytoma Texas Lubbock - Solitary fibrous rumor Texas CProPathl · Spindle <-.:II lipoma Texas CSt Lukes Episcopal Hospital) • Spindle cell lipoma Texas Sugar La.nd · Spindle cell lipoma Wasbjng-ton (Seattle VA Medjcal Center) - Neoplastic fibroproliihative process, low grade growth West Virginia (Greenbrier Valley Medical Center) - Dermatofibrosarcoma Wisconsin Madison - Spindle ceiJ lipoma Wjsconsio <MeritCr t-losnjmll - Solitary fibrous rumor Australia CNorth Oueonsland P.athology Group) - Solitary fibrous tumor Australia (Royal Hoban Hospital) . Solitary fibrous rumor Australia CRoyal Prince .Alfred Hospital\ • Spindle cell lipoma Austrn!ia (Su11ivan Nicolaides Pathology> - Spindle cell lipoma Braiil CLabomtorio Anatomia Puthologica Ect.iologia> - Spindle cell lipoma Canada (!>asgua Hospitall · Spindle cell lipoma Canada (University Hospital of Sherbrookel - Spindle cell lipoma India. Karnataka • Schwannoma Japan (Asashi General Hosniral) - Epithelioid hemangioendothelioma Jppan (Kyoto Unjymjty Hospjta!l - Solitary fibrous tumor Oman (Khoula Hospital> .. Solitary fibrous tumor Oatar (Hamad Medical (;omorationl - SoJi[ary fibrous rumor. myxoid variant Saudj Arabia (King Fahad National Guard Hosnitan - Spindle ce.U lipoma United Kingdom COx ford Study Grouol - Spindle cellli]l(>ma

Case 9 - Diagnosis: ·Spindle ceU lipoma, neck

T-Y0600, M-91501

Diresows Note: It may be lhnt Spindle cell lipoma will eventually be recognized as a morphologic variant of solitary fibrous tumorlhcmangiop(.'TiC}1om. (drc)

Case 9 References: Dal Cin P, Sciot R, Polto P, ct al. Lesions of 13<1 Mary Occur Independently of Deletion of 16q in Spindle Cell/ Pleomorphic

Lipomas. Histopatilo/1991; 31 (3):222-225. Oiaz.Cascajo C, Borghi Sand Weyers W. Fibrous SJ)indle Cell Lipoma .. Report of a New Variant. Am./ Dennatopatho1200J~

23(2): 11 2-115. Siddiqui MA, Su L, Michael CW and Pu RT . . Synchronous Ordinary Lipoma and Spindle-Cell Lipoma Diagnosed by Fine Needle

Aspiration. Diag11 Cytopatilo/2006; 34(6):455-456. Harvell JD. Multiple Spindle Cell Lipomas and Dennatotibrosarcoma Protubc-rans with a Single Patient. Evidence for u Common

Neoplastic Process of lntcrstitiol Dendritic Cells? JAm A cad Dermato/2003; 48( I ):82-85.

16 CTfll., April2007 "Minutes"' (Subscriplion A)

Sus1cr S, Nascimento AG, Mieuinen M. c:t al. Solitary Fibrous Tumors of Soft Tissue. A Clinic:opatl1ologic and lmmunohistcx:hcmical Study of 12 Cases. Am J Surg Pa1ho/ 1995; 19(1 1): 1257·1266.

Bnmnemann RB, Rojy Ordonez NG, ot al. E>tora-Plcunil Soli~ary Fibrous Tumor. A Clinicopadtologic Study of 24 Cases. Mod Pntlro/ 1999; 12(11):1034-1042.

Case No. 10, Accession No. 30152

Anahejm <Orange County Medical Center) .. Lciornyosal·como Bqldwjn Pmk lKaiser Permanentc) .. Leiomyosarcoma (4) ~ • Ll:iomyosorcoma C!oyis • l..ciomyos.arcoma vs. atypical leiomyoma Glendale • Pleomorphic leiomyosarcoma Hayward/Frqnont • Leiomyosarcoma l.oog Baeb C!,.ono Beach VA HO<!)i!Ail - Lctomyosarcoma (2) Los Aneelcs • Leiomyosarcoma Mgnterey Peninsula CCommunirv Hosnital o(Monterev Peninsula> - Leiomyosarcom:a Oakland • l.ciomyosarcoma Oakland fA!arnoda County Medical Ccmcr) .. Leiomyosofrcoma Sacn1mcoto lUC pavjs Medical Center> - Leiomyosarcoma San Djcgo .. Leiomyosarcoma Snn Djcgo CNnval Medical Center) .. Leiomyosarcoma San Djego (UCSDl - Smooth muscle rumor of undcnennined malignant potcmiul Sania Bprbam ~ Biz.arre leiomyoma Sarua Rosp CSanta Rosa.Mcmorial Hosnjtnl> .. Leiomyosarcoma (3) Sonoma CSoooma VaJJev Hospital\ • Leiomyosarcoma Woodland Hms - L<.-iomyosarcoma Alabama CBamist Medical Cc!ller) · l.ciomyosan:oma Arkansas CUnjyersitv of Arkansas for Mcdjca! Scjcns:esl - leiomyosarcoma, fOf'CDtm Colomdo. Ft. Collins - Leiomyosarcomtl f lorida CMunrgc Regional Mcsljcpl Centql .. Leiom)'osarcoma Gcqrgja Decatur .. Leiomyosarcomn Georgja <Wcllstllf Kennesrone Hospitall .. Leiomyosarcoma Illinois, llurr 1\jdgo - Pleomorphic rhabdomyosarcoma (I); Loiomyosorcomo (I) Illinois 01Pi!ol;:md Regional Medical Center) .. Leiomyosarcoma lmnois ll..gyo!a Universirv of Chicago) • lnlimal sarcoma Indiana CHowoN Regional Medical Center) .. Leiomyosarcoma Kansas (Cy!gsheck !.abora•OO', LLCJ - Lci<>myosarcoma vs. bizarre leiomyoma (1 ); l.ciomyosareoma (I) Kenrucky CUoj\-crsitv oflooisvillel • LeiomyosatCOma Marv1and CNor!hwe:n Hospiml) - leiomyosan:oma Mar; land <Unjymjsv of Maryland) - Leiomyosarroma Massaehu!ctts <Bcyqly HosnjtaD - Leiomyosarcoma Ma!\ychusctu. Peabodv • Leiomyosarcoma, rorcnrm Massachusetts {TuAs-Ne\v England Medicpl Ccorcr> - Leiomyosarcoma Michiean (Qqklnnd HosojtaD - Leiomyosni'(Oll13 M jchjgan (Pp!hology Services of West MjcbjgQn) ~ Leiomyosarcoma Minnesotp (fajryjew Rjdges Hosnilal\ - I..ciomyosnrcoma Mis~urj CMjssouri Delta Medical Centcrl - Malignant fibrous histiocytoma Montona (forensic Science Division) • Lciomyosnrcomo Ncbraslsq CCrejahton Unversitvl - Leiomyosarcoma ~ew Mc;xico Albuquerque - Le;omyowcoma New York Q.Jgssau University Mcdjgtl Cquer) - 8iz.arTe leiomyoma New york lS1ony Brook Universirt Hosoitnl> - Symplastjc leiomyoma New York <SUNy pownstate Medical Center) - Atypical leiomyoma Nonh Carol jna (Mountain Area Pathology> .. Pleomorphic malignant fibrous histiocytoma Ohio (McCullough-Hyde Memorial Hospiuall - Leiomyosarcoma Pcnnsylytmh\ <Drexel University College) • Leiomyosarcoma Pennsylyunjq CLchjgh Vallev Hospital) - Lciomyos.arcomo Pennsylyanjg <Mt Nittany Medical Ceo!er) - Leiomyosarcoma Pueno Rico CUnjversity of Puerto Rico) • Leiomyosarcoma South Dakma CLCM Regident~l - Pleomorphic k-iomyosarooma Texu, Cm11l Boac:h · Fibrous biStiocoyoma atypical subcu1a11cous T<.<"-', Hougon - Malignanllibrous hiSiiocytoma

CTrR, Aptol2007 "Minutes" (Subs<ription A)

April 2007

17

TexM. Lubbock - Leiomyosarcoma Texas fProPathl - Leiomyosarcoma Texas fSt. Lukes Episcooal Hospital) * Leiomyosarcoma Texas. Sugar L1nd - Leiomyosarcoma Washington <Seattle VA fvtedical C-enter) .. Leiomyosarcoma with cellular pleomorphism West Virginia <Greenbrier Valley Medical Center) - Proliferative myositis Wjsconsjn. Madison - L.eiomyos"rcoma Wi"sconsin <Meriter Hosoitall - Leiomyosarcoma Australia (North o·ueensland Palhology (')f()uri) - Pleomorphic leiomyosarcoma !\us!n•lja C&>Yiil Hobilrl Hospital! - Leiomyosarcoma Australia IRoval Prince Alfred Hosoital1 - Leiomyosarcoma (6), Smooth muscle tumor of uncertain malignant potential (I) Aus-tralia <Sullivarl Nicolaides Pathologv> - Leiomyosarcoma DUtzil (Laboratorio A.natomia PathoJogica Ec1iolog'ial - Leiomyosarcoma Canada {Pasqua Hospit81l - Leiomyosarcoma Can·oda (lJniversitv Hosnital ofSherbrookel - Leiomyosarcoma India. Knmataka - Chondroid chordoma Japan <Asashi General Hospital) .. Pleomorphic leiomyosarcoma Japan <Kyoto UniverSicy Hospital) - Leiomyosarcoma Oman <Khoula Hospjtal) - Leiomyosarcoma Oinar <Hamad Medical Corooration> • PleOmorphic -leiomyosarcoma Saudi Arabia (King Follad Notional Guard Hosnitall - Leiomyosarcoma Unjted Kjngdom <Oxford Study Group) - Leiomyosarcoma

Case I 0 - Diagnosis: Pleomorphic leiomyosarcoma, forearm

TCY8500, M-88903

Case 10 .. References: Odo Y Miyajima K, Kawaguchi K, et al. Pleomorphic Leiomyosarcoma. Clinicopathologic and lmmunohistOchetnical Srudy with

Special Emphasis on ltS'Oistinction from Ordinary Leiomyosarcoma and Malignant Fibrous Histiocytoma. Am./ Surg Pathof 2001; 25(8): 1030-1038.

Kaddu S, Beham A, Ccrroni L, ct a!. Cutaneous Leiomyosarcoma. Am J Surg PaJhoJ 1991; 2( 19):979-987. Cannier JN and Pollock R£. Soft 1lssue Sarcomas. Cl Cancer J Cli.n 2004; 54(2): 94-I 09

18 CTTR, Apri1 2007 "Minutes" (Subscription A)