skeletal muscle physiology laboratory - san diego …€¦ · skeletal muscle physiology laboratory...

Skeletal Muscle Physiology Laboratory Samuel R. Ward, PT, PhD Professor Departments of Radiology, Orthopaedic Surgery, and Bioengineering Vice Chair of Research, Orthopaedic Surgery University of California San Diego

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Skeletal Muscle Physiology Laboratory

Samuel R. Ward, PT, PhD Professor Departments of Radiology, Orthopaedic Surgery, and Bioengineering

Vice Chair of Research, Orthopaedic Surgery University of California San Diego

Page 2: Skeletal Muscle Physiology Laboratory - San Diego …€¦ · Skeletal Muscle Physiology Laboratory Samuel R. Ward, PT, PhD Professor Departments of Radiology, Orthopaedic Surgery,

Shoulder R01 HD073180

Spine DoD WX81XHW

Normal Pathological

ClinicalProblem-MuscleDegenera4on

Page 3: Skeletal Muscle Physiology Laboratory - San Diego …€¦ · Skeletal Muscle Physiology Laboratory Samuel R. Ward, PT, PhD Professor Departments of Radiology, Orthopaedic Surgery,

Control

Sham

Repair

ModelSystems

Scar

Human Rat Mouse

Page 4: Skeletal Muscle Physiology Laboratory - San Diego …€¦ · Skeletal Muscle Physiology Laboratory Samuel R. Ward, PT, PhD Professor Departments of Radiology, Orthopaedic Surgery,

B"Perilipin"Laminin"DAPI"

BiologicalTools

Biopsy/Histology ‘omics

Stem Cell Biology Patient/Animal Function

Page 5: Skeletal Muscle Physiology Laboratory - San Diego …€¦ · Skeletal Muscle Physiology Laboratory Samuel R. Ward, PT, PhD Professor Departments of Radiology, Orthopaedic Surgery,

Goal-MuscleRecovery/repair

CollagenCapillary

MuscleFiber

TendonRepair

TendonHealing

An4-fibro4cRX

MuscleInjury

(regens4m)

CellordrugRx

Exercise

Lieber and Ward, AJP Cell Phsyiol, 2014

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