semnalizarea transmembranara
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Semnalizarea transmb umf carol davilaTRANSCRIPT
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Semnalizarea transmembranara
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• "Variability is the law of life, and as no two faces are the same, so no two bodies are alike..."
Sir William Osler
• Lingvistica
• Semiotica
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Diversitate si specializare - comunicare
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• 75-100 mii de miliarde de celule: • 75 000 000 000 000 -100 000 000 000 000• 40 000 mii de miliarde : bacterii, in tracul digestiv
• 10% (4 000 miliarde): tesuturi solide• 40-45% din total celule sanguine si celule imune :
– 30 000 miliarde de celule rosii– 2 000 miliarde plachete– 500 milioane de leucocite– 1 000 miliarde limfocite si celule imune
– Durata de viata a hematiilor 120 zile
– 4 luni = formarea si disparitia a 30 000 miliarde de celule rosii– 120 zile = 10.4 milioane de secunde (10,368,000)
– 30 000 mld / 10.4 mil = 2.89 milioane hematii ~ 3 milioane/ secunda
Re: How many cells does a human lose every second?Date: Wed Feb 7 19:07:19 2001Posted By: Steve Mack, Post-doc/Fellow, Molecular and Cell Biology, Children's Hospital Oakland Research Institute
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Figure 2—10. Diagram illustrating how G proteins switch effectors on and off. (Modified and reprinted, with permission, from Linder M, Gilman AG: G proteins. Sci Am 1992;267:56.)
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Cyclic Nucleotide Metabolism - cAMP SIGMA-ALDRICH
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AMPciclic- PKA
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PLC-PKC-Ca2+
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Receptori cu activitate enzimatica intrinseca
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The Mitogen-activated Protein Kinase (MAPK) Cascades
SIGMA-ALDRICH
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Calea Jak-STAT
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The JAK/STAT Signaling Pathway SIGMA-ALDRICH
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Calea factorului de transcriptie NF-kB
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Apoptoza
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Actiunea hormonilor steroizi
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Concluzii
• Comunicarea permite integrarea functionala
• Moleculele de comunicare pot fi secretate sau exprimate pe suprafata
• In patologie comunicarea este alterata
• Unele molecule actioneaza la suprafata altele au receptori intracelulari
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Concluzii II
• Transferul de informatie se realizeaza pe cai prestabilite
• Caile se pot intersecta (noduri de comunicare)
• Farmacologia semnifica manipularea cailor de semnalizare
• Literatura legata de comunicarea celulara ampla, in mare masura gratuita
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