socisoci corrispondenticorrispondenti soci/strasburger.pdf · 2019. 1. 31. · socisoci...

SociSociSociSoci corrispondenticorrispondenticorrispondenticorrispondenti

www.accademiapeloritana.it

Christian Joseph STRASBURGER

Vorst (currently Tönisvorst), November 6th, 1958 [email protected]

� Professor of Medicine, Charité Universitätsmedizin, Berlin, � Board certified specialist in internal medicine and endocrinology � II Classe: Socio Corrispondente (2017-).

• Attività e cariche pubbliche

• Attività culturali o Post-doctoral fellow of the Minerva Foundation (Max- Planck

Foundation) at the Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel (1986-1988)

o Editorial Board member: Pituitary Growth Hormone & IGF Research Growth Regulation since 1998

o Editor: European Journal of Endocrinology 1999-2007 o Editorial Council: Journal of Endocrinological Investigation since 2001 o Board of Governors, German National Anti-Doping

Agency (NADA) o Member of the Health-, Medicine- and Research committee of the World Anti

Doping Agency (WADA) o International member of the Italian National Scientific Habilitation

Commission, Abilitazione Scientifica Nationale, Settore Concorsuale: 06/D2 - Endocrinologia, Nefrologia e Scienze Della Alimentazione E Del Benessere

• Attività gestionali o Chief: Division of Clinical Endocrinology, Dept. of Medicine for

Endocrinology, Diabetes and Nutritional Medicine, Charité Universitätsmedizin, Berlin, Campus Mitte.(posizione presente)

o Ludwig-Maximilians-Universität Munich, Head of the Neuroendocrine Unit, Senior lecturer in Internal Medicine, Endocrinology, Consultant in Internal Medicine for the Innenstadt University Hospital (fino al 2002)

o Resident at the Dept. of Medicine, Medical University Lübeck, Germany (fino al 1990



• Premi e riconoscimenti o 1985 Doctoral thesis awarded with "summa cum laude" o 1986 Recipient of the Professor Otto Roth Award for the best

doctoral thesis at the Faculty of Clinical Medicine of the Medizinischen Universität zu Lübeck

o 1995 Recipient of the Jürgen Bierich Memorial Award, presented by the Association for Pediatric Endocrinology in Germany for the publication of: "Immunofunctional Assay of Human Growth Hormone (hGH) in Serum: A Possible Consensus for Quantitative hGH Measurement" by C.J. Strasburger, Z. Wu, C.-D. Pflaum, R. A. Dressendörfer

o 2000 Honorary Medal of the Dopingopfer-Hilfe e.V. (Society for the Support of Doping Victims), in recognition of the development of a method for the detection of growth hormone doping in sports.

o 2006 European Medal Award, Society for Endocrinology (UK)

• Adesione ad altre società di valenza culturale o European Society for Endocrinology (ESE) Endocrine Society (USA) o German Endocrine Society o German Society of Internal Medicine Growth Hormone Research Society o International Society for Insulin-like Growth Factor Research Pituitary

Society1997 - 2000 o Council member of the German Endocrine Society o President and organizer of the German Endocrine Society's year 2000 annual

meeting (joint meeting with the German Diabetes Association) in Munich, May 31 through June 3rd 2000, 6500 participants

o 1998 - 2012 Council member of the International Growth Hormone Research Society (GRS), 2008-2010 President of GRS

o 2005 Elected corresponding member European Society for Pediatric Endocrinology (ESPE)

• Profilo scientifico, con indicazione dei campi di interesse Pituitary disorders, structure-function relationship in peptide- and proteohormones and their receptors, physiology and clinical applications of growth hormone, GH antagonists, neuroendocrine regulation of energy homeostasis, stress hormones, abuse of hormones in sports, interaction between the hormones and immune systems, analytical methods for hormone determinations.More than 220 peer reviewed articles, more than 20 book chapters, H-index =50

• Elenco delle pubblicazioni • Schilbach K, Strasburger CJ, Bidlingmaier M. Biochemical investigations in

diagnosis and follow up of acromegaly. Pituitary. 2017 Feb 6. doi: 10.1007/s11102-017-0792-z. [Epub ahead of print] Review. PubMed PMID: 28168377.



• Hybsier S, Schulz T, Wu Z, Demuth I, Minich WB, Renko K, Rijntjes E, Köhrle J, Strasburger CJ, Steinhagen-Thiessen E, Schomburg L. Sex-specific and inter-individual differences in biomarkers of selenium status identified by a calibrated ELISA for selenoprotein P. Redox Biol. 2016 Dec 29;11:403-414. doi: 10.1016/j.redox.2016.12.025. [Epub ahead of print] PubMed PMID: 28064116; PubMed Central PMCID: PMC5220167.

• Strasburger CJ, Vanuga P, Payer J, Pfeifer M, Popovic V, Bajnok L, Góth M, Olšovská V, Trejbalová L, Vadasz J, Fima E, Koren R, Amitzi L, Bidlingmaier M, Hershkovitz O, Hart G, Biller BM. MOD-4023, a long-acting carboxy-terminal peptide-modified human growth hormone: results of a Phase 2 study in growth hormone-deficient adults. Eur J Endocrinol. 2017 Mar;176(3):283-294. doi:10.1530/EJE-16-0748. PubMed PMID: 27932411.

• Deutschbein T, Bidlingmaier M, Schopohl J, Strasburger CJ, Petersenn S. Anthropometric factors have significant influence on the outcome of the GHRH-arginine test: establishment of normative data for an automated immunoassay specifically measuring 22 kDa human growth hormone. Eur J Endocrinol. 2017 Mar;176(3):273-281. doi: 10.1530/EJE-16-0668. PubMed PMID: 27932410.

• Kreitschmann-Andermahr I, Buchfelder M, Kleist B, Kohlmann J, Menzel C, Buslei R, Kołtowska-Häggsträm M, Strasburger C, Siegel S. PREDICTORS OF QUALITY OF LIFE IN 165 PATIENTS WITH ACROMEGALY: RESULTS FROM A SINGLE-CENTER STUDY. Endocr Pract. 2017 Jan;23(1):79-88. doi: 10.4158/EP161373.OR. PubMed PMID: 27749131.

• Glaudo M, Letz S, Quinkler M, Bogner U, Elbelt U, Strasburger CJ, Schnabel D, Lankes E, Scheel S, Feldkamp J, Haag C, Schulze E, Frank-Raue K, Raue F, Mayr B, Schöfl C. Heterozygous inactivating CaSR mutations causing neonatal hyperparathyroidism: function, inheritance and phenotype. Eur J Endocrinol. 2016 Nov;175(5):421-31. doi: 10.1530/EJE-16-0223. PubMed PMID: 27666534.

• Christiansen JS, Backeljauw PF, Bidlingmaier M, Biller BM, Boguszewski MC, Casanueva FF, Chanson P, Chatelain P, Choong CS, Clemmons DR, Cohen LE, Cohen P, Frystyk J, Grimberg A, Hasegawa Y, Haymond MW, Ho K, Hoffman AR, Holly JM,Horikawa R, Höybye C, Jorgensen JO, Johannsson G, Juul A, Katznelson L, Kopchick JJ, Lee KO, Lee KW, Luo X, Melmed S, Miller BS, Misra M, Popovic V, Rosenfeld RG, Ross J, Ross RJ, Saenger P, Strasburger CJ, Thorner MO, Werner H, Yuen K. Growth Hormone Research Society perspect ive on the development of long-acting growth hormone preparations. Eur J Endocrinol. 2016 Jun;174(6):C1-8. doi: 10.1530/EJE-16-0111. PubMed PMID: 27009113; PubMed Central PMCID: PMC5081743.

• Janssen JA, Hofland LJ, Strasburger CJ, van den Dungen ES, Thevis M. Potency of Full-Length MGF to Induce Maximal Activation of the IGF-I R Is Similar toRecombinant Human IGF-I at High Equimolar Concentrations. PLoS One. 2016 Mar18;11(3):e0150453. doi: 10.1371/journal.pone.0150453. PubMed PMID: 26991004; PubMed Central PMCID: PMC4798685.

• Strasburger CJ, Karavitaki N, Störmann S, Trainer PJ, Kreitschmann-Andermahr I, Droste M, Korbonits M, Feldmann B, Zopf K, Sanderson VF, Schwicker D, Gelbaum D, Haviv A, Bidlingmaier M, Biermasz NR. Patient-reported outcomes of



parenteral somatostatin analogue injections in 195 patients with acromegaly. Eur J Endocrinol. 2016 Mar;174(3):355-62. doi: 10.1530/EJE-15-1042. PubMed PMID: 26744896; PubMed Central PMCID: PMC4722610.

• Kreitschmann-Andermahr I, Siegel S, Kleist B, Kohlmann J, Starz D, Buslei R, Koltowska-Häggström M, Strasburger CJ, Buchfelder M. Diagnosis and management of acromegaly: the patient's perspective. Pituitary. 2016 Jun;19(3):268-76. doi: 10.1007/s11102-015-0702-1. PubMed PMID: 26742496.

• Jumpertz von Schwartzenberg R, Elbelt U, Ventz M, Mai K, Kienitz T, Maurer L, Rose T, Rückert JC, Strasburger CJ, Spranger J. Palliative treatment ofuncontrollable hypercalcemia due to parathyrotoxicosis: denosumab as rescue therapy. Endocrinol Diabetes Metab Case Rep. 2015;2015:150082. doi: 10.1530/EDM-15-0082. PubMed PMID: 26605043; PubMed Central PMCID: PMC4653612.

• Allen DB, Backeljauw P, Bidlingmaier M, Biller BM, Boguszewski M, Burman P, Butler G, Chihara K, Christiansen J, Cianfarani S, Clayton P, Clemmons D, Cohen P, Darendeliler F, Deal C, Dunger D, Erfurth EM, Fuqua JS, Grimberg A, Haymond M,Higham C, Ho K, Hoffman AR, Hokken-Koelega A, Johannsson G, Juul A, Kopchick J,Lee P, Pollak M, Radovick S, Robison L, Rosenfeld R, Ross RJ, Savendahl L,Saenger P, Toft Sorensen H, Stochholm K, Strasburger C, Swerdlow A, Thorner M. GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults. Eur J Endocrinol. 2016 Feb;174(2):P1-9. doi: 10.1530/EJE-15-0873. PubMed PMID: 26563978; PubMed Central PMCID: PMC4674592.

• Pleil A, van der Lely AJ, Badia X, Brue T, Buchfelder M, Burman P, Ghigo E, Gomez R, Jorgensen JO, Luger A, van der Lans-Bussemaker J, Webb S, Strasburger C.Development of a Prediction Model of Disease Activity in Support of ClinicalPractice - the Acrodat Experience. Value Health. 2015 Nov;18(7):A708. doi:10.1016/j.jval.2015.09.2664. PubMed PMID: 26533969.

• Honegger J, Schlaffer S, Menzel C, Droste M, Werner S, Elbelt U, Strasburger C, Störmann S, Küppers A, Streetz-van der Werf C, Deutschbein T, Stieg M,Rotermund R, Milian M, Petersenn S; Pituitary Working Group of the German Societyof Endocrinology.. Diagnosis of Primary Hypophysitis in Germany. J Clin Endocrinol Metab. 2015 Oct;100(10):3841-9. doi: 10.1210/jc.2015-2152. PubMed PMID: 26262437.

• Hernández-Ramírez LC, Gabrovska P, Dénes J, Stals K, Trivellin G, Tilley D,Ferrau F, Evanson J, Ellard S, Grossman AB, Roncaroli F, Gadelha MR, Korbonits M;International FIPA Consortium.. Landscape of Familial Isolated and Young-OnsetPituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers. J ClinEndocrinol Metab. 2015 Sep;100(9):E1242-54. PubMed PMID: 26186299; PubMed Central PMCID: PMC4570169.

• Elbelt U, Ahnis A, Riedl A, Burkert S, Schuetz T, Ordemann J, Strasburger CJ, Klapp BF. Associations of physical activity with depressiveness and coping in subjects with high-grade obesity aiming at bariatric surgery: a cross-sectional study. Biopsychosoc Med. 2015 Jun 25;9:16. doi: 10.1186/s13030-015-0042-4. PubMed PMID: 26110016; PubMed Central PMCID: PMC4479107.



• Honegger J, Buchfelder M, Schlaffer S, Droste M, Werner S, Strasburger C,Störmann S, Schopohl J, Kacheva S, Deutschbein T, Stalla G, Flitsch J, Milian M, Petersenn S, Elbelt U; Pituitary Working Group of the German Society ofEndocrinology.. Treatment of Primary Hypophysitis in Germany. J Clin EndocrinolMetab. 2015 Sep;100(9):3460-9. doi: 10.1210/jc.2015-2146. PubMed PMID: 26091204.

• Ebinger M, Ipsen N, Leonards CO, Empl L, Hanne L, Liman T, Mai K, Strasburger CJ, Spranger J, Endres M. Circulating insulin-like growth factor binding protein-3 predicts one-year outcome after ischemic stroke. Exp Clin Endocrinol Diabetes. 2015 Sep;123(8):461-5. doi: 10.1055/s-0035-1554632. PubMed PMID: 26069074.

• Junnila RK, Strasburger CJ, Bidlingmaier M. Pitfalls of insulin-like growth factor-i and growth hormone assays. Endocrinol Metab Clin North Am. 2015 Mar;44(1):27-34. doi: 10.1016/j.ecl.2014.10.003. Review. PubMed PMID: 25732639.

• Melmed S, Popovic V, Bidlingmaier M, Mercado M, van der Lely AJ, Biermasz N, Bolanowski M, Coculescu M, Schopohl J, Racz K, Glaser B, Goth M, Greenman Y, Trainer P, Mezosi E, Shimon I, Giustina A, Korbonits M, Bronstein MD, Kleinberg D, Teichman S, Gliko-Kabir I, Mamluk R, Haviv A, Strasburger C. Safety and efficacy of oral octreotide in acromegaly: results of a multicenter phase III trial. J Clin Endocrin ol Metab. 2015 Apr;100(4):1699-708. doi: 10.1210/jc.2014-4113. PubMed PMID: 25664604.

• Schöfl C, Grussendorf M, Honegger J, Tönjes A, Thyroke-Gronostay D, Mayr B, Schopohl J; participants of German Acromegaly Register.. Failure to achieve disease control in acromegaly: cause analysis by a registry-based survey. Eur JEndocrinol. 2015 Apr;172(4):351-6. doi: 10.1530/EJE-14-0844. PubMed PMID: 25599707.

• Schopohl J, Gu F, Rubens R, Van Gaal L, Bertherat J, Ligueros-Saylan M, Trovato A, Hughes G, Salgado LR, Boscaro M, Pivonello R; Pasireotide B2305 Study Group.. Pasireotide can induce sustained decreases in urinary cortisol and provide clinical benefit in patients with Cushing's disease: results from an open-ended, open-label extension trial. Pituitary. 2015 Oct;18(5):604-12. doi: 10.1007/s11102-014-0618-1. PubMed PMID: 25537481; PubMed Central PMCID: PMC4560758.

• Sandow N, Klene W, Elbelt U, Strasburger CJ, Vajkoczy P. Intraoperative indocyanine green videoangiography for identification of pituitary adenomas using a microscopic transsphenoidal approach. Pituitary. 2015 Oct;18(5):613-20. doi: 10.1007/s11102-014-0620-7. PubMed PMID: 25492407.

• Hübener C, Bidlingmaier M, Wu Z, Diebold J, Delius M, Friese K, Strasburger CJ, Hasbargen U. Human placental growth hormone: a potential new biomarker in gestational trophoblastic disease. Gynecol Oncol. 2015 Feb;136(2):264-8. doi: 10.1016/j.ygyno.2014.11.077. PubMed PMID: 25448485.

• Mo D, Blum WF, Rosilio M, Webb SM, Qi R, Strasburger CJ. Ten-year change in quality of life in adults on growth hormone replacement for growth hormone deficiency: an analysis of the hypopituitary control and complications study. J Clin



Endocrinol Metab. 2014 Dec;99(12):4581-8. doi: 10.1210/jc.2014-2892. PubMed PMID: 25233155.

• Lehmphul I, Brabant G, Wallaschofski H, Ruchala M, Strasburger CJ, Köhrle J, Wu Z. Detection of 3,5-diiodothyronine in sera of patients with altered thyroid status using a new monoclonal antibody-based chemiluminescence immunoassay. Thyroid. 2014 Sep;24(9):1350-60. doi: 10.1089/thy.2013.0688. PubMed PMID: 24967815.

• Droste M, Domberg J, Buchfelder M, Mann K, Schwanke A, Stalla G, Strasburger CJ. Therapy of acromegalic patients exacerbated by concomitant type 2 diabetes requires higher pegvisomant doses to normalise IGF1 levels. Eur J Endocrinol. 2014 Jul;171(1):59-68. doi: 10.1530/EJE-13-0438. Erratum in: Eur J Endocrinol. 2014 Dec;171(6):X5. PubMed PMID: 24913198.

• Giustina A, Chanson P, Kleinberg D, Bronstein MD, Clemmons DR, Klibanski A, van der Lely AJ, Strasburger CJ, Lamberts SW, Ho KK, Casanueva FF, Melmed S; Acromegaly Consensus Group.. Expert consensus document: A consensus on the medical treatment of acromegaly. Nat Rev Endocrinol. 2014 Apr;10(4):243-8. doi: 10.1038/nrendo.2014.21. Review. PubMed PMID: 24566817.

• Pivonello R, Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M, Trovato A, Hughes G, Salgado LR, Lacroix A, Schopohl J, Biller BM; Pasireotide B2305 Study Group.. Pasireotide treatment significantly improves clinical signsand symptoms in patients with Cushing's disease: results from a Phase III study. Clin Endocrinol (Oxf). 2014 Sep;81(3):408-17. doi: 10.1111/cen.12431. PubMed PMID: 24533697.

• Clemmons DR, Molitch M, Hoffman AR, Klibanski A, Strasburger CJ, Kleinberg DL, Ho K, Webb SM, Bronstein MD, Bouillon R, Ben-Shlomo A, Hamrahian AH, Chanson P, Barkan AL, Merriam GR, Blackman MR, Salvatori R. Growth hormone should be used only for approved indications. J Clin Endocrinol Metab. 2014 Feb;99(2):409-11. doi: 10.1210/jc.2013-4187. PubMed PMID: 24423315.

• Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M, Sen K, Salgado LR, Colao A, Biller BM; Pasireotide B2305 Study Group.. High variability in baseline urinary free cortisol values in patients with Cushing's disease. Clin Endocrinol (Oxf). 2014 Feb;80(2):261-9. doi: 10.1111/cen.12259. PubMed PMID: 23746264; PubMed Central PMCID: PMC4231220.

• Junnila RK, Wu Z, Strasburger CJ. The role of human growth hormone's C-terminal disulfide bridge. Growth Horm IGF Res. 2013 Jun;23(3):62-7. doi: 10.1016/j.ghir.2013.02.002. PubMed PMID: 23478141.

• Schöfl C, Franz H, Grussendorf M, Honegger J, Jaursch-Hancke C, Mayr B, Schopohl J; participants of the German Acromegaly Register.. Long-term outcome in patients with acromegaly: analysis of 1344 patients from the German Acromegaly Register. Eur J Endocrinol. 2012 Dec 10;168(1):39-47. doi: 10.1530/EJE-12-0602. PubMed PMID: 23087126.

• Biller BM, Ji HJ, Ahn H, Savoy C, Siepl EC, Popovic V, Coculescu M, Roemmler J, Gavrila C, Cook DM, Strasburger CJ. 12-month effects of once-weekly sustained-release growth hormone treatment in adults with GH deficiency.



Pituitary. 2013 Sep;16(3):311-8. doi: 10.1007/s11102-012-0422-8. PubMed PMID: 22915288.

• Manolopoulou J, Alami Y, Petersenn S, Schopohl J, Wu Z, Strasburger CJ, Bidlingmaier M. Automated 22-kD growth hormone-specific assay without interference from Pegvisomant. Clin Chem. 2012 Oct;58(10):1446-56. PubMed PMID: 22908135.

• Melmed S, Casanueva FF, Klibanski A, Bronstein MD, Chanson P, Lamberts SW, Strasburger CJ, Wass JA, Giustina A. A consensus on the diagnosis and treatment of acromegaly complications. Pituitary. 2013 Sep;16(3):294-302. doi:10.1007/s11102-012-0420-x. PubMed PMID: 22903574; PubMed Central PMCID: PMC3730092.

• Kroiss M, Quinkler M, Johanssen S, van Erp NP, Lankheet N, Pöllinger A, Laubner K, Strasburger CJ, Hahner S, Müller HH, Allolio B, Fassnacht M. Sunitinib in refractory adrenocortical carcinoma: a phase II, single-arm, open-label trial.J Clin Endocrinol Metab. 2012 Oct;97(10):3495-503. doi: 10.1210/jc.2012-1419. PubMed PMID: 22837187.

• Barroso O, Handelsman DJ, Strasburger C, Thevis M. Analytical challenges in the detection of peptide hormones for anti-doping purposes. Bioanalysis. 2012 Jul;4(13):1577-90. doi: 10.4155/bio.12.128. Review. PubMed PMID: 22831474.

• Tuvia S, Atsmon J, Teichman SL, Katz S, Salama P, Pelled D, Landau I, Karmelin I, Bidlingmaier M, Strasburger CJ, Kleinberg DL, Melmed S, Mamluk R. Oral octreotide absorption in human subjects: comparable pharmacokinetics toparenteral octreotide and effective growth hormone suppression. J Clin Endocrinol Metab. 2012 Jul;97(7):2362-9. doi: 10.1210/jc.2012-1179. PubMed PMID: 22539587.

• Carpenter B, Hemsworth GR, Wu Z, Maamra M, Strasburger CJ, Ross RJ, Artymiuk PJ. Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody. Structure. 2012 Mar 7;20(3):487-97. doi: 10.1016/j.str.2012.01.019. PubMed PMID: 22405007.

• Colao A, Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M, Schoenherr U, Mills D, Salgado LR, Biller BM; Pasireotide B2305 Study Group.. A 12-month phase 3 study of pasireotide in Cushing's disease. N Engl J Med. 2012 Mar 8;366(10):914-24. doi: 10.1056/NEJMoa1105743. Erratum in: N Engl J Med. 2012 Aug 23;367(8):780. PubMed PMID: 22397653.

• van der Lely AJ, Biller BM, Brue T, Buchfelder M, Ghigo E, Gomez R, Hey-Hadavi J, Lundgren F, Rajicic N, Strasburger CJ, Webb SM, Koltowska-Häggström M. Long-term safety of pegvisomant in patients with acromegaly: comprehensive review of 1288 subjects in ACROSTUDY. J Clin Endocrinol Metab. 2012 May;97(5):1589-97. doi: 10.1210/jc.2011-2508. PubMed PMID: 22362824.

• Hartleb S, Plöckinger U, Stalla GK, Tuschy U, Weber MM, Pfützner A, Kann PH; German KIMS Board.; German KIMS Pharmacogenetics Study Group.. Additive effect of GHRd3 and COLIA1 polymorphisms on the GH-substitution dose in GH-deficient adults. Pharmacogenomics. 2011 Dec;12(12):1653-61. doi: 10.2217/pgs.11.113. PubMed PMID: 22026923.



• Romijn JA, Strasburger CJ. The European Journal of Endocrinology: changing of the guard. Eur J Endocrinol. 2011 Oct;165(4):489-90. doi: 10.1530/EJE-11-0726. PubMed PMID: 21957122.

• Valassi E, Santos A, Yaneva M, Tóth M, Strasburger CJ, Chanson P, Wass JA, Chabre O, Pfeifer M, Feelders RA, Tsagarakis S, Trainer PJ, Franz H, Zopf K,Zacharieva S, Lamberts SW, Tabarin A, Webb SM; ERCUSYN Study Group.. The European Registry on Cushing's syndrome: 2-year experience. Baseline demographic and clinical characteristics. Eur J Endocrinol. 2011 Sep;165(3):383-92. doi: 10.1530/EJE-11-0272. PubMed PMID: 21715416.

• Francis F, Burger I, Poll EM, Reineke A, Strasburger CJ, Dohmen G, Gilsbach JM, Kreitschmann-Andermahr I. Can cardiac surgery cause hypopituitarism? Pituitary. 2012 Mar;15(1):30-6. doi: 10.1007/s11102-011-0322-3. PubMed PMID: 21706189.

• Attanasio AF, Jung H, Mo D, Chanson P, Bouillon R, Ho KK, Lamberts SW, Clemmons DR; HypoCCS International Advisory Board.. Prevalence and incidence of diabetes mellitus in adult patients on growth hormone replacement for growth hormone deficiency: a surveillance database analysis. J Clin Endocrinol Metab. 2011 Jul;96(7):2255-61. doi: 10.1210/jc.2011-0448. PubMed PMID: 21543424.

• Hoefig CS, Köhrle J, Brabant G, Dixit K, Yap B, Strasburger CJ, Wu Z. Evidence for extrathyroidal formation of 3-iodothyronamine in humans as provided by a novel monoclonal antibody-based chemiluminescent serum immunoassay. J Clin Endocrinol Metab. 2011 Jun;96(6):1864-72. doi: 10.1210/jc.2010-2680. PubMed PMID:21490071.

• Bielohuby M, Sawitzky M, Stoehr BJ, Stock P, Menhofer D, Ebensing S, Bjerre M, Frystyk J, Binder G, Strasburger C, Wu Z, Christ B, Hoeflich A, Bidlingmaier M. Lack of dietary carbohydrates induces hepatic growth hormone (GH) resistance in rats. Endocrinology. 2011 May;152(5):1948-60. doi: 10.1210/en.2010-1423. PubMed PMID: 21427215.

• Biller BM, Ji HJ, Ahn H, Savoy C, Siepl EC, Popovic V, Coculescu M, Roemmler J, Gavrila C, Cook DM, Strasburger CJ. Effects of once-weekly sustained-release growth hormone: a double-blind, placebo-controlled study in adult growth hormone deficiency. J Clin Endocrinol Metab. 2011 Jun;96(6):1718-26. doi: 10.1210/jc.2010-2819. PubMed PMID: 21411551.

• Schopohl J, Strasburger CJ, Caird D, Badenhoop K, Beuschlein F, Droste M, Plöckinger U, Petersenn S; German Lanreotide Study Group.. Efficacy and acceptability of lanreotide Autogel® 120 mg at different dose intervals inpatients with acromegaly previously treated with octreotide LAR. Exp Clin Endocrinol Diabetes. 2011 Mar;119(3):156-62. doi: 10.1055/s-0030-1267244. PubMed PMID: 21086246.

• Elbelt U, Schuetz T, Hoffmann I, Pirlich M, Strasburger CJ, Lochs H.Differences of energy expenditure and physical activity patterns in subjects with various degrees of obesity. Clin Nutr. 2010 Dec;29(6):766-72. doi: 10.1016/j.clnu.2010.05.003. PubMed PMID: 20627487.



• Lima GA, Gadelha MR, Strasburger CJ, Wu Z. Serum levels of 20K-hGH and 22K-hGH isoforms in acromegalic patients. Front Horm Res. 2010;38:87-93. doi: 10.1159/000318498. Review. PubMed PMID: 20616499.

• Ferrandis E, Pradhananga SL, Touvay C, Kinoshita C, Wilkinson IR, Stafford K, Wu Z, Strasburger CJ, Sayers JR, Artymiuk PJ, Ross RJ. Immunogenicity, toxicology, pharmacokinetics and pharmacodynamics of growth hormone ligand-receptor fusions. Clin Sci (Lond). 2010 Aug 17;119(11):483-91. doi: 10.1042/CS20100241. PubMed PMID: 20597861.

• Igreja S, Chahal HS, King P, Bolger GB, Srirangalingam U, Guasti L, Chapple JP, Trivellin G, Gueorguiev M, Guegan K, Stals K, Khoo B, Kumar AV, Ellard S, Grossman AB, Korbonits M; International FIPA Consortium.. Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families. Hum Mutat. 2010 Aug;31(8):950-60. doi: 10.1002/humu.21292. PubMed PMID: 20506337; PubMed Central PMCID: PMC3065644.

• Berg C, Petersenn S, Lahner H, Herrmann BL, Buchfelder M, Droste M, Stalla GK, Strasburger CJ, Roggenbuck U, Lehmann N, Moebus S, Jöckel KH, Möhlenkamp S, Erbel R, Saller B, Mann K; Investigative Group of the Heinz Nixdorf Recall Study and the German Pegvisomant Observational Study Board and Investigators.. Cardiovascular risk factors in patients with uncontrolled and long-term acromegaly: comparison with matched data from the general population and the effect of disease control. J Clin Endocrinol Metab. 2010 Aug;95(8):3648-56. doi: 10.1210/jc.2009-2570. PubMed PMID: 20463098.

• Wu Z, Devany E, Balarini G, Junnila R, Bidlingmaier M, Strasburger CJ. Specific monoclonal antibodies and ultrasensitive immunoassays for 20K and 22K human growth hormone. Growth Horm IGF Res. 2010 Jun;20(3):239-44. doi:10.1016/j.ghir.2010.02.006. PubMed PMID: 20304691.

• Sievers C, Brübach K, Saller B, Schneider HJ, Buchfelder M, Droste M, Mann K,Strasburger CJ, Stalla GK; German Pegvisomant Investigators.. Change of symptoms and perceived health in acromegalic patients on pegvisomant therapy: a retrospective cohort study within the German Pegvisomant Observational Study (GPOS). Clin Endocrinol (Oxf). 2010 Jul;73(1):89-94. doi: 10.1111/j.1365-2265.2009.03773.x. PubMed PMID: 20050861.

• Webb SM, Mo D, Lamberts SW, Melmed S, Cavagnini F, Pecori Giraldi F, Strasburger CJ, Zimmermann AG, Woodmansee WW; International HypoCCS AdvisoryBoard.. Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. J Clin Endocrinol Metab. 2010 Feb;95(2):630-8. doi: 10.1210/jc.2009-0806. PubMed PMID: 20022992.

• Bidlingmaier M, Strasburger CJ. Growth hormone. Handb Exp Pharmacol. 2010;(195):187-200. doi: 10.1007/978-3-540-79088-4_8. Review. PubMed PMID: 20020365.

• Lepenies J, Wu Z, Stewart PM, Strasburger CJ, Quinkler M. IGF-1, IGFBP-3 and mALS in adult patients with chronic kidney disease. Growth Horm IGF Res. 2010 Apr;20(2):93-100. doi: 10.1016/j.ghir.2009.10.002. PubMed PMID: 19932629.



• Lima GA, Wu Z, Silva CM, Barbosa FR, Dias JS, Schrank Y, Strasburger CJ, Gadelha MR. Growth hormone isoforms in acromegalic patients before and after treatment with octreotide LAR. Growth Horm IGF Res. 2010 Apr;20(2):87-92. doi:10.1016/j.ghir.2009.10.001. PubMed PMID: 19884028.

• Buchfelder M, Schlaffer S, Droste M, Mann K, Saller B, Brübach K, Stalla GK, Strasburger CJ; German Pegvisomant Observational Study.. The German ACROSTUDY:past and present. Eur J Endocrinol. 2009 Nov;161 Suppl 1:S3-S10. doi: 10.1530/EJE-09-0350. PubMed PMID: 19684061.

• Woodmansee WW, Hartman ML, Lamberts SW, Zagar AJ, Clemmons DR; International HypoCCS Advisory Board.. Occurrence of impaired fasting glucose in GH-deficient adults receiving GH replacement compared with untreated subjects. Clin Endocrinol(Oxf). 2010 Jan;72(1):59-69. doi: 10.1111/j.1365-2265.2009.03612.x. PubMed PMID: 19438908.

• Trainer PJ, Ezzat S, D'Souza GA, Layton G, Strasburger CJ. A randomized, controlled, multicentre trial comparing pegvisomant alone with combinationtherapy of pegvisomant and long-acting octreotide in patients with acromegaly.Clin Endocrinol (Oxf). 2009 Oct;71(4):549-57. doi:10.1111/j.1365-2265.2009.03620.x. PubMed PMID: 19438906.

• Buchfelder M, Weigel D, Droste M, Mann K, Saller B, Brübach K, Stalla GK,Bidlingmaier M, Strasburger CJ; Investigators of German Pegvisomant ObservationalStudy.. Pituitary tumor size in acromegaly during pegvisomant treatment:experience from MR re-evaluations of the German Pegvisomant Observational Study. Eur J Endocrinol. 2009 Jul;161(1):27-35. doi: 10.1530/EJE-08-0910. PubMed PMID: 19411302.

• Petersenn S, Buchfelder M, Gerbert B, Franz H, Quabbe HJ, Schulte HM, Grussendorf M, Reincke M; Participants of the German Acromegaly Register.. Ageand sex as predictors of biochemical activity in acromegaly: analysis of 1485 patients from the German Acromegaly Register. Clin Endocrinol (Oxf). 2009Sep;71(3):400-5. doi: 10.1111/j.1365-2265.2009.03547.x. PubMed PMID: 19226273.

• Kienitz T, Allolio B, Strasburger CJ, Quinkler M. Sex-specific regulation of ENaC and androgen receptor in female rat kidney. Horm Metab Res. 2009May;41(5):356-62. doi: 10.1055/s-0029-1192033. PubMed PMID: 19224431.

• Melmed S, Colao A, Barkan A, Molitch M, Grossman AB, Kleinberg D, Clemmons D,Chanson P, Laws E, Schlechte J, Vance ML, Ho K, Giustina A; Acromegaly Consensus Group.. Guidelines for acromegaly management: an update. J Clin Endocrinol Metab. 2009 May;94(5):1509-17. doi: 10.1210/jc.2008-2421. Review. PubMed PMID: 19208732.

• Bidlingmaier M, Suhr J, Ernst A, Wu Z, Keller A, Strasburger CJ, Bergmann A. High-sensitivity chemiluminescence immunoassays for detection of growth hormonedoping in sports. Clin Chem. 2009 Mar;55(3):445-53. doi: 10.1373/clinchem.2008.112458. PubMed PMID: 19168559.

• Berg CA, Pokrajac A, Bidlingmaier M, Strasburger CJ, Shalet SM, Trainer PJ.Use of a GH receptor antagonist (GHRA) to explore the relationship between GH



andIGF-I in adults with severe GH deficiency (GHD). Clin Endocrinol (Oxf). 2009Mar;70(3):439-45. doi: 10.1111/j.1365-2265.2008.03481.x. PubMed PMID: 19067728.

• Webb SM, Strasburger CJ, Mo D, Hartman ML, Melmed S, Jung H, Blum WF,Attanasio AF; HypoCCS International Advisory Board.. Changing patterns of theadult growth hormone deficiency diagnosis documented in a decade-long globalsurveillance database. J Clin Endocrinol Metab. 2009 Feb;94(2):392-9. doi:10.1210/jc.2008-0713. PubMed PMID: 19001512.

• Petersenn S, Buchfelder M, Reincke M, Strasburger CM, Franz H, Lohmann R,Quabbe HJ, Plöckinger U; Participants of the German Acromegaly Register.. Resultsof surgical and somatostatin analog therapies and their combination in acromegaly: a retrospective analysis of the German Acromegaly Register. Eur JEndocrinol. 2008 Nov;159(5):525-32. doi: 10.1530/EJE-08-0498. PubMed PMID:18755874.

• Konopelska S, Kienitz T, Hughes B, Pirlich M, Bauditz J, Lochs H, Strasburger CJ, Stewart PM, Quinkler M. Hepatic 11beta-HSD1 mRNA expression in fatty liver and nonalcoholic steatohepatitis. Clin Endocrinol (Oxf). 2009 Apr;70(4):554-60.doi: 10.1111/j.1365-2265.2008.03358.x. PubMed PMID: 18665910.

• Webb SM, Badia X, Barahona MJ, Colao A, Strasburger CJ, Tabarin A, van Aken MO, Pivonello R, Stalla G, Lamberts SW, Glusman JE. Evaluation of health-related quality of life in patients with Cushing's syndrome with a new questionnaire. EurJ Endocrinol. 2008 May;158(5):623-30. doi: 10.1530/EJE-07-0762. PubMed PMID:18426820.

• Faust M, Strasburger CJ. [Growth hormone therapy in adults. Attempt to assessa decade of use]. Internist (Berl). 2008 May;49(5):527-8, 530-2, 534 passim. doi:10.1007/s00108-008-2140-x. Review. German. PubMed PMID: 18418567.

• Quinkler M, Hahner S, Wortmann S, Johanssen S, Adam P, Ritter C, Strasburger C, Allolio B, Fassnacht M. Treatment of advanced adrenocortical carcinoma with erlotinib plus gemcitabine. J Clin Endocrinol Metab. 2008 Jun;93(6):2057-6 2. doi:10.1210/jc.2007-2564. Erratum in: J Clin Endocrinol Metab. 2008 Aug;93(8):3230.Ritte, Christian [corrected to Ritter, Christian]. PubMed PMID: 18334586.

• Brenner N, Kopetschke R, Ventz M, Strasburger CJ, Quinkler M, Gerl H. Cushing's syndrome due to ACTH-secreting pheochromocytoma. Can J Urol. 2008 Feb;15(1):3924-7. PubMed PMID: 18304406.

• Strasburger CJ. New endocrine replacement regimens. Horm Res. 2007;68 Suppl 5:177. doi: 10.1159/000110619. PubMed PMID: 18174741.

• Strasburger CJ, Buchfelder M, Droste M, Mann K, Stalla GK, Saller B; German Pegvisomant Investigators.. Experience from the German pegvisomant observational study. Horm Res. 2007;68 Suppl 5:70-3. doi: 10.1159/000110481. PubMed PMID:18174713.

• Laron Z, Bidlingmaier M, Strasburger CJ. Indications, limitations and pitfalls in the determination of human growth hormone, IGF-I and their bindingproteins.



Pediatr Endocrinol Rev. 2007 Oct;5 Suppl 1:555-69. Review. PubMed PMID: 18167466.

• Konopelska S, Quinkler M, Strasburger CJ, Ventz M. Difficulties in the medical treatment of prolactinoma in a patient with schizophrenia--a case report with a review of the literature. J Clin Psychopharmacol. 2008 Feb;28(1):120-2.doi: 10.1097/jcp.0b013e3181603f8f. Review. PubMed PMID: 18204364.

• van der Klaauw AA, Kienitz T, Strasburger CJ, Smit JW, Romijn JA. Malignant pituitary corticotroph adenomas: report of two cases and a comprehensive review of the literature. Pituitary. 2009;12(1):57-69. doi: 10.1007/s11102-007-0080-4. Review. PubMed PMID: 18176844.

• Arafat AM, Möhlig M, Weickert MO, Perschel FH, Purschwitz J, Spranger J, Strasburger CJ, Schöfl C, Pfeiffer AF. Growth hormone response during oralglucose tolerance test: the impact of assay method on the estimation of reference values in patients with acromegaly and in healthy controls, and the role of gender, age, and body mass index. J Clin Endocrinol Metab. 2008 Apr;93(4):1254-62. doi: 10.1210/jc.2007-2084. PubMed PMID: 18171702.

• Radetti G, Wu Z, Elsedfy HH, El Kholy M, Bozzola M, Strasburger CJ. Pegvisomant-primed GH stimulation test. Clin Endocrinol (Oxf). 2008 Jun;68(6):951-6. PubMed PMID: 18031320.

• Bidlingmaier M, Strasburger CJ. Technology insight: detecting growth hormone abuse in athletes. Nat Clin Pract Endocrinol Metab. 2007 Nov;3(11):769-77. Review. PubMed PMID: 17955018.

• Wiegand S, Richardt A, Remer T, Wudy SA, Tomlinson JW, Hughes B, Grüters A, Stewart PM, Strasburger CJ, Quinkler M. Reduced 11beta-hydroxysteroid dehydrogenase type 1 activity in obese boys. Eur J Endocrinol. 2007Sep;157(3):319-24. PubMed PMID: 17766714.

• Wilkinson IR, Ferrandis E, Artymiuk PJ, Teillot M, Soulard C, Touvay C, Pradhananga SL, Justice S, Wu Z, Leung KC, Strasburger CJ, Sayers JR, Ross RJ. A ligand-receptor fusion of growth hormone forms a dimer and is a potentlong-acting agonist. Nat Med. 2007 Sep;13(9):1108-13. PubMed PMID: 17721547.

• Strasburger CJ, Wu Z, Bidlingmaier M. hGH-abuse in athletes. Ann Endocrinol(Paris). 2007 Sep;68(4):306-7. PubMed PMID: 17651684.

• Quinkler M, Strelow F, Pirlich M, Rohde W, Biering H, Lochs H, Gerl H, Strasburger CJ, Ventz M. Assessment of suspected insulinoma by 48-hour fasting test: a retrospective monocentric study of 23 cases. Horm Metab Res. 2007 Jul;39(7):507-10. PubMed PMID: 17611903.

• Kienitz T, Quinkler M, Strasburger CJ, Ventz M. Long-term management in five cases of TSH-secreting pituitary adenomas: a single center study and review ofthe literature. Eur J Endocrinol. 2007 Jul;157(1):39-46. Review. PubMed PMID:17609400.

• Keller A, Wu Z, Kratzsch J, Keller E, Blum WF, Kniess A, Preiss R, Teichert J, Strasburger CJ, Bidlingmaier M. Pharmacokinetics and pharmacodynamics of GH:dependence on route and dosage of administration. Eur J Endocrinol. 2007 Jun;156(6):647-53. PubMed PMID: 17535864.



• Schiessl B, Strasburger CJ, Bidlingmaier M, Gutt B, Kirk SE, Oberhoffer R, Friese K. Role of placental growth hormone in the alteration of maternal arterial resistance in pregnancy. J Reprod Med. 2007 Apr;52(4):313-6. Erratum in: J ReprodMed. 2009 Jun;54(6):412. Bidlingmeier, Martin [corrected to Bidlingmaier, Martin]. PubMed PMID: 17506372.

• Bidlingmaier M, Strasburger CJ. Growth hormone assays: current methodologies and their limitations. Pituitary. 2007;10(2):115-9. Review. PubMed PMID: 17429592.

• Müssig K, Gallwitz B, Honegger J, Strasburger CJ, Bidlingmaier M, Machicao F, Bornemann A, Ranke MB, Häring HU, Petersenn S. Pegvisomant treatment in gigantism caused by a growth hormone-secreting giant pituitary adenoma. Exp Clin Endocrinol Diabetes. 2007 Mar;115(3):198-202. PubMed PMID: 17427111.

• Bidlingmaier M, Strasburger CJ. What endocrinologists should know about growth hormone measurements. Endocrinol Metab Clin North Am. 2007 Mar;36(1):101-8. Review. PubMed PMID: 17336737.

• Murray RD, Bidlingmaier M, Strasburger CJ, Shalet SM. The diagnosis of partial growth hormone deficiency in adults with a putative insult to the hypothalamo-pituitary axis. J Clin Endocrinol Metab. 2007 May;92(5):1705-9. PubMed PMID: 17327383.

• Morrison KM, Bidlingmaier M, Stadler S, Wu Z, Skriver L, Strasburger CJ. Sample pre-treatment determines the clinical usefulness of acid-labile subunit immunoassays in the diagnosis of growth hormone deficiency and acromegaly. Eur J Endocrinol. 2007 Mar;156(3):331-9. PubMed PMID: 17322493.

• Schreiber I, Buchfelder M, Droste M, Forssmann K, Mann K, Saller B,Strasburger CJ; German Pegvisomant Investigators.. Treatment of acromegaly with the GH receptor antagonist pegvisomant in clinical practice: safety and efficacy evaluation from the German Pegvisomant Observational Study. Eur J Endocrinol. 2007 Jan;156(1):75-82. PubMed PMID: 17218728.

• Franiel T, Biering H, Strasburger C, Klingebiel R. [Increasing iron accumulation of the adenohypophysis in the framework of ahemochromatosis--characteristic depiction using magnetic resonance tomography].Rofo. 2006 Oct;178(10):1035-6. German. PubMed PMID: 17021982.

• Ströhle A, Feller C, Strasburger CJ, Heinz A, Dimeo F. Anxiety modulation bythe heart? Aerobic exercise and atrial natriuretic peptide. Psychoneuroendocrinology. 2006 Oct;31(9):1127-30. PubMed PMID: 17010527.

• Bidlingmaier M, Kim J, Savoy C, Kim MJ, Ebrecht N, de la Motte S, Strasburger CJ. Comparative pharmacokinetics and pharmacodynamics of a newsustained-release growth hormone (GH), LB03002, versus daily GH in adults with GH deficiency. J Clin Endocrinol Metab. 2006 Aug;91(8):2926-30. PubMed PMID: 16720652.

• Fazeli M, Zarkesh-Esfahani H, Wu Z, Maamra M, Bidlingmaier M, Pockley AG, Watson P, Matarese G, Strasburger CJ, Ross RJ. Identification of a monoclonalantibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation. J Immunol Methods. 2006 May 30;312(1-2):190-200. PubMed PMID: 16690078.



• Strasburger CJ. IGF-I and mortality in patients with acromegaly. J Endocrinol Invest. 2005;28(11 Suppl International):78-80. Review. PubMed PMID: 16625852.

• Schiessl B, Strasburger C, Bidlingmaier M, Mylonas I, Jeschke U, Kainer F, Friese K. Plasma- and urine concentrations of nitrite/nitrate and cyclic Guanosinemonophosphate in intrauterine growth restricted and preeclamptic pregnancies. Arch Gynecol Obstet. 2006 Jun;274(3):150-4. PubMed PMID: 16532320.

• Colao A, Pivonello R, Auriemma RS, De Martino MC, Bidlingmaier M, Briganti F, Tortora F, Burman P, Kourides IA, Strasburger CJ, Lombardi G. Efficacy of 12-month treatment with the GH receptor antagonist pegvisomant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance. Eur J Endocrinol. 2006 Mar;154(3):467-77. PubMed PMID: 16498061.

• Biering H, Saller B, Bauditz J, Pirlich M, Rudolph B, Johne A, Buchfelder M, Mann K, Droste M, Schreiber I, Lochs H, Strasburger CJ; German pegvisomant investigators.. Elevated transaminases during medical treatment of acromegaly: a review of the German pegvisomant surveillance experience and a report of a patient with histologically proven chronic mild active hepatitis. Eur J Endocrinol. 2006 Feb;154(2):213-20. PubMed PMID: 16452533.

• Biering H, Bohner G, Strasburger CJ. [Autoimmune hypophysitis--two case reports]. Dtsch Med Wochenschr. 2005 Dec 9;130(49):2826-8. German. PubMed PMID: 16317610.

• Strasburger CJ, Bidlingmaier M. How robust are laboratory measures of growth hormone status? Horm Res. 2005;64 Suppl 2:1-5. PubMed PMID: 16286762.

• Feelders RA, Bidlingmaier M, Strasburger CJ, Janssen JA, Uitterlinden P,Hofland LJ, Lamberts SW, van der Lely AJ, de Herder WW. Postoperative evaluation of patients with acromegaly: clinical significance and timing of oral glucose tolerance testing and measurement of (free) insulin-like growth factor I, acid-labile subunit, and growth hormone-binding protein levels. J Clin Endocrinol Metab. 2005 Dec;90(12):6480-9. PubMed PMID: 16159936.

• Biering H, Bauditz J, Brenner N, Stein H, Lochs H, Strasburger CJ. Primary neuroendocrine carcinoma of inguinal lymph node. Horm Res. 2005;64(1):16-9.PubMed PMID: 16088203.

• Biering H, Strasburger CJ. [The 10-minute office visit. Untreated acromegalyshortens life expectancy. You must be able to state the suspected diagnosis]. MMWFortschr Med. 2005 Apr 7;147(14):55-6. German. PubMed PMID: 15887688.

• Clemmons DR, Strasburger C. Monitoring the response to treatment inacromegaly. J Clin Endocrinol Metab. 2004 Nov;89(11):5289-91. PubMed PMID: 15531471.

• Herrmann BL, Strasburger CJ. [Growth hormone-receptor antagonist pegvisomant]. Dtsch Med Wochenschr. 2004 Oct 29;129(44):2356-8. German. PubMed PMID: 15497105.



• Maamra M, Kopchick JJ, Strasburger CJ, Ross RJ. Pegvisomant, a growth hormone-specific antagonist, undergoes cellular internalization. J Clin Endocrinol Metab. 2004 Sep;89(9):4532-7. PubMed PMID: 15356058.

• Hoffman AR, Strasburger CJ, Zagar A, Blum WF, Kehely A, Hartman ML; T002 Study Group.. Efficacy and tolerability of an individualized dosing regimen foradult growth hormone replacement therapy in comparison with fixed bodyweight-based dosing. J Clin Endocrinol Metab. 2004 Jul;89(7):3224-33. PubMed PMID: 15240596.

• Strasburger CJ. Taking one step at a time. Clin Endocrinol (Oxf). 2004 May;60(5):540. PubMed PMID: 15104555.

• Giustina A, Casanueva FF, Cavagnini F, Chanson P, Clemmons D, Frohman LA,Gaillard R, Ho K, Jaquet P, Kleinberg DL, Lamberts SW, Lombardi G, Sheppard M,Strasburger CJ, Vance ML, Wass JA, Melmed S; Pituitary Society and the EuropeanNeuroendocrine Association.. Diagnosis and treatment of acromegaly complications. J Endocrinol Invest. 2003 Dec;26(12):1242-7. PubMed PMID: 15055479.

• Bidlingmaier M, Wu Z, Strasburger CJ. Problems with GH doping in sports. JEndocrinol Invest. 2003 Sep;26(9):924-31. PubMed PMID: 14964447.

• Schüle C, Baghai T, Schmidbauer S, Bidlingmaier M, Strasburger CJ, Laakmann G. Reboxetine acutely stimulates cortisol, ACTH, growth hormone and prolactin secretion in healthy male subjects. Psychoneuroendocrinology. 2004 Feb;29(2):185-200. PubMed PMID: 14604600.

• Clemmons DR, Chihara K, Freda PU, Ho KK, Klibanski A, Melmed S, Shalet SM,Strasburger CJ, Trainer PJ, Thorner MO. Optimizing control of acromegaly:integrating a growth hormone receptor antagonist into the treatment algorithm. J Clin Endocrinol Metab. 2003 Oct;88(10):4759-67. Review. PubMed PMID: 14557452.

• Blum WF, Shavrikova EP, Edwards DJ, Rosilio M, Hartman ML, Marín F, Valle D,van der Lely AJ, Attanasio AF, Strasburger CJ, Henrich G, Herschbach P. Decreased quality of life in adult patients with growth hormone deficiency compared withgeneral populations using the new, validated, self-weighted questionnaire,questions on life satisfaction hypopituitarism module. J Clin Endocrinol Metab.2003 Sep;88(9):4158-67. PubMed PMID: 12970281.

• Schiessl B, Strasburger CJ, Bidlingmaier M, Spannagl M, Ugele B, Kainer F.Decreasing resistance in the maternal uterine and peripheral arterial system isapparently unrelated to plasma and urinary levels of nitrite/nitrate and cyclic-guanosinmonophosohate during the course of normal pregnancies. J Perinat Med. 2003;31(4):281-6. PubMed PMID: 12951882.

• Meinhardt U, Eblé A, Besson A, Strasburger CJ, Sraer JD, Mullis PE.Regulation of growth-hormone-receptor gene expression by growth hormone andpegvisomant in human mesangial cells. Kidney Int. 2003 Aug;64(2):421-30. PubMedPMID: 12846737.

• Pantel J, Grulich-Henn J, Bettendorf M, Strasburger CJ, Heinrich U, Amselem S. Heterozygous nonsense mutation in exon 3 of the growth hormone receptor (GHR) in severe GH insensitivity (Laron syndrome) and the issue of the origin



andfunction of the GHRd3 isoform. J Clin Endocrinol Metab. 2003 Apr;88(4):1705-10. PubMed PMID: 12679461.

• Schiessl B, Strasburger CJ, Spannagl M, Kainer F. Decreasing peripheral resistance during pregnancy monitored at the cubital artery. Eur J Clin Invest. 2003 Apr;33(4):346-51. PubMed PMID: 12662166.

• Seidel B, Glasow A, Schutt M, Kiess W, Wu Z, Strasburger CJ, Kratzsch J.Association between the GH receptor/exon 3 genotype and the level of exon3-positive GH-binding protein in human serum. Eur J Endocrinol. 2003Mar;148(3):317-24. PubMed PMID: 12611612.

• Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, StrasburgerCJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P,Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL. The distribution and mechanism of action of ghrelin in the CNS demonstrates anovel hypothalamic circuit regulating energy homeostasis. Neuron. 2003 Feb 20;37(4):649-61. PubMed PMID: 12597862.

• Grottoli S, Gauna C, Tassone F, Aimaretti G, Corneli G, Wu Z, Strasburger CJ, Dieguez C, Casanueva FF, Ghigo E, Maccario M. Both fasting-induced leptin reduction and GH increase are blunted in Cushing's syndrome and in simple obesity. Clin Endocrinol (Oxf). 2003 Feb;58(2):220-8. PubMed PMID: 12580939.

• Wu Z, Bidlingmaier M, Friess SC, Kirk SE, Buchinger P, Schiessl B, Strasburger CJ. A new nonisotopic, highly sensitive assay for the measurement of human placental growth hormone: development and clinical implications. J ClinEndocrinol Metab. 2003 Feb;88(2):804-11. PubMed PMID: 12574217.

• Schüle C, Baghai T, Bidlingmaier M, Strasburger C, Laakmann G. Endocrinological effects of mirtazapine in healthy volunteers. ProgNeuropsychopharmacol Biol Psychiatry. 2002 Dec;26(7-8):1253-61. PubMed PMID: 12502011.

• Veldhuis JD, Bidlingmaier M, Anderson SM, Evans WS, Wu Z, Strasburger CJ. Impact of experimental blockade of peripheral growth hormone (GH) receptors on the kinetics of endogenous and exogenous GH removal in healthy women and men. J Clin Endocrinol Metab. 2002 Dec;87(12):5737-45. PubMed PMID: 12466380.

• Schüle C, Baghai T, Goy J, Bidlingmaier M, Strasburger C, Laakmann G. The influence of mirtazapine on anterior pituitary hormone secretion in healthy male subjects. Psychopharmacology (Berl). 2002 Aug;163(1):95-101. PubMed PMID: 12185405.

• Simpson H, Savine R, Sönksen P, Bengtsson BA, Carlsson L, Christiansen JS, Clemmons D, Cohen P, Hintz R, Ho K, Mullis P, Robinson I, Strasburger C, TanakaT, Thorner M; GRS Council.. Growth hormone replacement therapy for adults: into the new millennium. Growth Horm IGF Res. 2002 Feb;12(1):1-33. Review. PubMed PMID: 12127299.

• Weiss S, Baumgart R, Jochum M, Strasburger CJ, Bidlingmaier M. Systemic regulation of distraction osteogenesis: a cascade of biochemical factors. J Bone Miner Res. 2002 Jul;17(7):1280-9. PubMed PMID: 12096842.

• Wu Z, Bidlingmaier M, Liu C, De Souza EB, Tschöp M, Morrison KM, StrasburgerCJ. Quantification of the soluble leptin receptor in human blood by



ligand-mediated immunofunctional assay. J Clin Endocrinol Metab. 2002 Jun;87(6):2931-9. PubMed PMID: 12050276.

• Auernhammer CJ, Fottner C, Engelhardt D, Bidlingmaier M, Strasburger CJ,Weber MM. Differential regulation of insulin-like growth factor-(IGF) I and IGF-binding protein (IGFBP) secretion by human peripheral blood mononuclear cells. Horm Res. 2002;57(1-2):15-21. PubMed PMID: 12006714.

• Toepfer M, Rieger J, Pfluger T, Hautmann H, Sitter T, Pfeifer KJ, Strasburger CJ. [Primary hypertrophic osteoarthropathy (Touraine-Solente-Golésyndrome)]. Dtsch Med Wochenschr. 2002 May 10;127(19):1013-6. German. PubMedPMID: 11997868.

• Attanasio AF, Bates PC, Ho KK, Webb SM, Ross RJ, Strasburger CJ, Bouillon R, Crowe B, Selander K, Valle D, Lamberts SW; Hypoptiuitary Control andComplications Study International Advisory Board.. Human growth hormone replacement in adult hypopituitary patients: long-term effects on body composition and lipid status--3-year results from the HypoCCS Database. J Clin Endocrinol Metab. 2002 Apr;87(4):1600-6. PubMed PMID: 11932289.

• Deladoëy J, Gex G, Vuissoz JM, Strasburger CJ, Wajnrajch MP, Mullis PE.Effect of different growth hormone (GH) mutants on the regulation of GH-receptor gene transcription in a human hepatoma cell line. Eur J Endocrinol. 2002Apr;146(4):573-81. PubMed PMID: 11916628.

• Muller AF, Lamberts SW, Janssen JA, Hofland LJ, Koetsveld PV, Bidlingmaier M, Strasburger CJ, Ghigo E, Van der Lely AJ. Ghrelin drives GH secretion during fasting in man. Eur J Endocrinol. 2002 Feb;146(2):203-7. PubMed PMID: 11834429.

• Baghai TC, Schüle C, Zwanzger P, Minov C, Holme C, Padberg F, Bidlingmaier M, Strasburger CJ, Rupprecht R. Evaluation of a salivary based combined dexamethasone/CRH test in patients with major depression. Psychoneuroendocrinology. 2002 Apr;27(3):385-99. PubMed PMID: 11818173.

• van der Lely AJ, Hutson RK, Trainer PJ, Besser GM, Barkan AL, Katznelson L, Klibanski A, Herman-Bonert V, Melmed S, Vance ML, Freda PU, Stewart PM, Friend KE, Clemmons DR, Johannsson G, Stavrou S, Cook DM, Phillips LS, Strasburger CJ, Hackett S, Zib KA, Davis RJ, Scarlett JA, Thorner MO. Long-term treatment ofacromegaly with pegvisomant, a growth hormone receptor antagonist. Lancet. 2001Nov 24;358(9295):1754-9. PubMed PMID: 11734231.

• Doehner W, Pflaum CD, Rauchhaus M, Godsland IF, Egerer K, Cicoira M, Florea VG, Sharma R, Bolger AP, Coats AJ, Anker SD, Strasburger CJ. Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia. Eur J Endocrinol. 2001 Dec;145(6):727-35. PubMed PMID: 11720897.

• Ranke MB, Feldt-Rasmussen U, Bang P, Baxter RC, Camacho-Hübner C, Clemmons DR, Juul A, Orskov H, Strasburger CJ. How should insulin-like growth factor I be measured? A consensus statement. Horm Res. 2001;55 Suppl 2:106-9. Review. PubMed PMID: 11684887.



• Strasburger CJ, Bidlingmaier M, Wu Z, Morrison KM. Normal values of insulin-like growth factor I and their clinical utility in adults. Horm Res. 2001;55 Suppl 2:100-5. Review. PubMed PMID: 11684886.

• Muller AF, Janssen JA, Lamberts SW, Bidlingmaier M, Strasburger CJ, Hofland L, van der Lely AJ. Effects of fasting and pegvisomant on the GH-releasing hormone and GH-releasing peptide-6 stimulated growth hormone secretion. Clin Endocrinol (Oxf). 2001 Oct;55(4):461-7. PubMed PMID: 11678828.

• Arlt W, Callies F, Koehler I, van Vlijmen JC, Fassnacht M, Strasburger CJ, Seibel MJ, Huebler D, Ernst M, Oettel M, Reincke M, Schulte HM, Allolio B. Dehydroepiandrosterone supplementation in healthy men w ith an age-related decline of dehydroepiandrosterone secretion. J Clin Endocrinol Metab. 2001 Oct;86(10):4686-92. PubMed PMID: 11600526.

• Bidlingmaier M, Wu Z, Strasburger CJ. Doping with growth hormone. J Pediatr Endocrinol Metab. 2001 Sep-Oct;14(8):1077-83. Review. PubMed PMID: 11592563.

• Zarkesh-Esfahani H, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A, Weetman AP, Strasburger CJ, Ross RJ. High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol. 2001 Oct 15;167(8):4593-9.PubMed PMID: 11591788.

• Maamra M, Bidlingmaier M, Postel-Vinay MC, Wu Z, Strasburger CJ, Ross RJ. Generation of human soluble leptin receptor by proteolytic cleavage of membrane-anchored receptors. Endocrinology. 2001 Oct;142(10):4389-93. PubMedPMID: 11564702.

• Morrison KM, Wu Z, Bidlingmaier M, Strasburger CJ. Findings and theoretical considerations on the usefulness of the acid-labile subunit in the monitoring of acromegaly. Growth Horm IGF Res. 2001 Jun;11 Suppl A:S61-3. Review. PubMed PMID: 11527090.

• Herschbach P, Henrich G, Strasburger CJ, Feldmeier H, Marín F, Attanasio AM, Blum WF. Development and psychometric properties of a disease-specific quality of life questionnaire for adult patients with growth hormone deficiency. Eur J Endocrinol. 2001 Sep;145(3):255-65. PubMed PMID: 11517005.

• Anker SD, Volterrani M, Pflaum CD, Strasburger CJ, Osterziel KJ, Doehner W, Ranke MB, Poole-Wilson PA, Giustina A, Dietz R, Coats AJ. Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone. J Am Coll Cardiol. 2001 Aug;38(2):443-52. PubMed PMID: 11499736.

• Maccario M, Aimaretti G, Grottoli S, Gauna C, Tassone F, Corneli G, Rossetto R, Wu Z, Strasburger CJ, Ghigo E. Effects of 36 hour fasting on GH/IGF-I axis and metabolic parameters in patients with simple obesity. Comparison with normal subjects and hypopituitary patients with severe GH deficiency. Int J Obes RelatMetab Disord. 2001 Aug;25(8):1233-9. PubMed PMID: 11477509.

• Veldhuis JD, Bidlingmaier M, Anderson SM, Wu Z, Strasburger CJ. Lowering total plasma insulin-like growth factor I concentrations by way of a novel, potent, and selective growth hormone (GH) receptor antagonist, pegvisomant(B2036-peg), augments the amplitude of GH secretory bursts and elevates



basal/nonpulsatile GH release in healthy women and men. J Clin Endocrinol Metab. 2001 Jul;86(7):3304-10. PubMed PMID: 11443205.

• Stadler S, Wu Z, Dressendörfer RA, Morrison KM, Khare A, Lee PD, StrasburgerCJ. Monoclonal anti-acid-labile subunit oligopeptide antibodies and their use in a two-site immunoassay for ALS measurement in humans. J Immunol Methods. 2001 Jun 1;252(1-2):73-82. PubMed PMID: 11334967.

• Wallace JD, Cuneo RC, Bidlingmaier M, Lundberg PA, Carlsson L, Boguszewski CL, Hay J, Boroujerdi M, Cittadini A, Dall R, Rosén T, Strasburger CJ. Changes in non-22-kilodalton (kDa) isoforms of growth hormone (GH) after administration of 22-kDa recombinant human GH in trained adult males. J Clin Endocrinol Metab. 2001 Apr;86(4):1731-7. PubMed PMID: 11297610.

• Maccario M, Tassone F, Gauna C, Oleandri SE, Aimaretti G, Procopio M, Grottoli S, Pflaum CD, Strasburger CJ, Ghigo E. Effects of short-term administration of low-dose rhGH on IGF-I levels in obesity and Cushing'ssyndrome: indirect evaluation of sensitivity to GH. Eur J Endocrinol. 2001 Mar;144(3):251-6. PubMed PMID: 11248744.

• Wallace JD, Cuneo RC, Bidlingmaier M, Lundberg PA, Carlsson L, Boguszewski CL, Hay J, Healy ML, Napoli R, Dall R, Rosén T, Strasburger CJ. The response ofmolecular isoforms of growth hormone to acute exercise in trained adult males. J Clin Endocrinol Metab. 2001 Jan;86(1):200-6. PubMed PMID: 11232001.

• Kratzsch J, Wu Z, Kiess W, Dehmel B, Bosse-Henck A, Reuter W, Pflaum CD, Strasburger CJ. The exon 3-retaining and the exon 3-deleted forms of the growth hormone-binding protein (GHBP) in human serum are regulated differently. ClinEndocrinol (Oxf). 2001 Jan;54(1):61-8. PubMed PMID: 11167927.

• Muller AF, Janssen JA, Hofland LJ, Lamberts SW, Bidlingmaier M, Strasburger CJ, van der Lely AJ. Blockade of the growth hormone (GH) receptor unmasks rapidGH-releasing peptide-6-mediated tissue-specific insulin resistance. J ClinEndocrinol Metab. 2001 Feb;86(2):590-3. PubMed PMID: 11158013.

• Tschöp M, Lahner H, Feldmeier H, Grasberger H, Morrison KM, Janssen OE, Attanasio AF, Strasburger CJ. Effects of growth hormone replacement therapy onlevels of cortisol and cortisol-binding globulin in hypopituitary adults. Eur JEndocrinol. 2000 Dec;143(6):769-73. PubMed PMID: 11124860.

• Tschöp M, Strasburger CJ, Töpfer M, Hautmann H, Riepl R, Fischer R, Hartmann G, Morrison K, Appenzeller M, Hildebrandt W, Biollaz J, Bärtsch P. Influence of hypobaric hypoxia on leptin levels in men. Int J Obes Relat Metab Disord. 2000Jun;24 Suppl 2:S151. PubMed PMID: 10997640.

• Strasburger CJ. Laboratory assessment of GH. Growth Horm IGF Res. 1998 Feb;8 Suppl A:41-6. Review. PubMed PMID: 10993590.

• Bidlingmaier M, Wu Z, Strasburger CJ. Test method: GH. Baillieres Best Pract Res Clin Endocrinol Metab. 2000 Mar;14(1):99-109. Review. PubMed PMID: 10932814.

• Maccario M, Aimaretti G, Corneli G, Gauna C, Grottoli S, Bidlingmaier M, Strasburger CJ, Dieguez C, Casanueva FF, Ghigo E. Short-term fasting abolishes the sex-related difference in GH and leptin secretion in humans. Am J Physiol Endocrinol Metab. 2000 Aug;279(2):E411-6. PubMed PMID: 10913042.



• Klug I, Dressendörfer R, Strasburger C, Kühl GP, Reiter HL, Reich A, Müller G, Meyer K, Kratzsch J, Kiess W. Cortisol and 17-hydroxyprogesterone levels in saliva of healthy neonates: normative data and relation to body mass index, arterial cord blood ph and time of sampling after birth. Biol Neonate. 2000 Jul;78(1):22-6. PubMed PMID: 10878418.

• Beuschlein F, Strasburger CJ, Siegerstetter V, Moradpour D, Lichter P, Bidlingmaier M, Blum HE, Reincke M. Acromegaly caused by secretion of growth hormone by a non-Hodgkin's lymphoma. N Engl J Med. 2000 Jun 22;342(25):1871-6. PubMed PMID: 10861322.

• Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ, Dimaraki EV, Stewart PM, Friend KE, Vance ML, Besser GM, Scarlett JA, ThornerMO, Parkinson C, Klibanski A, Powell JS, Barkan AL, Sheppard MC, Malsonado M,Rose DR, Clemmons DR, Johannsson G, Bengtsson BA, Stavrou S, Kleinberg DL, CookDM, Phillips LS, Bidlingmaier M, Strasburger CJ, Hackett S, Zib K, Bennett WF, Davis RJ. Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant. N Engl J Med. 2000 Apr 20;342(16):1171-7. PubMed PMID: 10770982.

• Laakmann G, Schüle C, Baghai T, Waldvogel E, Bidlingmaier M, Strasburger C. Mirtazapine: an inhibitor of cortisol secretion that does not influence growthhormone and prolactin secretion. J Clin Psychopharmacol. 2000 Feb;20(1):101-3.PubMed PMID: 10653218.

• Tschöp M, Pflaum CD, Strasburger CJ, Gärtner R, Schopohl J. [21-year old patient with a pituitary microadenoma and gynecomastia of recent onset].Internist (Berl). 1999 Dec;40(12):1327-32. German. PubMed PMID: 10642920.

• Juul A, Bernasconi S, Chatelain P, Hindmarsh P, Hochberg Z, Hokken-Koelega A, de Muinck Keizer-Schrama SM, Kiess W, Oberfield S, Parks J, Strasburger CJ, Volta C, Westphal O, Skakkebaek NE. Diagnosis of growth hormone (GH) deficiency and the use of GH in children with growth disorders. Horm Res. 1999 Dec;51(6):284-99. Review. PubMed PMID: 10640890.

• Aimaretti G, Colao A, Corneli G, Pivonello R, MacCario M, Morrison K, Pflaum CD, Strasburger CJ, Lombardi G, Ghigo E. The study of spontaneous GH secretion after 36-h fasting distinguishes between GH-deficient and normal adults. Clin Endocrinol (Oxf). 1999 Dec;51(6):771-7. PubMed PMID: 10619983.

• Strasburger CJ. Methods in determining growth hormone concentrations: an immunofunctional assay. Pediatrics. 1999 Oct;104(4 Pt 2):1024-8. PubMed PMID: 10506257.

• Binder G, Benz MR, Elmlinger M, Pflaum CD, Strasburger CJ, Ranke MB. Reduced human growth hormone (hGH) bioactivity without a defect of the GH-1 gene in three patients with rhGH responsive growth failure. Clin Endocrinol (Oxf). 1999 Jul;51(1):89-95. PubMed PMID: 10468970.

• Thorner MO, Strasburger CJ, Wu Z, Straume M, Bidlingmaier M, Pezzoli SS, Zib K, Scarlett JC, Bennett WF. Growth hormone (GH) receptor blockade with a PEG-modified GH (B2036-PEG) lowers serum insulin-like growth factor-I but does not acutely stimulate serum GH. J Clin Endocrinol Metab. 1999 Jun;84(6):2098-103. PubMed PMID: 10372717.



• Ziegler R, Grussendorf M, Lehnert H, Schumm-Draeger PM, Strasburger CJ. [Endocrinology]. Internist (Berl). 1999 Apr;40(4):349-55. Review. German. PubMed PMID: 10354934.

• Marshall L, Derad I, Strasburger CJ, Fehm HL, Born J. A determinant factor in the efficacy of GHRH administration in promoting sleep: high peak concentration versus recurrent increasing slopes. Psychoneuroendocrinology. 1999 Apr;24(3):363-70. PubMed PMID: 10101739.

• Wu Z, Bidlingmaier M, Dall R, Strasburger CJ. Detection of doping with human growth hormone. Lancet. 1999 Mar 13;353(9156):895. PubMed PMID: 10093984.

• Erkens JH, Dieleman SJ, Dressendörfer RA, Strasburger CJ. A time-resolved fluoroimmunoassay for cortisol in unextracted bovine plasma or serum with optimized procedures to eliminate steroid binding protein interference and to minimize non-specific streptavidin-europium binding. J Steroid Biochem Mol Biol. 1998 Oct;67(2):153-61. PubMed PMID: 9877216.

• Bozzola M, Radetti G, Elmlinger M, Strasburger CJ. [Does the growth hormone pharmacokinetic profile help to predict the treatment response?]. Arch Pediatr. 1998;5 Suppl 4:322S-326S. French. PubMed PMID: 9853077.

• Nijland EA, Strasburger CJ, Popp-Snijders C, van der Wal PS, van der Veen EA. A five day treatment with daily subcutaneous injections of growth hormone-releasing peptide-2 causes response attenuation and does not stimulate insulin-like growth factor-I secretion in healthy young men. Eur J Endocrinol. 1998 Oct;139(4):395-401. PubMed PMID: 9820615.

• Dressendorfer RA, Strasburger CJ, Bidlingmaier F, Klug I, Kistner A, Siebler T, Kiess W. Development of a highly sensitive nonisotopic immunoassay for the determination of salivary 17-hydroxyprogesterone: reference ranges throughout childhood and adolescence. Pediatr Res. 1998 Nov;44(5):650-5. PubMed PMID: 9803445.

• Tschöp M, Strasburger CJ, Hartmann G, Biollaz J, Bärtsch P. Raised leptin concentrations at high altitude associated with loss of appetite. Lancet. 1998Oct 3;352(9134):1119-20. PubMed PMID: 9798594.

• de Mello-Coelho V, Gagnerault MC, Souberbielle JC, Strasburger CJ, Savino W,Dardenne M, Postel-Vinay MC. Growth hormone and its receptor are expressed in human thymic cells. Endocrinology. 1998 Sep;139(9):3837-42. PubMed PMID: 9724037.

• Niebauer J, Pflaum CD, Clark AL, Strasburger CJ, Hooper J, Poole-Wilson PA, Coats AJ, Anker SD. Deficient insulin-like growth factor I in chronic heart failure predicts altered body composition, anabolic deficiency, cytokine and neurohormonal activation. J Am Coll Cardiol. 1998 Aug;32(2):393-7. PubMed PMID:9708466.

• Oertel H, Strasburger CJ, Kann P, Quabbe HJ. [Recommendations for the indications for growth hormone substitution in adult age groups. Working group for pituitary gland and pituitary tumors of the German Society for Endocrinology]. Dtsch Med Wochenschr. 1998 Jul 10;123(28-29):883-6. German. PubMed PMID: 9693660.



• Sauer J, Renner U, Hopfner U, Lange M, Müller A, Strasburger CJ, Pagotto U, Arzt E, Stalla GK. Interleukin-1 beta enhances interleukin-1 receptor antagonist content in human somatotroph adenoma cell cultures. J Clin Endocrinol Metab. 1998 Jul;83(7):2429-34. PubMed PMID: 9661623.

• Tschöp M, Behre HM, Nieschlag E, Dressendörfer RA, Strasburger CJ. A time-resolved fluorescence immunoassay for the measurement of testosterone in saliva: monitoring of testosterone replacement therapy with testosterone buciclate. Clin Chem Lab Med. 1998 Apr;36(4):223-30. PubMed PMID: 9638347.

• Hartmann G, Krug A, Bidlingmaier M, Hacker U, Eigler A, Albrecht R, Strasburger CJ, Endres S. Spontaneous and cationic lipid-mediated uptake of antisense oligonucleotides in human monocytes and lymphocytes. J Pharmacol Exp Ther. 1998 May;285(2):920-8. PubMed PMID: 9580645.

• Rowlinson SW, Behncken SN, Rowland JE, Clarkson RW, Strasburger CJ, Wu Z, Baumbach W, Waters MJ. Activation of chimeric and full-length growth hormone receptors by growth hormone receptor monoclonal antibodies. A specific conformational change may be required for full-length receptor signaling. J Biol Chem. 1998 Feb 27;273(9):5307-14. PubMed PMID: 9478989.

• Alkadhi H, Tschöp M, Marschang A, Langenmayer I, Feucht HE, Strasburger CJ. [A 35-year old male patient with fever and painful swelling of the pectoral glands following a short visit to Sri Lanka]. Dtsch Med Wochenschr. 1998 Jan 30;123(5):114-8. German. PubMed PMID: 9487296.

• Blackburn A, Dressendörfer RA, Blum WF, Erhard M, Brem G, Strasburger CJ, Wolf E. Interactions of insulin-like growth factor (IGF)-II and growth hormone in vivo: circulating levels of IGF-I and IGF-binding proteins in transgenic mice. Eur J Endocrinol. 1997 Dec;137(6):701-8. PubMed PMID: 9437240.

• Bidlingmaier M, Auernhammer CJ, Feldmeier H, Strasburger CJ. Effects of growth hormone and insulin-like growth factor I binding to natural killer cells. Acta Paediatr Suppl. 1997 Nov;423:80-1. PubMed PMID: 9401547.

• Strasburger CJ, Dattani MT. New growth hormone assays: potential benefits. Acta Paediatr Suppl. 1997 Nov;423:5-11. Review. PubMed PMID: 9401531.

• Deuschle M, Blum WF, Strasburger CJ, Schweiger U, Weber B, Körner A, Standhardt H, Gotthardt U, Schmider J, Pflaum CD, Heuser I. Insulin-like growthfactor-I (IGF-I) plasma concentrations are increased in depressed patients. Psychoneuroendocrinology. 1997 Oct;22(7):493-503. PubMed PMID: 9373883.

• Strasburger CJ, Schopohl J, Kann P, Oertel H. [Diagnostic criteria for the indication of growth hormone substitution in adults. The Hypophysis and Hypophyseal Tumor Working Group of the German Society for Endocrinology]. Dtsch Med Wochenschr. 1997 Jul 4;122(27):861-3. Review. German. PubMed PMID: 9280697.

• Wolf OT, Neumann O, Hellhammer DH, Geiben AC, Strasburger CJ, Dressendörfer RA, Pirke KM, Kirschbaum C. Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men. J Clin Endocrinol Metab. 1997 Jul;82(7):2363-7. PubMed PMID: 9215320.



• Kratzsch J, Schreiber G, Selisko T, Keller E, Pflaum CD, Strasburger CJ. Measurement of serum exon 3-retaining growth hormone-binding protein in children and adolescents by radioimmunoassay. Horm Res. 1997;48(6):252-7. PubMed PMID:9402241.

• Attanasio AF, Lamberts SW, Matranga AM, Birkett MA, Bates PC, Valk NK, Hilsted J, Bengtsson BA, Strasburger CJ. Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset beforeand during human GH treatment. Adult Growth Hormone Deficiency Study Group. JClin Endocrinol Metab. 1997 Jan;82(1):82-8. PubMed PMID: 8989238.

• Auernhammer CJ, Feldmeier H, Nass R, Pachmann K, Strasburger CJ. Insulin-like growth factor I is an independent coregulatory modulator of natural killer (NK) cell activity. Endocrinology. 1996 Dec;137(12):5332-6. PubMed PMID:8940354.

• Strasburger CJ. Recognizing minorities: the 22-kD growth hormone exclusion assay (GHEA)--an invited commentary. Eur J Endocrinol. 1996 Nov;135(5):536-7. PubMed PMID: 8980153.

• Gertler A, Grosclaude J, Strasburger CJ, Nir S, Djiane J. Real-time kinetic measurements of the interactions between lactogenic hormones and prolactin-receptor extracellular domains from several species support the model of hormone-induced transient receptor dimerization. J Biol Chem. 1996 Oct 4;271(40):24482-91. PubMed PMID: 8798708.

• Strasburger CJ, Kiess W. Which route of growth hormone administration serves best? An invited commentary. Eur J Endocrinol. 1996 Sep;135(3):289-90. PubMed PMID: 8890718.

• Strasburger CJ, Wu Z, Pflaum CD, Dressendörfer RA. Immunofunctional assay of human growth hormone (hGH) in serum: a possible consensus for quantitative hGHmeasurement. J Clin Endocrinol Metab. 1996 Jul;81(7):2613-20. PubMed PMID:8675586.

• Feldmeier H, Nass R, Strasburger CJ. [Growth hormone substitution in adulthood. Use of recombinant human GH--strict diagnostic criteria]. FortschrMed. 1996 Jun 10;114(16):205-9. Review. German. PubMed PMID: 8767931.

• Eisen C, Meyer C, Dressendörfer R, Strasburger C, Decker H, Wehling M. Biotin-labelled and photoactivatable aldosterone and progesterone derivatives as ligands for affinity chromatography, fluorescence immunoassays and photoaffinity labelling. Eur J Biochem. 1996 Apr 15;237(2):514-8. PubMed PMID: 8647093.

• Auernhammer CJ, Strasburger CJ. Effects of growth hormone and insulin-like growth factor I on the immune system. Eur J Endocrinol. 1995 Dec;133(6):635-45.Review. PubMed PMID: 8548046.

• Kiess W, Meidert A, Dressendörfer RA, Schriever K, Kessler U, König A, Schwarz HP, Strasburger CJ. Salivary cortisol levels throughout childhood andadolescence: relation with age, pubertal stage, and weight. Pediatr Res. 1995Apr;37(4 Pt 1):502-6. PubMed PMID: 7596692.

• Nass R, Huber RM, Klauss V, Müller OA, Schopohl J, Strasburger CJ. Effect ofgrowth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in



adulthood. JClin Endocrinol Metab. 1995 Feb;80(2):552-7. PubMed PMID: 7852519.

• Dressendörfer RA, Heim JM, Gerzer R, Strasburger CJ. A non-isotopic immunoassay for guanosine 3':5'-cyclic monophosphate using a cyclic GMP-biotin conjugate as tracer. J Immunoassay. 1995 Feb;16(1):37-53. PubMed PMID: 7775661.

• Kirschbaum C, Scherer G, Strasburger CJ. Pituitary and adrenal hormone responses to pharmacological, physical, and psychological stimulation in habitualsmokers and nonsmokers. Clin Investig. 1994 Oct;72(10):804-10. PubMed PMID: 7865987.

• Renner U, Brockmeier S, Strasburger CJ, Lange M, Schopohl J, Müller OA, von Werder K, Stalla GK. Growth hormone (GH)-releasing peptide stimulation of GHrelease from human somatotroph adenoma cells: interaction with GH-releasinghormone, thyrotropin-releasing hormone, and octreotide. J Clin Endocrinol Metab. 1994 May;78(5):1090-6. PubMed PMID: 8175966.

• Strasburger CJ. Implications of investigating the structure-functionrelationship of human growth hormone in clinical diagnosis and therapy. Horm Res.1994;41 Suppl 2:113-9; discussion 120. Review. PubMed PMID: 7522207.

• Drummer C, Heer M, Dressendörfer RA, Strasburger CJ, Gerzer R. Reduced natriuresis during weightlessness. Clin Investig. 1993 Sep;71(9):678-86. PubMed PMID: 8241716.

• Schopohl J, Vogl T, Strasburger CJ. [Imaging procedures in hypothalamic-hypophyseal diseases]. Internist (Berl). 1993 Aug;34(8):733-40. German. PubMed PMID: 8375987.

• Kirschbaum C, Strasburger CJ, Langkrär J. Attenuated cortisol response to psychological stress but not to CRH or ergometry in young habitual smokers. Pharmacol Biochem Behav. 1993 Mar;44(3):527-31. PubMed PMID: 8451256.

• Dressendörfer RA, Kirschbaum C, Rohde W, Stahl F, Strasburger CJ. Synthesis of a cortisol-biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement. J Steroid Biochem Mol Biol. 1992 Dec;43(7):683-92. PubMed PMID: 1472460.

• Kirschbaum C, Wüst S, Strasburger CJ. 'Normal' cigarette smoking increases free cortisol in habitual smokers. Life Sci. 1992;50(6):435-42. PubMed PMID:1734161.

• Strasburger CJ, Kohen F. Two-site and competitive chemiluminescentimmunoassays. Methods Enzymol. 1990;184:481-96. PubMed PMID: 2388585.

• Strasburger CJ. Antigenic epitope mapping of the human growth hormone molecule: a strategy to standardize growth hormone immunoassays. Acta PaediatrScand Suppl. 1990;370:82-6. PubMed PMID: 1701952.

• Kirschbaum C, Strasburger CJ, Jammers W, Hellhammer DH. Cortisol and behavior: 1. Adaptation of a radioimmunoassay kit for reliable and inexpensive salivary cortisol determination. Pharmacol Biochem Behav. 1989 Dec;34(4):747-51. PubMed PMID: 2623029.



• Strasburger CJ, Binder L, Elberg G, Cohen-Chapnik N, Kohen F, Gertler A.Indication of different lactogen and somatogen binding sites in the human growth hormone molecule as probed with monoclonal antibodies. Mol Cell Endocrinol. 1989 Nov;67(1):55-62. PubMed PMID: 2482210.

• Strasburger CJ, Kohen F. Chemiluminescent labelled streptavidin (STAV) as a universal marker in steroid and peptide immunoassays. J Biolumin Chemilumin. 1989 Jul;4(1):112-8. PubMed PMID: 2801206.

• Strasburger C, Barnard G, Toldo L, Zarmi B, Zadik Z, Kowarski A, Kohen F. Somatotropin as measured by a two-site time-resolved immunofluorometric assay. Clin Chem. 1989 Jun;35(6):913-7. PubMed PMID: 2659222.

• Strasburger CJ, Kostyo J, Vogel T, Barnard GJ, Kohen F. The antigenicepitopes of human grown hormone as mapped by monoclonal antibodies. Endocrinology. 1989 Mar;124(3):1548-57. PubMed PMID: 2465140.

• Strasburger CJ, Amir-Zaltsman Y, Kohen F. The avidin-biotin reaction as auniversal amplification system in immunoassays. Prog Clin Biol Res.1988;285:79-100. PubMed PMID: 3231651.

• Orlando C, Caldini AL, Barni T, Wood WG, Strasburger CJ, Natali A, Maver A, Forti G, Serio M. Ceruloplasmin and transferrin in human seminal plasma: are theyan index of seminiferous tubular function? Fertil Steril. 1985 Feb;43(2):290-4. PubMed PMID: 3917951.

• Gadow A, Fricke H, Strasburger CJ, Wood WG. Synthesis and evaluation ofluminescent tracers and hapten-protein conjugates for use in luminescence immunoassays with immobilised antibodies and antigens. A critical study of macro solid phases for use in immunoassay systems, Part II. J Clin Chem Clin Biochem. 1984 May;22(5):337-47. PubMed PMID: 6470624.

• Wood WG, Fricke H, Haritz J, Gadow A, Krausz HS, Tode B, Strasburger CJ, Scriba PC. An evaluation of four different luminescence immunoassay systems:CELIA (chemiluminescent immunoassay), SPALT (solid-phase antigen luminescence technique), ILMA (immunoluminometric assay) and ILSA (immunoluminometric labelled second antibody). A critical study of macro solid phases for use in immunoassay systems, Part III. J Clin Chem Clin Biochem. 1984 May;22(5):349-56. PubMed PMID: 6432936.

• Schulz E, Busse FW, Strasburger C, Herhahn J, Wood WG, Sack K. [Serum gentamicin level after intratracheal application in ventilated patients withnormal and reduced kidney function]. Dtsch Med Wochenschr. 1983 Dec 23;108(51-52):1964-7. German. PubMed PMID: 6653435.

• Wood WG, Fricke H, von Klitzing L, Strasburger CJ, Scriba PC. Solid phase antigen luminescent immunoassays (SPALT) for the determination of insulin, insulin antibodies and gentamicin levels in human serum. J Clin Chem Clin Biochem. 1982 Nov;20(11):825-31. PubMed PMID: 6759609.

• Fricke H, Strasburger CJ, Wood WG. Enzyme enhanced luminescence immunoassay for the determination of transferrin concentrations in serum. J Clin Chem Clin Biochem. 1982 Feb;20(2):91-4. PubMed PMID: 7040594.

(febbraio 2017)

socisoci corrispondenticorrispondenti soci/strasburger.pdf · 2019. 1. 31. · socisoci...

Documents