YORK EXPERT WORKSHOPSIN THE

SOCIO ECONOMICEVALUATION OF

MEDICINES

CENTRE FORHEALTH ECONOMICS

MODULE 1: 28th-30th June 2005

MODULE 2: 29th June-1st July 2005

MODULE 3: 4th-8th July 2005

St. William’s College Conference Centre

England

Centre for Health EconomicsA Centre for Excellence

The York Expert Workshops are now in their 12th year. Over thisperiod, decision-makers’ demands for information on the cost-effectiveness of medicines have become more extensive and moresophisticated. At least 7 European countries and several managedcare groups in the USA now require formal submissions ofeconomic data as part of the reimbursement process.

In order to keep pace with these developments, the YorkExpert Workshops programme was re-designed in 2004, withgreat success. The major change is that our advanced workshophas been extended from 3 to 5 days and structured according tothe main steps necessary to generate estimates of cost-effectiveness for a specific decision-maker, such as areimbursement agency or health care payer. The new workshopgoes beyond the exposition of general principles and includesdetailed discussion of the analytic approaches required to compilean economic dossier, using a mixture of tutored sessions andpractical exercises.

In order to compensate for the increased duration and cost ofthe advanced workshop, the foundations (introductory)workshop has been shortened to 3 days. The content remains thesame as previously, but the programme is now more intensive.Therefore, this workshop offers the opportunity for those new toeconomic evaluation to get themselves up to speed in an evenshorter period of time and at lower cost. Care has also beentaken to ensure that the foundations workshop provides anadequate introduction for those wishing to take the advancedworkshop.

OBJECTIVESTo inform and promote understanding in key areas of quality oflife assessment and health economic evaluations.• How to decide whether a particular evaluation is necessary.• How to choose a particular methodology.• How to identify the data required and appropriate instruments

for data collection.• How to undertake appropriate analysis.• How to communicate the results effectively

CREATED FOR• Anyone involved in initiating, undertaking, managing or

interpreting economic evaluations or quality of life assessments of medicines.

• Within: • pharmaceutical companies• clinical and health services research• health care decision-making

WORKSHOP DOCUMENTATIONEach participant will receive a full documentation pack related tothe day’s teaching and containing selected articles for furtherstudy plus a bibliography linked to the subject area.

PROGRAMMEMODULE 1

Foundations of Economic Evaluation in Health Care

28th-30th June 2005 Leaders: Michael Drummond, Mark Sculpher

This foundations workshop includes a comprehensive coverage of allkey issues in the methodology and practice of economic evaluation.It is designed for those, new to the field, wishing to appreciate andappraise studies done by others, or requiring a foundation for moreadvanced study. It will include discussion of the main design featuresof studies, such as costing methods, health state preference valuation,integrating economic analysis with clinical trials and modellingapproaches. Also, given the increasing demands for studies by healthcare decision makers, such as the National Institute for ClinicalExcellence (NICE) in the UK, there will be in-depth discussion ofofficial requirements and the perspectives of decision makers.

The majority of the formal lectures will be given by ProfessorDrummond and Professor Sculpher. In addition there will be anumber of tutored practical group exercises. The workshop feeincludes a copy of the newly published 3rd edition of ‘Methods forthe Economic Evaluation of Health Care Programmes’ by MichaelDrummond and others.

28th June Introduction to economic evaluationam • Introduction to the basic methods of economic

evaluation• Theoretical foundations of economic evaluation.

pm • Guidelines for the conduct of economic evaluation.• Critical appraisal exercise – how to tell a good study

from a bad one.Evening • Welcome reception

29th June Measuring and valuing costs and benefitsam • Identifying and measuring costs in economic

evaluations• Discounting future costs.• Allowing for uncertainty in economic evaluations.

pm • Measuring and valuing benefits in economic evaluations.• ‘Utilities’, quality-adjusted life-years and

willingness-to-pay• Preference measurement exercise.

Evening • Course dinner

30th June Synthesising and using economic dataam • Trial based economic evaluations.

• Modelling approaches; decision trees, Markov models.pm • Using economic evaluation in decision-making.

• International economic evaluation guidelines.• Panel session.

Workshop ends at 4.00pm. on 30th June.

MODULE 3

Meeting Decision Makers’ Requirements: Advanced Methods for Cost-Effectiveness Analysis4th-8th July 2005 Leaders: Mark Sculpher, Michael Drummond, Karl Claxton

This workshop deals with advanced methods in cost-effectivenessanalysis for pharmaceuticals and other health care technologies. It isstructured around the analytical steps required to develop economicanalyses to inform decision makers such as reimbursement agencies,hospital managers and formulary committees. It is focusedparticularly on the 2004 National Institute for Clinical Excellence(NICE) methods guidance for cost-effectiveness analysis. In additionto presentations, the course will include a series of small groupexercises focusing on the development and analysis of a decisionmodel, and will include some PC-based work.

In order to be eligible for this module, participants must befamiliar with, and understand, Drummond et al 1997 (Methods forthe Economic Evaluation of Health Care Programmes, Oxford:OUP, 2nd Edition), or have attended a relevant foundation course ineconomic evaluation such Module 1.

The Faculty will come from the Team for Economic Evaluationand Health Technology Assessment at the Centre for HealthEconomics. The workshop fee includes a copy of ‘EconomicEvaluation in Health Care: Merging Theory with Practice’ edited byMichael Drummond and Ali McGuire.

4th July • Policy context.• Analytical requirements for decision making.• Scoping decision problems.• Analysis of trial-based data.• Using sample data to show uncertainty in

cost-effectiveness.• Regression analysis for cost-effectiveness.• Sub-group analysis.• Analysing multi-national trials.

5th July • Use of decision modelling for cost-effectiveness.• Different types of decision model.• Markov models and extensions.• Comprehensive decision modelling.• Incorporating effectiveness evidence in models.• Meta analysis and regression.• Indirect comparisons.• Incorporating cost evidence into models.

6th July • Incorporating utility evidence in models.• Data sources for utility.• Mapping between different measures.• Electronic literature searching for cost-effectiveness.• Generalisability and transferability in cost-effectiveness.

7th July • Dealing with uncertainty in decision models.• Probabilistic sensitivity analysis.• Cost-effectiveness acceptability curves.• Scenario analysis.• Dealing with heterogeneity.• Value of perfect information. • Value of sample information.

8th July • Cost-effectiveness analysis for policy making.• Assessing quality in decision models.• Methodological guidelines.• Future developments in the field.

MODULE 2

Quality of Life

29th June-1st July 2005Leader: Paul Kind

This 3-day workshop provides a detailed introduction to the theoryand practice of quality of life measurement with particular emphasison its use in economic evaluation. Workshop lectures cover allaspects of the design, construction and use of quality of lifemeasures. Linked ‘hands-on’ sessions deal with the use of preferencemethods for valuing health such as time trade-off and standardgamble, as well as simpler, non-preference methods. The Workshopincludes a state-of-the-art review of quality of life measurementcovering the principal generic instruments including SF-36 and itsderivatives, HUI and EQ-5D, as well as the status of other patient-reported outcome measures. Methods for deriving appropriateoutcome measures in the absence of quality of life data in clinicaltrials, will be demonstrated. Particular attention will be given to theuse of quality of life data in technology appraisals published by theUK National Institute for Clinical Excellence (NICE).

The Workshop delivers a comprehensive grounding in this highlyspecialised field and is designed to provide an in-depth briefing forthose concerned with the measurement and valuation of healthoutcomes in the evaluation of new health technologies.

Workshop lectures include:

Concepts and methodology:How are measures designed and constructed?• Quality of life measurement strategies – concepts and

misconceptions.• Beyond the Washington Panel – a theoretical framework.• Preference-based valuation methods.

Quality of life measures: reviewing the evidence:What are the strengths and weaknesses of the principal measures?• Standards and practice in condition-specific instruments.• A critical review of generic measures, including SF-36, QWB,

SIP, NHP, HUI and EQ5D.• Psychometric testing / assessing performance.

Measuring quality of life in practice:How are measures currently used in evaluative studies?• Criteria for instrument selection / guidelines in analysis

and reporting.• Quality of life measurement in clinical trials.• Quality of life data in economic analysis.

Linked practical sessions include:• Valuation techniques – including time trade-off and standard

gamble.• Analysis of quality of life data.• Interpreting the evidence – case studies of published literature.

REGISTRATION FORMPlease complete and return to:Vanessa Windass, Workshop CoordinatorYork Expert WorkshopsCentre for Health EconomicsAlcuin A. Block, University of YorkYORK, YO10 5DD, United Kingdomor Fax to: UK: 01904 321402International: +44 1904 321402e-mail: irss82@york.ac.uk

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Method of Payment: Payment can be made by cheque in GB pounds made payable to the University of York. Payment can also be made by credit card*(Visa or MasterCard), or the University can issue an invoice* upon receipt of an official Purchase Order.* Please contact us for details of these payment methods.

Cancellation: A full refund of course fees (less 10% administrative charge) will bemade for cancellations received in writing at least one month priorto the workshops. Substitutes can be made but please e-mail or faxnew delegate details when known. Cancellations made less than onemonth prior to the workshops are not refundable.

VAT Number: GB 647 2055 41

I would like to register for:

MODULE 1

Foundations of Economic Evaluation in Health Care (28th-30th June 2005)

£1200.00 + VAT @ 17.5% = £1410.00 (before 8th April 2005)

£1259.57 + VAT @ 17.5% = £1480.00 (after 8th April 2005)

£834.04 + VAT @ 17.5% = £980.00 (Public Sector rate only)

MODULE 2

Quality of Life (29th June – 1st July 2005)

£1200.00 + VAT @ 17.5% = £1410.00 (before 8th April 2005)

£1259.57 + VAT @ 17.5% = £1480.00 (after 8th April 2005)

£834.04 + VAT @ 17.5% = £980.00 (Public Sector rate only)

MODULE 3

Meeting Decision Makers’ Requirements: Advanced Methods for Cost-Effectiveness Analysis(4th-8th July 2005)

£1982.98 + VAT @ 17.5% = £2330.00 (before 8th April 2005)

£2085.11 + VAT @ 17.5% = £2450.00 (after 8th April 2005)

£1387.23 + VAT @ 17.5% = £1630.00 (Public Sector rate only)

TOTAL £

PLEASE CONTACT USIMMEDIATELY TO

RESERVE YOUR PLACE.

Tel: +44 (0)1904 321450Fax: +44 (0)1904 321402e-mail: irss82@york.ac.uk

Internet:www.york.ac.uk/inst/che/expert.htm

on-line booking now available

WORKSHOP DATES

MODULE 1: 28th-30th June 2005

MODULE 2: 29th June-1st July 2005

MODULE 3: 4th-8th July 2005

Workshop Venue

St. William’s College Conference Centre5 College Street, York, United Kingdom(Adjacent to York Minster)

Accommodation

Delegates are responsible for booking their accommodation andarranging payment directly with a hotel of their own choice. Oncedelegates have completed and returned their Registration Form tothe Workshop Coordinator, a letter of confirmation will be sentalong with details for booking accommodation in York. Meanwhile,for accommodation ideas, see the following internet sites:www.york.roomcheck.co.ukorwww.tripadvisor.com(search for ‘York, North Yorkshire’)Please note that the workshop venue does not have accommodationon-site, and that accommodation fees are additional and separateto the registration fee.

Meals

Coffee and Tea refreshments will be provided during the morningand afternoon sessions and a Buffet Lunch served. There will be aWelcome Reception and a Course Dinner hosted on two separateevenings of each workshop. These are all included in the workshopregistration fee for delegates.

Fees

Early booking rate (before 8th April 2005)MODULE 1 or MODULE 2: £1410.00 per module inclusive of VAT @ 17.5%MODULE 3: £2330.00 inclusive of VAT @ 17.5%

After 8th April 2005MODULE 1 or MODULE 2: £1480.00 per module inclusive of VAT @ 17.5%MODULE 3: £2450.00 inclusive of VAT @ 17.5%

Special discount for public sector employeesModule 1 or Module 2: £980.00 per module inclusive of VAT @ 17.5%MODULE 3: £1630.00 inclusive of VAT @ 17.5%

PLEASE CONTACT US IMMEDIATELY TO RESERVE YOUR PLACE:

Tel: +44 (0)1904 321450Fax: +44 (0)1904 321402e-mail: irss82@york.ac.ukInternet: www.york.ac.uk/inst/che/expert.htm

On-line booking now available.

St.William’s College;interior and exterior

MARK SCULPHERMark Sculpher is a Professor of Health Economics and leads theTeam for Economic Evaluation and Health Technology Assessmentat the Centre for Health Economics, University of York. Between1988 and 1997 he worked at the Health Economics Research Groupat Brunel University; during 1998 he was a Visiting Professor in theDepartment of Clinical Epidemiology and Biostatistics at McMasterUniversity in Canada. Mark leads the economics component ofYork’s input into technology assessment reviews for the NationalInstitute for Clinical Excellence (NICE). He was chair of NICE’sTask Group which developed updated methods for cost-effectivenessanalysis. He is also currently a member of NICE’s AppraisalCommittee. He has extensive knowledge of all areas of economicevaluation, particularly decision modelling.

KARL CLAXTONKarl Claxton is a Senior Lecturer in the Department of Economicsand Related Studies at the University of York. In 1997/98 he was avisiting Harkness Fellow at the Harvard Center for Risk Analysis,Harvard School of Public Health and since 1999 he has held anadjunct appointment at Harvard as an Assistant Professor of Healthand Decision Sciences. His research interests encompass theeconomic evaluation of health care technologies. The key areas ofinterests, which were the focus of his doctoral work include:Bayesian decision theory; the value-of-information analysis; settingpriorities in clinical research and development; and the efficientdesign of clinical trials. In September 1999 he was appointed to the National Institute for Clinical Excellence Appraisal Committee.The committee meets monthly to appraise new and existing heathcare technologies and develop guidance for the NHS on the use ofthese technologies. Karl Claxton received a PhD in Economics, aMSc in Health Economics and a BA in Economics from theUniversity of York.

Other researchers with specific areas of expertise will also contributeto the Workshops.

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THE COURSE LEADERS

Well respected in health economics in the UK and overseas, MikeDrummond, Paul Kind, Mark Sculpher and Karl Claxton will ensurethe Workshops are accessible, informative and enjoyable, whetheryour background is in pharmaceuticals or clinical research.

MIKE DRUMMONDMike Drummond is a Professor of Health Economics and Director of the Centre for Health Economics at the University of York. He is a past-president of the International Society for TechnologyAssessment in Health Care and author of the best known textbookon the Methods for the Economic Evaluation of Health CareProgrammes. He has extensive experience of research into theeconomic evaluation of medicines and has consulted with manymajor companies. He has also advised the World HealthOrganization, the European Union and a number of governments onpolicies for economic evaluation of health technology. He is currentlya member of the Guidelines Review Panels of the National Institutefor Clinical Excellence (NICE) in the UK.

PAUL KINDPaul Kind is the Principal Investigator in the Outcomes ResearchGroup, at the University of York. He has more than 25 yearsexperience as a researcher in the field of health status measurementand has specialist knowledge of all aspects of the design and use ofmeasures of health outcomes. He is a regular contributor topostgraduate teaching courses in Europe and the USA. He has been a Visiting Professor at the University of Wisconsin-Madison wherehe lectured on Outcome Measurement in the Department ofPreventive Medicine. In addition to his work at the Centre, Paulcollaborates with clinicians and researchers in the pharmaceuticalindustry in several different therapeutic areas and acts as aninternational consultant in the field of outcome management. As a founder member of the EuroQoL Group, Paul has unrivalledknowledge of the EQ-5D.

NB: The Centre for Health Economics reserves the right to amend this provisional course slightly, but all delegates will be informed of precise programme details prior to the Workshops.

YORK – A SUPERB SETTINGSet in rolling green English countryside, within easy reach of stunning moorland scenery in the Yorkshire Dales and North York Moors, York is a fascinating and beautiful walled medieval city. History abounds – from Roman heritage, the famous Jorvik Viking Centre to the magnificent Minster and through to the present day.

ST. WILLIAM’S COLLEGESt. William’s College, in College Street, York is a superb half-timbered medieval building. Built in 1461 in the shadow of YorkMinster, it was originally a college for Minster priests. One of York’s most atmospheric buildings, St. William’s College has awealth of interesting features and has been restored to its formerglory; housing a popular restaurant and used for conferences,exhibitions and receptions.

YORK EXPERT WORKSHOPS IN THE

SOCIO ECONOMIC EVALUATION OF MEDICINESCENTRE FOR HEALTH ECONOMICS

For further information about the Centre for Health Economics visit our internet web site at:www.york.ac.uk/inst/che/

This brochure can be viewed on-line at:www.york.ac.uk/inst/che/expert.htm

on-line booking now available