share: report back from sabcs focusing on metastatic breast cancer
DESCRIPTION
Stephen C. Malamud, MD, Department of Medicine, Beth Israel Medical Center, presented at SHARE on the latest news from the San Antonio Breast Cancer Symposium (SABCS) 2013 as it relates to metastatic disease. If you'd like to view the complete webinar, go to www.sharecancersupport.org/malamud The information in this presentation is not intended to be a substitute for professional medical advice, diagnosis or treatment. The presentation was given on February 20, 2014.TRANSCRIPT
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San Antonio Breast Cancer Symposium- 2013
The Future of Metastatic Breast Cancer
Stephen C. Malamud MDMedical OncologyBeth Israel Medical Center-Comprehensive Cancer Center
Breast Cancer:Surgery for Stage IV ?
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Tata Memorial Study
Tata Memorial (India)- 350 patients from 2005-2012 Endpoint- overall survival Projected benefit: median survival-
increase in survival from 18 to 24 months Initial therapy in experimental arm-
CAF+/- T Stratifications: number and type of
metastases, ER status, age, menopause Subset analysis: age, ER status, HER2
status, number and type of metastases
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Study size: 271 (2008-12) Endpoint: overall survival Initial therapy: primary site local
therapy Stratification: none described Inclusion of radiotherapy: yes Subset analysis planned: age,
ER/Her2/triple negative, one organ site; bone only; all other solitary bone lesions; multiple bone lesions
Turkish Study:
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Tata Memorial Study:
Turkey: both groups median age 52 Tata Memorial: 47 and 48 Turkey: tumor size- more T2 and T4 tumors in ST arm; grade
similar between 2 arms Tata Memorial: tumor size: not described; grade not
described Both studies: Lymph node involvement not described Tata Memorial: ER+: 51% and 49% Turkey- fewer ER+ and more Triple Negative patients on the
ST arm Metastatic burden: Tata- balanced for >3 lesions, Turkey-
single organ site more frequent in surgical arm Bone only metastases- Tata- balanced between arms; Turkey-
fewer in ST arm, non-bone metastases more frequent in ST arm
Study characteristics:Comparative Analysis
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