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September 2006 Vol. LXXXV, No. 1

MonthlyMeetingMedicinal Chemistry Symposium,Vendor Fair and Career Services

Education NightMay 11, 2006

NationalChemistry WeekEvents

Local SectionWebsitesby Don Rickter

2 The Nucleus September 2006

October 22, 2006 – Wellesley College Science CenterPhyllis A. Brauner Memorial Lecture by Dr. Bassam Shakhashiri

Dr. Bassam Shakhashiri is a Professor of Chemistry at the University of Wisconsin-Madisonand is the William T. Evjue Distinguished Chair for the Wisconsin Idea. Professor Shakhashirihas captivated audiences with his scientific demonstrations at a variety of locations, includingBoston’s Museum of Science, the National Academy of Sciences, and the Smithsonian’sNational Air and Space Museum in Washington.

Room 277, 11 am – 12 pm and 2 pm – 3 pm The Sunday presentations are free and open to the public. Tickets are available on a first come,first serve basis, though reservations are recommended. To reserve tickets, please contact Mar-ilou Cashman either via email [email protected] (preferred) or by phone 1-800-872-2054before October 19, 2006. Tickets will be available for pick-up outside of the Science Center onthe 22nd. Parking is free. For directions to Wellesley College, please visit http://www.welles-ley.edu/Admin/travel.html. While at Wellesley, a visit to the arboretum and greenhouses(which are open to the public) is a must. For more information, visit http://www.wellesley.edu/FOH/greenhouse.html.

Kicking off National Chemistry Week 2006 festivitiesJoin us in a variety of hands-on activities related to the yearly theme. Taking place from 10 am– 3:30 pm on October 22, 2006 inside the Wellesley Science Center. For more information,please visit www.nesacs.org.

October 28, 2006Boston Children’s Museum

NCW volunteers will be on hand to perform demonstrations and assist in hands-on activitiesrelated to the yearly theme.

Museum of Science, BostonNCW volunteers will be on hand to perform demonstrations and assist in hands-on activitiesrelated to the yearly theme.

October 22 – 28, 2006K-12 students participate in the NCW poster competition. Grades 9-12 may participate in thepuzzle contest as well. See www.nesacs.org for detailed information.

National Chemistry Week EventsCelebrating

Your Home – It’s All Built on Chemistry!!

The Nucleus is distributed to the members of the Northeastern Section of the American Chemical Society, to the secretaries of the Local Sections, and to editors of all local A.C.S. Section publications.Forms close for advertising on the 1st of the month of the preceding issue. Text must be received by theeditor six weeks before the date of issue.Editor: Michael P. Filosa, editor, Ph.D., ZINK Imaging Incorporated, 1265 Main Street,

Waltham, MA 02451 Email: Michael.Filosa(at)zink.com; Tel: 781-386-8479.Associate Editors: Myron S. Simon, 20 Somerset Rd., W. Newton, MA 02465, Tel: 617-332-5273

Nancy Simons, Analytical Chemist, Corporate R&D, Boston Scientific Corp., 1 Boston Scientific Place A4, Natick, MA 01760-1537. Email: Nancy.Simons(at)bsci.com; Tel. 508-650-8603; Fax 508-647-2329Sheila E Rodman, Malden, MA. Email:serodman(at)hotmail.com Tel: 781-771-4116.

Board of Publications: Mary Mahaney (Chair), Martin Idelson, Vivian K. Walworth Business Manager: Karen Piper, 19 Mill Rd., Harvard, MA 01451, Tel: 978-456-8622Advertising Manager: Vincent J. Gale, P.O. Box 1150, Marshfield, MA 02050,

Tel: 781-837-0424; FAX: 781-837-1453Contributing Editors: Morton Hoffman, Feature Editor; Dennis Sardella, Book Reviews; Calendar Coordinator: Sheila Rodman, email: serodman(at)hotmail.comPhotographers: Morton Z. Hoffman, Ying Wei and James PhillipsProofreaders: Donald O. Rickter, Myron S. Simon, Vivian K. WalworthWebpage: Webmaster: Sathish Rangarajan, sathish.rangan2(at)gmail.comCopyright 2006, Northeastern Section of the American Chemical Society, Inc.

The Nucleus September 2006 3

The Northeastern Section of the AmericanChemical Society, Inc.Office: Marilou Cashman, 23 Cottage St., Natick, MA 01760. 1-800-872-2054 (Voice or FAX) or 508-653-6329. e-mail: mcash0953(at)aol.comAny Section business may be conducted via the business office above.NESACS Homepage:http://www.NESACS.orgSathish Rangarajan, WebmasterACS Hotline, Washington, D.C.: 1-800-227-5558Officers 2006Chair:Patricia MabroukChemistry Department, Northeastern UniversityBoston, MA 02115617 373 2845; p.mabrouk(at)neu.eduChair-Elect:Mukund Chorghade14 Carlson Circle, Natick, MA 01760-4205508-651-7809 and 508-308-3891Chorghade(at)comcast.netImmediate Past Chair:Amy TapperPeptimmune64 Sidney Street, Suite 380, Cambridge, MA 02139617-715-8005; amy.tapper(at)peptimmune.comSecretary:Michael SingerSigma RBI3 Strathmore Rd. Natick, MA 01760-2447508-651-8151x291 msinger(at)sial.comTreasurer:James Piper19 Mill Rd., Harvard, MA 01451978-456-3155 piper28(at)attglobal.netAuditor:Anthony RosnerArchivist:Myron S. Simon20 Somerset Rd. Newton, MA 02465; 617-332-5273romysimon(at)mindspring.comTrustees:Joseph A. Lima, Esther A.H. Hopkins, Michael E. Strem Councilors Alternate CouncilorsTerm Ends 12/31/2006Michaeline F. Chen Wallace J. GleekmanCatherine E. Costello Howard R. MaynePatricia A. Mabrouk Alfred ViolaJulia H. Miwa Barbara G. WoodDorothy J. Phillips David WarrTerm Ends 12/31/2007Thomas R. Gilbert Arlene W. LightMichael J. Hearn Timothy B. FrigoMichael Singer Mary MahaneyPamela Nagafuji Mark FroimowitzTerm Ends 12/31/2008Doris I. Lewis Patrick M. GordonMorton Z. Hoffman Michael P. FilosaChristine Jaworek-Lopes Lawrence ScottMary Burgess Liming ShaoDonald O. Rickter S. B. Rajur

All Chairs of standingCommittees, the editor of THE NUCLEUS, and the Trustees of SectionFunds are members of theBoard of Directors. AnyCouncilor of the American Chemical Societyresiding within the section area is an ex officiomember of the Board of Directors.

ContentsNational Chemistry Week Events __________________________2

Announcements________________________________________4NESACS Vendor Fair, Call for Nominations for the Esselen Award,New England Environmental Research Symposium, New Members

Monthly Meeting _______________________________________5Joint with Medicinal Chemistry: New Trends in Oncology (Part II)

Local Section Websites by Don Rickter _____________________6

Announcements________________________________________7Brandeis Chemists, Dreyfus Foundation Award

High School Chemistry Club Flyer _________________________9

Book Prizes of NESACS by M. Simon______________________10

Announcement _______________________________________10ACS NE Regional Undergraduate Day

Connections To Chemistry 2006 _________________________11

2006 Education Night Awards ___________________________12

Pictures from Education Night by Eileen Yue________________13

Cover: Dr. Michael Block, AstraZeneca R&D, evening speaker at the Septem-ber meeting. He will speak on “The Development of Selective Aurora A and BInhibitors” as part of the symposium on Oncology. (Photo by Lori Perrin.)

Deadlines: November 2006 Issue: September 15, 2006December 2006 Issue: October 13, 2006


Call forNominationsGustavus John Esselen Awardfor Chemistry in the PublicInterestThe Northeastern Section (NESACS)is inviting nominations for its presti-gious Gustavus John Esselen Awardfor Chemistry in the Public Interest.This award is given annually to achemical scientist whose scientific andtechnical work has contributed to thepublic well-being and has therebycommunicated the positive values ofthe chemical profession. The signifi-cance of this work should have becomeapparent within the five years preced-ing nomination. The awardee shall bea living resident of the United States orCanada at the time of the nomination.

There is no limitation to the fieldof chemistry. The selection committeefocuses on the general public recogni -tion of the work, as well as its scien-tific/technical significance.

The Award consists of a bronzemedal and the sum of $5,000. Travelexpenses incidental to the conferringof the award will be reimbursed. Theaward will be presented at the April 12,2007 meeting of the Section. TheAwardee is expected to deliver anaddress related to the work for whichthe honor is conferred.

Nominations shall include thenames of two co-sponsors, a biographyof the nominee, a description of thework, which has been recognized ascommunicating the positive values ofthe chemical profession, along withcopies of pertinent articles and popularnews and feature articles indicative ofpublic interest. Joint nominations areacceptable. Further information isavailable at www.nesacs.org. Nominations Due October 15, 2006. Award recipients will be notified byFebruary 1, 2007.Nominations shall be directed to: Dr. Robert Langer, c/o Karen Piper19 Mill Rd., Harvard, MA 01451. Inquiries may be made to RobertLanger, Tel. (617) 253-3107;

e-mail: rlanger(at)mit.edu or Karen Piper: Tel. (978) 456-8622 e-mail:piper28(at)attglobal.net. ◆◆

Corporate Patrons and GolfIridiumAstra Zeneca R&D BostonGenzyme Drug Discovery & DevHovioneIBMIRIX PharmaceuticalsJohnson-Matthey Pharma SolutionsLyophilization Service of New Eng-

landPhasex CorporationStrem Chemicals, Inc.Zone EnterprisesCorporate Sponsors and GolfRhodiumAerodyne Research, Inc.Cambridge Isotope LaboratoriesCambridge Major LaboratoriesNew England BioLabs, Inc.PfizerSigma-RBIShasun Pharma SolutionsDonors and Golf TungstenConsulting Resources Corp.Dishman PharmaceuticalsAnd Chemicals LimitedHoughton Chemical CompanyOrganix, Inc.Vertex

The Northeastern Section of the Amer-ican Chemical Society will hold a ven -dor fair jointly with the MedicinalChemistry Symposium on Thursday,September 21, 2006 3-7 pm at theHoliday Inn Select, 15 MiddlesexCanal Park Road, Woburn, MA. If yourbusiness provides technical products orservices for pharmaceutical, medicinal,analytical chemists, biochemists orother related technical disciplines, thisis your chance to network with overone hundred qualified prospects. Thisis a chance to meet face-to-face withexisting customers, to generate newbusiness opportunities and to introducenew products and services.

If you are interested in this vendorfair please contact: Marilou Cashman,NESACS Office [email protected]: $400 per 6-foot table (address checks to NESACS).◆◆

NortheasternSection-AmericanChemicalSocietyVendor Fair

Save theDate!The 5th Annual New England Environmental ResearchSymposiumSaturday, November 11, 20069:00 am – 3:00 pmBridgewater State CollegeUndergraduate and graduate studentresearch posters in all environmentaldisciplines are welcome. Please email Ed Brush (ebrush(at)bridgew.edu) to add yourname to our email distribution list. Aformal “Call for Abstracts” will be sentelectronically in mid-September. ◆◆

NewMembersInvitation to attend a meetingYou are cordially invited to attend oneof our upcoming Section meetings as aguest of the Section at the social hourand dinner preceding the meeting.

Please call Marilou Cashman at800-872-2054, 508-653-6329 or:Mcash(at)aol.com by noon of the firstThursday of the month, letting herknow that you are a new member. ◆◆


Monthly MeetingThe 871st Meeting of the Northeastern Section of the AmericanChemical Society organized by the Medicinal Chemistry Section of NESACSSymposium: NEW TRENDS IN ONCOLOGY (Part II)Thursday - September 21, 2006Holiday Inn Select Hotel, 15 Middlesex Canal Park Road, Woburn, MA2.30:4.30 p.m.: In conjunction with the Symposium: Career Services Program

and Resume Reviews. Presentations by Mukund Chorghade, Jen-nifer Sass and Megan Driscoll of Pharmalogics Corporation.Please bring a copy of your CV.

3:00:7:00 p.m.: NESACS Vendor FairSymposium Program:2:45 pm Refreshments3:00 pm Welcome

Raj (SB) Rajur, Program Chair3:05 pm Introductiory Remarks

Norton Peet, North Andover, MA3:15 pm TBA4:00 pm TBA4:45 pm Toward Improved Topoisomerase I Inhibitor Anticancer Agents;

Beverly A. Teicher, PhD , Vice President, Oncology Research, Gen-zyme Corporation, Framingham, MA.

5:30 pm Novel Small-Molecule Inhibitors of Oncogenic Protein Kinases:Tackling Selectivity and Resistance; Tomi Sawyer, Senior-VicePresident, Drug Discovery, ARIAD Pharmaceuticals, Cambridge,MA.

6:15 pm Social Hour6:45 pm Dinner 7:45 pm The Development of Selective Aurora A and B Inhibitors,

Michael Block, Director of Chemistry, Cancer Research Center,AstraZeneca R&D, Boston, MA.

Dinner reservations should be made no later than 12:00 noon on Thursday,September 14, 2006. If you prefer to pay at the door , please contact MarilouCashman at (800) 872-2054 or (508) 653-6329 or [email protected] not canceled at least 24 hours in advance must be paid. Mem -bers, $28.00; Non-members, $30.00; Retirees, $15.00; Students, $10.00. Any-one who needs handicapped services/transportation, please call a few days inadvance so that suitable arrangements can be made.Directions to Holiday Inn Hotel (http://www.radisson.com/woburnma)A. From Boston - Cambridge - Points North: Take Route I-93 to Route95/128 West. After 1 mile, take Exit 35 South to Route 38 (Main Street). *After about 500 feet at the traf fic light, turn right into Middlesex Canal Streetto the hotel entrance.B. From the West: Take Route 95/128 North to Exit 35 South (Route 38 -Main Street. Follow directions from * above.THE PUBLIC IS INVITED

Beverly TeicherToward Improved TopoisomeraseI Inhibitor Anticancer Agents.Toposiomerase I is a nuclear enzymeinvolved in unwinding DNA duringreplication. The Topo I enzyme bindsdirectly to DNA and produces a singlestrand-break allowing strand passageand then relegation to restore theduplex DNA. Topo I is essential forcell proliferation but is very difficult toover-express in cells. Camptothecin isa natural product that inhibits Topo I insuch a way that the cleavedDNA/enzyme/camptothecin complexforms a stable unit which is called the“cleavable complex,” thus trapping thecell with DNA strand breaks, a lethalevent. Two camptothecin derivatives,topotecan and irinotecan, are approvedanticancer drugs. A limitation of theseagents results from pH-sensitive open-ing of the lactone ring of the camp-tothecin structure. The ring-openedform of the molecules is toxic to nor -mal tissue but is not an effective Topo Iinhibitor. We are exploring the possi-bility that non-camptothecin Topo Iinhibitors can be developed with animproved therapeutic index andincreased broad spectrum anticanceractivity.

Beverly A. Teicher is Vice Presi-dent of Oncology Research at Gen-zyme Corporation, Framingham, MA.Upon completion of her Ph.D. in Bioor-ganic Chemistry at the Johns HopkinsUniversity, Dr. Teicher accepted apostdoctoral position at Yale Univer-sity School of Medicine. Her postdoc -toral training focused on thedevelopment of models to study theresponse of hypoxic cells to anticancertherapies and synthesis of potentialhypoxic cell selective cytotoxic agents.Dr. Teicher joined the staff of theDana-Farber Cancer Institute as anAssistant Professor of Pathology androse to the rank of Associate Professorof Medicine and Radiation Therapy,Harvard Medical School at the Dana-Farber Cancer Institute and Joint Cen-ter for Radiation Therapy. Dr. Teicherpioneered the application of perfluoro-chemical and hemoglobin oxygendelivery agents in cancer therapy and

Continued on page 8


InorganicColloquiumat UMassDartmouthThe 11th Boston Regional InorganicColloquium (BRIC-11) will be held onSaturday, October 14, 2006 at UMassDartmouth, North Dartmouth, MA.

Invited speakers are: Ms. Kather-ine Lovejoy (MIT), Professors ZhifengRen (Boston College), DwightSweigart (Brown University), andKlaus Theopold (University ofDelaware). Registration will be at 9:00am and talks will run from 9:30 am –4:15 pm. Lunch will be served at noon.Driving instructions as well as a cam-pus map can be found on the UMassDartmouth homepage (http://www.umassd.edu/directions)

Individuals interested in attendingare asked to please contactJgolen(at)umassd.edu (508-999-8245)

Which local section of the AmericanChemical Society had the first website? Websites are now a powerful toolfor communication by individuals andall kinds of organizations, but theyhave been around only for a decade orso. My memory is that the CincinnatiSection and the Virginia Blue RidgeSection were among the pioneers.These two were up and running byAugust 1995. This was at a time in theprimitive past when most companiesdid not have web sites and very fewindividuals did. The number of web-sites of local sections doubled byNovember 1995 with the addition ofOle Miss and NE Oklahoma. Therewas another doubling, to eight sec-tions, in a few weeks. There were six-

teen by June 1996. Now most of the189 local sections (and the 33 ACSDivisions) have at least one websiteeach. Their styles vary, but all are use-ful, valuable resources for communica-tion within our chemical society andrelated sites.

Our NESACS site was first up on16 September 1996. We can celebrateits tenth anniversary this month. Weare grateful to Arthur Obermayer forhis vision, showing what internet pres -ence can do for our members. He andBetty Solbjor created our first websiteat a time when it was a difficult, pio-neering project. There were no tem-plates available. Arthur was aided by atask force chaired by Doris Lewis. Itsmembers included Myke Simon, DonRickter, and the late Stan Israel. TheBoard of Publications at that time waschaired by Joe Billo. He was aided byJoe Lima, Doris Lewis, Myke Simon,and the late Arno Heyn.

I found in my archives the contentof our first loading of our website.Today it looks primitive — just twelvepages of text like that published in TheNucleus — with no pictures or graph-ics. The officers were listed (with PatSamuel as Chair and Marty Idelson asChair-elect). The big event was theOctober meeting at Regis College,with Dr. James Thackeray of ShipleyCompany speaking on Photoresists.

All of our Websters, Webmasters,and Web Divas — including SathishRangarajan, Samuel P. Kounaves,Rachel Schindler, Frank R. Gorga,Michele Mandrioli, Marietta Schwartz,and, of course, Arthur Obermayer andBetty Solbjor, deserve big thanks fromall of us for keeping our website inter -esting, accurate, and timely.

I thank Prof. Emel Yakali of theUniversity of Cincinnati for sharingthe history of the website of theCincinnati Section. Their March 15,1995, meeting was the first one to beplaced on the website meetingarchives. Their newsletter CINTACS

or Mguo(at)umassd.edu (508-999-8871) before October 4th. The collo-quium is sponsored in part by BRIC,EPIX Pharmaceuticals, STREMChemicals, and UMASS Dartmouth ◆◆

Local Section Websitesby Don Rickter

Continued on page 7

DreyfusFoundationAward to Northeastern ProfessorPenny Beuning, Assistant Professor ofChemistry & Chemical Biology atNortheastern University has beennamed as a recipient of the prestigious2006 Camille and Henry DreyfusFoundation New Faculty Award. Pennyjoined Northeastern July 2006 follow-ing postdoctoral research with Profes-sor Graham Walker (MIT Biology) andreceived her doctorate in chemistryfrom the University of Minnesota in2000, working with Professor KarenMusier-Forsyth. Professor Beuning’sresearch group is investigating repairpathways linked to DNA polymeraseenzymes and uncovering new mecha-nisms of resistance to DNA damage.Outside of the laboratory, Penny hasserved as President of the Boston chap-ter of Graduate Women in Science[GWIS] since 2002. ◆◆

Conjunctionof Phoenixes By Don RickterHas anyone else noticed the conjunc-tion of phoenixes this year? Ournational meetings in 2006 are held intwo great cities with interesting histo-ries. Atlanta rose from the ashes of warand adopted the phoenix as its symbolin 1888. San Francisco has had a cityflag since 1900, which pictures thebird rising from the flames — not of1906, which was in the future, but ofthe disastrous fire of 1852.

Of course, we chemists use thephoenix as a symbol of the intercon-version of matter and energy, and asthe emblem of the American ChemicalSociety. NOTE ADDED:

New Orleans, where we had our2003 Spring National Meeting, alsouses the phoenix as a symbol of itsrenewal after Katrina. ◆◆

BrandeisChemistsHonored Brandeis University chemists DagmarRinge and Greg Petsko received theAbram L. Sachar Award on June 8,2006. Dagmar Ringe is the Lucille P.Markey Professor of Biochemistry andChemistry. Greg Petsko is the Gyulaand Katica Tauber Professor of Bio-chemistry and Molecular Pharmacody-namics. The award is presented by theBrandeis University National Women’sCommittee and honors individualswho have made outstanding contribu-tions to education and to the enhance -ment of knowledge.

Ringe and Petsko are the firstBrandeis faculty members to receivethe Sachar Award and Petsko is thefirst man to be so honored.

Established in 1968, the SacharAward is the highest honor bestowedby the Brandeis University NationalWomen’s Committee. Past recipientsinclude opera director Sarah Caldwell,actress Helen Hayes, medical physicistand Nobel laureate Rosalyn S. Yalow,and former Surgeon General M. Joce-lyn Elders. ◆◆

came out quarterly at the time. TheSpring 1995 issue had a statement bythe then chair, Jim Hershberger, thatthe section already had a website, cre -ated by Jeff Nauss. The Virginia BlueRidge Section home page goes back to1995. The current webmaster, GwenSibert, has records going back to 1998,but we have been unable to documentthe beginning of the website. ◆◆


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SPECTROSCOPIC SERVICES • LCMS (APCI and API-ES) • NMR (300 MHz) • GCMS (EI)

Local Section SitesContinued from page 6


tumor imaging. Dr. Teicher also eluci-dated mechanisms by which solidtumors are resistant to antitumoragents, especially antitumor alkylatingagents. Dr. Teicher hypothesized thattumors growing in a host woulddevelop drug resistance through mech-anisms involving the host and estab-lished a model system where drugresistance in a solid tumor was devel -oped in vivo. Dr. Teicher went on toincorporate antiangiogenic agents intosolid tumor treatment paradigms. InJuly 1997, Dr. Teicher was appointedResearch Advisor in Cancer Drug Dis-covery at Lilly Research Laboratories.While there she founded and chairedthe Tumor Microenvironment ActionGroup, chaired the Cell Cycle ActionGroup, and headed the In Vivo TumorModels Group. Dr. Teicher joined Gen-zyme Corporation in January 2002.Dr. Teicher is a very active member ofthe international scientific community.She has authored or co-authored morethan 400 scientific publications, hasedited seven books, is senior editor for

the journal Clinical Cancer Researchand is series editor for the Cancer DrugDiscovery and Development bookseries.

Tomi SawyerNovel Small-Molecule Inhibitorsof Oncogenic Protein Kinases:Tackling Selectivity andResistanceOncogenic protein kinases are keytherapeutic targets for drug discovery.X-ray crystallographic, biochemicaland cellular studies have revealed bothstructural and mechanistic propertiesof several oncogenic protein kinases.In an increasing number of cases,resistance to inhibition has been shownto involve critical amino acid muta-tions in the ATP or proximate bindingsites for small-molecule inhibitors.These challenges are being addressedby both chemical biology and drugdesign strategies. A case example isT315I mutation of Bcr-Abl kinase anddrug discovery campaigns focused onthe generation, optimization and devel-opment of novel small-moleculeinhibitors of Bcr -Abl kinase andmutants thereof. The clinical signi-

fance of selectivity and resistance willbe discussed in terms of future direc-tions.

Tomi Sawyer received a B.Sc.degree in Chemistry at Moorhead StateUniversity (now Minnesota State Uni-versity–Moorhead) and Ph.D. inOrganic Chemistry at the University ofArizona. His research has integratedsynthetic chemistry, drug design, struc-tural biology, chemoinformatics, bio-chemistry, cell biology and in vivodisease models with a focus on cancer .Tomi’s drug discovery track recordincludes contributions to clinical can-didates and/or noteworthy moleculartools for several therapeutic targets,including GPCR receptors(melanocortin), aspartyl proteases(renin and HIV protease), and proteinkinases (Src and Abl). He has pub-lished more than 200 scientific articles,reviews, commentaries, monographsand books. Tomi is an inventor withmore than 50 issued patents and patentfilings. He worked at Upjohn Com-pany and Parke-Davis/Warner-Lambert(now both Pfizer Global Research &Development), and is currently Senior-Vice President, Drug Discovery, atARIAD Pharmaceuticals. He is con-currently Adjunct Professor, Chemistry,as well as Biochemistry & MolecularBiology, University of Massachusettsand also Adjunct Professor, CancerBiology, at University of Massachu-setts School of Medicine. Tomi hasserved on the highlights advisory panelof Nature Reviews Drug Discoveryand the editorial advisory boards ofTrends in the Pharmacological Sci-ences, Expert Reviews in MolecularMedicine, Expert Opinion on Investi-gational Drugs, Journal of MedicinalChemistry, Chemistry and Biology,Current Medicinal Chemistry (Anti-Cancer Agents), Current Organic Syn-thesis, Expert Reviews in MolecularMedicine, Expert Opinion on Thera-peutic Patents (Oncology), DrugDesign and Discovery, PharmaceuticalResearch, Molecular Biotechnology,and Biopolymers (Peptide Science).Most recently, he has been appointedEditor-in-Chief, Chemical Biology &Drug Design.

SymposiumContinued from page 5

Continued on page 11

Book PrizesBook Prizes of theNortheastern Section By M.S.Simon

The Phyllis BraunerMemorial Book Prize: The prize is a memorial to an out-standing member of the NortheasternSection, Dr.Phyllis Brauner. Sheserved in many offices of the Section,in 1974 became the first woman Chairof the Section, and contributed to theactivities of the Section with her bold,innovative ideas and practical ways ofcarrying them out. She taught at Sim -mons College and Framingham StateCollege and was an inspiring teacher.Her research and education interestsare mirrored in the prize, which isgiven to a student who excels in theundergraduate oral presentation at theNortheast Student Chemistry ResearchConference (NSCRC).

The students are judged by theEducation Chair and a committee ofthe Conference judges. A book is cho-sen by members of the Education

Committee to reflect the broad topicof science. A presentation bookplateinside the cover honors both Dr .Brauner and the awardee. The book ispresented at the Conference and theawardee is acknowledged at the MayMeeting of the Section. The Arno Heyn Memorial Book Prize The prize is a memorial to Dr.ArnoHeyn, a distinguished, long-serving

The Fifteenth Annual ACS NortheastRegional Undergraduate Day will beheld in celebration of National Chem-istry Week (October 22 -28) on Satur-day, November 4, in the Life Sciencesand Engineering Building at BostonUniversity (24 Cummington St.,Boston). The keynote speaker will beDr. John Essigmann of MIT, who willspeak on “Design of Novel Anticancer

continued on page 16

Agents that Hijack Transcription Fac-tors.” A complete program will bepublished in the October issue of TheNucleus. We invite undergraduate stu-dents in the region and their advisorsto attend.

In addition to research talks, therewill be a workshop on hands-on chem-istry for children; seminars on graduateschool preparation, industrial careersand alternative employment pathways;and a graduate industry fair withrésumé review and information aboutACS career services. There will be a$10 registration fee to offset the cost oflunch, which will be provided, andworkshop materials.

The event is sponsored byNESACS, and is hosted by the Depart-ment of Chemistry and Chemia, theACS Student Affiliates Chapter at B.U.

For more information, contactMatt Vigneau at 617-353-2503; fax:617-353-6466; mvigneau(at)bu.edu ◆◆

ACS Northeast RegionalUndergraduate DaySaturday, November 4, 2006



Michael BlockThe Development of SelectiveAurora A and B InhibitorsAurora kinases are viewed as attractivepotential targets for anti-cancer ther-apy. The three human sub-types,Aurora A, B and C, are serine / threo-nine kinases that are only expressedduring mitosis and play a role in chro -mosome segregation and cytokinesis.Aurora A and B are over-expressed inparallel in multiple tumor types,whereas Aurora C is not. The presenta-tion will outline the identification andoptimization of quinazoline basedinhibitors that are selective for eitherAurora A or Aurora B.

Michael Block began his careerwith a 1st class honors degree in Chem-istry from the University of Edinburghin 1982 and then moved to the Univer -sity of Cambridge to study for his Ph.D.with Professor Alan Battersby, workingon the synthesis of Vitamin B12 biosyn-thetic precursors. From 1985 to 1987he held a NATO Postdoctoral Fellow-ship, working with Professor DavidCane at Brown University on synthesisof labeled biosynthetic precursors ofthe polyether antibiotic Monensin. In1988 he joined ICI Pharmaceuticals asa medicinal chemist and has remainedwith the company as it first becameZeneca and then through a mergerbecame AstraZeneca. He has workedin a number of different disease areas,focusing in the early part of his careeron cardiovascular and antibacterialtherapy, and including two years inprocess research and development.From 1997 to 2002 he was involved inbuilding research at AstraZeneca in thearea of diabetes and obesity. In March2002 he moved to Boston to help leadthe newly established Oncologyresearch group, and formally took upthe position of Director of Chemistryfor Cancer at the AstraZeneca R&Dsite in Boston in January 2004.◆◆

SymposiumContinued from page 8

The Northeastern Section of the Amer-ican Chemical Society (NESACS) andthe Education Committee of the North-eastern Section invite high schoolchemistry teachers to a program atBurlington High School (Burlington,MA) on Wednesday, October 18th, 3:30– 8:00 PM. This program will helpconnect high school teachers with thenumerous education resources that areavailable from the American ChemicalSociety. Five workshops will beoffered that involve hands-on activitiesin computer programs for quantumproperties that determine molecularbehavior, in using probes for data col-lection and analysis in the laboratory,using engineering in traditional chemi-cal topics, exploring the NationalChemistry Week theme Your Home:It’s All Built on Chemistry, and startingan ACS sponsored high school chem-istry club, as a partner with the ACSStudent Affiliates Program for collegestudents.

Program3:30 – 4:00 Registration and

Refreshments4:00 – 4:25 Welcome and Overview4:30 – 6:10 Workshops6:15 – 8:00 Dinner and Keynote

AddressThe deadline for registration is Fri-day, October13th. The registration feeis $18.00 and is non-refundable afterOctober 11th. Workshop and program-related materials, dinner, a one-yearsubscription to ChemMatters, and acertificate for three hours of Profes-sional Development will be providedto all workshop participants. The detailed program and registrationform can be obtained from theNESACS Web site www.nesacs.orgunder Connections to Chemistry 2006.For additional information, contact Dr.Ruth Tanner, Chair, Education Com-mittee, NESACS: 978/934-3662 [email protected] ◆◆

Connections To Chemistry2006

Your one-stop source to career-relatedlinks in the Chemical Sciences

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Awards Meeting at Northeastern University

Forty-Eighth Annual Avery A. AshdownHigh School Chemistry Contest

STUDENT SCHOOL TEACHER/ADVISORFirst Place-The Simmons College AwardErbo Xu Lexington H. S. Judith Scott

Second PlacePatrick Wu Acton-Boxborough H.S. Carol Murphree

Third Place(tie)Vivek R. Sant Andover H. S. Leo LafondMichael J. Shu Andover H.S. Leo LafondMatthew Arsenault Burlington H.S. Peter Nassiff

Honorable Mention – First YearDaniel Fudenberg Lexington H.S. Jeffrey ShorterWoosuk Hong Groton School Sandra KellyJames Pelletier Attleboro H.S. Catherine Botsford-MilneWarren Tai Lexington H.S. Jim WoodJanice He Groton School Sandra KellyJennifer Schloss Concord-Carlisle H.S. Michael VelaWinston S. Hill Belmont H.S. Kathy McGrane

Honorable Mention – Second YearAndrew Feldman Framingham H.S. Ronee KrashesJohn T. Cheng Andover H.S. Leo LafondZara Seibel Wayland H.S. Jay ChandlerJeffrey Yuan Wayland H.S. Jay ChandlerRussell Wolf Wayland H.S. Jay ChandlerAnandh Swaminathan Acton-Boxborough H.S Carol MurphreeGeorge Hong Acton-Boxborough H.S Carol Murphree

The Phillip Levins Memorial PrizeXiaoxuan Shen University of New Hampshire Prof. Sterling

A.Tomellini, Advisor

2006 Undergraduate Research ScholarsJames Flack Norris and Theodore William RichardsScholars

Boston CollegeKerry Heinzelmann Prof. Evan Kantrowitz, AdvisorSynthesis of New Inhibitors of Dihydrooratase

Harvard CollegeChayasith Uttamapinant Prof. Gregory Verdine, AdvisorSynthesis of 4’-fluorinated Oligonucleotides and Their

Use as RNA Glycosylase Inhibitors

Massachusetts Institute of TechnologyJessica Lynch Prof. Timothy Swager, AdvisorEngineering a Monovalent Avidin with Femtomolar Affinity

University of Massachusetts DartmouthTodd Andrade Prof. Donald W. Boerth, AdvisorDNA adduct formation in plants by interaction with phenoxy

and carbamate pesticides

NESACS Undergraduate Grants-in-AidBrandeis UniversityJessica C. DeMott Prof. Oleg V. Ozerov, AdisorHypercoordinate Main Group PNP Pincer Complexes

Simmons CollegeTania M. Cabrera Prof. Richard Gurey, AdvisorControlling the size, orientation, density, and nucleation of calcium oxalate

monohydrate crystals using self-assembled monolayers

Stonehill CollegeJessica N. Falco Prof. Louis J. Liotta, AdvisrThe Synthesis of Vinyl Pyrrolidine and Subsequent Synthesis of Polyhudroxy-

lated Pyrrolidines from Commercially Available Sugars

Stonehill CollegeJames T. Hummel Prof. Louis J. Liotta, AdvisoThe Synthesis of Vinyl and Polyhydroxylated Pyrrolidines and Subsequent

Purification using High Performance Liquid Chromatography

Dr. Phyllis A. Brauner Memorial Book AwardHarvard UniversityAlisa A. Mueller Prof. Gregory Verdine, Adviso

Project SEEDBoston UniversityMentor: Prof. John SnyderChernita Sprinkle BostonRafael Vega-Constabile Brighton

Northeastern UniversityMentor: Dr. Patricia A. MabroukRui Qiao (Cindy) Guan BostonYingxian (Sammantha) Lu Dorchester

Stonehill CollegeMentor: Dr. Cheryl SchnitzerDiane Deng RandolphKevin Deane BrocktonRyan P. Lake BrocktonNathan Joe Macedo New BedfordJohn Sirois North Easton

The Theodore Williams Richards Award for Excellence in Teaching

Arthur Giovannangeli, Jr. Contoocook Valley Regional H.S., Peterborough, NHGary Sypteras Minuteman Regional H.S., Lexington, MA

Aula Landis SocietyLeo Lafond Andover High School, MACathleen Little Pinkerton Academy, NHKathy Liu Walnut Hill School, MARalph Sherwood Chelmsford High School, MA

Education Night, May 11, 2006

Left to right, new inductees into the Aula Landis Society, Cathleen Little of PinkertonAcademy, NH; Kathy Liu, Walnut Hill School, MA; Vivek R. Sant receiving the awardfor Leo Lafond, Andover High School, MA; and Ralph Sherwood, Chelmsford HighSchool, MA.


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Left to right, Wally Gleekman, retired Brookline HS, Chair of T. W. Richards AwardCommittee, Chris Doona, Army Materials Laboratory, Natick, member T. W. RichardsAward Committee, and Arthur Giovannangeli, Jr., from Contoocook Valley RegionalHigh School, Peterborough, NH, recipient of the Theodore William Richards Awardfor Secondary School Teaching.

Alisa Mueller of Harvard Univer-sity, Winner of the Dr. Phyllis A.Brauner Memorial Book Awardwith Susan Brauner, sister ofPhyllis Brauner.

Gary Sypteras of MinutemanRegional High School, Lexington,MA, recipient of the TheodoreWilliam Richards Award for Sec-ondary School Teaching, with Dr.Tim Rose, Brandeis University,member of the T. W. RichardsAward Committee.

Education Awards photos by Eileen Yue


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Check the NESACS Homepagefor late additions:http://www.NESACS.orgNote also the Chemistry Department webpages for travel directions and updates.These include:http://chemserv.bc.edu/seminar.htmlhttp://www.bu.edu/chemistry/events/http://www.chem.brandeis.edu/colloquium.shtmlhttp://www-chem.harvard.edu/events/http://web.mit.edu/chemistry/www.chem.neu.edu/web/calendar/index.htmlhttp://chem.tufts.edu/seminars.html [CHEM.]http://ase.tufts.edu/chemical/seminar.htm

[CHEM. ENGG.]http://www.chem.umb.edu/www.umassd.edu/cas/chemistry/seminars.cfmwww.uml.edu/Dept/Chemistry/speakers.htmlhttp://www.unh.edu/chemistry/seminars.html

SEP 7Dr. Jianshu Cao (MIT)“Statistical Analysis of Single MoleculeMeasurements”Boston College, Merkert 130 4:00PM

SEP 13Dr. James Golen (Univ. of Mass., Dartmouth)“So, You Want a Job”U. Mass Dartmouth, Building Group II, Rm 1154:00 PM

SEP 14Dr. Christopher Murray (IBM, T. J. WatsonResearch Center)“Preparation and Properties of MulticomponentNanocrystal Superlattices: Building withArtificial Atoms.”Boston College, Merkert 130 4:00PM

SEP 20Dr. Jeff Salisbury, Mayo Clinic, “Centrin-based Regulation of CentrioleDuplication”

U. Mass Dartmouth, Building Group II, Rom 1154:00 PM

SEP 21Dr. Norbert Scherer (Univ. of Chicago)Title: TBABoston College, Merkert 130 4:00PMProf. Eugene Barry (Univ. of Mass, Lowell)“The Capillary Column in Gas Chromatography:It Keeps Getting Better”Univ. of New Hampshire, Iddles Auditorium,Rm. L103 11:10AM

SEP 19Dr. Colin Nuckolls (Columbia University)Title: TBABoston College, Merkert 130 4:00PM

SEP 26Dr. Nicola Pohl (Iowa State University)Title: TBABoston College, Merkert 130 4:00PM

SEP 27Dr. Gary Weisman, Univ. of New Hampshire,Durham, “Cross-Bridged Tetraamine Ligands: Synthesis,Coordination Chemistry, and Biomedical Utility” U. Mass Dartmouth, Building Group II, Rm 1154:00 PM

SEP 28 Dr. Nicola Pohl (Iowa State University)Title: TBABoston College, Merkert 130 4:00PMProf. Roger Giese (Northeastern Univ.)“Measurement and Meaning of DNA Adducts”Univ. of New Hampshire, Iddles Auditorium, RM L103 11:10 AM

Notices for the NucleusCalendar should be sent to:Sheila E Rodman 250 Kennedy DriveUnit #403, Malden, MA 02148.E-MAIL: serodman(at)hotmail.com

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member of the Northeastern Section.Arno occupied most of the offices ofthe Section at various times, but hismost lasting contributions were madewhen he was the Editor of theNUCLEUS of the Northeastern Sec-tion. Under his guidance this publica-tion became the outstandingnewsletter among all those publishedby Sections of the American ChemicalSociety.

The prize is awarded annually to aperson or persons deemed to havemade the most important contribu-tion(s) to publications of the North-eastern Section. The awardee ischosen by the Arno Heyn Book PrizeCommittee which is chaired by theChair of the Publications Committee.Other Committee members include theEditor of the Nucleus, two members ofthe Board of Directors appointed bythe Section Chair, the Chair of theAwards Committee and the SectionChair, ex officio. The prize is a bookselected by the awardee, who is askedto choose a book that will have longtime meaning and value to her/him. Abookplate mounted inside the bookcover honors both the award recipientand the memory of Dr.Heyn. Presenta-tion of the award(s) takes place at theNovember meeting of the Section. ◆◆

Book PrizesContinued from page 10

sept06nucleus mikeviv web - nesacs · 2017. 10. 31. · houghton chemical company organix, inc....

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