sleep disorders a pathophysiological model by allan hobson … · rem sleep behavior disorder older...
TRANSCRIPT
SLEEP DISORDERS
A Pathophysiological Model
byAllan Hobson
Harvard Medical School
Normal Sleep is a Product of
Dynamic Neuronal Interaction
Changes in the Balance of Neuronal Interaction Causes Abnormal Sleep
BRAIN STEMas a set of Coupled OscillatorsCircadian-HypothalamusUltradian-PonsRespiratory-Medulla
MEDIATING FACTORSSet point Changes Timing Errors
NARCOLEPSYGelineau’s Tetrad
Sleep AttacksCataplexyHypnogogic HallucinationHypnopompic Hallucination
SLEEP APNEA SYNDROMESCentral Factors
Peripheral FactorsInteraction
REM SLEEP BEHAVIOR DISORDER
Older MenAct Out DreamsLoss of Muscle InhibitionHarbinger of Parkinson’s Disease