sensing hypoxiasensing hypoxia in the cellin the cell and ... · sensing hypoxiasensing hypoxia in...
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Sensing HypoxiaSensing HypoxiaSensing HypoxiaSensing Hypoxia in the Cellin the Cellin the Cellin the Cell and the Organismand the Organismand the Organismand the Organism
September 20 September 20 September 20 September 20 –––– 23, 2012 23, 2012 23, 2012 23, 2012 Essen, GermanyEssen, GermanyEssen, GermanyEssen, Germany
COST ACTION TD0901COST ACTION TD0901COST ACTION TD0901COST ACTION TD0901
HypoxiaNet (COST TD0901) “Sensing Hypoxia in the Cell and the Organism”
September 20 – 23, 2012 Institut für Physiologie, Essen, Germany
Meeting chairmen: Prof. Joachim FANDREY, Essen Prof. Eric METZEN, Essen Scientific Advisory Committee: Dr. Eoin CUMMINS, Dublin Prof. Max GASSMANN, Zurich Prof. Dörthe KATSCHINSKI, Göttingen Dr. Olga KRIZANOVA, Bratislava Prof. José LÓPEZ-BARNEO, Sevilla Prof. Patrick MAXWELL, London Prof. Johanna MYLLYHARJU, Oulu Dr. Lara OGUNSHOLA, Zurich Prof. Silvia PASTOREKOVA, Bratislava Prof. Christopher PUGH, Oxford Dr. Cormac TAYLOR, Dublin Prof. Roland WENGER, Zurich Meeting Sponsors:
HypoxiaNet (COST TD0901) “Sensing Hypoxia in the Cell and the Organism”
September 20 – 23, 2012 Institut für Physiologie, Essen, Germany
Thursday, Sept. 20, 2012 12:00 – 13:50 Registration, light lunch
13:50 Welcome
14:00 – 16:00 Basic Science Workgroup 1 Roland Wenger
M. Coleman “2-Oxoglutarate Oxygenases Target the Protein Synthesis Apparatus“
S. Lee ”Switching proteome in response to oxygen tension”
D. Mole ”Dissecting the transcriptional and epigenetic response to hypoxia across the genome”
A. Görlach “Hypoxia and NOX enzymes“
H. Mairbäurl ”AMPK or hypoxia, what dominates the mitochondria?”
16:00 – 16:30 Coffee
16:30 – 18:30 Technology Workgroup 2 Johanna Myllyharju
M. Percy ”The region C terminal to the hydroxyacceptor proline of HIF-2alpha crucial for its regulation“
A. Bremm ”HIF-1alpha regulation by the Lys11-specific deubiquitinase Cezanne“
M. Queisser “Hoil-1L ubiquitin-ligase regulates cellular adaptation to hypoxia”
D. Hoogewijs ”A novel oxygen-binding globin expressed in the hypoxic testis”
L. Poellinger “Epigenetic Mechanisms Regulating the Hypoxic Response“
18:30 – 20:00 Dinner buffet
20:00 H. Franklin Bunn:
"Hypoxia, Erythropoiesis and Novel Approaches to Treating Anemias"
HypoxiaNet (COST TD0901) “Sensing Hypoxia in the Cell and the Organism”
September 20 – 23, 2012 Institut für Physiologie, Essen, Germany
Friday, Sept. 21, 2012
08:30 – 10:30 Pharmacology Workgroup 3 Teresa Pereira
O. Krizanova “NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model“
P. McLoughlin “Gremlin plays a key, lung specific role in hypoxic pulmonary hypertension“
L. Ogunshola “Hypoxia and blood-brain barrier dysfunction: Is HIF-1 the culprit?“
P. Sonveaux “Targeting the lactate transporter MCT1 inhibits lactate-induced HIF-1 activation and tumor angiogenesis“
V. Sée “Cellular adaptation to low oxygen environment; live cell imaging and systems biology approaches“
10:30 – 11:00 Coffee
11:00 – 11:30 Celeste Simon: “Hypoxia, Metabolism, and Tumor Progression”
11:30 – 13:00 Translational medicine Workgroup 4 Max Gassmann
M. Schneider ”Translational aspects of oxygen sensing in visceral medicine”
M. Bernaudin ”Hypoxia, Erythropoietin and Brain Tumor“
J. Myllyharju ”Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis”
T. Serebrovskaya “How different intermittent hypoxia training (IHT) modalities influence tissue oxygenation and mitochondrial metabolism“
13:00 – 14:00 Lunch buffet
14:00 – 16:00 Inflammatory Hypoxia Thorsten Cramer
C. Taylor “Hydroxylase-dependent regulation of Interleukin-1-induced inflammatory pathways“
B. Brüne ”Impact of hypoxia/HIF-1 on plasmacytoid DC development”
B. Marteyn ”Local hypoxia induction during Shigella infection”
M. von Köckritz-Blickwede ”Novel role of HIF-1Α in the formation of antimicrobial mast cell extracellular traps“
S. Walmsley “Regulation of neutrophilic inflammation by the HIF/PHD pathway“
V. Kempf
“Activation of HIF-1 in infections: mechanisms and functional consequences”
16:00 – 16:30 Coffee
16:30 – 18:30 10 short selected presentations from posters Carine Michiels Bakker, W (#2) – Binó, L (#5) – Bonafé, M (#6) – Bosco, M (#7) – Gardie, B (#12) Kunze, R (#21) – Mylonis, I (#27) – Neumann, D (#29) – Papkovsky, D (#31) – Skapare, E (#35)
18:30 – 21:30 Running dinner poster session combined with industrial exhibition and presentation
HypoxiaNet (COST TD0901) “Sensing Hypoxia in the Cell and the Organism”
September 20 – 23, 2012 Institut für Physiologie, Essen, Germany
Saturday, Sept. 22, 2012
08:30 – 10:30 Workshop Animal Models in Hypoxia Research Chris Pugh
V. Haase “Insights into oxygen-dependent regulation of erythropoiesis from animal models“
S. Renshaw "Zebrafish as a model for studying hypoxia signalling in vivo“
D. Abele “Marine fish and invertebrates - a bottom up view of HIF pathway evolution“
A. Avivi “Hypoxia-Tolerance and Cancer Resistance in the Subterranean Rodent, the Blind Mole-Rat, Spalax“
T. Hankeln “Respiration in insects: the evolution and functional relevance of globins”
10:30 – 11:00 Coffee
11:00 – 11:30 Peter J. Ratcliffe: “Oxygen sensing by 2-OG oxygenases“
11:30 – 12:30 Transcriptional Regulation Eric Metzen
P. Jaakola “P62/SQSTM1 regulates Hypoxia Response by Attenuating PHD3 Activity through Aggregate Sequestration and Enhanced Degradation“
J. Schödel “Genome-wide HIF-binding in renal cancer“
D. Villar Lozano “Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions“
12:30 – 13:30 Lunch buffet
13:30 – 15:30 Metabolism Dörthe Katschinski
J. Aragonés López ”The role of the HIF2α oxygen-sensing pathway on mtorc1 activity“
M. Deckers “Mitochondrial dynamics“
S. Behrends ”Heme oxygenase isoforms differ in their subcellular trafficking during hypoxia and are differentially modulated by cytochrome P450 reductase”
N. Forsyth “BMP2 repression and engineered oxygen control measures promote human mesenchymal stem cell recovery“
B. Wielockx ”HIF-1α is a Protective Factor in Conditional PHD2 Deficient Mice Suffering from Severe HIF-2α-Induced Excessive Erythropoiesis”
15:30 – 16:00 Walk/transfer to Margarethenhöhe
16:00 – 19:00 "Industrial Essen – Wealth and Responsibility"
19:00 Conference Dinner Hülsmannshof
HypoxiaNet (COST TD0901) “Sensing Hypoxia in the Cell and the Organism”
September 20 – 23, 2012 Institut für Physiologie, Essen, Germany
Sunday, Sept. 23, 2012
09:00 – 10:30 Oncology George Simos
S. Chouaib ”influence of hypoxic stress on anti-tumor response”
M. Evans “Ion channel regulation by the LKB1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level“
T. Gorr “Endogenous myoglobin in breast cancer cells and its unorthodox roles: an update”
E. Cummins “Mechanisms of hydroxylase-dependent intestinal epithelial cell protection“
E. Berra “The role of PHD3 SUMOylation in the cellular response to hypoxia“
10:30 – 11:00 Coffee
11:00 – 13:00 Systemic aspects Martina Muckenthaler
T. Acker “The Hypoxic Tumor Niche: Mechanisms and Therapeutic Perspectives“
J. Dulak ”HIF-regulated gene therapy for hind limb ischemia”
S. Rocha ”Oxygen Sensing and Key Biological Processes in the Cell“
N. Weissmann “Mechanisms of ischemia-reperfusion induced lung Injury – NADPH oxidases and TRPC channels“
G. Cairo “Hepcidin-dependent control of body iron homeostasis by erythropoiesis”
13:00 Lunch, End of scientific meeting
14:00 – 16:00 Management Committee Business Meeting (MC members only)