sensing the swell by aoife morrin
TRANSCRIPT
![Page 1: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/1.jpg)
1
Sensing the Swell
Aoife Morrin Dublin City University
![Page 2: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/2.jpg)
Responsive materials
Formats amenable to
electrochemical control and sensing
Tissue Hydration Skin
Patch
Gas Sensor Skin Tattoo
Protein Mining in Skin ISF
• Non-invasive• Early detection of
eczema flare-ups
• Non-invasive• Detection of acetone
as a marker for occult liver pathology
• Minimally-invasive• Melanoma biomarker
extraction from ISF
Conformable, conducting materials for skin electronics
Conformable, responsive materials for skin gas sensing
Smart nanomaterials for protein capture in
skin
Gorey, B., Smyth, M.R., White, B., Morrin, A. (2014). Journal of Materials Chemistry C, 2(30):6004-6009.
![Page 3: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/3.jpg)
3
Semi-wet and typically inert – host-network Ability to control diffusional behaviour of
molecules Responsive swelling
Hydrogels
![Page 4: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/4.jpg)
4
Responsive swelling
![Page 5: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/5.jpg)
pH responsive hydrogel O
OO
O
NH2
OO
NH2+
O
OO
OH
NHO
ONH
OH
OO
O
PEGDGE Jeffamine EDR 148
Epoxy-amine network
![Page 6: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/6.jpg)
6
Conformable electrode substrate
Bare
1 coating
2 coatings
Tracking biospecific swelling using impedance
Z' /ohm
0 2000 4000 6000 8000 10000 12000 14000 16000 18000
- Z
'' / o
hm
0
5000
10000
15000
20000
25000
30000
35000
Water 1 uM glucose5 uM glucose10 uM glucose50 uM glucose100 uM glucose1 mM glucose3 mM glucose4 mM glucose 6 mM glucose10 mM glucose
1 mM glucose
10 mM glucose
….at least a 1000-fold improvement in LOD
MacKenna, N., Calvert, P., Morrin, A. (2015). Analyst. DOI: 10.1039/C4AN02252A
![Page 7: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/7.jpg)
7
MO
rGO
MO
Controlled release – electro-stimulation
MacKenna, N., Calvert, P., Morrin, A., Wallace, G.G., Moulton, S. (2015). J. Mater. Chem. B, 3:2530-2537.
![Page 8: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/8.jpg)
8
Time (min)
0 100 200 300 400
Sw
elli
ng
Rat
io
0
5
10
15
20
Increasing [acid]
Low pH(~ pH 3-
4)
O
OO
OH
NHO
ONH
OH
OO
O
High pH
Controlled release – pH-stimulation
![Page 9: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/9.jpg)
Response times
9
Disk Thick film
Not radically improved
Superporous
Aim to completely eliminate diffusional barrier
![Page 10: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/10.jpg)
10
Inducing superporosity Limitation on polymerisation using CO2 gas generation Oxygen gas generation via hydrogen peroxide catalysis
on Ag NPs
![Page 11: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/11.jpg)
11
Superporous hydrogels
![Page 12: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/12.jpg)
12
Response Times
Bulk Gel200-500 min
Superporous Gel20-40 s
![Page 13: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/13.jpg)
Following On…..
Tissue Hydration Skin
Patch
Gas Sensor Skin Tattoo
Protein Mining in Skin ISF
• Non-invasive• Early detection of
eczema flare-ups
• Non-invasive• Detection of acetone
as a marker for occult liver pathology
• Minimally-invasive• Melanoma biomarker
extraction from ISF
Conformable, conducting materials for skin electronics
Conformable, responsive materials for skin gas sensing
Smart nanomaterials for protein capture in
skin
![Page 14: Sensing the Swell by Aoife Morrin](https://reader031.vdocuments.mx/reader031/viewer/2022013003/55be863dbb61eb1f5b8b4606/html5/thumbnails/14.jpg)
Thanks!To my group and my collaborators:
Esp: Nicky MacKenna Prof. Paul Calvert Prof. Simon Moulton Prof. Gordon Wallace
14