sinapsis - neurotransmisores · neurotransmisores. classic characteristics: •synthesized in the...
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Sinapsis - NeurotransmisoresNelson D. Villalba M.D. M.Sc.
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¿Qué es la SINAPSIS?
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Sinapsis
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Sinapsis Eléctrica
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Sinapsis Química
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Síntesis/
Almacenamiento
Liberación
Interacción con el receptor
Reciclaje
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Sinapsis Química
here.
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Neurotransmisores
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Classic Characteristics:
• Synthesized in the neuron.
• Become localized in presynaptic terminal.
• Bind to receptor site on postsynaptic membrane.
• Removed by a specific mechanism from its specific site of action.
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Catecholamine synthesis
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Classification
• Small molecule transmitters:
Amino acids:
Dietary amino acids.
GABA
Monoamines:
Catecholamines.
Indoleamines.
• Acetylcholine.
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Amino Acids
• Dietary:
Aspartate.
Glycine.
• Gamma aminobutyric acid (GABA):
From decarboxylation of glutamate.
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Monoamines
• Catecholamines:
Derived from tyrosine.
Include:
Dopamine.
Norepinephrine.
Epinephrine.
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Monoamines
• Indoleamine:
Derived from tryptophan.
Includes:
Serotonin.
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SystemsSerotonin
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GABA receptor binding sites
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