senior principal scientist or research scientist

8/6/2019 Senior Principal Scientist or Research Scientist

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ROBERT W. GOULET, Ph.D.20 Northwood Dr.Labadie, MO 63055(636) 742-2699 (Home)(636) 399-1632 (Cell)[email protected]

SummaryInsightful, deliberative Senior Principal Scientist with extensive knowledge indeveloping scientific programs, cheminformatic and computational chemistry toolsused in the pharmaceutical industry. These tools have impacted both local and global teams. Background includes developing several web-based tools. Used commercial tools and integrated them within internal computational environment. Am known for my ability to carefully indentify and weigh all options before making decisions, able to easily adapt to new situations and ensure project completion benefiting the organization and customer. Work well within a team or individually,continuously strive to learn, apply, teach and develop successful solutions using ingenious methods.

Professional ExperiencePfizer, Inc., St Louis, MO 2007 to PresentSenior Principal Scientist* Using experience from developing local patent analysis tools, significantly co

ntributed to the Global Patent Analysis Tools team goal of developing and delivering several tools by the end of 2009 enabling scientists to more easily and quickly get a better understanding of the IP space.* As member of the Structural and Computational Chemistry group in PGRD St Louis, developed innovative computational tools and procedures that enabled researches to test and evaluate drug candidates ensuring only the most desirable ones would be synthesized. Developed docking protocols, QSAR models, independently and in collaboration with computational chemists for use in Pfizeras compute infrastructure, as well as lead generation or scaffold hoping tools that became part ofa set of global Lead Generation tools.

Pfizer, Inc., Ann Arbor, MI 2004 to 2007Senior Principal Scientist

* As a member of a global team developing application to allow computational chemists to build and publish QSAR models, implemented many of the statistical components used, helped define and develop the standards of the application's components, as well as worked with end-users ensuring the application met their needsand was easy to use. This tool has been very well received by computational chemists within Discovery, PDM, and other groups becoming the preferred tool to develop and deploys QSAR models.* Served as leader of a global team that set the best practices and educating users in the publication of computational models within Pfizer's internal computing environment. Responsibilities included organizing team, setting goals, objectives, and holding monthly meetings. We successfully increased productivity of newmodel publications and their use via Pfizeras various global desktop applications.

* Key developer on a local Java application that bridged the computational biology and chemistry fields for use in evaluating targets drugability. Although we stopped development of this application, the requirements, work-flows, and use cases developed were incorporated into various global efforts.

Pfizer, Inc., Ann Arbor, MI 2001 to 2004Research Associate* As a member of global team developing a molecular visualization application, set the specifications for accessing and running computational models published on Pfizer's computational servers, defined and wrote the User Help documentation


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used within the application, as well as involved in developing and giving training classes on using the application. Also employed Contextual Inquiry and Use Testing expertise to the application design which has allowed users to work more efficiently with the application.* Using my knowledge and expertise in developing computational models/tools, worked on a global team to define standards for Pfizer's global computational servers. Because of this, it allowed a smooth transfer of all models from the local Ann Arbor environment to the global computational environment enabling the retirement of several applications, free up local resources and eliminate duplicationof effort saving the company money.* As a team member to streamline in vitro measurements of ADME/Tox properties, lead the development and implementation of a web-based application to calculate in silico ADME/Tox and other properties. The application was well received and used not only by team members, but by all scientists at the Ann Arbor laboratoriesand several other Pfizer research sites. Many of the best practices establishedin this application were incorporated into newer Pfizer tools.* Key member of the team that formed the BioImaging Center at Pfizer, Inc.. Based on my experience in using micro-CT to study the structural-mechanical properties of bone and strong computer background, defined the specifications for micro-CT usage and computer-network requirements of the Center.

Warner Lambert, Ann Arbor, MI 1997 to 2001Senior Scientist* Lead developer of web based tools which allowed computational chemists to post

alignment, pharmacophore, or docking models to a computational application server. Medical chemists on numerous projects used these tools and models to save time by testing hypotheses and/or assessing how well their ideas for ligands mightbind to a target before actually synthesizing them. Several compounds were nominated for further development as a direct result of ligands modeled utilizing these tools.* Coordinated efforts with Tripos, Inc. to conduct Contextual Inquiry/Use Testing studies to improve our local web-tools as well as their molecular visualization program used by the tools. This effort resulted in much easier and well received web-tools by Ann Arbor colleagues; and enabled the vendor to produce a much more marketable visualization tool.

Warner Lambert, Ann Arbor, MI 1996 to 1997

Senior Systems Programmer* Collaborated with the Informatics group to develop, setup, and implement automatic procedures to calculate several in silico PK/physiochemical properties which were loaded into the global corporate database; and to automatically update local copies of the corporate chemical structure database (in 2D and 3D formats) for use by Ann Arbor computational chemists in their analyses. These procedureswere later adopted by Pfizer in newer database systems.

Warner Lambert, Ann Arbor, MI 1995 to 1996Systems Programmer* Maintained and directed system administration for CADD computing environment,developed proposals/budgets for maintenance and future enhancements of CADD computing environment, installation of scientific software, coordinated licensing an

d software installation with vendors, and evaluated and recommended new softwarefor the group.* Acted as liaison between CADD group and Ann Arbor Data Center (AADC) for computer or networking issues.* Setup, maintained and served as webmaster for Ann Arbor CADD intranet website.

University of Michigan, Ann Arbor, MI 1993-1995Postdoctoral Fellow at the Orthopaedic Research Laboratories, Dept. of Orthopaedic Surgery* Developed software upgrades for specific segments controlling the micro-comput


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ed tomography (cone beam scanner developed by Dr. Lee Feldkamp) system in the Laboratory, and improved elements of the associated image reconstruction and analyses algorithms. Taught members of the Orthopaedic Research Labs how to operatethe micro-CT scanner, and worked with them to develop protocols for scanning andanalyzing specimens for their projects.* Research included the evaluation of a canine osteoarthritis model, the determination of structural and mechanical properties of cortical bone in a transgenetic mouse model, failure characterization of vertebral trabecular bone, and the assessment of structural and mechanical properties differences due to donor age inhuman vertebral trabecular tissue.

Relevant Skills:Programming: Perl, HTML, Python, Java, R(statistical)-scripting, MOE SVL, Daylight Toolkit, FORTRAN, C, JavaScript, CGI/Bin, CShellSoftware Development: Pipeline Pilot protocols, Perl and Python scripts, Web applications, Java applications, Java/Swing, GA and other scientific applications for use in the drug design process, 2D & 3D Image analysis and visualization programs

Software Packages: Computational Chemistry software (MOE, Tripos, Daylight, OpenEye, GOLD, Schrodinger), Pipeline Pilot, Spotfire, Image analysis programs, NetBeans, Eclipse, Dreamweaver, Microsoft Word, Microsoft Excel, Microsoft PowerPoint, Microsoft Visio, Statistical analysis programs

Operating Systems: UNIX, IRIX, Windows 2000/XP-Professional, Linux and Macintosh

Education:Ph.D. in Bioengineering December, 1993The University of Michigan, Ann Arbor, MIM.S.E. in Bioengineering December, 1986The University of Michigan, Ann Arbor, MIM.S.E. in Mechanical Engineering December, 1986The University of Michigan, Ann Arbor, MIB.S.E. in Engineering Science May, 1984The University of Michigan, Ann Arbor, MI

Ongoing professional development courses

Professional Societies / Activities:Member, The American Chemistry Society

Professional References:Available upon request

Publications / Presentations:Author on Peer Reviewed Journal Articles* Kibbey, C., Goulet, R.W., Hughes, J., Kuhn, M., Li, D., Luty, B., Samuelson, S., Schefzick, S. and Sng, S-T: In silico Model Generator (isMG): A QSPR ModelingEnvironment built on a Distributed Computing Framework, submitted in preparatio

n, 2009.* McCreadie, BR, Goulet, RW, Feldkamp, LA, Goldstein, SA: Hierarchical structureof bone and micro-computed tomography. Advances in Experimental Medicine and Biology, 469: 67-83, 2001.* Sherick, DG, Buchman, SR, Goulet, RW, Goldstein, SA: A new technique for the quantitative analysis of cranial suture biology. The Cleft Palate Craniofacial Journal, 37(1): 5-11, 2000.* Buchman, SR, Sherick, DG, Goulet, RW, Goldstein, SA: Use of microcomputed tomography scanning as a new technique for the evaluation of membranous bone. The Journal of Craniofacial Surgery, 9(1): 48-54, 1998.


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* Zysset, P.K., Goulet, R.W., Hollister, S.J.: A global relationship between trabecular bone morphology and homogenized elastic properties. Journal of Biomechanical Engineering, 120(5):640-646, 1998.* Guldberg, RE, Caldwell, NJ, Guo, XE, Goulet, RW, Hollister, SJ, Goldstein, SA:Mechanical stimulation of tissue repair in the hydraulic bone chamber. Journalof Bone and Mineral Research, 12(8): 1295-302, 1997.* Jepsen, KJ, Schaffler, MB, Kuhn, JL, Goulet, RW, Bonadio, J, Goldstein, SA: Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue. Journal of Biomechanics, 30(11-12): 1141-7, 1997.* Dedrick, DK, Goulet, RW, O'Connor, BL, Brandt, KD: Preliminary report: increased porosity of the subchondral plate in an accelerated canine model of osteoarthritis. Osteoarthritis and Cartilage, 5(1): 71-4, 1997.* Goulet, R.W., Goldstein, S.A., Ciarelli, M.J., Kuhn, J.L, Brown, M.B., Feldkamp, L.A.: The relationship between the structural and orthogonal mechanical properties of trabecular bone. Journal of Biomechanics, 27(4):375-389, 1994.* Dedrick, D.K., Goldstein, S.A., Brandt, K.D., O'Connor, B.L., Goulet, R.W., Albrecht, M.: A longitudinal study of subchondral plate and trabecular bone in cruciate-deficient dogs with osteoarthritis followed up for 54 months. Arthritis& Rheumatism, 36(10): 1460-1467, 1993.* Goldstein, S.A., Goulet, R.W., and McCubbrey, D.A.: Measurement and significance of three dimensional architecture to the mechanical integrity of trabecularbone. Calcif. Tissue Int., 53(Supp 1): S127-S133, 1993.* Fyhrie, D.P., Fazzalari, N.L., Goulet, R.W., Goldstein, S.A.: Direct calculation of the surface-to-volume ratio for human cancellous bone. Journal of Biomec

hanics, 26(8):955-967, 1992.* Dedrick, D.K., Goulet, R., Huston, L., Goldstein, S.A., Bole, G.G.: Early bone changes in experimental osteoarthritis using microscopic computed tomography.Journal of Rheumatology, 27(18):44-45, 1991.* Kuhn, J.L., Goldstein, S.A., Feldkamp, L.A., Goulet, R.W., Jesion, G.: Evaluation of a microcomputed tomography system to study trabecular bone structure. Journal of Orthopaedic Research, 8(6):833-842, 1990.* Kuhn, J.L., Goulet, R.W, Pappas, M., Goldstein, S.A.: Morphometric and anisotropic symmetries of the canine distal femur. Journal of Orthopaedic Research, 8(5):776-780, 1990.* Layton, M.W., Goldstein, S.A, Goulet, R.W., Feldkamp, L.A., Bole, G.G.: Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computerized axial tomography. Journal of Arthritis and Rheumatism. 31(1

1):1400-1405, 1988.

Author on Published Abstracts* Ortwine, D.F., Dunbar, B.W., Goulet, R.W., Humblet, C.; Lunney, E.A.; Narasimhan, L.; O'Donnell, T.J.; Rojnuckaran, D.: Modeling on the web: Intranet-based drug design software. 224th ACS National Meeting, Boston, MA, United States, August 18-22, 2002.* Blankley, C.J., Gifford, E., Goulet, R.W., Humblet, C., OaDonnel, TJ: WebPK.5th Annual Drug Discovery Symposium, PGRD Ann Arbor Laboratories, 2000.* Goulet, R.W., Hollister, S.J.: Determination of minimum microstructural analysis volumes for trabecular bone using 3-D stereology and FFT analysis. Trans. of Ortho. Res. Soc., 21:715, 1996.* Smith, E.A., Guo, X.E., Goulet, R.W., Hollister, S.J., Goldstein, S.A.: Predi

ction of local strains in human vertebral bone specimens using CT-based finite element models. Trans. of Ortho. Res. Soc., 21:604, 1996.* Guo, X.E., Weissman, D.E., Goulet, R.W., Hollister, S.J., Derwin, K.A., Goldstein, S.A.: Characterization of local failure in vertebral trabecular bone. Trans. Orthop. Res. Soc., 20, 1995.* Dedrick, D.K., Goulet, R.W., O'Connor, B.L., Brandt, K.D.: Changes in subchondral plate and cancellous bone in an accelerated canine model of osteoarthritis.Trans. Orthop. Res. Soc., 20, 1995.

* McCubbrey, D.A., Mascha, E.J., Goulet, R.W., Goldstein, S.A.: Relationships between trabecular architecture and failure properties of whole vertebrae in the


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beagle. Trans. Orthop. Res. Soc., 19(1):55, 1994.* McCubbrey, D.A., Yian, E.H., Goulet, R.W., Shih, M-S., Parfitt, A.M., Goldstein, S.A.: The effects of calcitonin on trabecular bone properties in the ovariectomized beagle. Trans. Orthop. Res. Soc., 18(1):53, 1993.* McCubbrey, D.A., Cody, D.D., Gross, G.J., Goulet, R.W., Goldstein, S.A.: Relationships between cancellous density, architecture, and material properties of the human proximal femur. Trans. 9th International Workshop on Bone Densitometry, 1992.* Goulet, R.W., Feldkamp, L.A., Goldstein, S.A.: Quantification of the architecture of cancellous bone by surface and volume orientation methods. Trans. of Ortho. Res. Soc., 17:159, 1992.* McCubbrey, D.A., Goldstein, S.A., Cody, D.D., Goulet, R.W., and Kuhn, J.L.: The regional density, architectural, and tissue properties of vertebral trabecular bone and their relation to whole bone failure properties. Trans. ASME WinterAnnual Mtg., 20:575-578, 1991.* Dedrick, D.K., Goulet, R.W., Widmer, W.R., O'Connor, B.L., Brandt, K.D., Goldstein, S.A.: Evaluation of trabecular bone in experimentally induced canine osteoarthritis. Trans. Ortho. Res. Soc., 16:332, 1991.* McCubbrey, D.A., Goulet, R.W., Goldstein, S.A., Shulick, A.M.: Vertebral bodyarchitecture and mechanical properties alterations due to ovariectomy in the beagle. Trans. Ortho. Res. Soc., 16:284, 1991.* Dedrick, D.K., Brandt, K., Goulet, R.W., Goldstein, S.A., O'Connor, B.: Subchondral plate (SP) and trabecular (T) bone in experimental osteoarthritis (OA).Arthritis and Rheumatism, 33(9):S91, 1990.

* Goldstein, S.A., Kuhn, J.L., Goulet, R.W., Choi, K., Hollister, S.J., Ciarelli, M.J., Matthews, L.S.: Properties and remodeling of trabecular bone. First World Congress of Biomech., 2:210, 1990.* Goldstein, S.A., Goulet, R.W., Kuhn, J.L., Feldkamp, L.A.: Experimental dataon cancellous bone architecture. First World Congress of Biomech., 2:45, 1990.* Hollister, S.J., Goulet, R.W., Goldstein, S.A.: Predicting trabecular bone stiffness using two methods of microstructural analysis. First World Congress ofBiomech., 1:210, 1990.* Hollister, S.J., Goldstein, S.A., Jepsen, K.J., Goulet, R.W.: Continuum and microstructural stress morphology relationships for trabecular bone subject to controlled implant loads. Trans. Ortho. Res. Soc., 15:74, 1990.* Dedrick, D.K., Goldstein, S.A., Goulet, R.W., Bole, G.G.: Early bone changesin experimental osteoarthritis. Arthritis and Rheumatism, 23(4):1095, 1989.

* Goulet, R.W., Feldkamp, L.A., Kubinski, D.J., Kuhn, J.L., Goldstein, S.A.: Predicting the architectural orientation of trabecular bone. Trans. Ortho. Res. Soc., 14:263, 1989.* Kuhn, J.L., Goulet, R.W., Goldstein, S.A., Feldkamp L.A.: A study of the variation of trabecular architectures in small volumes of bone using a micro-computedtomography system. J. Biomech., 21(10):853, 1988.* Layton, M.W., Goldstein, S.A., Goulet, R.W., Feldkamp, L.A., Bole, G.G.: Evaluation of subchondral bone architecture in experimental osteoarthritis by microscopic computerized axial tomography. Trans. Ortho. Res. Soc., 13:489, 1988.* Goldstein, S.A., Kuhn, J.L., Hollister, S.J., Goulet, R.W., Loubert, P.V., Sweet, K., Matthews, L.S.: The relationship between experimentally controlled loads and trabecular bone remodeling. Trans. Ortho. Res. Soc., 13:102, 1988.* Goulet, R.W., Ciarelli, M.J., Goldstein, S.A., Kuhn, J.L., Feldkamp, L.A., Kru

ger, D., Viviano, D., Champlain, F., Matthews, L.S.: The effects of architecture and morphology on the mechanical properties of trabecular bone. Trans. Ortho.Res. Soc., 13:73, 1988.* Goldstein, S.A., Ku, J.L., Hollister, S.J., Goulet, R.W., Champlain, F.W., Matthews, L.S.: Experimentally controlled trabecular bone remodeling: effects of applied stress. Trans. Ortho. Res.Soc., 12:461, 1987.* Goldstein, S.A., Ku, J.L., Goulet, R., Feldkamp, L.A., Ciarelli, M., Kruger, D., Jesion, G., Matthews, L.S.: The relationship between three-dimensional architecture of trabecular bone and its mechanical properties. 1987 Biomechanics Symposium, Amer. Soc. Mech. Engin., 84:287-89, June 1987.


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Presentations at National Conferences* aAn Integrated Desktop Computing Environment for Chemistsa, presented at the Bridging Pharma and IT conference, Boston, MA, September, 2007.* aComputational Chemistry Desktop Applications For Chemistsa, presented at theCHI Intelligent Drug Discovery & Development Conference, Philadelphia, PA, May,2003.* aMaking WebTools work for Chemistsa, presented at the 6th International Conference on Chemical Structures, in The Netherlands, June, 2002.* "Quantification of the Architecture of Cancellous Bone by Surface and Volume Orientation Methods", presented at the 38th meeting of the Orthopaedic Research Society, Washington, DC, February, 1992.* "Predicting the Architectural Orientation of Trabecular Bone," presented at the 35th meeting of the Orthopaedic Research Society, Las Vegas, NV, February, 1989.* "The Effects of Architecture and Morphology on the Mechanical Properties of Trabecular Bone," presented at the 34th meeting of the Orthopaedic Research Society, Atlanta, GA, February, 1988.

senior principal scientist or research scientist

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